{"id":"https://openalex.org/W2015412456","doi":"https://doi.org/10.1109/mhs.2012.6492401","title":"3D-aggregated dermal stem cells with partial-pluripotency","display_name":"3D-aggregated dermal stem cells with partial-pluripotency","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2015412456","doi":"https://doi.org/10.1109/mhs.2012.6492401","mag":"2015412456"},"language":"en","primary_location":{"id":"doi:10.1109/mhs.2012.6492401","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2012.6492401","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101781347","display_name":"Masaki Kondo","orcid":"https://orcid.org/0000-0003-0558-3404"},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaki Kondo","raw_affiliation_strings":["Department of Immunology, Nagoya University Graduate School of Medicine, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Immunology, Nagoya University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103113989","display_name":"Hideki Kamiya","orcid":"https://orcid.org/0000-0003-3197-2542"},"institutions":[{"id":"https://openalex.org/I16528096","display_name":"Aichi Medical University","ror":"https://ror.org/02h6cs343","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Kamiya","raw_affiliation_strings":["Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 21 Karimata, Yazako, Nagakute, 480-1195, Japan"],"affiliations":[{"raw_affiliation_string":"Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 21 Karimata, Yazako, Nagakute, 480-1195, Japan","institution_ids":["https://openalex.org/I16528096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004035181","display_name":"Tetsuji Okawa","orcid":null},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuji Okawa","raw_affiliation_strings":["Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074436447","display_name":"Sachiko Ito","orcid":"https://orcid.org/0000-0001-9313-7089"},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sachiko Ito","raw_affiliation_strings":["Department of Immunology, Nagoya University Graduate School of Medicine, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Immunology, Nagoya University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039594119","display_name":"Naomi Nishio","orcid":"https://orcid.org/0000-0002-2292-4701"},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naomi Nishio","raw_affiliation_strings":["Department of Immunology, Nagoya University Graduate School of Medicine, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Immunology, Nagoya University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082272844","display_name":"Tatsuhito Himeno","orcid":"https://orcid.org/0000-0002-5677-1125"},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuhito Himeno","raw_affiliation_strings":["Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108218161","display_name":"Yutaka Oiso","orcid":null},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Oiso","raw_affiliation_strings":["Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106027150","display_name":"Jiro Nakamura","orcid":"https://orcid.org/0000-0003-3385-6916"},"institutions":[{"id":"https://openalex.org/I16528096","display_name":"Aichi Medical University","ror":"https://ror.org/02h6cs343","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jiro Nakamura","raw_affiliation_strings":["Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 21 Karimata, Yazako, Nagakute, 480-1195, Japan"],"affiliations":[{"raw_affiliation_string":"Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 21 Karimata, Yazako, Nagakute, 480-1195, Japan","institution_ids":["https://openalex.org/I16528096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055649452","display_name":"Ken\u2010ichi Isobe","orcid":"https://orcid.org/0000-0002-5351-8407"},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-ichi Isobe","raw_affiliation_strings":["Department of Immunology, Nagoya University Graduate School of Medicine, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Immunology, Nagoya University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5101781347"],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07091489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"156","last_page":"159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homeobox-protein-nanog","display_name":"Homeobox protein NANOG","score":0.774940013885498},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell","display_name":"Induced pluripotent stem cell","score":0.7711120843887329},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.7299109697341919},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.7040091156959534},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6683394908905029},{"id":"https://openalex.org/keywords/amniotic-epithelial-cells","display_name":"Amniotic epithelial cells","score":0.4612542390823364},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.4599754810333252},{"id":"https://openalex.org/keywords/stem-cell-marker","display_name":"Stem cell marker","score":0.4545530378818512},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44400909543037415},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"Cell