{"id":"https://openalex.org/W2018452726","doi":"https://doi.org/10.1109/nabic.2009.5393630","title":"Feature selection for siRNA efficacy prediction using natural computation","display_name":"Feature selection for siRNA efficacy prediction using natural computation","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2018452726","doi":"https://doi.org/10.1109/nabic.2009.5393630","mag":"2018452726"},"language":"en","primary_location":{"id":"doi:10.1109/nabic.2009.5393630","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nabic.2009.5393630","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 World Congress on Nature &amp; Biologically Inspired Computing (NaBIC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033484647","display_name":"Chakresh Kumar Jain","orcid":"https://orcid.org/0000-0002-9226-7719"},"institutions":[{"id":"https://openalex.org/I154970844","display_name":"Jaypee Institute of Information Technology","ror":"https://ror.org/05sttyy11","country_code":"IN","type":"education","lineage":["https://openalex.org/I154970844"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Chakresh Kumar Jain","raw_affiliation_strings":["Department of Biotechnology, Jaypee Institute of Information Technology, Noida, India","Department of Biotechnology, Jaypee Institute of Information Technology Univesrity, Noida, India"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Jaypee Institute of Information Technology, Noida, India","institution_ids":["https://openalex.org/I154970844"]},{"raw_affiliation_string":"Department of Biotechnology, Jaypee Institute of Information Technology Univesrity, Noida, India","institution_ids":["https://openalex.org/I154970844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060469822","display_name":"Yamuna Prasad","orcid":"https://orcid.org/0000-0002-3709-7956"},"institutions":[{"id":"https://openalex.org/I64295750","display_name":"Indian Institute of Technology Indore","ror":"https://ror.org/01hhf7w52","country_code":"IN","type":"education","lineage":["https://openalex.org/I64295750"]},{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yamuna Prasad","raw_affiliation_strings":["Department of Computer Science and Engineering, Indian Institute of Technology, New Delhi, India","Department of Computer Sceince and Engineering, Indian Institute of Technology, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Indian Institute of Technology, New Delhi, India","institution_ids":["https://openalex.org/I68891433"]},{"raw_affiliation_string":"Department of Computer Sceince and Engineering, Indian Institute of Technology, New Delhi, India","institution_ids":["https://openalex.org/I64295750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033484647"],"corresponding_institution_ids":["https://openalex.org/I154970844"],"apc_list":null,"apc_paid":null,"fwci":0.3937,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.61724241,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":null,"first_page":"1759","last_page":"1764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.8410254716873169},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.700668215751648},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"Gene silencing","score":0.6545488834381104},{"id":"https://openalex.org/keywords/small-interfering-rna","display_name":"Small interfering RNA","score":0.5095865726470947},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.490178644657135},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4488513767719269},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4465222954750061},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.42865750193595886},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.41388171911239624},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.3456326723098755},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.3253568410873413},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3051339387893677},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.2343616485595703},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1840086579322815}],"concepts":[{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.8410254716873169},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.700668215751648},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6545488834381104},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.5095865726470947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.490178644657135},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4488513767719269},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4465222954750061},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.42865750193595886},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.41388171911239624},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3456326723098755},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3253568410873413},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3051339387893677},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2343616485595703},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1840086579322815}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nabic.2009.5393630","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nabic.2009.5393630","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 