{"id":"https://openalex.org/W2080994879","doi":"https://doi.org/10.1109/nems.2012.6196728","title":"Closed-looped nano stimulation microscope for living cell membrane","display_name":"Closed-looped nano stimulation microscope for living cell membrane","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W2080994879","doi":"https://doi.org/10.1109/nems.2012.6196728","mag":"2080994879"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2012.6196728","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2012.6196728","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057532667","display_name":"Takayuki Hoshino","orcid":"https://orcid.org/0000-0003-4376-7853"},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]},{"id":"https://openalex.org/I127317711","display_name":"Tokyo University of Agriculture","ror":"https://ror.org/05crbcr45","country_code":"JP","type":"education","lineage":["https://openalex.org/I127317711"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takayuki Hoshino","raw_affiliation_strings":["Bio-Application and Systems Engineering, Tokyo University of Agriculture\uc2a0and\uc2a0Technology, Tokyo, Japan","[Bio-Application and Systems Engineering, Tokyo University of Agriculture and Technology, Japan]"],"affiliations":[{"raw_affiliation_string":"Bio-Application and Systems Engineering, Tokyo University of Agriculture\uc2a0and\uc2a0Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I127317711"]},{"raw_affiliation_string":"[Bio-Application and Systems Engineering, Tokyo University of Agriculture and Technology, Japan]","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054498473","display_name":"Keisuke Morishima","orcid":"https://orcid.org/0000-0003-1146-3900"},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"Osaka University","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]},{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Morishima","raw_affiliation_strings":["Tokyo Noko Daigaku, Fuchu, Tokyo, JP","[Osaka University,Japan]"],"affiliations":[{"raw_affiliation_string":"Tokyo Noko Daigaku, Fuchu, Tokyo, JP","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"[Osaka University,Japan]","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057532667"],"corresponding_institution_ids":["https://openalex.org/I127317711","https://openalex.org/I92614990"],"apc_list":null,"apc_paid":null,"fwci":0.2851,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.77228302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"264","issue":null,"first_page":"82","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microscope","display_name":"Microscope","score":0.7576161623001099},{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.6811972260475159},{"id":"https://openalex.org/keywords/electron-beam-induced-deposition","display_name":"Electron beam-induced deposition","score":0.6427546739578247},{"id":"https://openalex.org/keywords/electron-microscope","display_name":"Electron microscope","score":0.5934631824493408},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5481727719306946},{"id":"https://openalex.org/keywords/scanning-electron-microscope","display_name":"Scanning electron microscope","score":0.537107527256012},{"id":"https://openalex.org/keywords/environmental-scanning-electron-microscope","display_name":"Environmental scanning electron microscope","score":0.531234085559845},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.48903927206993103},{"id":"https://openalex.org/keywords/electron-beam-lithography","display_name":"Electron-beam lithography","score":0.48843351006507874},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.48639729619026184},{"id":"https://openalex.org/keywords/conventional-transmission-electron-microscope","display_name":"Conventional transmission electron microscope","score":0.46352726221084595},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.39280304312705994},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.3258282244205475},{"id":"https://openalex.org/keywords/scanning-transmission-electron-microscopy","display_name":"Scanning transmission electron microscopy","score":0.14915725588798523},{"id":"https://openalex.org/keywords/resist","display_name":"Resist","score":0.12365052103996277},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11527964472770691},{"id":"https://openalex.org/keywords/transmission-electron-microscopy","display_name":"Transmission electron microscopy","score":0.1013871431350708}],"concepts":[{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.7576161623001099},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.6811972260475159},{"id":"https://openalex.org/C109486029","wikidata":"https://www.wikidata.org/wiki/Q5358152","display_name":"Electron