therapy","score":0.41033047437667847},{"id":"https://openalex.org/keywords/adult-stem-cell","display_name":"Adult stem cell","score":0.3581502437591553},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33581632375717163},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06951957941055298}],"concepts":[{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.774940013885498},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7711120843887329},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7299109697341919},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.7040091156959534},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6683394908905029},{"id":"https://openalex.org/C138851942","wikidata":"https://www.wikidata.org/wiki/Q4747406","display_name":"Amniotic epithelial cells","level":5,"score":0.4612542390823364},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4599754810333252},{"id":"https://openalex.org/C136302470","wikidata":"https://www.wikidata.org/wiki/Q7607299","display_name":"Stem cell marker","level":3,"score":0.4545530378818512},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44400909543037415},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.41033047437667847},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.3581502437591553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33581632375717163},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06951957941055298},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mhs.2012.6492401","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2012.6492401","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 International Symposium on Micro-NanoMechatronics and Human Science (MHS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6100000143051147}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1967467247","https://openalex.org/W1979417832","https://openalex.org/W1981999091","https://openalex.org/W1990183146","https://openalex.org/W2000156766","https://openalex.org/W2002179012","https://openalex.org/W2005707140","https://openalex.org/W2009804171","https://openalex.org/W2023230379","https://openalex.org/W2043950060","https://openalex.org/W2077806591","https://openalex.org/W2090573293","https://openalex.org/W2110586785","https://openalex.org/W2125987139","https://openalex.org/W2138977668","https://openalex.org/W2150600914"],"related_works":["https://openalex.org/W4323566320","https://openalex.org/W2517286276","https://openalex.org/W2911073388","https://openalex.org/W2525877122","https://openalex.org/W2335409602","https://openalex.org/W2602092987","https://openalex.org/W2083646121","https://openalex.org/W3119363889","https://openalex.org/W4249047955","https://openalex.org/W3206298437"],"abstract_inverted_index":{"Current":[0],"stem":[1,50,66,132,209],"cell":[2,166,200,210],"therapy":[3,202],"is":[4],"expected":[5],"to":[6,38,46,55,138,141,206],"be":[7,192,204],"an":[8],"efficient":[9],"method":[10],"for":[11,52],"replacement":[12],"of":[13,23,151,199],"lost":[14],"cells":[15,24,35,51,76,93,102,133,143,181],"in":[16,105,208],"many":[17],"intractable":[18],"diseases,":[19],"and":[20,31,61,89,94,121,161,176,184,196,203],"several":[21,40],"types":[22],"are":[25,44],"considered":[26],"candidate":[27],"sources":[28],"including":[29],"iPSCs":[30],"ESCs.":[32],"However,":[33],"these":[34,92,126],"still":[36],"need":[37],"elucidate":[39],"serious":[41],"problems.":[42],"We":[43,72,108,112,124,147],"trying":[45],"establish":[47],"safe":[48],"pluripotent":[49,110],"early":[53],"use":[54],"clinic.":[56],"Here":[57],"we":[58,87,136],"have":[59],"identified":[60],"established":[62],"3D":[63,106,127],"spheroidal":[64,130],"dermal":[65,75,131],"cells,":[67,153],"which":[68],"possess":[69],"partial":[70],"pluripotency.":[71],"cultured":[73,95,170],"the":[74,149,155,193],"from":[77],"GFP":[78],"carrying":[79],"C57BL/6":[80],"male":[81],"mice.":[82],"After":[83],"their":[84],"second":[85],"passage,":[86],"dissociate":[88],"quickly":[90],"aggregate":[91],"on":[96,144,171],"U-bottom":[97],"96-well":[98],"low-cell-adhesion":[99],"plates.":[100],"The":[101,179],"self":[103],"aggregated":[104],"structure.":[107],"examined":[109],"markers.":[111],"found":[113,148],"that":[114,189],"3D-aggregated":[115],"sphere":[116,128],"expressed":[117],"Nanog,":[118],"Oct4,":[119],"Sox2":[120],"SSEA-1":[122],"protein.":[123],"named":[125],"as":[129,159],"(sDSCs).":[134],"Then":[135],"tried":[137],"differentiate":[139],"sDSCs":[140,168,190],"ectodermal-lineage":[142],"PA6":[145],"cells.":[146],"appearance":[150],"neuron-like":[152],"having":[154],"neuronal":[156],"markers":[157],"such":[158],"Neurofilament":[160],"S-100b":[162],"positive.":[163],"For":[164],"endodermal-lineage":[165],"induction,":[167],"were":[169],"collagen-coated":[172],"dishes":[173],"with":[174],"FBS":[175],"Activin":[177],"A.":[178],"differentiated":[180],"express":[182],"\u03b1-fetoprotein":[183],"Pdx-1.":[185],"This":[186],"study":[187],"shows":[188],"would":[191],"low":[194],"risk":[195],"potential":[197],"applications":[198],"transplantation":[201],"able":[205],"breakthrough":[207],"treatment.":[211]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
