{"id":"https://openalex.org/W2572867922","doi":"https://doi.org/10.1109/mhs.2016.7824183","title":"Relationship between dynamic stress field and ECM production in regenerated cartilage tissue","display_name":"Relationship between dynamic stress field and ECM production in regenerated cartilage tissue","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2572867922","doi":"https://doi.org/10.1109/mhs.2016.7824183","mag":"2572867922"},"language":"en","primary_location":{"id":"doi:10.1109/mhs.2016.7824183","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2016.7824183","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103841358","display_name":"Keisuke Fukuda","orcid":null},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Keisuke Fukuda","raw_affiliation_strings":["Graduate School of Engineering, Kyushu University, Japan#TAB#"],"affiliations":[{"raw_affiliation_string":"Graduate School of Engineering, Kyushu University, Japan#TAB#","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065256248","display_name":"Yoshifumi Shigyo","orcid":null},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshifumi Shigyo","raw_affiliation_strings":["Graduate School of Engineering, Kyushu University, Japan#TAB#"],"affiliations":[{"raw_affiliation_string":"Graduate School of Engineering, Kyushu University, Japan#TAB#","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004383579","display_name":"Hideaki Ariura","orcid":null},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki Ariura","raw_affiliation_strings":["Graduate School of Engineering, Kyushu University, Japan#TAB#"],"affiliations":[{"raw_affiliation_string":"Graduate School of Engineering, Kyushu University, Japan#TAB#","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035215390","display_name":"Seiji Omata","orcid":"https://orcid.org/0000-0003-0985-8567"},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Omata","raw_affiliation_strings":["Dept. of Micro-nano Systems Engineering, Nagoya University, Japan"],"affiliations":[{"raw_affiliation_string":"Dept. of Micro-nano Systems Engineering, Nagoya University, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076152053","display_name":"Takehiro Morita","orcid":null},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takehiro Morita","raw_affiliation_strings":["Faculty of Engineering, Kyushu University, Japan 744 Motooka, Nishi-ku, Fukuoka city, Fukuoka, 819-0395 Japan"],"affiliations":[{"raw_affiliation_string":"Faculty of Engineering, Kyushu University, Japan 744 Motooka, Nishi-ku, Fukuoka city, Fukuoka, 819-0395 Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063181861","display_name":"Tetsuo Yamaguchi","orcid":"https://orcid.org/0000-0003-1943-7790"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Yamaguchi","raw_affiliation_strings":["Faculty of Engineering, Kyushu University, Japan 744 Motooka, Nishi-ku, Fukuoka city, Fukuoka, 819-0395 Japan"],"affiliations":[{"raw_affiliation_string":"Faculty of Engineering, Kyushu University, Japan 744 Motooka, Nishi-ku, Fukuoka city, Fukuoka, 819-0395 Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039539494","display_name":"Yoshinori Sawae","orcid":"https://orcid.org/0000-0001-9255-5297"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Sawae","raw_affiliation_strings":["Faculty of Engineering, Kyushu University, Japan 744 Motooka, Nishi-ku, Fukuoka city, Fukuoka, 819-0395 Japan"],"affiliations":[{"raw_affiliation_string":"Faculty of Engineering, Kyushu University, Japan 744 Motooka, Nishi-ku, Fukuoka city, Fukuoka, 819-0395 Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5103841358"],"corresponding_institution_ids":["https://openalex.org/I135598925"],"apc_list":null,"apc_paid":null,"fwci":0.3785,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.7293305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.9376000165939331,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.9143000245094299,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cartilage","display_name":"Cartilage","score":0.8126747608184814},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.5753438472747803},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4878525733947754},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.4794694185256958},{"id":"https://openalex.org/keywords/chondrocyte","display_name":"Chondrocyte","score":0.46665358543395996},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.40092161297798157},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.35713058710098267},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.35298311710357666},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09320032596588135},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.057614266872406006}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.8126747608184814},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5753438472747803},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4878525733947754},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4794694185256958},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.46665358543395996},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.40092161297798157},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.35713058710098267},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35298311710357666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09320032596588135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.057614266872406006},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mhs.2016.7824183","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2016.7824183","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2031287613"],"related_works":["https://openalex.org/W3113789775","https://openalex.org/W4232436370","https://openalex.org/W2490525963","https://openalex.org/W2168602801","https://openalex.org/W1480797633","https://openalex.org/W4313424032","https://openalex.org/W2039195542","https://openalex.org/W3214112236","https://openalex.org/W2897130206","https://openalex.org/W1965971430"],"abstract_inverted_index":{"Mechanical":[0],"stresses":[1],"exerted":[2,89],"in":[3,16,33,90,129,140,152],"articular":[4],"cartilage":[5,35,75,92,150,182],"during":[6],"daily":[7],"joint":[8,58,155],"movements":[9],"can":[10],"stimulate":[11,133],"the":[12,34,52,69,74,81,91,104,107,110,121,146,159,163,166,175],"metabolism":[13],"of":[14,20,28,44,162,180],"chondrocytes":[15,29,134],"cartilage.":[17,55],"Upregulative":[18],"effects":[19,173],"mechanical":[21],"stimuli":[22],"on":[23,103,165,174],"extracellular":[24],"matrix":[25],"(ECM)":[26],"biosynthesis":[27],"have":[30],"been":[31],"utilized":[32],"tissue":[36,39,76],"for":[37],"regenerative":[38],"engineering.":[40],"However,":[41],"dynamic":[42],"functionalities":[43],"these":[45],"regenerated":[46,181],"cartilages":[47],"were":[48],"lacked":[49],"compared":[50,119],"with":[51,120],"natural":[53],"arthrodial":[54],"Natural":[56],"synovial":[57,154],"surfaces":[59,151],"are":[60],"contacting":[61],"and":[62,136,178],"sliding":[63],"each":[64],"other.":[65],"As":[66],"a":[67,153],"result,":[68],"loading":[70],"condition":[71],"applied":[72],"to":[73,115],"is":[77,88,100,113,156],"not":[78],"simple.":[79],"Under":[80],"contact":[82,98],"between":[83,149],"surfaces,":[84],"non-uniform":[85],"stress":[86,96,118,128],"distribution":[87,177],"tissue.":[93,142,183],"The":[94],"shear":[95,117],"at":[97],"area":[99],"highly":[101],"depended":[102],"distance":[105],"from":[106],"surface.":[108],"Moreover,":[109],"surface":[111,130],"region":[112,131],"exposed":[114],"larger":[116],"deep":[122],"region.":[123],"We":[124],"hypothesized":[125],"that":[126],"high":[127],"may":[132],"selectively":[135],"establish":[137],"anisotropic":[138],"structure":[139],"elaborated":[141],"In":[143],"this":[144],"study,":[145],"relative":[147],"motion":[148,161],"simulated":[157],"by":[158],"rolling-sliding":[160],"roller":[164],"cultured":[167],"chondrocyte-agarose":[168],"construct.":[169],"Then,":[170],"we":[171],"investigated":[172],"ECM":[176],"morphology":[179]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}