{"id":"https://openalex.org/W4405756103","doi":"https://doi.org/10.1109/metroxraine62247.2024.10796151","title":"Multivariate Developmental Pattern of Cortical Thickness, Brain Functional Connectivity and Behaviour: a Multi-Block Partial Least Square Discriminant Analysis","display_name":"Multivariate Developmental Pattern of Cortical Thickness, Brain Functional Connectivity and Behaviour: a Multi-Block Partial Least Square Discriminant Analysis","publication_year":2024,"publication_date":"2024-10-21","ids":{"openalex":"https://openalex.org/W4405756103","doi":"https://doi.org/10.1109/metroxraine62247.2024.10796151"},"language":"en","primary_location":{"id":"doi:10.1109/metroxraine62247.2024.10796151","is_oa":false,"landing_page_url":"https://doi.org/10.1109/metroxraine62247.2024.10796151","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Metrology for eXtended Reality, Artificial Intelligence and Neural Engineering (MetroXRAINE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002124548","display_name":"Emma Tassi","orcid":"https://orcid.org/0000-0001-7901-1543"},"institutions":[{"id":"https://openalex.org/I4210087357","display_name":"Ospedale Maggiore","ror":"https://ror.org/0053ctp29","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087357"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Emma Tassi","raw_affiliation_strings":["IRCCS Ca’ Granda Ospedale Maggiore Policlinico,Dept. of Neurosciences and Mental Health,Milan,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Ca’ Granda Ospedale Maggiore Policlinico,Dept. of Neurosciences and Mental Health,Milan,Italy","institution_ids":["https://openalex.org/I4210087357","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001305118","display_name":"Federica Goffi","orcid":"https://orcid.org/0000-0002-3744-0566"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Goffi","raw_affiliation_strings":["Politecnico di Milano,Department of Electronics, Information and Bioengineering,Milan,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Politecnico di Milano,Department of Electronics, Information and Bioengineering,Milan,Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043835253","display_name":"Carolina Bonivento","orcid":"https://orcid.org/0000-0003-3354-7494"},"institutions":[{"id":"https://openalex.org/I4210152066","display_name":"IRCCS Eugenio Medea","ror":"https://ror.org/05ynr3m75","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152066","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carolina Bonivento","raw_affiliation_strings":["Polo FVG Scientific Institute IRCCS ‘Eugenio Medea’, Pasian di Prato,Udine,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polo FVG Scientific Institute IRCCS ‘Eugenio Medea’, Pasian di Prato,Udine,Italy","institution_ids":["https://openalex.org/I4210152066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088345979","display_name":"Maddalena Mauri","orcid":"https://orcid.org/0000-0002-7507-4675"},"institutions":[{"id":"https://openalex.org/I4210152066","display_name":"IRCCS Eugenio Medea","ror":"https://ror.org/05ynr3m75","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152066","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maddalena Mauri","raw_affiliation_strings":["Child Psychopathology Unit Scientific Institute IRCCS Eugenio Medea,Bosisio Parini,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child Psychopathology Unit Scientific Institute IRCCS Eugenio Medea,Bosisio Parini,Italy","institution_ids":["https://openalex.org/I4210152066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032786158","display_name":"Nivedita Agarwal","orcid":"https://orcid.org/0000-0002-1387-9566"},"institutions":[{"id":"https://openalex.org/I4210152066","display_name":"IRCCS Eugenio Medea","ror":"https://ror.org/05ynr3m75","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152066","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nivedita Agarwal","raw_affiliation_strings":["Scientific Institute IRCCS E. Medea,Neuroimaging Lab,Bosisio Parini,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Institute IRCCS E. Medea,Neuroimaging Lab,Bosisio Parini,Italy","institution_ids":["https://openalex.org/I4210152066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075137791","display_name":"Rossano Girometti","orcid":"https://orcid.org/0000-0002-0904-5147"},"institutions":[{"id":"https://openalex.org/I129043915","display_name":"University of Udine","ror":"https://ror.org/05ht0mh31","country_code":"IT","type":"education","lineage":["https://openalex.org/I129043915"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossano Girometti","raw_affiliation_strings":["Institute of Radiology, University of Udine,Department of Medicine,Udine,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Radiology, University of Udine,Department of Medicine,Udine,Italy","institution_ids":["https://openalex.org/I129043915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004331148","display_name":"Yvan Torrente","orcid":"https://orcid.org/0000-0002-2705-3984"},"institutions":[{"id":"https://openalex.org/I4210087357","display_name":"Ospedale Maggiore","ror":"https://ror.org/0053ctp29","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087357"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Yvan