{"id":"https://openalex.org/W2789391247","doi":"https://doi.org/10.1109/mhs.2017.8305288","title":"Model-based feedback control of synthetic biomolecular circuits","display_name":"Model-based feedback control of synthetic biomolecular circuits","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W2789391247","doi":"https://doi.org/10.1109/mhs.2017.8305288","mag":"2789391247"},"language":"en","primary_location":{"id":"doi:10.1109/mhs.2017.8305288","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2017.8305288","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012594690","display_name":"Yutaka Hori","orcid":"https://orcid.org/0000-0002-3253-4985"},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yutaka Hori","raw_affiliation_strings":["Department of Applied Physics and Physico-Informatics, Keio University, Kanagawa, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Applied Physics and Physico-Informatics, Keio University, Kanagawa, Japan","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012594690"],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16393824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":null,"first_page":"1","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9778000116348267,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9763000011444092,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.7851616144180298},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6500835418701172},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.5489254593849182},{"id":"https://openalex.org/keywords/feedback-control","display_name":"Feedback control","score":0.5413448810577393},{"id":"https://openalex.org/keywords/feedback-loop","display_name":"Feedback loop","score":0.5223337411880493},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.4441235065460205},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.4096614718437195},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.36833980679512024},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.2365327775478363},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2103044092655182},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.12914833426475525},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.10327097773551941}],"concepts":[{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.7851616144180298},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6500835418701172},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.5489254593849182},{"id":"https://openalex.org/C3018651601","wikidata":"https://www.wikidata.org/wiki/Q183635","display_name":"Feedback control","level":2,"score":0.5413448810577393},{"id":"https://openalex.org/C186886427","wikidata":"https://www.wikidata.org/wiki/Q5441213","display_name":"Feedback loop","level":2,"score":0.5223337411880493},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.4441235065460205},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.4096614718437195},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.36833980679512024},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2365327775478363},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2103044092655182},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.12914833426475525},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.10327097773551941},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mhs.2017.8305288","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2017.8305288","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1645305843","https://openalex.org/W2061094822","https://openalex.org/W2062162460"],"related_works":["https://openalex.org/W2120971204","https://openalex.org/W2166646476","https://openalex.org/W2530775458","https://openalex.org/W2626881661","https://openalex.org/W2140005900","https://openalex.org/W4367368619","https://openalex.org/W2324377423","https://openalex.org/W2074649795","https://openalex.org/W2105065825","https://openalex.org/W2081562518"],"abstract_inverted_index":{"The":[0,57],"advance":[1],"of":[2,11,30,37,55,70],"synthetic":[3,12],"biology":[4],"has":[5,39],"opened":[6],"up":[7],"many":[8],"potential":[9],"applications":[10],"biocircuits,":[13],"including":[14],"sensing,":[15],"computation":[16],"and":[17,27,32,49,63],"high-value":[18],"chemical":[19],"production":[20],"using":[21],"biological":[22],"cells.":[23],"To":[24],"enable":[25,67],"rational":[26],"robust":[28],"design":[29,36],"large-scale":[31],"complex":[33],"systems,":[34],"model-guided":[35],"biocircuits":[38],"been":[40],"increasingly":[41],"important.":[42],"Here":[43],"we":[44],"review":[45],"a":[46],"combined":[47],"theoretical":[48],"experimental":[50],"platform":[51],"for":[52],"model-based":[53],"optimization":[54],"biocircuits.":[56],"framework":[58],"combines":[59],"feedback":[60,81],"control":[61],"theory":[62],"microfluidic":[64],"technology":[65],"to":[66],"rapid":[68],"characterization":[69],"biocircuit":[71],"dynamics":[72],"in":[73,80],"vitro":[74],"based":[75],"on":[76],"advanced":[77],"mathematical":[78],"tools":[79],"control.":[82]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}