{"id":"https://openalex.org/W2108015506","doi":"https://doi.org/10.1109/nems.2011.6017326","title":"Imaging and measuring the protein distribution of lymphoma cells using atomic force microscopy","display_name":"Imaging and measuring the protein distribution of lymphoma cells using atomic force microscopy","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W2108015506","doi":"https://doi.org/10.1109/nems.2011.6017326","mag":"2108015506"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2011.6017326","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2011.6017326","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100453893","display_name":"Mi Li","orcid":"https://orcid.org/0000-0002-8379-0057"},"institutions":[{"id":"https://openalex.org/I142078773","display_name":"Shenyang Institute of Automation","ror":"https://ror.org/00ft6nj33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I142078773","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mi Li","raw_affiliation_strings":["Chinese Academy and Sciences, Beijing, China","State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, China","State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China"],"affiliations":[{"raw_affiliation_string":"Chinese Academy and Sciences, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China","institution_ids":["https://openalex.org/I142078773","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040326170","display_name":"Lianqing Liu","orcid":"https://orcid.org/0000-0002-2271-5870"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I142078773","display_name":"Shenyang Institute of Automation","ror":"https://ror.org/00ft6nj33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I142078773","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianqing Liu","raw_affiliation_strings":["State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China","institution_ids":["https://openalex.org/I142078773","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023212284","display_name":"Ning Xi","orcid":"https://orcid.org/0000-0001-8276-5696"},"institutions":[{"id":"https://openalex.org/I142078773","display_name":"Shenyang Institute of Automation","ror":"https://ror.org/00ft6nj33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I142078773","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ning Xi","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA","State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China","institution_ids":["https://openalex.org/I142078773","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037720177","display_name":"Yuechao Wang","orcid":"https://orcid.org/0000-0002-4062-6898"},"institutions":[{"id":"https://openalex.org/I142078773","display_name":"Shenyang Institute of Automation","ror":"https://ror.org/00ft6nj33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I142078773","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuechao Wang","raw_affiliation_strings":["State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China","institution_ids":["https://openalex.org/I142078773","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109102616","display_name":"Zaili Dong","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I142078773","display_name":"Shenyang Institute of Automation","ror":"https://ror.org/00ft6nj33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I142078773","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zaili Dong","raw_affiliation_strings":["State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China","institution_ids":["https://openalex.org/I142078773","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079186859","display_name":"Guangyong Li","orcid":"https://orcid.org/0000-0002-4999-5710"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I142078773","display_name":"Shenyang Institute of Automation","ror":"https://ror.org/00ft6nj33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I142078773","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Guangyong Li","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, USA","State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China","institution_ids":["https://openalex.org/I142078773","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064074469","display_name":"Osamu Tabata","orcid":"https://orcid.org/0000-0002-9192-0544"},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Tabata","raw_affiliation_strings":["Department of Micro Engineering, Kyoto University, Kyoto, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Micro Engineering, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069785333","display_name":"Xiubin Xiao","orcid":null},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiubin Xiao","raw_affiliation_strings":["Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069604153","display_name":"Weijing Zhang","orcid":"https://orcid.org/0000-0003-0730-7606"},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijing Zhang","raw_affiliation_strings":["Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I2802541053"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5100453893"],"corresponding_institution_ids":["https://openalex.org/I142078773","https://openalex.org/I19820366","https://openalex.org/I4210112820"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15443507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"188","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12224","display_name":"Nanofabrication and Lithography Techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12466","display_name":"Near-Field Optical Microscopy","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atomic-force-microscopy","display_name":"Atomic force microscopy","score":0.7240667343139648},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5610691905021667},{"id":"https://openalex.org/keywords/force-spectroscopy","display_name":"Force