{"id":"https://openalex.org/W2575677348","doi":"https://doi.org/10.1109/mhs.2016.7824176","title":"ECM-mimicking thermoresponsive surface for manipulating hepatocyte sheets with maintenance of hepatic functions","display_name":"ECM-mimicking thermoresponsive surface for manipulating hepatocyte sheets with maintenance of hepatic functions","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2575677348","doi":"https://doi.org/10.1109/mhs.2016.7824176","mag":"2575677348"},"language":"en","primary_location":{"id":"doi:10.1109/mhs.2016.7824176","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2016.7824176","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017429197","display_name":"Jun Kobayashi","orcid":"https://orcid.org/0000-0003-0493-6386"},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Jun Kobayashi","raw_affiliation_strings":["Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062378145","display_name":"Yoshikatsu Akiyama","orcid":"https://orcid.org/0000-0002-4918-6294"},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikatsu Akiyama","raw_affiliation_strings":["Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021209820","display_name":"Masayuki Yamato","orcid":"https://orcid.org/0000-0002-3146-1024"},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Yamato","raw_affiliation_strings":["Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046565682","display_name":"Teruo Okano","orcid":"https://orcid.org/0000-0002-4470-9842"},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Teruo Okano","raw_affiliation_strings":["Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017429197"],"corresponding_institution_ids":["https://openalex.org/I4210136522"],"apc_list":null,"apc_paid":null,"fwci":0.3451,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.66512141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/internalization","display_name":"Internalization","score":0.6881359219551086},{"id":"https://openalex.org/keywords/hepatocyte","display_name":"Hepatocyte","score":0.6245283484458923},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.6112874746322632},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5935503840446472},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"Epidermal growth factor","score":0.5539490580558777},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5235604643821716},{"id":"https://openalex.org/keywords/heparin","display_name":"Heparin","score":0.5036489367485046},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"Hepatocyte growth factor","score":0.4526866674423218},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4519091844558716},{"id":"https://openalex.org/keywords/glycosaminoglycan","display_name":"Glycosaminoglycan","score":0.44637593626976013},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"Cell adhesion","score":0.4203941822052002},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.41652196645736694},{"id":"https://openalex.org/keywords/adhesion","display_name":"Adhesion","score":0.41573113203048706},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.35828882455825806},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.27667659521102905},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.2320418655872345},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2262764871120453}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.6881359219551086},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6245283484458923},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6112874746322632},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5935503840446472},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5539490580558777},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5235604643821716},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5036489367485046},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.4526866674423218},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4519091844558716},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.44637593626976013},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4203941822052002},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41652196645736694},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.41573113203048706},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.35828882455825806},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27667659521102905},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2320418655872345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2262764871120453},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mhs.2016.7824176","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2016.7824176","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.49000000953674316}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1995182111","https://openalex.org/W2041018126","https://openalex.org/W2058221324","https://openalex.org/W2064027952","https://openalex.org/W2319364912","https://openalex.org/W2405302860"],"related_works":["https://openalex.org/W4366318089","https://openalex.org/W2068721292","https://openalex.org/W4225584766","https://openalex.org/W2145545797","https://openalex.org/W2764950946","https://openalex.org/W2952148578","https://openalex.org/W1973571232","https://openalex.org/W2398019254","https://openalex.org/W2031297001","https://openalex.org/W1993156922"],"abstract_inverted_index":{"Hepatic":[0],"cellular":[1],"sheet-based":[2],"tissue":[3],"engineering":[4],"is":[5,212],"an":[6,67],"attractive":[7],"method":[8],"for":[9],"the":[10,28,34,43,93,125,149,159,163,173,192],"treatment":[11],"of":[12,33,97,120,127,145,180,194,206],"liver":[13,210,220],"diseases.":[14],"However,":[15],"cultured":[16,146,160],"hepatocytes":[17,98,147,161],"rapidly":[18],"lose":[19],"their":[20],"viability":[21],"and":[22,65,95,112,143,162,178,208],"phenotypic":[23],"functions":[24,102,201],"on":[25,63,130,148],"isolation":[26],"from":[27,172],"native":[29],"in":[30,116],"vivo":[31],"microenvironment":[32],"liver.":[35],"For":[36],"providing":[37],"extracellular":[38],"matrix":[39],"(ECM)-mimicking":[40],"micro-environment":[41],"to":[42,60,214,218],"isolated":[44],"hepatocytes,":[45],"poly(N-isopropylacrylamide)":[46],"(PIPAAm)-grafted":[47],"cell":[48,81,89,170,188,196],"culture":[49,90,189],"surface":[50,91,132],"was":[51,133],"functionalized":[52],"with":[53,70,99,198],"heparin,":[54],"which":[55],"has":[56],"a":[57,137,168,216],"similar":[58],"structure":[59],"heparan":[61],"sulfate":[62],"proteoglycans":[64],"possesses":[66],"affinity":[68],"interaction":[69],"heparin-binding":[71,75],"proteins":[72],"such":[73,103],"as":[74,104,167],"EGF-like":[76],"growth":[77,164],"factor":[78],"(HB-EGF).":[79],"A":[80],"cultivation":[82],"system":[83],"using":[84],"HB-EGF":[85,108,121,150],"bound":[86,151],"heparin-immobilized":[87,131],"thermoresponsive":[88,182,187],"maintains":[92],"survival":[94],"adhesion":[96],"highly":[100],"hepatic":[101,195,200],"albumin":[105],"secretion.":[106],"Bound":[107],"stimulated":[109],"EGF":[110,128],"receptor":[111],"MAPK":[113],"family":[114],"ERK1/2":[115],"dose-dependent":[117],"manner.":[118],"Time-course":[119],"stimulation":[122,142],"revealed":[123],"that":[124],"internalization":[126],"receptors":[129],"partially":[134],"suppressed":[135],"during":[136],"few":[138],"days":[139],"incubation.":[140],"Sustained":[141],"activation":[144],"surfaces":[152,190],"were":[153],"also":[154],"confirmed.":[155],"In":[156,184],"addition,":[157],"both":[158],"factors":[165],"detached":[166],"contiguous":[169],"sheet":[171],"surface,":[174],"accompanied":[175],"by":[176,202],"swelling":[177],"expanding":[179],"grafted":[181],"polymer.":[183],"conclusion,":[185],"ECM-mimicking":[186],"facilitated":[191],"manipulation":[193],"sheets":[197],"maintaining":[199],"changing":[203],"temperature.":[204],"Creation":[205],"transferable":[207],"functional":[209],"tissues":[211],"considered":[213],"have":[215],"potential":[217],"treat":[219],"disease.":[221]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
