{"id":"https://openalex.org/W4292862675","doi":"https://doi.org/10.1109/memea54994.2022.9856414","title":"Development of a novel potentiometric PHD/SPE biosensor for the determination of phenylalanine","display_name":"Development of a novel potentiometric PHD/SPE biosensor for the determination of phenylalanine","publication_year":2022,"publication_date":"2022-06-22","ids":{"openalex":"https://openalex.org/W4292862675","doi":"https://doi.org/10.1109/memea54994.2022.9856414"},"language":"en","primary_location":{"id":"doi:10.1109/memea54994.2022.9856414","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea54994.2022.9856414","pdf_url":null,"source":{"id":"https://openalex.org/S4363605601","display_name":"2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028855891","display_name":"Angelo Ferlazzo","orcid":"https://orcid.org/0000-0003-2844-1441"},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Angelo Ferlazzo","raw_affiliation_strings":["University of Messina.,Dept. of Engineering,Messina,Italy","Dept. of Engineering, University of Messina., Messina, Italy"],"affiliations":[{"raw_affiliation_string":"University of Messina.,Dept. of Engineering,Messina,Italy","institution_ids":["https://openalex.org/I112862951"]},{"raw_affiliation_string":"Dept. of Engineering, University of Messina., Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058297405","display_name":"Claudia Espro","orcid":"https://orcid.org/0000-0003-4081-1716"},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Espro","raw_affiliation_strings":["University of Messina.,Dept. of Engineering,Messina,Italy","Dept. of Engineering, University of Messina., Messina, Italy"],"affiliations":[{"raw_affiliation_string":"University of Messina.,Dept. of Engineering,Messina,Italy","institution_ids":["https://openalex.org/I112862951"]},{"raw_affiliation_string":"Dept. of Engineering, University of Messina., Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016970014","display_name":"Daniela Iannazzo","orcid":"https://orcid.org/0000-0003-2190-0035"},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Iannazzo","raw_affiliation_strings":["University of Messina.,Dept. of Engineering,Messina,Italy","Dept. of Engineering, University of Messina., Messina, Italy"],"affiliations":[{"raw_affiliation_string":"University of Messina.,Dept. of Engineering,Messina,Italy","institution_ids":["https://openalex.org/I112862951"]},{"raw_affiliation_string":"Dept. of Engineering, University of Messina., Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040381725","display_name":"G. Neri","orcid":"https://orcid.org/0000-0001-8999-060X"},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Neri","raw_affiliation_strings":["University of Messina.,Dept. of Engineering,Messina,Italy","Dept. of Engineering, University of Messina., Messina, Italy"],"affiliations":[{"raw_affiliation_string":"University of Messina.,Dept. of Engineering,Messina,Italy","institution_ids":["https://openalex.org/I112862951"]},{"raw_affiliation_string":"Dept. of Engineering, University of Messina., Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028855891"],"corresponding_institution_ids":["https://openalex.org/I112862951"],"apc_list":null,"apc_paid":null,"fwci":0.6445,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.56633372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"11","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.9259987473487854},{"id":"https://openalex.org/keywords/potentiometric-titration","display_name":"Potentiometric titration","score":0.7981342077255249},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6175137758255005},{"id":"https://openalex.org/keywords/succinimide","display_name":"Succinimide","score":0.612128734588623},{"id":"https://openalex.org/keywords/phenylalanine","display_name":"Phenylalanine","score":0.541089653968811},{"id":"https://openalex.org/keywords/working-electrode","display_name":"Working electrode","score":0.44732898473739624},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.41959431767463684},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.3556514382362366},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.328046590089798},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.24075627326965332},{"id":"https://openalex.org/keywords/electrochemistry","display_name":"Electrochemistry","score":0.21098405122756958},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.15835362672805786},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1411009132862091}],"concepts":[{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.9259987473487854},{"id":"https://openalex.org/C124614425","wikidata":"https://www.wikidata.org/wiki/Q1813495","display_name":"Potentiometric