{"id":"https://openalex.org/W2305657469","doi":"https://doi.org/10.1109/mhs.2015.7438332","title":"A new method for fabricating cell-embedded ECM capsules and ECM-loaded spheroids","display_name":"A new method for fabricating cell-embedded ECM capsules and ECM-loaded spheroids","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2305657469","doi":"https://doi.org/10.1109/mhs.2015.7438332","mag":"2305657469"},"language":"en","primary_location":{"id":"doi:10.1109/mhs.2015.7438332","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2015.7438332","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008837563","display_name":"Fumiya Tao","orcid":"https://orcid.org/0000-0002-9714-7396"},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Fumiya Tao","raw_affiliation_strings":["Yokohama City University, Yokohama, Kanagawa, Japan"],"affiliations":[{"raw_affiliation_string":"Yokohama City University, Yokohama, Kanagawa, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003500065","display_name":"Nobuhiko Kojima","orcid":"https://orcid.org/0000-0003-2555-0570"},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiko Kojima","raw_affiliation_strings":["Yokohama City University, Yokohama, Kanagawa, Japan"],"affiliations":[{"raw_affiliation_string":"Yokohama City University, Yokohama, Kanagawa, Japan","institution_ids":["https://openalex.org/I89630735"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008837563"],"corresponding_institution_ids":["https://openalex.org/I89630735"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.14315981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9420999884605408,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12224","display_name":"Nanofabrication and Lithography Techniques","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spheroid","display_name":"Spheroid","score":0.7541623711585999},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4607246220111847},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3767545819282532},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.330777645111084},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1284058392047882}],"concepts":[{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.7541623711585999},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4607246220111847},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3767545819282532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.330777645111084},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1284058392047882},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mhs.2015.7438332","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2015.7438332","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2043548457"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487","https://openalex.org/W1986764834","https://openalex.org/W657579294"],"abstract_inverted_index":{"A":[0],"typical":[1],"three-dimensional":[2],"culture":[3],"of":[4,22,55,62,79,113,144,158,169,176],"hepatocytes":[5],"is":[6,51],"to":[7,32,186],"embed":[8],"cells":[9,89,117,147],"in":[10,118],"extracellular":[11],"matrix":[12],"(ECM)":[13],"capsule":[14,120],"by":[15,104],"using":[16,43],"an":[17],"emulsion":[18],"method.":[19],"However,":[20,108],"usage":[21],"oil":[23],"causes":[24],"cellular":[25,95],"damage.":[26],"In":[27,151,179],"this":[28,152,156],"study,":[29,153],"we":[30,68,101,137,154,181],"aimed":[31],"establish":[33],"a":[34,52,183],"new":[35,184],"method":[36,185],"for":[37],"forming":[38],"cell-embedded":[39,56],"ECM":[40,57,66,81,119,161,188],"capsules":[41,58,103,189],"without":[42],"oil.":[44],"We":[45,75],"also":[46],"report":[47],"\u201cECM-loaded":[48,163],"spheroids\u201d":[49],"which":[50],"different":[53],"type":[54],"having":[59],"less":[60],"amount":[61],"ECM.":[63],"To":[64],"form":[65],"capsule,":[67],"utilized":[69],"the":[70,91,105,109,114,142],"methylcellulose":[71],"(MC)":[72],"medium":[73],"[1].":[74],"injected":[76],"1":[77],"\u03bcl":[78],"undiluted":[80],"(Matrigel":[82],"or":[83],"collagen)":[84],"suspending":[85],"2000":[86],"Hep":[87,115],"G2":[88,116],"into":[90],"MC":[92,106],"medium.":[93,107],"The":[94,165],"damage":[96],"was":[97,121,148,172],"obviously":[98],"reduced":[99],"when":[100],"made":[102],"albumin":[110,166],"secretion":[111,167],"activity":[112,168],"half":[122],"level":[123],"compared":[124],"with":[125,160],"normal":[126,177],"multicellular":[127],"spheroids":[128,171,195],"because":[129],"too":[130],"much":[131],"gels":[132],"inhibited":[133],"cell-to-cell":[134],"interaction.":[135],"When":[136],"used":[138],"30-times":[139],"diluted":[140],"Matrigel,":[141],"thickness":[143],"gel":[145],"between":[146],"significantly":[149],"reduced.":[150],"called":[155],"kind":[157],"spheroid":[159],"as":[162],"spheroid\u201d.":[164],"ECM-loaded":[170,191,194],"higher":[173,197],"than":[174,200],"that":[175],"spheroids.":[178,202],"conclusion,":[180],"established":[182],"fabricate":[187],"and":[190,193],"spheroids,":[192],"demonstrated":[196],"hepatic":[198],"function":[199],"conventional":[201]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}