{"id":"https://openalex.org/W2304035820","doi":"https://doi.org/10.1109/mhs.2015.7438242","title":"Fabrication of functional liver tissues by cell sheet-based bioassembler technologies","display_name":"Fabrication of functional liver tissues by cell sheet-based bioassembler technologies","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2304035820","doi":"https://doi.org/10.1109/mhs.2015.7438242","mag":"2304035820"},"language":"en","primary_location":{"id":"doi:10.1109/mhs.2015.7438242","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2015.7438242","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017429197","display_name":"Jun Kobayashi","orcid":"https://orcid.org/0000-0003-0493-6386"},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Jun Kobayashi","raw_affiliation_strings":["Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062378145","display_name":"Yoshikatsu Akiyama","orcid":"https://orcid.org/0000-0002-4918-6294"},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikatsu Akiyama","raw_affiliation_strings":["Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021209820","display_name":"Masayuki Yamato","orcid":"https://orcid.org/0000-0002-3146-1024"},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Yamato","raw_affiliation_strings":["Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046565682","display_name":"Teruo Okano","orcid":"https://orcid.org/0000-0002-4470-9842"},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Teruo Okano","raw_affiliation_strings":["Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017429197"],"corresponding_institution_ids":["https://openalex.org/I4210136522"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.14264515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.6769073605537415},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.6460889577865601},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.6139006614685059},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"Hepatocyte growth factor","score":0.5452994108200073},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5272476077079773},{"id":"https://openalex.org/keywords/cell-encapsulation","display_name":"Cell encapsulation","score":0.4874589443206787},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.480507493019104},{"id":"https://openalex.org/keywords/hepatocyte","display_name":"Hepatocyte","score":0.4691556692123413},{"id":"https://openalex.org/keywords/heparin","display_name":"Heparin","score":0.456196129322052},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.453025758266449},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.42482441663742065},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3904220461845398},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.36501869559288025},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.354384183883667},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.31935828924179077},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20607981085777283},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1728433072566986},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.09332230687141418}],"concepts":[{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.6769073605537415},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6460889577865601},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.6139006614685059},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.5452994108200073},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5272476077079773},{"id":"https://openalex.org/C193855658","wikidata":"https://www.wikidata.org/wiki/Q5058189","display_name":"Cell encapsulation","level":3,"score":0.4874589443206787},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.480507493019104},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4691556692123413},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.456196129322052},{"id":"https://openalex.org/C163688615","wikidata":"https://www.wikidata.org/wiki/Q15883629","display_name":"3D cell culture","level":3,"score":0.453025758266449},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.42482441663742065},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3904220461845398},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.36501869559288025},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.354384183883667},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.31935828924179077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20607981085777283},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1728433072566986},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09332230687141418},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mhs.2015.7438242","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2015.7438242","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1605481523","https://openalex.org/W1980780439","https://openalex.org/W1995182111","https://openalex.org/W2042554154","https://openalex.org/W2064027952","https://openalex.org/W2086798913","https://openalex.org/W2405302860"],"related_works":["https://openalex.org/W2031297001","https://openalex.org/W1993156922","https://openalex.org/W4283786831","https://openalex.org/W2904501357","https://openalex.org/W2888875135","https://openalex.org/W2074640863","https://openalex.org/W2899380208","https://openalex.org/W4392400975","https://openalex.org/W3199840668","https://openalex.org/W4376129326"],"abstract_inverted_index":{"Hepatocyte-based":[0],"tissue":[1,56],"engineering":[2],"is":[3,60,105],"an":[4],"attractive":[5],"method":[6],"for":[7,48,142],"the":[8,25,31,50,63,94,113,147],"treatment":[9],"of":[10,30,43,53,65,98,116,151,162],"liver":[11],"diseases.":[12],"However,":[13],"hepatocytes":[14],"rapidly":[15],"lose":[16],"their":[17,77],"viability":[18],"and":[19,68,74,96],"phenotypic":[20],"functions":[21,145],"on":[22],"isolation":[23],"from":[24],"native":[26,66,119],"in":[27,71,117],"vivo":[28,72,118],"microenvironment":[29],"liver.":[32],"To":[33],"overcome":[34],"these":[35,159],"problems,":[36],"our":[37],"laboratory":[38],"has":[39,139],"designed":[40,90,141],"new":[41,160],"types":[42,161],"thermoresponsive":[44,87,163],"cell":[45,54,101,124,153,164],"culture":[46,125,165],"surfaces":[47,88],"advancing":[49],"next":[51],"stage":[52],"sheet-based":[55],"engineering.":[57],"One":[58],"approach":[59,104],"to":[61,91,106],"resemble":[62,112],"microstructures":[64],"tissues":[67,73],"organs.":[69],"Most":[70],"organs":[75],"have":[76],"own":[78],"unique":[79],"structures,":[80],"such":[81,132],"as":[82,133],"multi-cellular,":[83],"micrometer-scale":[84],"organizations.":[85],"Micropatterned":[86],"were":[89],"enable":[92],"both":[93],"culturing":[95],"recovery":[97],"patterned":[99],"heterotypic":[100],"sheets.":[102],"Another":[103],"use":[107],"extracellular":[108],"matrices":[109],"(ECMs),":[110],"which":[111,127],"surrounding":[114],"environments":[115],"tissues.":[120],"Heparin-functionalized":[121],"poly(N-isopropylacrylamide)":[122],"(PIPAAm)-grafted":[123],"surface,":[126],"interacts":[128],"with":[129],"heparin-binding":[130,134],"proteins":[131],"EGF-like":[135],"growth":[136],"factor":[137],"(HB-EGF),":[138],"been":[140],"maintaining":[143],"hepatic":[144,152],"during":[146],"cultivation.":[148],"The":[149],"function":[150],"sheet":[154],"was":[155],"maintained":[156],"by":[157],"using":[158],"surfaces.":[166]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}