{"id":"https://openalex.org/W2086450427","doi":"https://doi.org/10.1109/nems.2010.5592478","title":"Investigation of a PDMS based micromixer for heterogeneous immunoassays of insulin","display_name":"Investigation of a PDMS based micromixer for heterogeneous immunoassays of insulin","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2086450427","doi":"https://doi.org/10.1109/nems.2010.5592478","mag":"2086450427"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2010.5592478","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2010.5592478","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009536465","display_name":"Zhikun Zhan","orcid":"https://orcid.org/0000-0002-9931-3300"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I142078773","display_name":"Shenyang Institute of Automation","ror":"https://ror.org/00ft6nj33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I142078773","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhikun Zhan","raw_affiliation_strings":["Chinese Academy of Sciences, Beijing, China","State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy and Sciences, Shenyang, China"],"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy and Sciences, Shenyang, China","institution_ids":["https://openalex.org/I142078773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103501433","display_name":"Yanli Qu","orcid":null},"institutions":[{"id":"https://openalex.org/I142078773","display_name":"Shenyang Institute of Automation","ror":"https://ror.org/00ft6nj33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I142078773","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanli Qu","raw_affiliation_strings":["State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy and Sciences, Shenyang, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy and Sciences, Shenyang, China","institution_ids":["https://openalex.org/I142078773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074750148","display_name":"Shuai Wang","orcid":"https://orcid.org/0000-0002-8895-5199"},"institutions":[{"id":"https://openalex.org/I142078773","display_name":"Shenyang Institute of Automation","ror":"https://ror.org/00ft6nj33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I142078773","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Wang","raw_affiliation_strings":["Chinese Academy of Sciences, Beijing, China","State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy and Sciences, Shenyang, China"],"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy and Sciences, Shenyang, China","institution_ids":["https://openalex.org/I142078773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109102616","display_name":"Zaili Dong","orcid":null},"institutions":[{"id":"https://openalex.org/I142078773","display_name":"Shenyang Institute of Automation","ror":"https://ror.org/00ft6nj33","country_code":"CN","type":"facility","lineage":["https://openalex.org/I142078773","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zaili Dong","raw_affiliation_strings":["State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy and Sciences, Shenyang, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy and Sciences, Shenyang, China","institution_ids":["https://openalex.org/I142078773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025411960","display_name":"Balaji Srinivasan","orcid":"https://orcid.org/0000-0002-1430-7818"},"institutions":[{"id":"https://openalex.org/I78715868","display_name":"University of Arkansas at Fayetteville","ror":"https://ror.org/05jbt9m15","country_code":"US","type":"education","lineage":["https://openalex.org/I78715868"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Balaji Srinivasan","raw_affiliation_strings":["Department of Mechanical Engineering, University of Arkansas, Fayetteville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Arkansas, Fayetteville, USA","institution_ids":["https://openalex.org/I78715868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068135140","display_name":"Steve Tung","orcid":"https://orcid.org/0000-0003-3713-4494"},"institutions":[{"id":"https://openalex.org/I78715868","display_name":"University of Arkansas at Fayetteville","ror":"https://ror.org/05jbt9m15","country_code":"US","type":"education","lineage":["https://openalex.org/I78715868"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Tung","raw_affiliation_strings":["Department of Mechanical Engineering, University of Arkansas, Fayetteville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Arkansas, Fayetteville, USA","institution_ids":["https://openalex.org/I78715868"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036337382","display_name":"Wen J. Li","orcid":"https://orcid.org/0000-0001-9616-6213"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen J Li","raw_affiliation_strings":["Centre for Micro and Nano Systems, Chinese University of Hong Kong, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Centre for Micro and Nano Systems, Chinese University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5009536465"],"corresponding_institution_ids":["https://openalex.org/I142078773","https://openalex.org/I19820366"],"apc_list":null,"apc_paid":null,"fwci":0.2111,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59906749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":null,"first_page":"616","last_page":"619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micromixer","display_name":"Micromixer","score":0.9895467758178711},{"id":"https://openalex.org/keywords/luminol","display_name":"Luminol","score":0.8945466876029968},{"id":"https://openalex.org/keywords/chemiluminescence","display_name":"Chemiluminescence","score":0.8131840825080872},{"id":"https://openalex.org/keywords/detection-limit","display_name":"Detection