{"id":"https://openalex.org/W1963646376","doi":"https://doi.org/10.1109/nems.2010.5592119","title":"Novel multiplex and quantitative genetic analysis method by CE-based SSCP","display_name":"Novel multiplex and quantitative genetic analysis method by CE-based SSCP","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1963646376","doi":"https://doi.org/10.1109/nems.2010.5592119","mag":"1963646376"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2010.5592119","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2010.5592119","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079269717","display_name":"Gyoo Yeol Jung","orcid":"https://orcid.org/0000-0002-9742-3207"},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I2799891827","display_name":"Korea Post","ror":"https://ror.org/00p45d091","country_code":"KR","type":"government","lineage":["https://openalex.org/I2799891827","https://openalex.org/I2801339556","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gyoo Yeol Jung","raw_affiliation_strings":["Department of Chemical Engineering, POSTECH, South Korea","Department of Chemical Engineering, POSTECH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, POSTECH, South Korea","institution_ids":["https://openalex.org/I2799891827","https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Chemical Engineering, POSTECH","institution_ids":["https://openalex.org/I2799891827","https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041840523","display_name":"Gi Won Shin","orcid":"https://orcid.org/0000-0002-1865-5019"},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I2799891827","display_name":"Korea Post","ror":"https://ror.org/00p45d091","country_code":"KR","type":"government","lineage":["https://openalex.org/I2799891827","https://openalex.org/I2801339556","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gi Won Shin","raw_affiliation_strings":["Department of Chemical Engineering, POSTECH, South Korea","Department of Chemical Engineering, POSTECH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, POSTECH, South Korea","institution_ids":["https://openalex.org/I2799891827","https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Chemical Engineering, POSTECH","institution_ids":["https://openalex.org/I2799891827","https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052371960","display_name":"Hee Sung Hwang","orcid":"https://orcid.org/0000-0002-2803-0282"},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I2799891827","display_name":"Korea Post","ror":"https://ror.org/00p45d091","country_code":"KR","type":"government","lineage":["https://openalex.org/I2799891827","https://openalex.org/I2801339556","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee Sung Hwang","raw_affiliation_strings":["Department of Chemical Engineering, POSTECH, South Korea","Department of Chemical Engineering, POSTECH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, POSTECH, South Korea","institution_ids":["https://openalex.org/I2799891827","https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Chemical Engineering, POSTECH","institution_ids":["https://openalex.org/I2799891827","https://openalex.org/I123900574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076883092","display_name":"Boram Chung","orcid":null},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I2799891827","display_name":"Korea Post","ror":"https://ror.org/00p45d091","country_code":"KR","type":"government","lineage":["https://openalex.org/I2799891827","https://openalex.org/I2801339556","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Boram Chung","raw_affiliation_strings":["Department of Chemical Engineering, POSTECH, South Korea","Department of Chemical Engineering, POSTECH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, POSTECH, South Korea","institution_ids":["https://openalex.org/I2799891827","https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Chemical Engineering, POSTECH","institution_ids":["https://openalex.org/I2799891827","https://openalex.org/I123900574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05934628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":null,"first_page":"906","last_page":"911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiplex","display_name":"Multiplex","score":0.7405052781105042},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6525677442550659},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.637425422668457},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6145182251930237},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.5665071606636047},{"id":"https://openalex.org/keywords/genomic-dna","display_name":"genomic DNA","score":0.5250194668769836},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.516769289970398},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.498288631439209},{"id":"https://openalex.org/keywords/multiplex-polymerase-chain-reaction","display_name":"Multiplex polymerase chain reaction","score":0.46967965364456177},{"id":"https://openalex.org/keywords/single-strand-conformation-polymorphism","display_name":"Single-strand conformation polymorphism","score":0.43574583530426025},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.42283928394317627},{"id":"https://openalex.org/keywords/polymerase-chain-reaction","display_name":"Polymerase chain reaction","score":0.361322283744812},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.34552913904190063},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12689828872680664}],"concepts":[{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.7405052781105042},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6525677442550659},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.637425422668457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6145182251930237},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5665071606636047},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.5250194668769836},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.516769289970398},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.498288631439209},{"id":"https://openalex.org/C90583042","wikidata":"https://www.wikidata.org/wiki/Q1952456","display_name":"Multiplex