titration","level":3,"score":0.7981342077255249},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6175137758255005},{"id":"https://openalex.org/C2776830054","wikidata":"https://www.wikidata.org/wiki/Q419430","display_name":"Succinimide","level":2,"score":0.612128734588623},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.541089653968811},{"id":"https://openalex.org/C69118416","wikidata":"https://www.wikidata.org/wiki/Q477099","display_name":"Working electrode","level":4,"score":0.44732898473739624},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.41959431767463684},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3556514382362366},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.328046590089798},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24075627326965332},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.21098405122756958},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.15835362672805786},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1411009132862091},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/memea54994.2022.9856414","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea54994.2022.9856414","pdf_url":null,"source":{"id":"https://openalex.org/S4363605601","display_name":"2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1156804380","https://openalex.org/W2019618531","https://openalex.org/W2093913384","https://openalex.org/W2317373418","https://openalex.org/W2506559119","https://openalex.org/W2767799322","https://openalex.org/W2796154991","https://openalex.org/W2809858763","https://openalex.org/W2886449871","https://openalex.org/W2892017379","https://openalex.org/W2902552274","https://openalex.org/W2945663689","https://openalex.org/W2956867603","https://openalex.org/W2980143430","https://openalex.org/W2992671353","https://openalex.org/W4245815463","https://openalex.org/W6674182561","https://openalex.org/W6756317262"],"related_works":["https://openalex.org/W2101686678","https://openalex.org/W2036273182","https://openalex.org/W2167251292","https://openalex.org/W2323402617","https://openalex.org/W3128421570","https://openalex.org/W2377117274","https://openalex.org/W1965506820","https://openalex.org/W2387610695","https://openalex.org/W1983638944","https://openalex.org/W2086898103"],"abstract_inverted_index":{"In":[0],"this":[1],"paper,":[2],"we":[3],"report":[4],"the":[5,14,30,39,52,56,76,84,89,95,99,110,116,124,128,143,147,155,158,161,172,196],"first":[6],"example":[7],"of":[8,17,22,62,70,94,101,157,198],"a":[9,23,67,72,182,200],"novel":[10,201],"potentiometric":[11,152,167],"sensor":[12],"for":[13,113,142,205],"real-time":[15],"monitoring":[16,145,206],"phenylalanine.":[18],"The":[19,44,92,137,166,193],"biosensor":[20,47,138,159,204],"consists":[21],"commercial":[24],"screen-printed":[25],"electrode":[26,33,58,78,175],"(SPE)":[27],"platform,":[28],"where":[29],"gold":[31,57,77],"working":[32],"has":[34],"been":[35],"covalently":[36],"functionalized":[37],"with":[38,75,83,169,210],"enzyme":[40,54,96],"phenylalanine":[41,102],"dehydrogenase":[42],"(PHD).":[43],"PHD/SPE":[45],"membrane-free":[46,202],"was":[48,118,139,176],"fabricated":[49],"by":[50,120],"immobilizing":[51],"PHD":[53,90],"to":[55,97,103,171,178],"using":[59,146],"3-3\u2019-dithiopropionic":[60],"acid":[61],"N-succinimide":[63],"ester":[64],"(DSP)":[65],"as":[66,160],"linker":[68],"capable":[69],"creating":[71],"thiol":[73],"bond":[74,82],"and":[79,107],"an":[80],"amide":[81],"amine":[85],"group":[86],"present":[87],"on":[88],"enzyme.":[91],"ability":[93],"catalyze":[98],"transformation":[100],"pyruvic":[104],"acid,":[105],"NADH,":[106],"ammonia,":[108],"under":[109],"conditions":[111,126],"used":[112],"analysis":[114],"through":[115],"biosensor,":[117],"evaluated":[119],"UV-Vis":[121],"analysis.":[122],"Under":[123],"experimental":[125],"adopted,":[127],"enzymatic":[129,203],"reaction":[130,162],"is":[131],"almost":[132],"completed":[133],"in":[134,208],"40\u201360":[135],"minutes.":[136],"then":[140],"tested":[141],"Phe":[144,207],"Open":[148],"Circuit":[149],"Potential":[150],"(OCP)":[151],"technique,":[153],"recording":[154],"potential":[156],"proceeded":[163],"over":[164,181],"time.":[165],"response":[168],"respect":[170],"Ag/AgCl":[173],"reference":[174],"found":[177],"be":[179],"linear":[180],"relatively":[183],"wide":[184],"concentration":[185],"range":[186],"(0\u20135000":[187],"<tex":[188],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[189],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mu":[190],"\\mathrm{M})$</tex>":[191],".":[192],"results":[194],"demonstrated":[195],"feasibility":[197],"developing":[199],"patients":[209],"phenylketonuria":[211],"(PKU).":[212]},"counts_by_year":[{"year":2023,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
