{"id":"https://openalex.org/W2091987775","doi":"https://doi.org/10.1109/nems.2010.5592121","title":"Single-cell-based measurement of supraphysiological thermal injury in carcinoma cells on a microchip","display_name":"Single-cell-based measurement of supraphysiological thermal injury in carcinoma cells on a microchip","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2091987775","doi":"https://doi.org/10.1109/nems.2010.5592121","mag":"2091987775"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2010.5592121","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2010.5592121","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059401981","display_name":"Yun-Hung Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I148099254","display_name":"National Chung Cheng University","ror":"https://ror.org/0028v3876","country_code":"TW","type":"education","lineage":["https://openalex.org/I148099254"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yun-Hung Lu","raw_affiliation_strings":["Department of Mechanical Engineering, National Chung Cheng University, Chiayi, Taiwan","Dept. of Mechanical Engineering, National Chung Cheng University, Chia-Yi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, National Chung Cheng University, Chiayi, Taiwan","institution_ids":["https://openalex.org/I148099254"]},{"raw_affiliation_string":"Dept. of Mechanical Engineering, National Chung Cheng University, Chia-Yi, Taiwan","institution_ids":["https://openalex.org/I148099254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103388750","display_name":"Ching\u2010Te Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I148099254","display_name":"National Chung Cheng University","ror":"https://ror.org/0028v3876","country_code":"TW","type":"education","lineage":["https://openalex.org/I148099254"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ching-Te Huang","raw_affiliation_strings":["Department of Mechanical Engineering, National Chung Cheng University, Chiayi, Taiwan","Dept. of Mechanical Engineering, National Chung Cheng University, Chia-Yi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, National Chung Cheng University, Chiayi, Taiwan","institution_ids":["https://openalex.org/I148099254"]},{"raw_affiliation_string":"Dept. of Mechanical Engineering, National Chung Cheng University, Chia-Yi, Taiwan","institution_ids":["https://openalex.org/I148099254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101915284","display_name":"Cheng-Han Tsai","orcid":"https://orcid.org/0000-0001-6467-9348"},"institutions":[{"id":"https://openalex.org/I148099254","display_name":"National Chung Cheng University","ror":"https://ror.org/0028v3876","country_code":"TW","type":"education","lineage":["https://openalex.org/I148099254"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Han Tsai","raw_affiliation_strings":["Department of Mechanical Engineering, National Chung Cheng University, Chiayi, Taiwan","Dept. of Mechanical Engineering, National Chung Cheng University, Chia-Yi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, National Chung Cheng University, Chiayi, Taiwan","institution_ids":["https://openalex.org/I148099254"]},{"raw_affiliation_string":"Dept. of Mechanical Engineering, National Chung Cheng University, Chia-Yi, Taiwan","institution_ids":["https://openalex.org/I148099254"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089823501","display_name":"Chun\u2010Ping Jen","orcid":"https://orcid.org/0000-0001-5558-5817"},"institutions":[{"id":"https://openalex.org/I148099254","display_name":"National Chung Cheng University","ror":"https://ror.org/0028v3876","country_code":"TW","type":"education","lineage":["https://openalex.org/I148099254"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun-Ping Jen","raw_affiliation_strings":["Department of Mechanical Engineering, National Chung Cheng University, Chiayi, Taiwan","Dept. of Mechanical Engineering, National Chung Cheng University, Chia-Yi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, National Chung Cheng University, Chiayi, Taiwan","institution_ids":["https://openalex.org/I148099254"]},{"raw_affiliation_string":"Dept. of Mechanical Engineering, National Chung Cheng University, Chia-Yi, Taiwan","institution_ids":["https://openalex.org/I148099254"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I148099254"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25832362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":null,"first_page":"898","last_page":"901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperthermia","display_name":"Hyperthermia","score":0.7236769199371338},{"id":"https://openalex.org/keywords/hela","display_name":"HeLa","score":0.6544166803359985},{"id":"https://openalex.org/keywords/calcein","display_name":"Calcein","score":0.5974812507629395},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5656617283821106},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5185004472732544},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.5