World Congress on Nature &amp; Biologically Inspired Computing (NaBIC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328353","display_name":"Jaypee Institute of Information Technology","ror":"https://ror.org/05sttyy11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1520518044","https://openalex.org/W1611419331","https://openalex.org/W1673359695","https://openalex.org/W1842283737","https://openalex.org/W1882899517","https://openalex.org/W1986687961","https://openalex.org/W1988783048","https://openalex.org/W1996164865","https://openalex.org/W2018729653","https://openalex.org/W2026012474","https://openalex.org/W2029052373","https://openalex.org/W2052312685","https://openalex.org/W2071596792","https://openalex.org/W2082213106","https://openalex.org/W2106082032","https://openalex.org/W2107235611","https://openalex.org/W2107941094","https://openalex.org/W2109609799","https://openalex.org/W2111759698","https://openalex.org/W2114003441","https://openalex.org/W2116649573","https://openalex.org/W2116973451","https://openalex.org/W2122577542","https://openalex.org/W2141182209","https://openalex.org/W2145638174","https://openalex.org/W2149538815","https://openalex.org/W2155760245","https://openalex.org/W2160923685","https://openalex.org/W2166802510","https://openalex.org/W2921034429","https://openalex.org/W4235886033","https://openalex.org/W6677101596","https://openalex.org/W6677490235","https://openalex.org/W6680613155"],"related_works":["https://openalex.org/W2024030923","https://openalex.org/W2047147668","https://openalex.org/W2050288958","https://openalex.org/W190167036","https://openalex.org/W2460036559","https://openalex.org/W2360935227","https://openalex.org/W2378738300","https://openalex.org/W2164747002","https://openalex.org/W2364993072","https://openalex.org/W2388226226"],"abstract_inverted_index":{"RNAi":[0,18,48],"is":[1,166,181,196],"a":[2,71,198],"naturally":[3],"occurring,":[4],"highly":[5],"conserved":[6],"phenomenon":[7],"of":[8,55,79,86,130,140,157,163,175,219,226,271],"RNA":[9,67],"mediated":[10],"gene":[11,43,99,148],"silencing":[12],"among":[13],"the":[14,53,77,89,94,98,109,137,146,161,167,182,190,217,223,230,255,268],"multicellular":[15],"organisms.":[16],"Currently,":[17],"has":[19,241],"been":[20,106,242],"successfully":[21],"applied":[22],"in":[23,32,40,76,136,189,267],"functional":[24],"genomics,":[25],"therapeutics":[26],"and":[27,34,92,228,237,261],"new":[28],"drug":[29],"target":[30],"identification":[31,174],"mammals":[33],"other":[35],"eukaryotes.":[36],"The":[37,83],"uniqueness":[38],"lies":[39],"sequence":[41,126,245,260],"specific":[42,149],"knock":[44],"down":[45],"which":[46,132],"made":[47],"an":[49,208],"indispensible":[50],"technology.":[51],"In":[52,202],"mechanism":[54],"RNAi,":[56],"small":[57],"21-25":[58],"bp":[59],"long":[60],",double":[61],"stranded":[62],"endogenously":[63],"or":[64],"exogenously":[65],"generated":[66],"molecule":[68],"via":[69],"DICER;":[70],"RNAase":[72],"III":[73],"enzyme,":[74],"resulting":[75],"formation":[78],"multidomain":[80],"RISC":[81,87],"structure.":[82],"slicer":[84],"activity":[85],"cleaves":[88],"complementary":[90],"mRNA":[91],"blocks":[93],"transcription":[95],"process,":[96],"consequently":[97],"function.":[100],"Many":[101],"siRNA":[102,131,150,159,179,220],"design":[103,114,180],"tools":[104],"have":[105,206],"developed":[107],"following":[108],"general":[110],"guidelines":[111,122],"like":[112],"rational":[113],"criteria":[115],"with":[116,152],"their":[117],"uniquely":[118],"defined":[119],"features.":[120,253],"These":[121],"are":[123,232,248,264],"based":[124,212,246],"upon":[125],"to":[127,186,215,222],"thermodynamic":[128,252,262],"features":[129,176,218,247,263],"plays":[133],"crucial":[134],"role":[135],"effective":[138,178,269],"designing":[139,270],"siRNA.":[141,272],"But":[142],"no":[143],"tool":[144],"provides":[145],"accurate":[147],"sequences":[151,165],"absolute":[153],"efficacy.":[154],"Furthermore,":[155],"selection":[156,195],"suitable":[158],"from":[160],"bunch":[162],"predicted":[164],"most":[168],"intriguing":[169],"challenge":[170],"even":[171],"now.":[172],"So":[173],"for":[177],"very":[183],"smoldering":[184],"issue":[185],"be":[187],"solved":[188],"present":[191],"scenario":[192],"since":[193],"feature":[194],"computationally":[197],"NP":[199],"hard":[200],"problem.":[201],"this":[203],"paper,":[204],"we":[205],"presented":[207],"ant":[209],"colony":[210],"optimization":[211],"meta-heuristic":[213],"methodology":[214],"identify":[216],"up":[221],"considerable":[224],"amount":[225],"accuracy":[227],"further":[229],"results":[231],"analyzed":[233],"using":[234],"linear":[235],"regression":[236],"ANCOVA":[238],"methods.":[239],"It":[240],"observed":[243],"that":[244,258],"comparatively":[249],"significant":[250],"than":[251],"Further":[254],"analysis":[256],"reveals":[257],"both":[259],"simultaneously":[265],"important":[266]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
