{"id":"https://openalex.org/W2132746614","doi":"https://doi.org/10.1109/nems.2009.5068724","title":"Anticancer drug delivery for tumor targeting and therapy","display_name":"Anticancer drug delivery for tumor targeting and therapy","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2132746614","doi":"https://doi.org/10.1109/nems.2009.5068724","mag":"2132746614"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2009.5068724","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2009.5068724","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100724937","display_name":"Yu Jin Kim","orcid":"https://orcid.org/0000-0003-4581-8589"},"institutions":[{"id":"https://openalex.org/I119575151","display_name":"Korea National University of Transportation","ror":"https://ror.org/03qqbe534","country_code":"KR","type":"education","lineage":["https://openalex.org/I119575151"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yu Jin Kim","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Chungju National University, Chungju, South Korea","Department of Chemical and Biological Engineering, Chungju National University, 72 Daehak-ro, 380-702, South Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Chungju National University, Chungju, South Korea","institution_ids":["https://openalex.org/I119575151"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Chungju National University, 72 Daehak-ro, 380-702, South Korea#TAB#","institution_ids":["https://openalex.org/I119575151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032160372","display_name":"Il\u2010Kyu Park","orcid":"https://orcid.org/0000-0002-0628-8530"},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Il-Kyu Park","raw_affiliation_strings":["Department of Applied Chemistry & Biological Engineering, Chungnam National University, Daejeon, South Korea","Department of Applied Chemistry & Biological Engineering, Chungnam National University, 220, Gung-dong, Yuseong-gu, Daejeon 305-764, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry & Biological Engineering, Chungnam National University, Daejeon, South Korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Department of Applied Chemistry & Biological Engineering, Chungnam National University, 220, Gung-dong, Yuseong-gu, Daejeon 305-764, South Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390267","display_name":"Jin Soo Kim","orcid":"https://orcid.org/0000-0002-5522-2255"},"institutions":[{"id":"https://openalex.org/I119575151","display_name":"Korea National University of Transportation","ror":"https://ror.org/03qqbe534","country_code":"KR","type":"education","lineage":["https://openalex.org/I119575151"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Soo Kim","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Chungju National University, Chungju, South Korea","Department of Chemical and Biological Engineering, Chungju National University, 72 Daehak-ro, 380-702, South Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Chungju National University, Chungju, South Korea","institution_ids":["https://openalex.org/I119575151"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Chungju National University, 72 Daehak-ro, 380-702, South Korea#TAB#","institution_ids":["https://openalex.org/I119575151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100825378","display_name":"Joon Hwang","orcid":null},"institutions":[{"id":"https://openalex.org/I119575151","display_name":"Korea National University of Transportation","ror":"https://ror.org/03qqbe534","country_code":"KR","type":"education","lineage":["https://openalex.org/I119575151"]},{"id":"https://openalex.org/I148099254","display_name":"National Chung Cheng University","ror":"https://ror.org/0028v3876","country_code":"TW","type":"education","lineage":["https://openalex.org/I148099254"]}],"countries":["KR","TW"],"is_corresponding":false,"raw_author_name":"Joon Hwang","raw_affiliation_strings":["Department of Aeronautical & Mechanical Engineering, Chungju National University (CITC), Chungli, Taiwan","Department of Aeronautical & Mechanical Engineering, Chungju National University, 72 Daehak-ro, 380-702, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Aeronautical & Mechanical Engineering, Chungju National University (CITC), Chungli, Taiwan","institution_ids":["https://openalex.org/I148099254"]},{"raw_affiliation_string":"Department of Aeronautical & Mechanical Engineering, Chungju National University, 72 Daehak-ro, 380-702, South Korea","institution_ids":["https://openalex.org/I119575151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102101141","display_name":"Eui-Sik Chung","orcid":null},"institutions":[{"id":"https://openalex.org/I145808223","display_name":"Hanbat National University","ror":"https://ror.org/00x514t95","country_code":"KR","type":"education","lineage":["https://openalex.org/I145808223"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eui-Sik Chung","raw_affiliation_strings":["Department of Mechanical Design Engineering, Hanbat National University, Daejeon, South Korea","Department of Mechanical Design Engineering, Hanbat National University, San 16-1, DuckMyoung-Dong, Yuseong-gu, Daejeon, 305-719, South Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Design Engineering, Hanbat National University, Daejeon, South Korea","institution_ids":["https://openalex.org/I145808223"]},{"raw_affiliation_string":"Department of Mechanical Design Engineering, Hanbat National University, San 16-1, DuckMyoung-Dong, Yuseong-gu, Daejeon, 305-719, South Korea#TAB#","institution_ids":["https://openalex.org/I145808223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015625444","display_name":"Kang Moo Huh","orcid":"https://orcid.org/0000-0002-2406-6659"},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kang Moo Huh","raw_affiliation_strings":["Department of Applied Chemistry & Biological Engineering, Chungnam National University, Daejeon, South Korea","Department of Applied Chemistry & Biological Engineering, Chungnam National University, 220, Gung-dong, Yuseong-gu, Daejeon 305-764, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry & Biological Engineering, Chungnam National University, Daejeon, South Korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Department of Applied Chemistry & Biological Engineering, Chungnam National University, 220, Gung-dong, Yuseong-gu, Daejeon 