Torrente","raw_affiliation_strings":["IRCCS Ca’ Granda Ospedale Maggiore Policlinico,Dept. of Neurosciences and Mental Health,Milan,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Ca’ Granda Ospedale Maggiore Policlinico,Dept. of Neurosciences and Mental Health,Milan,Italy","institution_ids":["https://openalex.org/I4210087357","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073440301","display_name":"Anna Maria Bianchi","orcid":"https://orcid.org/0000-0002-8290-7460"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Maria Bianchi","raw_affiliation_strings":["Politecnico di Milano,Department of Electronics, Information and Bioengineering,Milan,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Politecnico di Milano,Department of Electronics, Information and Bioengineering,Milan,Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001821773","display_name":"Maria Nobile","orcid":"https://orcid.org/0000-0002-9917-4275"},"institutions":[{"id":"https://openalex.org/I4210152066","display_name":"IRCCS Eugenio Medea","ror":"https://ror.org/05ynr3m75","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152066","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Nobile","raw_affiliation_strings":["Child Psychopathology Unit Scientific Institute IRCCS Eugenio Medea,Bosisio Parini,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child Psychopathology Unit Scientific Institute IRCCS Eugenio Medea,Bosisio Parini,Italy","institution_ids":["https://openalex.org/I4210152066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090717556","display_name":"Eleonora Maggioni","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eleonora Maggioni","raw_affiliation_strings":["Politecnico di Milano,Department of Electronics, Information and Bioengineering,Milan,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Politecnico di Milano,Department of Electronics, Information and Bioengineering,Milan,Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064520148","display_name":"Paolo Brambilla","orcid":"https://orcid.org/0000-0002-4021-8456"},"institutions":[{"id":"https://openalex.org/I4210087357","display_name":"Ospedale Maggiore","ror":"https://ror.org/0053ctp29","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087357"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Brambilla","raw_affiliation_strings":["IRCCS Ca’ Granda Ospedale Maggiore Policlinico,Dept. of Neurosciences and Mental Health,Milan,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Ca’ Granda Ospedale Maggiore Policlinico,Dept. of Neurosciences and Mental Health,Milan,Italy","institution_ids":["https://openalex.org/I4210087357","https://openalex.org/I4210153126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5002124548"],"corresponding_institution_ids":["https://openalex.org/I4210087357","https://openalex.org/I4210153126"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26758476,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"383","last_page":"388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.2393999993801117,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.2393999993801117,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13748","display_name":"Advanced Statistical Modeling Techniques","score":0.22859999537467957,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.7352529168128967},{"id":"https://openalex.org/keywords/block","display_name":"Block (permutation group theory)","score":0.6086347103118896},{"id":"https://openalex.org/keywords/linear-discriminant-analysis","display_name":"Linear discriminant analysis","score":0.596121609210968},{"id":"https://openalex.org/keywords/discriminant","display_name":"Discriminant","score":0.5912383794784546},{"id":"https://openalex.org/keywords/pattern-analysis","display_name":"Pattern analysis","score":0.5230011343955994},{"id":"https://openalex.org/keywords/multivariate-analysis","display_name":"Multivariate analysis","score":0.5056767463684082},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5045758485794067},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4936298131942749},{"id":"https://openalex.org/keywords/square","display_name":"Square (algebra)","score":0.48044154047966003},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.44875746965408325},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3811037242412567},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.18798166513442993},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.1486322283744812}],"concepts":[{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.7352529168128967},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.6086347103118896},{"id":"https://openalex.org/C69738355","wikidata":"https://www.wikidata.org/wiki/Q1228929","display_name":"Linear discriminant analysis","level":2,"score":0.596121609210968},{"id":"https://openalex.org/C78397625","wikidata":"https://www.wikidata.org/wiki/Q192487","display_name":"Discriminant","level":2,"score":0.5912383794784546},{"id":"https://openalex.org/C2985264313","wikidata":"https://www.wikidata.org/wiki/Q378859","display_name":"Pattern