{"id":"https://openalex.org/W4292862356","doi":"https://doi.org/10.1109/memea54994.2022.9856514","title":"Robust examination of cell apoptosis timing in presence of noisy environment","display_name":"Robust examination of cell apoptosis timing in presence of noisy environment","publication_year":2022,"publication_date":"2022-06-22","ids":{"openalex":"https://openalex.org/W4292862356","doi":"https://doi.org/10.1109/memea54994.2022.9856514"},"language":"en","primary_location":{"id":"doi:10.1109/memea54994.2022.9856514","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea54994.2022.9856514","pdf_url":null,"source":{"id":"https://openalex.org/S4363605601","display_name":"2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014451390","display_name":"Arianna Mencattini","orcid":"https://orcid.org/0000-0002-3753-0457"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Arianna Mencattini","raw_affiliation_strings":["Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033016897","display_name":"Paola Casti","orcid":"https://orcid.org/0000-0001-7489-3022"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Casti","raw_affiliation_strings":["Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073056076","display_name":"Joanna Filippi","orcid":"https://orcid.org/0000-0002-1253-972X"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Joanna Filippi","raw_affiliation_strings":["Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042631815","display_name":"Michele D\u2019Orazio","orcid":"https://orcid.org/0000-0003-3719-9976"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele D'Orazio","raw_affiliation_strings":["Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041876122","display_name":"Sara Cardarelli","orcid":null},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Cardarelli","raw_affiliation_strings":["Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033525208","display_name":"Gianni Antonelli","orcid":"https://orcid.org/0000-0002-4658-4000"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianni Antonelli","raw_affiliation_strings":["Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062989429","display_name":"Eugenio Martinelli","orcid":"https://orcid.org/0000-0002-6673-2066"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eugenio Martinelli","raw_affiliation_strings":["Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Rome Tor Vergata,Dept. of Electronic Engineering,Rome,Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Dept. of Electronic Engineering, Univ. of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I116067653"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10688","display_name":"Image and Signal Denoising Methods","score":0.9700999855995178,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.8151962757110596},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6253377795219421},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.5974686741828918},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5715195536613464},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5444811582565308},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4844529628753662},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4685229957103729},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.43026822805404663},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.41876351833343506},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3302386999130249},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.32605117559432983}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8151962757110596},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6253377795219421},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5974686741828918},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5715195536613464},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5444811582565308},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4844529628753662},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4685229957103729},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.43026822805404663},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41876351833343506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3302386999130249},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32605117559432983},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/memea54994.2022.9856514","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea54994.2022.9856514","pdf_url":null,"source":{"id":"https://openalex.org/S4363605601","display_name":"2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"},{"id":"pmh:oai:art.torvergata.it:2108/430264","is_oa":false,"landing_page_url":"https://hdl.handle.net/2108/430264","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2052853635","https://openalex.org/W2139410361","https://openalex.org/W2147688960","https://openalex.org/W2158025958","https://openalex.org/W2193477726","https://openalex.org/W2194775991","https://openalex.org/W2790952646","https://openalex.org/W2913774914","https://openalex.org/W2942580548","https://openalex.org/W2946231017","https://openalex.org/W3006117844","https://openalex.org/W3148768901","https://openalex.org/W3167868688","https://openalex.org/W3176564999","https://openalex.org/W6680561749"],"related_works":["https://openalex.org/W4293226380","https://openalex.org/W2382997850","https://openalex.org/W3148810057","https://openalex.org/W4226493464","https://openalex.org/W4312417841","https://openalex.org/W3133861977","https://openalex.org/W2951211570","https://openalex.org/W3103566983","https://openalex.org/W3167935049","https://openalex.org/W3029198973"],"abstract_inverted_index":{"The":[0],"process":[1],"of":[2,78,115,131,202,208,213,231,238,245],"programmable":[3],"cell":[4,21,94,98],"death,":[5],"i.e.,":[6],"apoptosis,":[7],"physiologically":[8],"occurs":[9],"during":[10],"development":[11],"and":[12,14,50,100,140,152,159,248],"aging":[13],"as":[15,28],"a":[16,29,58,146,169,185,206,222],"homeostatic":[17],"mechanism":[18,31],"to":[19,47,84,90,108,148],"maintain":[20],"populations":[22],"in":[23,32,57,65,163],"tissues.":[24],"Apoptosis":[25],"also":[26],"happens":[27],"defense":[30],"immune":[33],"reactions":[34],"or":[35,42],"when":[36],"cells":[37,247],"are":[38,114],"damaged":[39],"by":[40,133,220,241],"disease":[41],"external":[43],"stimuli":[44],"(drugs).":[45],"Due":[46],"its":[48],"complexity":[49],"the":[51,76,150,193,203,232],"fact":[52],"that":[53],"apoptosis":[54,67,85,110,151,175,180,214],"fate":[55],"resolves":[56],"very":[59,156],"short":[60],"time":[61],"(a":[62],"few":[63],"hours":[64],"general),":[66],"mechanisms":[68],"have":[69],"been":[70],"extensively":[71],"studied":[72],"only":[73],"recently":[74],"with":[75,121,155,177],"advent":[77],"advanced":[79],"time-lapse":[80],"microscopy.":[81],"Timing":[82],"related":[83,101],"stages":[86],"is":[87,105],"strongly":[88],"correlated":[89],"many":[91],"factors":[92],"including":[93],"type,":[95],"drug":[96,122],"dose,":[97],"microenvironment,":[99],"cross-talks":[102],"whose":[103],"knowledge":[104],"too":[106],"little":[107],"predict":[109],"duration.":[111],"Such":[112],"times":[113,154],"fundamental":[116],"importance":[117],"since":[118],"they":[119],"linked":[120],"efficacy,":[123],"immunotherapy":[124],"treatment,":[125],"cancer-immune":[126],"interaction":[127],"effectiveness.":[128],"In":[129],"light":[130],"this,":[132],"exploiting":[134],"video":[135,204],"analysis,":[136],"deep":[137],"learning":[138,196],"algorithms,":[139],"multiple":[141],"linear":[142,224],"regression,":[143],"we":[144,165,198],"presented":[145],"platform":[147],"examine":[149],"blebbing":[153],"high":[157],"accuracy":[158],"precision":[160],"levels.":[161],"More":[162],"detail,":[164],"artificially":[166],"generated,":[167],"through":[168],"computer":[170],"vision":[171],"analysis":[172],"platform,":[173],"synthetic":[174],"videos":[176,244],"randomly":[178],"variated":[179],"timing":[181,215],"profiles.":[182],"By":[183],"using":[184],"pre-trained":[186],"Convolutional":[187],"Neural":[188],"Network":[189],"(CNN)":[190],"architecture":[191],"within":[192],"so-called":[194],"transfer":[195],"procedure,":[197],"encoded":[199],"each":[200],"frame":[201],"into":[205],"list":[207],"numerical":[209],"descriptors.":[210],"Automatic":[211],"examination":[212],"profiles":[216],"was":[217],"then":[218],"accomplished":[219],"training":[221],"multivariate":[223],"regression":[225],"(MLR)":[226],"model.":[227],"An":[228],"extended":[229],"version":[230],"work":[233],"will":[234],"present":[235],"further":[236],"advancement":[237],"this":[239],"research":[240],"considering":[242],"real":[243],"dying":[246],"additional":[249],"confounding":[250],"effects.":[251]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}