000498294830322},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.47639814019203186},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.44992977380752563},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.3970579504966736},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.36393603682518005},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.35393548011779785},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3452555239200592},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.33398014307022095},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30715811252593994},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17453762888908386},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.13330426812171936}],"concepts":[{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.7236769199371338},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.6544166803359985},{"id":"https://openalex.org/C2776872141","wikidata":"https://www.wikidata.org/wiki/Q413006","display_name":"Calcein","level":3,"score":0.5974812507629395},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5656617283821106},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5185004472732544},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5000498294830322},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.47639814019203186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44992977380752563},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3970579504966736},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36393603682518005},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.35393548011779785},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3452555239200592},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33398014307022095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30715811252593994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17453762888908386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13330426812171936},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2010.5592121","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2010.5592121","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6100000143051147,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1965997941","https://openalex.org/W1978027717","https://openalex.org/W2048427272","https://openalex.org/W2067445353","https://openalex.org/W2070418129","https://openalex.org/W2079960458","https://openalex.org/W2121484578","https://openalex.org/W2137034111"],"related_works":["https://openalex.org/W2372231441","https://openalex.org/W2370495375","https://openalex.org/W2379924649","https://openalex.org/W2357943637","https://openalex.org/W2358382349","https://openalex.org/W2391226321","https://openalex.org/W2363095948","https://openalex.org/W2393570706","https://openalex.org/W2357232925","https://openalex.org/W2383798804"],"abstract_inverted_index":{"Hyperthermia":[0],"affects":[1],"certain":[2],"regulatory":[3],"proteins,":[4],"kinases":[5],"or":[6],"cyclins,":[7],"resulting":[8],"in":[9,29,58,87,113,178],"alternations":[10],"to":[11,17,20,68,79,136],"the":[12,21,30,39,46,54,81,94,123,128,146,179],"cell":[13,22,34,51,117,161],"cycle":[14],"and":[15,53,78,111,170],"even":[16],"apoptosis.":[18],"Damage":[19],"plasma":[23],"membrane":[24,102],"is":[25,42,67],"a":[26,33,70,138],"key":[27],"factor":[28],"killing":[31],"of":[32,49,56,64,83,101,125,175],"by":[35,104],"hyperthermia.":[36],"Analysis":[37],"at":[38,93,119],"single-cell":[40,95],"level":[41],"necessary":[43],"for":[44,75],"understanding":[45],"fundamental":[47],"mechanisms":[48],"hyperthermia-induced":[50],"death":[52],"generation":[55],"thermotolerance":[57],"surviving":[59],"cells.":[60],"The":[61,152,172],"main":[62],"purpose":[63],"this":[65,114],"study":[66],"fabricate":[69],"hydrogel":[71,182],"chip":[72],"with":[73,130,181],"microwells":[74,133,149,183],"cellular":[76],"patterning":[77],"demonstrate":[80],"measurement":[82,100],"supraphysiological":[84,166],"thermal":[85,176],"injury":[86,103,177],"human":[88],"carcinoma":[89],"cells":[90,126],"(HeLa":[91],"cells)":[92],"level.":[96],"To":[97],"accomplish":[98],"this,":[99],"dye":[105],"leakage":[106,158],"post-thermal":[107],"insult":[108],"was":[109,134,184],"performed":[110],"reported":[112],"work.":[115],"For":[116],"concentrations":[118],"0.5":[120],"\u00d7":[121],"106cells/mL,":[122],"occupancy":[124],"on":[127,145],"microchip":[129,180],"40":[131],"\u03bcm":[132,148],"up":[135],"86.6%,":[137],"value":[139],"far":[140],"higher":[141],"than":[142],"that":[143,156],"found":[144],"30":[147],"(approximately":[150],"78.5%).":[151],"fluorescent":[153],"images":[154],"showed":[155],"calcein":[157],"occurred":[159],"when":[160],"membranes":[162],"were":[163],"damaged":[164],"under":[165],"temperatures":[167],"between":[168],"43":[169],"50\u00b0C.":[171],"single-cell-based":[173],"experiment":[174],"therefore":[185],"successfully":[186],"demonstrated.":[187]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