spectroscopy","score":0.5449177622795105},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.5066555142402649},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.49409106373786926},{"id":"https://openalex.org/keywords/monoclonal-antibody","display_name":"Monoclonal antibody","score":0.44762465357780457},{"id":"https://openalex.org/keywords/suspension-culture","display_name":"Suspension culture","score":0.43422043323516846},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.4138127863407135},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"Molecular imaging","score":0.4106265604496002},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.39043521881103516},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.387717068195343},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.25827208161354065},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.25639718770980835},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.11326467990875244},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10302460193634033},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08257538080215454}],"concepts":[{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.7240667343139648},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5610691905021667},{"id":"https://openalex.org/C119473381","wikidata":"https://www.wikidata.org/wiki/Q49298","display_name":"Force spectroscopy","level":3,"score":0.5449177622795105},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5066555142402649},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.49409106373786926},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.44762465357780457},{"id":"https://openalex.org/C2993787908","wikidata":"https://www.wikidata.org/wiki/Q189111","display_name":"Suspension culture","level":3,"score":0.43422043323516846},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4138127863407135},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.4106265604496002},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39043521881103516},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.387717068195343},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25827208161354065},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.25639718770980835},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11326467990875244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10302460193634033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08257538080215454},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/nems.2011.6017326","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2011.6017326","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},{"id":"pmh:oai:hub.hku.hk:10722/213203","is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/213203","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference_Paper"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1512026049","https://openalex.org/W1608019706","https://openalex.org/W1966386667","https://openalex.org/W1971040914","https://openalex.org/W1974388785","https://openalex.org/W1974941450","https://openalex.org/W1985900564","https://openalex.org/W1996710470","https://openalex.org/W1999160007","https://openalex.org/W2000426297","https://openalex.org/W2005545805","https://openalex.org/W2014440750","https://openalex.org/W2069706217","https://openalex.org/W2075185987","https://openalex.org/W2078861590","https://openalex.org/W2089154372","https://openalex.org/W2091291743","https://openalex.org/W2101995865","https://openalex.org/W2106059993","https://openalex.org/W2110569167","https://openalex.org/W2114845832","https://openalex.org/W2118224516","https://openalex.org/W2118354484","https://openalex.org/W2170755361","https://openalex.org/W3150248096"],"related_works":["https://openalex.org/W2358867906","https://openalex.org/W2754534125","https://openalex.org/W2966850207","https://openalex.org/W2810374473","https://openalex.org/W2951904964","https://openalex.org/W2435530302","https://openalex.org/W4394343277","https://openalex.org/W4394473706","https://openalex.org/W4394329934","https://openalex.org/W4248339225"],"abstract_inverted_index":{"Atomic":[0],"force":[1],"microscopy":[2],"(AFM)":[3],"has":[4],"proven":[5],"to":[6,40,49],"be":[7],"a":[8,118],"powerful":[9],"tool":[10],"for":[11,121,129],"imaging":[12],"the":[13,21,50,55,58,86,90,104,127,133],"topographic":[14],"properties":[15],"of":[16,43,57,132,136],"biological":[17],"samples":[18],"and":[19,28,54,73],"measuring":[20],"molecular":[22,29,134],"specific":[23],"binding":[24],"forces":[25],"at":[26],"cellular":[27],"levels.":[30],"However,":[31],"there":[32],"are":[33],"still":[34],"great":[35],"difficulties":[36],"in":[37,69,78],"using":[38],"AFM":[39,77,105],"acquire":[41],"images":[42],"mammalian":[44,124],"suspension":[45,51,123],"live":[46,65],"cells":[47,66],"due":[48],"growth":[52],"manner":[53],"softness":[56],"cell":[59,92],"membrane.":[60],"In":[61,84],"this":[62],"paper,":[63],"lymphoma":[64,91],"were":[67],"trapped":[68],"microfabricated":[70,114],"patterned":[71,115],"pillars":[72,116],"then":[74],"imaged":[75],"by":[76,97],"phosphate":[79],"buffered":[80],"saline":[81],"(PBS)":[82],"solution.":[83],"addition,":[85],"CD20":[87],"distribution":[88],"on":[89],"surface":[93],"was":[94],"visualized":[95],"three-dimensionally":[96],"tethering":[98],"rituximabs":[99],"(anti-CD20":[100],"monoclonal":[101],"antibody)":[102],"onto":[103],"tips.":[106],"The":[107],"experimental":[108],"results":[109],"indicate":[110],"that":[111],"immobilization":[112],"with":[113],"provides":[117],"novel":[119],"way":[120,128],"anchoring":[122],"cells,":[125],"opening":[126],"further":[130],"investigation":[131],"mechanisms":[135],"rituximab's":[137],"anti-cancer":[138],"effect.":[139]},"counts_by_year":[],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}