{"id":"https://openalex.org/W1977926420","doi":"https://doi.org/10.1109/nems.2010.5592162","title":"Investigations of bio markers for human lymphoblastoid cells using Atomic Force Microscopy","display_name":"Investigations of bio markers for human lymphoblastoid cells using Atomic Force Microscopy","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1977926420","doi":"https://doi.org/10.1109/nems.2010.5592162","mag":"1977926420"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2010.5592162","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2010.5592162","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041747112","display_name":"Ruiguo Yang","orcid":"https://orcid.org/0000-0002-1361-4277"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ruiguo Yang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA","Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI. 48823, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI. 48823, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023212284","display_name":"Ning Xi","orcid":"https://orcid.org/0000-0001-8276-5696"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ning Xi","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA","Department of Electrical and Computer Engineering, Michigan State University, 2120, Engineering Building, East Lansing, MI 48824-1226, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Michigan State University, 2120, Engineering Building, East Lansing, MI 48824-1226, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109883719","display_name":"Carmen Kar Man Fung","orcid":null},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmen Kar Man Fung","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA","Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI. 48823, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI. 48823, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015332770","display_name":"King Wai Chiu Lai","orcid":"https://orcid.org/0000-0001-5002-2273"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"King Wai Chiu Lai","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA","Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI. 48823, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI. 48823, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069690145","display_name":"Kristina Seiffert-Sinha","orcid":"https://orcid.org/0000-0002-4797-9418"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina Seiffert-Sinha","raw_affiliation_strings":["Division of Dermatology and Cutaneous Sciences, Center for Investigative Dermatology, Michigan State University, East Lansing, MI, USA","Division of Dermatology and Cutaneous Sciences, Center for Investigative Dermatology, Michigan State University, East Lansing, MI, 48823, USA"],"affiliations":[{"raw_affiliation_string":"Division of Dermatology and Cutaneous Sciences, Center for Investigative Dermatology, Michigan State University, East Lansing, MI, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Division of Dermatology and Cutaneous Sciences, Center for Investigative Dermatology, Michigan State University, East Lansing, MI, 48823, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007075153","display_name":"Animesh A. Sinha","orcid":"https://orcid.org/0000-0003-3213-7813"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Animesh A Sinha","raw_affiliation_strings":["Division of Dermatology and Cutaneous Sciences, Center for Investigative Dermatology, Michigan State University, East Lansing, MI, USA","Division of Dermatology and Cutaneous Sciences, Center for Investigative Dermatology, Michigan State University, East Lansing, MI, 48823, USA"],"affiliations":[{"raw_affiliation_string":"Division of Dermatology and Cutaneous Sciences, Center for Investigative Dermatology, Michigan State University, East Lansing, MI, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Division of Dermatology and Cutaneous Sciences, Center for Investigative Dermatology, Michigan State University, East Lansing, MI, 48823, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101874786","display_name":"Weijing Zhang","orcid":"https://orcid.org/0000-0002-1178-6059"},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijing Zhang","raw_affiliation_strings":["Department of Oncology, Chinese Academy of Military Medical Science, Beijing, China","Department of Oncology, Chinese Academy of Military Medical Science, Beijing, 100071, China"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, Chinese Academy of Military Medical Science, Beijing, China","institution_ids":["https://openalex.org/I2802541053"]},{"raw_affiliation_string":"Department of Oncology, Chinese Academy of Military Medical Science, Beijing, 100071, China","institution_ids":["https://openalex.org/I2802541053"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5041747112"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":null,"apc_paid":null,"fwci":0.4366,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.63059927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"129","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphoma","display_name":"Lymphoma","score":0.7179882526397705},{"id":"https://openalex.org/keywords/cd20","display_name":"CD20","score":0.7010101079940796},{"id":"https://openalex.org/keywords/rituximab","display_name":"Rituximab","score":0.6080030202865601},{"id":"https://openalex.org/keywords/atomic-force-microscopy","display_name":"Atomic force microscopy","score":0.5770019888877869},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.5023219585418701},{"id":"https://openalex.org/keywords/monoclonal-antibody","display_name":"Monoclonal