polymerase chain reaction","level":4,"score":0.46967965364456177},{"id":"https://openalex.org/C129219603","wikidata":"https://www.wikidata.org/wiki/Q1788683","display_name":"Single-strand conformation polymorphism","level":4,"score":0.43574583530426025},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42283928394317627},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.361322283744812},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34552913904190063},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12689828872680664}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2010.5592119","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2010.5592119","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1483828791","https://openalex.org/W1761387917","https://openalex.org/W1972985557","https://openalex.org/W1974634319","https://openalex.org/W1992999651","https://openalex.org/W1995709832","https://openalex.org/W2038898812","https://openalex.org/W2041894315","https://openalex.org/W2053343727","https://openalex.org/W2070201411","https://openalex.org/W2083767818","https://openalex.org/W2093009120","https://openalex.org/W2096298665","https://openalex.org/W2103028520","https://openalex.org/W2112982595","https://openalex.org/W2119451993","https://openalex.org/W2133424486","https://openalex.org/W2138236513","https://openalex.org/W2141540339","https://openalex.org/W2146417179","https://openalex.org/W2149646185","https://openalex.org/W2161222316","https://openalex.org/W2169827599","https://openalex.org/W2258565525","https://openalex.org/W4234856234","https://openalex.org/W6692765044"],"related_works":["https://openalex.org/W2382987076","https://openalex.org/W1549773993","https://openalex.org/W975244596","https://openalex.org/W1975323116","https://openalex.org/W2066005224","https://openalex.org/W2083048402","https://openalex.org/W2367685784","https://openalex.org/W1585187208","https://openalex.org/W2113143881","https://openalex.org/W2898255346"],"abstract_inverted_index":{"Recent":[0],"development":[1],"of":[2,28,53,58,83,133,136,190,221,252,288],"molecular":[3,18,22,140],"biological":[4],"tools":[5],"has":[6],"created":[7],"several":[8],"research":[9],"fields":[10],"such":[11,123,323],"as":[12,124,324],"systems":[13],"biology,":[14],"omics":[15],"studies,":[16],"and":[17,31,36,74,104,150,163,192,246,301,331],"diagnostics.":[19],"Among":[20],"them,":[21],"diagnostics":[23],"is":[24,109,127,159,284],"a":[25,40,46,93,129],"new":[26,295],"area":[27,97],"clinical":[29],"diagnosis,":[30],"it":[32,273,302],"includes":[33],"all":[34],"tests":[35],"methods":[37],"to":[38,91,211],"identify":[39],"disease":[41,47,75],"or":[42,51,225],"the":[43,59,88,106,115,241,285,294,307,317,320],"predisposition":[44],"for":[45,236,277,316],"analyzing":[48],"DNA,":[49],"RNA":[50],"proteins":[52],"an":[54],"organism.":[55],"After":[56,114],"completion":[57],"human":[60],"genome":[61],"project,":[62],"enormous":[63],"reports":[64],"on":[65,172,268],"genetic":[66,112,116,144,201],"variations":[67,73],"were":[68],"reported":[69],"which":[70,79,98,183,283],"cause":[71],"phenotypic":[72],"conditions.":[76],"DNA":[77,84,95,107,137,148,157,178,185],"microarray,":[78],"can":[80,198,255],"detect":[81,167,199,212],"thousands":[82],"sequences":[85],"simultaneously,":[86],"was":[87,233,274,291],"major":[89,286],"technology":[90],"discover":[92],"novel":[94],"sequence":[96,108],"could":[99,208],"differentiate":[100],"between":[101],"one":[102],"condition":[103],"another;":[105],"generally":[110],"called":[111],"marker.":[113],"marker":[117,253],"discovery,":[118],"validation":[119],"by":[120,161,170,187,195,217,258,293],"quantitative":[121],"method":[122],"real-time":[125,151,164],"qPCR":[126,152,165],"often":[128],"required":[130],"step":[131],"because":[132,156,272],"error-prone":[134,160],"nature":[135,162],"microarray.":[138],"For":[139],"diagnosis":[141],"using":[142],"discovered":[143],"markers,":[145],"however,":[146],"both":[147],"microarray":[149,158],"are":[153],"not":[154,275],"appropriate":[155],"cannot":[166],"multiple":[168,200,213],"targets":[169,215],"limitation":[171],"fluorescence":[173,196],"dye.":[174],"Capillary":[175],"electrophoresis-based":[176],"single-strand":[177],"conformation":[179],"polymorphism":[180],"analysis":[181],"(CE-SSCP),":[182],"separates":[184],"molecules":[186],"conformational":[188],"difference":[189],"ssDNA":[191],"quantifies":[193],"them":[194],"intensity,":[197],"markers":[202],"quantitatively.":[203],"We":[204],"have":[205],"demonstrated":[206,235],"CE-SSCP":[207],"be":[209,256,314],"used":[210],"pathogen":[214],"quantitatively":[216],"its":[218],"genomic":[219],"regions":[220],"16S":[222,226],"rRNA":[223,227],"gene":[224],"itself.":[228],"Moreover,":[229],"multiplex":[230],"mRNA":[231],"quantification":[232],"also":[234,264],"seven":[237],"mRNAs":[238],"involved":[239],"in":[240,319],"central":[242],"carbon":[243],"metabolic":[244],"pathway,":[245],"this":[247,259],"result":[248],"showed":[249,303],"that":[250,298],"expression":[251,332],"genes":[254],"monitored":[257],"method.":[260],"In":[261],"addition,":[262],"we":[263,299],"did":[265],"some":[266],"modification":[267],"conventional":[269,308],"CE":[270,289],"settings":[271],"optimized":[276],"SSCP":[278],"analysis.":[279,333],"Conventional":[280],"polymer":[281,296],"matrix,":[282],"component":[287],"separation,":[290],"replaced":[292],"matrix":[297],"developed,":[300],"better":[304],"resolution":[305],"than":[306],"one.":[309],"Additionally,":[310],"more":[311],"examples":[312],"will":[313],"shown":[315],"potentials":[318],"various":[321],"applications":[322],"copy":[325],"number":[326],"variations,":[327],"single":[328],"nucleotide":[329],"polymorphism,":[330]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}