limit","score":0.676171064376831},{"id":"https://openalex.org/keywords/polydimethylsiloxane","display_name":"Polydimethylsiloxane","score":0.6064872741699219},{"id":"https://openalex.org/keywords/immunoassay","display_name":"Immunoassay","score":0.5621750950813293},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"Hydrogen peroxide","score":0.51240473985672},{"id":"https://openalex.org/keywords/chemiluminescent-immunoassay","display_name":"Chemiluminescent immunoassay","score":0.489246129989624},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.46131041646003723},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.4346464276313782},{"id":"https://openalex.org/keywords/analytical-chemistry","display_name":"Analytical Chemistry (journal)","score":0.4218367338180542},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.40014374256134033},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.16279631853103638},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.15618282556533813},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.0756005048751831},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.07273200154304504}],"concepts":[{"id":"https://openalex.org/C2780982322","wikidata":"https://www.wikidata.org/wiki/Q3312230","display_name":"Micromixer","level":3,"score":0.9895467758178711},{"id":"https://openalex.org/C2776316542","wikidata":"https://www.wikidata.org/wiki/Q408061","display_name":"Luminol","level":3,"score":0.8945466876029968},{"id":"https://openalex.org/C145802702","wikidata":"https://www.wikidata.org/wiki/Q2931725","display_name":"Chemiluminescence","level":2,"score":0.8131840825080872},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.676171064376831},{"id":"https://openalex.org/C2779849746","wikidata":"https://www.wikidata.org/wiki/Q411955","display_name":"Polydimethylsiloxane","level":2,"score":0.6064872741699219},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.5621750950813293},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.51240473985672},{"id":"https://openalex.org/C2994453816","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Chemiluminescent immunoassay","level":4,"score":0.489246129989624},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.46131041646003723},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4346464276313782},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.4218367338180542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40014374256134033},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.16279631853103638},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.15618282556533813},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0756005048751831},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07273200154304504},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2010.5592478","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2010.5592478","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W71147808","https://openalex.org/W1993707958","https://openalex.org/W1994343964","https://openalex.org/W2026242786","https://openalex.org/W2030354055","https://openalex.org/W2044693075","https://openalex.org/W2072741204","https://openalex.org/W2144983353","https://openalex.org/W2145926335","https://openalex.org/W2152610199","https://openalex.org/W6681401573"],"related_works":["https://openalex.org/W2040059514","https://openalex.org/W1773337","https://openalex.org/W2012265633","https://openalex.org/W2000041396","https://openalex.org/W2068428112","https://openalex.org/W2043628164","https://openalex.org/W2018874307","https://openalex.org/W2058228121","https://openalex.org/W2806655157","https://openalex.org/W2388284523"],"abstract_inverted_index":{"An":[0],"experimental":[1],"study":[2],"was":[3],"carried":[4],"out":[5],"to":[6,77,87,113],"evaluate":[7],"the":[8,28,35,39,44,52,55,69,80,89,92,114,122,135,140,144],"performance":[9],"of":[10,19,38,68,91,103,109,125,139],"a":[11,62],"polydimethylsiloxane":[12],"(PDMS)":[13],"based":[14,25,71],"micromixer":[15,145],"for":[16],"heterogeneous":[17],"immunoassays":[18],"insulin.":[20],"The":[21,66,94],"detection":[22,123],"method":[23],"is":[24,59,73,84,127,146],"on":[26],"coupling":[27],"highly":[29,63],"specific":[30],"double-antibody":[31],"sandwich":[32],"immunoassay":[33,142],"with":[34,75],"sensitive":[36,64],"chemiluminescence":[37,47,72],"Luminol-Hydrogen":[40],"Peroxide":[41],"reaction.":[42,93],"Both":[43],"immune":[45],"and":[46,54,79],"reactions":[48],"are":[49],"conducted":[50],"in":[51,143],"micromixer,":[53],"resultant":[56],"light":[57,82],"emission":[58],"detected":[60],"by":[61],"photometer.":[65],"behavior":[67],"luminol":[70],"parabolic":[74],"respect":[76],"time,":[78],"maximum":[81],"intensity":[83],"used":[85],"here":[86],"represent":[88],"output":[90],"current":[95],"results":[96],"indicate":[97],"that":[98],"at":[99],"an":[100,106],"actuation":[101,107],"pressure":[102],"15":[104],"psi,":[105],"frequency":[108],"30":[110],"Hz":[111],"leads":[112],"best":[115],"reaction":[116,137],"result.":[117],"At":[118],"these":[119],"operating":[120],"conditions,":[121],"limit":[124],"insulin":[126,141],"about":[128],"10":[129],"<sup":[130],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[131],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">-14</sup>":[132],"mol/L":[133],"while":[134],"total":[136],"time":[138],"less":[147],"than":[148],"5":[149],"minutes.":[150]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}