{"id":"https://openalex.org/W4405755161","doi":"https://doi.org/10.1109/metroxraine62247.2024.10797069","title":"Polygenic Risk Scores are Associated to A\u03b2-\u03c4 Protein Accumulation in Alzheimer's Disease","display_name":"Polygenic Risk Scores are Associated to A\u03b2-\u03c4 Protein Accumulation in Alzheimer's Disease","publication_year":2024,"publication_date":"2024-10-21","ids":{"openalex":"https://openalex.org/W4405755161","doi":"https://doi.org/10.1109/metroxraine62247.2024.10797069"},"language":"en","primary_location":{"id":"doi:10.1109/metroxraine62247.2024.10797069","is_oa":false,"landing_page_url":"https://doi.org/10.1109/metroxraine62247.2024.10797069","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Metrology for eXtended Reality, Artificial Intelligence and Neural Engineering (MetroXRAINE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010081232","display_name":"Irene Treccani","orcid":null},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Irene Treccani","raw_affiliation_strings":["University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060511698","display_name":"Giorgio Dolci","orcid":"https://orcid.org/0009-0002-7817-7984"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Dolci","raw_affiliation_strings":["University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003571740","display_name":"Lorenza Brusini","orcid":"https://orcid.org/0000-0001-5357-5180"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenza Brusini","raw_affiliation_strings":["University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091352402","display_name":"Federica Cruciani","orcid":"https://orcid.org/0000-0001-7258-1463"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Cruciani","raw_affiliation_strings":["University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082628560","display_name":"Ilaria Boscolo Galazzo","orcid":"https://orcid.org/0000-0002-4153-3749"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Boscolo Galazzo","raw_affiliation_strings":["University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042078827","display_name":"Gloria Menegaz","orcid":"https://orcid.org/0000-0002-6889-3461"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gloria Menegaz","raw_affiliation_strings":["University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Verona,Dept. of Engineering for Innovation Medicine,Verona,Italy","institution_ids":["https://openalex.org/I119439378"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26991966,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1171","last_page":"1176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5012999773025513,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5012999773025513,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"Polygenic risk score","score":0.6922138333320618},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.566869854927063},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.43185606598854065},{"id":"https://openalex.org/keywords/tau-protein","display_name":"Tau protein","score":0.42630642652511597},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.372546911239624},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3721074163913727},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3388622999191284},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3005948066711426},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2795758545398712},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25733304023742676},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22390279173851013},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.07879719138145447}],"concepts":[{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.6922138333320618},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.566869854927063},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.43185606598854065},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.42630642652511597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.372546911239624},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3721074163913727},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3388622999191284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3005948066711426},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2795758545398712},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25733304023742676},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22390279173851013},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.07879719138145447},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/metroxraine62247.2024.10797069","is_oa":false,"landing_page_url":"https://doi.org/10.1109/metroxraine62247.2024.10797069","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Metrology for eXtended Reality, Artificial Intelligence and Neural Engineering (MetroXRAINE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8470115619","display_name":null,"funder_award_id":"2018.0855.2019","funder_id":"https://openalex.org/F4320324084","funder_display_name":"Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona"}],"funders":[{"id":"https://openalex.org/F4320324084","display_name":"Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona","ror":"https://ror.org/04wkyys07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W62564638","https://openalex.org/W1534628288","https://openalex.org/W2004293194","https://openalex.org/W2105557181","https://openalex.org/W2108676263","https://openalex.org/W2110048796","https://openalex.org/W2128581044","https://openalex.org/W2160163880","https://openalex.org/W2163953557","https://openalex.org/W2165840723","https://openalex.org/W2511515754","https://openalex.org/W2763584856","https://openalex.org/W2789976306","https://openalex.org/W2794167820","https://openalex.org/W2908109475","https://openalex.org/W2916749909","https://openalex.org/W2951347155","https://openalex.org/W2977883299","https://openalex.org/W2981153408","https://openalex.org/W2983117441","https://openalex.org/W2995513418","https://openalex.org/W3095896158","https://openalex.org/W3096706298","https://openalex.org/W3211198154","https://openalex.org/W4286494256","https://openalex.org/W4308216589","https://openalex.org/W4311261902","https://openalex.org/W4311929625","https://openalex.org/W4386154930","https://openalex.org/W4389817612","https://openalex.org/W4393866613"],"related_works":["https://openalex.org/W2966784606","https://openalex.org/W4387710762","https://openalex.org/W4403449186","https://openalex.org/W4403449770","https://openalex.org/W2925191670","https://openalex.org/W3214513703","https://openalex.org/W3104505697","https://openalex.org/W2348030048","https://openalex.org/W4403629111","https://openalex.org/W4385496395"],"abstract_inverted_index":{"Alzheimer's":[0],"(AD)":[1],"is":[2],"a":[3,32,85,99,177],"complex":[4],"and":[5,13,19,38,65,70,93,96,107,133,151,153,165],"multi-domain":[6],"neurodegenerative":[7],"disease":[8,36],"characterized":[9],"by":[10],"amyloid-\u03b2":[11],"(A\u03b2)":[12],"proteins":[14,30],"aggregation":[15],"holding":[16],"both":[17],"genotype":[18],"phenotype":[20],"signatures.":[21],"Increasing":[22],"evidence":[23],"suggests":[24],"that":[25,118],"the":[26,53,60,131,146,159,162,182],"accumulation":[27],"of":[28,87,103],"-\u03c4":[29],"plays":[31],"crucial":[33],"role":[34],"in":[35,48,145],"onset":[37],"progression.":[39],"In":[40,137],"order":[41],"to":[42,58,130,161],"shade":[43],"light":[44],"on":[45,84,98],"these":[46,119],"issues,":[47],"this":[49],"study":[50],"we":[51],"exploited":[52],"Partial":[54],"Least":[55],"Squares":[56],"model":[57,81,160],"investigate":[59],"link":[61],"between":[62,149],"neuroimaging-derived":[63],"features":[64],"genetic":[66],"factors.":[67],"Cortical":[68],"thickness":[69],"Polygenic":[71],"Risk":[72],"Scores":[73],"were":[74],"used":[75],"as":[76],"pheno/geno-typing":[77],"features,":[78],"respectively.":[79,136],"The":[80,114],"was":[82,143,154],"trained":[83],"cohort":[86],"subjects":[88],"including":[89],"healthy":[90],"controls":[91],"(CN)":[92],"AD":[94,134,152],"patients,":[95],"tested":[97],"discovery":[100],"set":[101],"consisting":[102],"-":[104,106,163,164],"\u03c4":[105],"<sup":[108,111,166,169],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[109,112,167,170],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">+</sup>\u03c4":[110],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">+</sup>individuals.":[113],"working":[115],"hypothesis":[116],"being":[117],"last":[120],"two":[121],"groups":[122],"with":[123,139,176],"different":[124],"biological":[125],"profiles":[126],"would":[127],"cluster":[128],"closer":[129],"CN":[132,150],"classes,":[135],"agreement":[138],"previous":[140],"results,":[141],"segregation":[142],"observed":[144],"latent":[147],"space":[148],"also":[155],"confirmed":[156],"when":[157],"applying":[158],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">+</sup>":[168],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">+</sup>discovery":[171],"set.":[172],"These":[173],"outcomes,":[174],"together":[175],"significant":[178],"association":[179],"found":[180],"among":[181],"respective":[183],"projection":[184],"weights,":[185],"encourage":[186],"further":[187],"investigation.":[188]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