305-764, South Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108506923","display_name":"Yong-Kyu Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I119575151","display_name":"Korea National University of Transportation","ror":"https://ror.org/03qqbe534","country_code":"KR","type":"education","lineage":["https://openalex.org/I119575151"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-kyu Lee","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Chungju National University, Chungju, South Korea","Department of Chemical and Biological Engineering, Chungju National University, 72 Daehak-ro, 380-702, South Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Chungju National University, Chungju, South Korea","institution_ids":["https://openalex.org/I119575151"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Chungju National University, 72 Daehak-ro, 380-702, South Korea#TAB#","institution_ids":["https://openalex.org/I119575151"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100724937"],"corresponding_institution_ids":["https://openalex.org/I119575151"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10519183,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"398","issue":null,"first_page":"919","last_page":"922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5918328762054443},{"id":"https://openalex.org/keywords/dynamic-light-scattering","display_name":"Dynamic light scattering","score":0.5286734104156494},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.47559985518455505},{"id":"https://openalex.org/keywords/drug-carrier","display_name":"Drug carrier","score":0.47266730666160583},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.4647684693336487},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"Targeted drug delivery","score":0.43762093782424927},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.363160640001297},{"id":"https://openalex.org/keywords/nanoparticle","display_name":"Nanoparticle","score":0.3327638506889343},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.324265718460083},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.2395002841949463},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.1250280737876892}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5918328762054443},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.5286734104156494},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47559985518455505},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.47266730666160583},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4647684693336487},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.43762093782424927},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.363160640001297},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.3327638506889343},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.324265718460083},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2395002841949463},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1250280737876892},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2009.5068724","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2009.5068724","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6800000071525574,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2154934","https://openalex.org/W34750704","https://openalex.org/W1574338658","https://openalex.org/W1628030746","https://openalex.org/W1973712257","https://openalex.org/W1983387455","https://openalex.org/W1985631236","https://openalex.org/W1990163407","https://openalex.org/W2030855909","https://openalex.org/W2038894713","https://openalex.org/W2052039265","https://openalex.org/W2052987601","https://openalex.org/W2059700588","https://openalex.org/W2090436854","https://openalex.org/W2108329256","https://openalex.org/W4233820214","https://openalex.org/W6634235368","https://openalex.org/W6676652028"],"related_works":["https://openalex.org/W2727899900","https://openalex.org/W3157244191","https://openalex.org/W4361283779","https://openalex.org/W1991750263","https://openalex.org/W3201778902","https://openalex.org/W2066459637","https://openalex.org/W2080630976","https://openalex.org/W2741112897","https://openalex.org/W2597042212","https://openalex.org/W2044430876"],"abstract_inverted_index":{"To":[0],"make":[1],"significant":[2],"progress":[3],"in":[4,34],"the":[5,71,75,82,92],"fight":[6],"against":[7],"cancer,":[8],"treatment":[9,104],"should":[10],"target":[11],"cells":[12],"more":[13],"specifically,":[14],"produce":[15],"fewer":[16],"side":[17],"effects,":[18],"be":[19],"easy":[20],"to":[21,68],"administer":[22],"and":[23,38,56,65,80,122,133,167],"deter":[24],"tumor":[25,36,39,99],"viability":[26],"on":[27],"multiple":[28],"levels.":[29],"We":[30],"have":[31],"attained":[32],"dramatic":[33],"vivo":[35],"shrinkage":[37],"vasculature":[40],"disruption":[41],"using":[42],"a":[43],"ternary":[44],"biomolecular":[45],"nanoparticle":[46],"comprised":[47],"of":[48,63,74,84,105,108,145,157],"polymeric":[49],"carrier":[50,89],"polysaccharide":[51],"heparin,":[52],"anticancer":[53,87],"drug":[54,88],"retinoid":[55,64],"targeting":[57,98],"ligand":[58],"folic":[59,66,111],"acid.":[60],"The":[61,110,143,154],"conjugation":[62],"acid":[67,112],"heparin":[69,85],"enhanced":[70,81],"water":[72],"solubility":[73],"drug,":[76],"enabled":[77],"selective":[78],"targeting,":[79],"role":[83],"as":[86],"by":[90,128,162],"eluding":[91],"coagulation":[93],"cascade.":[94],"This":[95],"approach":[96],"for":[97,103],"holds":[100],"great":[101],"promise":[102],"various":[106],"types":[107],"cancer.":[109],"linked":[113],"heparin-retinoid":[114],"conjugates":[115,147],"(HFR)":[116],"reactions":[117],"was":[118,126,148,160],"conjugated":[119],"with":[120,150],"ester":[121],"amide":[123],"bonding":[124],"which":[125],"confirmed":[127],"Fourier":[129],"transform":[130],"infrared":[131],"(FT-IR)":[132],"proton":[134],"nuclear":[135],"magnetic":[136],"resonance":[137],"(":[138],"<sup":[139],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[140],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">1</sup>":[141],"H-NMR).":[142],"ratio":[144],"HFR":[146,158],"measured":[149,161],"Ultra-Violet":[151],"spectrometry":[152],"(UV-spectrometry).":[153],"particle":[155],"size":[156],"nanoparticles":[159],"dynamic":[163],"light":[164],"scattering":[165],"(DLS),":[166],"transmission":[168],"electron":[169],"microscopy":[170],"(TEM).":[171]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
