{"id":"https://openalex.org/W2089994888","doi":"https://doi.org/10.1109/mhs.2011.6102167","title":"Development of observation system to investigate both intracellular calcium concentration and mechanical stimuli to mammalian embryos","display_name":"Development of observation system to investigate both intracellular calcium concentration and mechanical stimuli to mammalian embryos","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2089994888","doi":"https://doi.org/10.1109/mhs.2011.6102167","mag":"2089994888"},"language":"en","primary_location":{"id":"doi:10.1109/mhs.2011.6102167","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2011.6102167","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067712691","display_name":"Koji Matsuura","orcid":"https://orcid.org/0000-0002-5960-738X"},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Koji Matsuura","raw_affiliation_strings":["Research Core for Interdisciplinary Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan","Research Core for Interdisciplinary Sciences, Okayama University, 3-1-1 Tsushima-Naka, Kita-Ku, Japan"],"affiliations":[{"raw_affiliation_string":"Research Core for Interdisciplinary Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Research Core for Interdisciplinary Sciences, Okayama University, 3-1-1 Tsushima-Naka, Kita-Ku, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075005872","display_name":"Koyo Watanabe","orcid":"https://orcid.org/0009-0001-5946-8746"},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koyo Watanabe","raw_affiliation_strings":["Research Core for Interdisciplinary Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan","Research Core for Interdisciplinary Sciences, Okayama University, 3-1-1 Tsushima-Naka, Kita-Ku, Japan"],"affiliations":[{"raw_affiliation_string":"Research Core for Interdisciplinary Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Research Core for Interdisciplinary Sciences, Okayama University, 3-1-1 Tsushima-Naka, Kita-Ku, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110363253","display_name":"Mieko Kodama","orcid":null},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mieko Kodama","raw_affiliation_strings":["Research Core for Interdisciplinary Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan","Research Core for Interdisciplinary Sciences, Okayama University, 3-1-1 Tsushima-Naka, Kita-Ku, Japan"],"affiliations":[{"raw_affiliation_string":"Research Core for Interdisciplinary Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Research Core for Interdisciplinary Sciences, Okayama University, 3-1-1 Tsushima-Naka, Kita-Ku, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110782782","display_name":"Yuka Kuroda","orcid":null},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Kuroda","raw_affiliation_strings":["Research Core for Interdisciplinary Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan","Research Core for Interdisciplinary Sciences, Okayama University, 3-1-1 Tsushima-Naka, Kita-Ku, Japan"],"affiliations":[{"raw_affiliation_string":"Research Core for Interdisciplinary Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Research Core for Interdisciplinary Sciences, Okayama University, 3-1-1 Tsushima-Naka, Kita-Ku, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013540987","display_name":"Keiji Naruse","orcid":"https://orcid.org/0000-0003-4100-6444"},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiji Naruse","raw_affiliation_strings":["Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan","Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-Cho, Kita-Ku, Japan"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-Cho, Kita-Ku, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5067712691"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":null,"apc_paid":null,"fwci":0.66303902,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.71874263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"290","issue":null,"first_page":"99","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/embryo","display_name":"Embryo","score":0.5656987428665161},{"id":"https://openalex.org/keywords/confocal-microscopy","display_name":"Confocal microscopy","score":0.5047715902328491},{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.4924517571926117},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4374775290489197},{"id":"https://openalex.org/keywords/confocal","display_name":"Confocal","score":0.4322611689567566},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.36755135655403137},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.36657047271728516},{"id":"https://openalex.org/keywords/analytical-chemistry","display_name":"Analytical Chemistry (journal)","score":0.34830474853515625},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.337615042924881},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3285921514034271},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30562448501586914},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.29322439432144165},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2484763264656067},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.15579283237457275},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.08633336424827576}],"concepts":[{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5656987428665161},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.5047715902328491},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.4924517571926117},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4374775290489197},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.4322611689567566},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.36755135655403137},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36657047271728516},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.34830474853515625},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.337615042924881},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3285921514034271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30562448501586914},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.29322439432144165},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2484763264656067},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.15579283237457275},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08633336424827576}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mhs.2011.6102167","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mhs.2011.6102167","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 International Symposium on Micro-NanoMechatronics and Human Science","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1970697780","https://openalex.org/W1990969714","https://openalex.org/W2023302931","https://openalex.org/W2047730310","https://openalex.org/W2054281060","https://openalex.org/W2086345059","https://openalex.org/W2101473414","https://openalex.org/W2101722224","https://openalex.org/W2117182829","https://openalex.org/W2119831617","https://openalex.org/W2125067769","https://openalex.org/W2139301465","https://openalex.org/W2157533783","https://openalex.org/W2160870513","https://openalex.org/W2164564297","https://openalex.org/W2164917360","https://openalex.org/W2259495851"],"related_works":["https://openalex.org/W2726111829","https://openalex.org/W2008049857","https://openalex.org/W2056668469","https://openalex.org/W4250585504","https://openalex.org/W1978803831","https://openalex.org/W2105513520","https://openalex.org/W2999303294","https://openalex.org/W2580002495","https://openalex.org/W82035557","https://openalex.org/W1539232953"],"abstract_inverted_index":{"Using":[0],"an":[1],"air-actuating":[2],"device,":[3],"we":[4],"investigated":[5],"the":[6,40,80,87,107,125,132,135,148,174],"cellular":[7],"response":[8,123],"to":[9,124,142],"mechanical":[10],"stimuli":[11],"(MS)":[12],"in":[13,39,60,106,122,173],"mouse":[14,63,149],"blastocysts.":[15],"Both":[16],"MS":[17],"and":[18,89,95,154],"intracellular":[19],"calcium":[20],"concentration":[21],"([Ca":[22],"<sup":[23,51,98,183],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[24,28,52,56,99,184,188],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2+</sup>":[25,53,185],"]":[26,54,186],"<sub":[27,55,187],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">i</sub>":[29,57,189],")":[30],"were":[31,92,117],"quantified":[32],"based":[33],"on":[34],"time-resolved":[35],"confocal":[36,69],"microscopy":[37],"images":[38],"polydimethylsiloxane":[41],"(PDMS)":[42],"microfluidic":[43],"channels":[44],"by":[45,159,193],"deforming":[46],"a":[47,61,74,103,143,160],"0.1-mm":[48],"membrane.":[49],"[Ca":[50,182],"was":[58,113,137],"measured":[59],"stained":[62],"embryo":[64,88],"with":[65,166],"Fluo-4":[66],"AM":[67],"using":[68],"fluorescence":[70],"microscopy.":[71],"We":[72],"captured":[73],"z-series":[75],"stack":[76],"of":[77,86,109,134,156,162,176,181],"sections":[78],"encompassing":[79],"entire":[81],"embryo.":[82,150],"When":[83,115],"translocation":[84],"velocities":[85],"shear":[90],"stress":[91],"40":[93],"\u03bcm/s":[94],"0.01":[96],"dyne/cm":[97],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sup>":[100],",":[101],"respectively,":[102],"10%":[104],"increase":[105,172],"sum":[108,155,175],"fluorescent":[110],"intensities":[111],"(FI)":[112],"observed.":[114],"blastocysts":[116,136],"compressed,":[118],"FI":[119,153,177],"also":[120],"increased":[121,158],"applied":[126],"MS.":[127,170,195],"Compressive":[128],"force":[129,144],"estimated":[130],"from":[131],"shape":[133],"approximately":[138],"0.5-2.0":[139],"\u03bcN":[140],"according":[141],"deformation":[145],"curve":[146],"for":[147],"The":[151,171],"average":[152],"FIs":[157],"factor":[161],"1.1-1.2":[163],"times":[164],"compared":[165],"those":[167],"observed":[168],"before":[169],"indicated":[178],"that":[179],"enhancement":[180],"would":[190],"be":[191],"induced":[192],"these":[194]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
