{"id":"https://openalex.org/W2573437404","doi":"https://doi.org/10.1109/mhs.2016.7824174","title":"Study on the effects of the hierarchical structures of collagen gels on the morphologies of engineered liver cancer tissues","display_name":"Study on the effects of the hierarchical structures of collagen gels on the morphologies of engineered liver cancer tissues","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2573437404","doi":"https://doi.org/10.1109/mhs.2016.7824174","mag":"2573437404"},"language":"en","primary_location":{"id":"doi:10.1109/mhs.2016.7824174","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2016.7824174","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028623998","display_name":"Kazuya Furusawa","orcid":"https://orcid.org/0000-0002-4465-3711"},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuya Furusawa","raw_affiliation_strings":["Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan"],"affiliations":[{"raw_affiliation_string":"Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061532585","display_name":"Masayuki Tsuchida","orcid":null},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Tsuchida","raw_affiliation_strings":["Graduate school of Life Science, Hokkaido University, Sapporo, Japan"],"affiliations":[{"raw_affiliation_string":"Graduate school of Life Science, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028623998"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1511283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-healing-hydrogels","display_name":"Self-healing hydrogels","score":0.7496755719184875},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5916739106178284},{"id":"https://openalex.org/keywords/morphology","display_name":"Morphology (biology)","score":0.5812773108482361},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.44199076294898987},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.441878080368042},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.39475110173225403},{"id":"https://openalex.org/keywords/chemical-engineering","display_name":"Chemical engineering","score":0.37784284353256226},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.35344475507736206},{"id":"https://openalex.org/keywords/polymer-chemistry","display_name":"Polymer chemistry","score":0.15276965498924255},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07082808017730713}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.7496755719184875},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5916739106178284},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.5812773108482361},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44199076294898987},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.441878080368042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39475110173225403},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.37784284353256226},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.35344475507736206},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.15276965498924255},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07082808017730713},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mhs.2016.7824174","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2016.7824174","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2304196408","https://openalex.org/W2332322221","https://openalex.org/W2398141085"],"related_works":["https://openalex.org/W2038809418","https://openalex.org/W2277257395","https://openalex.org/W2485176123","https://openalex.org/W3112245919","https://openalex.org/W4211054287","https://openalex.org/W2891312418","https://openalex.org/W2493939882","https://openalex.org/W2503803213","https://openalex.org/W2800680006","https://openalex.org/W2379987675"],"abstract_inverted_index":{"We":[0],"have":[1],"developed":[2],"the":[3,7,34,44,67,74,92,99],"method":[4],"to":[5],"control":[6,66],"macroscopic":[8,75,100],"morphologies":[9,69],"of":[10,21,70,77,84,102],"engineered":[11],"liver":[12],"cancer":[13],"tissues":[14],"(ELCTs)":[15],"by":[16,72],"using":[17],"three":[18],"dimensional":[19],"culture":[20,35,93],"HepG2":[22,37],"cells":[23,38],"in":[24,43,55],"collagen":[25,45,78,103],"gels":[26],"with":[27,47],"and":[28,86],"without":[29,57],"a":[30],"multichannel":[31,48,58],"structure.":[32,59],"During":[33],"period,":[36],"formed":[39],"rod-like":[40],"cell":[41,52],"aggregates":[42,53],"gel":[46],"structure,":[49],"whereas":[50],"sphere-like":[51],"observed":[54],"ELCT":[56],"The":[60],"results":[61],"showed":[62],"that":[63],"we":[64],"can":[65],"microscopic":[68],"ELCTs":[71,90],"regulating":[73],"structure":[76,101],"hydrogels.":[79,104],"By":[80],"contrast,":[81],"time":[82],"courses":[83],"diameter":[85],"aspect":[87],"ratio":[88],"for":[89],"during":[91],"period":[94],"were":[95],"not":[96],"dependent":[97],"on":[98]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}