analysis","level":2,"score":0.5230011343955994},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.5056767463684082},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5045758485794067},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4936298131942749},{"id":"https://openalex.org/C135692309","wikidata":"https://www.wikidata.org/wiki/Q111124","display_name":"Square (algebra)","level":2,"score":0.48044154047966003},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44875746965408325},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3811037242412567},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.18798166513442993},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.1486322283744812},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/metroxraine62247.2024.10796151","is_oa":false,"landing_page_url":"https://doi.org/10.1109/metroxraine62247.2024.10796151","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Metrology for eXtended Reality, Artificial Intelligence and Neural Engineering (MetroXRAINE)","raw_type":"proceedings-article"},{"id":"pmh:oai:re.public.polimi.it:11311/1287800","is_oa":false,"landing_page_url":"https://hdl.handle.net/11311/1287800","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.8399999737739563}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1988165548","https://openalex.org/W1989792142","https://openalex.org/W1990134753","https://openalex.org/W2001696757","https://openalex.org/W2032017538","https://openalex.org/W2035446733","https://openalex.org/W2056199791","https://openalex.org/W2058046532","https://openalex.org/W2063897123","https://openalex.org/W2101135654","https://openalex.org/W2125330552","https://openalex.org/W2125546989","https://openalex.org/W2290550151","https://openalex.org/W2787801287","https://openalex.org/W4220740581","https://openalex.org/W4282029559","https://openalex.org/W4319834179","https://openalex.org/W4391984573","https://openalex.org/W6755076800"],"related_works":["https://openalex.org/W2350751952","https://openalex.org/W1999647744","https://openalex.org/W2362114017","https://openalex.org/W3147024994","https://openalex.org/W2063246903","https://openalex.org/W2374055396","https://openalex.org/W1978302214","https://openalex.org/W2021817983","https://openalex.org/W2104382484","https://openalex.org/W3008559849"],"abstract_inverted_index":{"The":[0,226],"intricate":[1],"relationship":[2],"between":[3,46,67],"emotional":[4],"and":[5,8,11,15,52,55,100,103,158,169,189,198,210,224,238,241],"behavioral":[6,56,214],"traits":[7,215],"brain":[9,47,50,101,208],"anatomy":[10],"function":[12,104,211],"during":[13,222],"childhood":[14,223],"adolescence":[16],"is":[17],"crucial":[18],"for":[19,73],"elucidating":[20],"the":[21,41,91,95,131,173],"neurobiological":[22],"basis":[23],"of":[24,44,61,115,124,133,162,187,207,233],"diverse":[25,237],"psychopathological":[26],"disorders":[27],"but":[28],"it":[29],"still":[30],"largely":[31],"unknown.":[32],"In":[33],"this":[34,234],"study,":[35],"we":[36,87],"aimed":[37],"to":[38,89,220],"quantitatively":[39],"evaluate":[40],"multivariate":[42,92],"patterns":[43],"association":[45,145],"activity,":[48],"cortical":[49,126,150],"characteristics,":[51],"core":[53],"clinical":[54,242],"features":[57],"in":[58,129,152,212],"a":[59,78,121,142,204],"sample":[60],"forty":[62],"subjects":[63],"with":[64,182],"age":[65],"ranging":[66],"11\u201321":[68],"years":[69],"who":[70],"were":[71,177],"referred":[72],"emotional-behavioral":[74],"problems.":[75],"By":[76,136],"exploiting":[77],"multi-block":[79],"partial":[80],"least":[81],"square":[82],"discriminant":[83],"analysis":[84],"(MBPLS-DA)":[85],"framework,":[86],"attempt":[88],"explain":[90],"relations":[93],"among":[94,148],"Child":[96],"Behavior":[97],"Checklist":[98],"(CBCL)":[99],"structure":[102,209],"assessed":[105],"via":[106],"magnetic":[107],"resonance":[108],"imaging":[109],"(MRI).":[110],"Based":[111],"on":[112],"individual":[113],"importance":[114],"each":[116,138],"block,":[117],"our":[118],"findings":[119],"showed":[120],"prominent":[122,143],"contribution":[123],"regional":[125,149],"thickness":[127,151],"data":[128],"explaining":[130],"variance":[132],"CBCL":[134,159,175],"scales.":[135],"analyzing":[137],"block's":[139],"loadings":[140],"individually,":[141],"positive":[144],"was":[146],"found":[147,179],"paracentral,":[153],"lateral":[154],"occipital":[155],"cortex,":[156,192],"precuneus":[157],"composite":[160],"scores":[161,176],"psychotic,":[163],"autism":[164],"spectrum":[165],"disorder":[166],"risk":[167],"profiles":[168],"withdrawn":[170],"scale.":[171],"Furthermore,":[172],"same":[174],"also":[178],"positively":[180],"associated":[181],"functional":[183],"connections":[184],"involving":[185],"regions":[186],"anterior":[188],"median":[190],"cingulate":[191],"caudate":[193],"nucleus,":[194],"inferior":[195],"parietal":[196],"lobule":[197],"angular":[199],"gyrus.":[200],"Our":[201],"investigation":[202],"suggests":[203],"key":[205],"role":[206],"shaping":[213],"that":[216],"might":[217],"be":[218],"predispose":[219],"psychopathology":[221],"adolescence.":[225],"proposed":[227],"MBPLS-DA":[228],"application":[229],"promotes":[230],"broader":[231],"adoption":[232],"technique":[235],"across":[236],"multimodal":[239],"MRI":[240],"datasets.":[243]},"counts_by_year":[],"updated_date":"2026-05-03T08:25:01.440150","created_date":"2025-10-10T00:00:00"}