beam-induced deposition","level":4,"score":0.6427546739578247},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.5934631824493408},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5481727719306946},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.537107527256012},{"id":"https://openalex.org/C55171895","wikidata":"https://www.wikidata.org/wiki/Q268401","display_name":"Environmental scanning electron microscope","level":3,"score":0.531234085559845},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.48903927206993103},{"id":"https://openalex.org/C200274948","wikidata":"https://www.wikidata.org/wiki/Q256845","display_name":"Electron-beam lithography","level":4,"score":0.48843351006507874},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.48639729619026184},{"id":"https://openalex.org/C178423520","wikidata":"https://www.wikidata.org/wiki/Q744818","display_name":"Conventional transmission electron microscope","level":4,"score":0.46352726221084595},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.39280304312705994},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3258282244205475},{"id":"https://openalex.org/C193016168","wikidata":"https://www.wikidata.org/wiki/Q874835","display_name":"Scanning transmission electron microscopy","level":3,"score":0.14915725588798523},{"id":"https://openalex.org/C53524968","wikidata":"https://www.wikidata.org/wiki/Q7315582","display_name":"Resist","level":3,"score":0.12365052103996277},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11527964472770691},{"id":"https://openalex.org/C146088050","wikidata":"https://www.wikidata.org/wiki/Q744818","display_name":"Transmission electron microscopy","level":2,"score":0.1013871431350708},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2012.6196728","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2012.6196728","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.6899999976158142}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1512126150","https://openalex.org/W1798313689","https://openalex.org/W1985329155","https://openalex.org/W1997501675","https://openalex.org/W2027939064","https://openalex.org/W2035059163","https://openalex.org/W2045018157","https://openalex.org/W2048926109","https://openalex.org/W2051430013","https://openalex.org/W2054960141","https://openalex.org/W2059413398","https://openalex.org/W2061099450","https://openalex.org/W2066224389","https://openalex.org/W2073671748","https://openalex.org/W2084100886","https://openalex.org/W2086032212","https://openalex.org/W2132218454","https://openalex.org/W2167235502","https://openalex.org/W2181827306","https://openalex.org/W2344165305","https://openalex.org/W6686079009"],"related_works":["https://openalex.org/W3039167395","https://openalex.org/W2290513624","https://openalex.org/W1979145844","https://openalex.org/W2079504822","https://openalex.org/W2125728177","https://openalex.org/W1967739121","https://openalex.org/W1637668819","https://openalex.org/W4240354518","https://openalex.org/W2001632281","https://openalex.org/W1585549528"],"abstract_inverted_index":{"Electron-beam":[0],"could":[1,97],"stimulate":[2],"a":[3,8,14,24,39,75],"living":[4,33],"cell":[5,34,47,57,80,131],"membrane":[6],"through":[7],"100-nm-thick":[9],"SiN":[10],"nanomembrane.":[11],"We":[12,109,133],"designed":[13],"co-axial":[15,161],"dual":[16],"microscope":[17,26,37,62,120],"with":[18,114],"an":[19],"electron-beam":[20,84,96],"lithography":[21],"system":[22,31,42,117,129,158],"and":[23,49,71,82,101,118],"fluorescence":[25,45,61,119],"to":[27,74,144,154],"investigate":[28],"bio-molecular":[29],"dynamic":[30],"of":[32,59,67,94,126,138],"membrane.":[35,132],"This":[36],"had":[38],"closed-looped":[40],"controlling":[41],"using":[43],"the":[44,50,60,64,68,72,79,83,95,106,112,123,127,136,139,146,150],"live":[46,56],"imaging":[48,58],"electron":[51],"beam":[52],"induced":[53],"stimulation.":[54],"The":[55],"provides":[63],"chemical":[65],"identity":[66],"target":[69,107,151],"molecule":[70,141],"response":[73],"following":[76],"stimulation":[77,88,104,116],"on":[78,105,130,149,159],"membrane,":[81],"can":[85],"induce":[86],"electro-chemical":[87],"in":[89],"hundreds":[90],"nanometer":[91],"resolution.":[92],"Scanning":[93],"provide":[98,122],"high-speed,":[99],"precise,":[100],"large":[102],"scale":[103],"molecules.":[108],"attempted":[110],"that":[111],"combination":[113],"this":[115,160],"would":[121],"closed-loop":[124,156],"control":[125,157],"bio-molecule":[128],"proposed":[134],"here":[135],"concept":[137],"virtual":[140],"environmental":[142],"display":[143],"study":[145],"functional":[147],"changes":[148],"behavior":[152],"due":[153],"our":[155],"microscope.":[162]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}