antibody","score":0.48613855242729187},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.476375550031662},{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.47314274311065674},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4653995931148529},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.4558999240398407},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.43104666471481323},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4124501943588257},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3923147916793823},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.34712162613868713},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3383232355117798},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30548807978630066},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3013445734977722},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.24118643999099731},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23848092555999756},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.21109679341316223},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.10981610417366028},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10835719108581543}],"concepts":[{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.7179882526397705},{"id":"https://openalex.org/C18031839","wikidata":"https://www.wikidata.org/wiki/Q5009796","display_name":"CD20","level":3,"score":0.7010101079940796},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.6080030202865601},{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.5770019888877869},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5023219585418701},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.48613855242729187},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.476375550031662},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.47314274311065674},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4653995931148529},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.4558999240398407},{"id":"https://openalex.org/C2777257650","wikidata":"https://www.wikidata.org/wiki/Q4833719","display_name":"B-cell lymphoma","level":3,"score":0.43104666471481323},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4124501943588257},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3923147916793823},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34712162613868713},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3383232355117798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30548807978630066},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3013445734977722},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.24118643999099731},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23848092555999756},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21109679341316223},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10981610417366028},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10835719108581543},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/nems.2010.5592162","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2010.5592162","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},{"id":"pmh:oai:hub.hku.hk:10722/213131","is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/213131","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference_Paper"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W206701898","https://openalex.org/W1993890252","https://openalex.org/W1995857679","https://openalex.org/W2023480994","https://openalex.org/W2024468612","https://openalex.org/W2077670953","https://openalex.org/W2090404922","https://openalex.org/W2092412094","https://openalex.org/W2103005036","https://openalex.org/W2104768467","https://openalex.org/W2108155295","https://openalex.org/W2170755361","https://openalex.org/W2264636885","https://openalex.org/W3198552453","https://openalex.org/W6673163988","https://openalex.org/W6675913491"],"related_works":["https://openalex.org/W2049439131","https://openalex.org/W1969480819","https://openalex.org/W2039226259","https://openalex.org/W2126167931","https://openalex.org/W3116220978","https://openalex.org/W2413577486","https://openalex.org/W2294463202","https://openalex.org/W2182701989","https://openalex.org/W2001794114","https://openalex.org/W3115345348"],"abstract_inverted_index":{"We":[0,64],"report":[1],"the":[2,16,31,44,59,69,91,96,100,128,134,138,142,158,168,171],"use":[3],"of":[4,18,47,93,110,130,133,152,160,170],"Atomic":[5],"Force":[6],"Microcopy":[7],"(AFM)":[8],"in":[9,30,105,108,127],"combination":[10],"with":[11,76],"Fluorescence":[12],"Microscopy":[13],"(FM)":[14],"for":[15],"investigation":[17],"non-Hodgkin's":[19],"type":[20],"B":[21,56,60,70],"cells":[22,72,107,176],"lymphoma":[23,62,71,106,161,175],"after":[24],"antibody":[25,41,67],"treatment.":[26],"Rituximab":[27,94,173],"is":[28,37,52],"used":[29],"treatment":[32,159],"this":[33],"cancer":[34],"type.":[35],"It":[36],"a":[38,164],"chimeric":[39],"monoclonal":[40],"directed":[42],"against":[43],"protein":[45],"Cluster":[46],"Differentiation":[48],"20":[49],"(CD20),":[50],"which":[51],"expressed":[53],"on":[54,174],"mature":[55],"cells,":[57],"including":[58],"cell":[61,112,115,135,143,153],"surface.":[63,144],"applied":[65],"anti-CD20":[66],"to":[68,95,166],"that":[73],"was":[74,80],"labeled":[75],"fluorophore.":[77],"Simultaneous":[78],"imaging":[79,89,102,146],"then":[81],"performed":[82],"by":[83,136],"both":[84],"FM":[85],"and":[86,114,147,155],"AFM.":[87],"Immunofluorescence":[88],"confirms":[90],"binding":[92],"CD20":[97],"protein;":[98],"while":[99],"AFM":[101,121,145],"revealed":[103],"changes":[104],"terms":[109],"mean":[111],"height":[113],"surface":[116],"roughness.":[117],"In":[118],"addition,":[119],"our":[120],"based":[122],"nanomanipulation":[123],"system":[124],"can":[125],"assist":[126],"analysis":[129],"mechanical":[131],"property":[132],"recording":[137],"force-displacement":[139],"curves":[140],"at":[141],"measurements":[148],"may":[149,156],"provide":[150],"biomarkers":[151],"behavior":[154],"facilitate":[157],"clinically":[162],"as":[163],"pretest":[165],"determine":[167],"effectiveness":[169],"drug":[172],"from":[177],"individual":[178],"patients.":[179]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}