{"id":"https://openalex.org/W2004875425","doi":"https://doi.org/10.1109/mhs.2013.6710411","title":"Electrokinetic intracellular delivery combined with vibration-assisted cell membrane perforation","display_name":"Electrokinetic intracellular delivery combined with vibration-assisted cell membrane perforation","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2004875425","doi":"https://doi.org/10.1109/mhs.2013.6710411","mag":"2004875425"},"language":"en","primary_location":{"id":"doi:10.1109/mhs.2013.6710411","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2013.6710411","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MHS2013","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060388998","display_name":"Tatsuya Ozawa","orcid":"https://orcid.org/0000-0001-8424-1562"},"institutions":[{"id":"https://openalex.org/I136259955","display_name":"Toyohashi University of Technology","ror":"https://ror.org/04ezg6d83","country_code":"JP","type":"education","lineage":["https://openalex.org/I136259955"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tatsuya Ozawa","raw_affiliation_strings":["Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan","Dept. of Mech. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan","institution_ids":["https://openalex.org/I136259955"]},{"raw_affiliation_string":"Dept. of Mech. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan","institution_ids":["https://openalex.org/I136259955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042348385","display_name":"Yasuharu Ito","orcid":null},"institutions":[{"id":"https://openalex.org/I136259955","display_name":"Toyohashi University of Technology","ror":"https://ror.org/04ezg6d83","country_code":"JP","type":"education","lineage":["https://openalex.org/I136259955"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuharu Ito","raw_affiliation_strings":["Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan","Dept. of Mech. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan","institution_ids":["https://openalex.org/I136259955"]},{"raw_affiliation_string":"Dept. of Mech. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan","institution_ids":["https://openalex.org/I136259955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038050436","display_name":"Moeto Nagai","orcid":"https://orcid.org/0000-0002-7852-7772"},"institutions":[{"id":"https://openalex.org/I136259955","display_name":"Toyohashi University of Technology","ror":"https://ror.org/04ezg6d83","country_code":"JP","type":"education","lineage":["https://openalex.org/I136259955"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Moeto Nagai","raw_affiliation_strings":["Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan","Dept. of Mech. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan","institution_ids":["https://openalex.org/I136259955"]},{"raw_affiliation_string":"Dept. of Mech. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan","institution_ids":["https://openalex.org/I136259955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038000762","display_name":"Takahiro Kawashima","orcid":null},"institutions":[{"id":"https://openalex.org/I136259955","display_name":"Toyohashi University of Technology","ror":"https://ror.org/04ezg6d83","country_code":"JP","type":"education","lineage":["https://openalex.org/I136259955"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Kawashima","raw_affiliation_strings":["Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan","Dept. of Mech. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan","institution_ids":["https://openalex.org/I136259955"]},{"raw_affiliation_string":"Dept. of Mech. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan","institution_ids":["https://openalex.org/I136259955"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001830605","display_name":"Takayuki Shibata","orcid":"https://orcid.org/0000-0003-0972-2950"},"institutions":[{"id":"https://openalex.org/I136259955","display_name":"Toyohashi University of Technology","ror":"https://ror.org/04ezg6d83","country_code":"JP","type":"education","lineage":["https://openalex.org/I136259955"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Shibata","raw_affiliation_strings":["Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan","Dept. of Mech. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan","institution_ids":["https://openalex.org/I136259955"]},{"raw_affiliation_string":"Dept. of Mech. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan","institution_ids":["https://openalex.org/I136259955"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5060388998"],"corresponding_institution_ids":["https://openalex.org/I136259955"],"apc_list":null,"apc_paid":null,"fwci":0.1998,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55178698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"12","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrokinetic-phenomena","display_name":"Electrokinetic phenomena","score":0.765381932258606},{"id":"https://openalex.org/keywords/pipette","display_name":"Pipette","score":0.6812018156051636},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.6371024250984192},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.5594552755355835},{"id":"https://openalex.org/keywords/hela","display_name":"HeLa","score":0.5512989163398743},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5398430824279785},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.5071351528167725},{"id":"https://openalex.org/keywords/cell-membrane","display_name":"Cell membrane","score":0.46094852685928345},{"id":"https://openalex.org/keywords/perforation","display_name":"Perforation","score":0.4590001106262207},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.45777106285095215},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42039719223976135},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.42025917768478394},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3891844153404236},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.36518847942352295},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13553127646446228},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08011320233345032},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.07150846719741821}],"concepts":[{"id":"https://openalex.org/C27703432","wikidata":"https://www.wikidata.org/wiki/Q2778467","display_name":"Electrokinetic phenomena","level":2,"score":0.765381932258606},{"id":"https://openalex.org/C151552171","wikidata":"https://www.wikidata.org/wiki/Q163373","display_name":"Pipette","level":2,"score":0.6812018156051636},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6371024250984192},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.5594552755355835},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.5512989163398743},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5398430824279785},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5071351528167725},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.46094852685928345},{"id":"https://openalex.org/C2778456384","wikidata":"https://www.wikidata.org/wiki/Q1508510","display_name":"Perforation","level":3,"score":0.4590001106262207},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45777106285095215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42039719223976135},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.42025917768478394},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3891844153404236},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36518847942352295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13553127646446228},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08011320233345032},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.07150846719741821},{"id":"https://openalex.org/C2778527123","wikidata":"https://www.wikidata.org/wiki/Q11750728","display_name":"Punching","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mhs.2013.6710411","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2013.6710411","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MHS2013","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2027840322","https://openalex.org/W2049757756","https://openalex.org/W2083720101","https://openalex.org/W2161203530","https://openalex.org/W2162046649","https://openalex.org/W2324415148"],"related_works":["https://openalex.org/W2527888227","https://openalex.org/W2335837029","https://openalex.org/W2043403464","https://openalex.org/W2236318108","https://openalex.org/W2333119910","https://openalex.org/W2358667400","https://openalex.org/W2018853599","https://openalex.org/W2087915282","https://openalex.org/W203183963","https://openalex.org/W2104894053"],"abstract_inverted_index":{"The":[0],"introduction":[1],"of":[2,22,45,62,109,117],"biological":[3,46],"macromolecules":[4],"such":[5],"as":[6],"DNA,":[7],"RNA,":[8],"and":[9,25,43,102],"proteins":[10],"into":[11,64],"living":[12,28,65],"cells":[13,47,67,118],"plays":[14],"a":[15,57,69,82,88,133],"crucial":[16],"role":[17],"in":[18,27,40,124,135],"the":[19,39,49,107,110,115,136,140,147,150,154],"fundamental":[20],"analysis":[21,44],"cellular":[23],"functions":[24],"mechanisms":[26],"systems.":[29],"Therefore,":[30],"we":[31,54,129],"have":[32],"been":[33],"developing":[34],"an":[35,122],"effective":[36],"platform":[37],"for":[38,86],"vitro":[41],"manipulation":[42],"at":[48],"single-cells.":[50],"In":[51],"this":[52],"paper,":[53],"successfully":[55],"demonstrated":[56],"novel":[58],"intracellular":[59],"delivery":[60],"method":[61,85],"DNA":[63],"HeLa":[66],"via":[68],"glass":[70],"micropipette":[71,151],"based":[72],"on":[73,98],"DC-biased":[74],"AC":[75],"electrokinetically":[76],"driven":[77],"flow.":[78],"We":[79],"also":[80,130],"proposed":[81],"vibration-assisted":[83],"insertion":[84,96,141],"penetrating":[87],"cell":[89,93,155],"membrane":[90],"to":[91,121,145],"reduce":[92,114],"damage.":[94],"Preliminary":[95],"tests":[97],"homemade":[99],"SICM":[100],"system":[101],"FEM":[103],"simulations":[104],"revealed":[105],"that":[106,132],"application":[108],"mechanical":[111],"oscillation":[112],"can":[113],"deformation":[116],"probably":[119],"due":[120],"increase":[123],"their":[125],"viscous":[126],"resistance.":[127],"Moreover,":[128],"found":[131],"change":[134],"ion":[137],"current":[138],"during":[139],"process":[142],"allows":[143],"us":[144],"detect":[146],"instant":[148],"when":[149],"tip":[152],"penetrates":[153],"membrane.":[156]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
