{"id":"https://openalex.org/W2968411588","doi":"https://doi.org/10.1109/memea.2019.8802207","title":"Classification of Patients with Bipolar Disorder and Their Healthy Siblings from Healthy Controls Using MRI","display_name":"Classification of Patients with Bipolar Disorder and Their Healthy Siblings from Healthy Controls Using MRI","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W2968411588","doi":"https://doi.org/10.1109/memea.2019.8802207","mag":"2968411588"},"language":"en","primary_location":{"id":"doi:10.1109/memea.2019.8802207","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea.2019.8802207","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056365159","display_name":"\u00c7i\u011fdem \u00d6zkan","orcid":"https://orcid.org/0000-0003-4356-6277"},"institutions":[{"id":"https://openalex.org/I120217413","display_name":"Izmir Institute of Technology","ror":"https://ror.org/03stptj97","country_code":"TR","type":"education","lineage":["https://openalex.org/I120217413"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ozkan Cigdem","raw_affiliation_strings":["Ozhak Engineering Ltd. Co., Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ozhak Engineering Ltd. Co., Izmir, Turkey","institution_ids":["https://openalex.org/I120217413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044966114","display_name":"Erencan Horuz","orcid":null},"institutions":[{"id":"https://openalex.org/I15059493","display_name":"\u0130zmir University of Economics","ror":"https://ror.org/04hjr4202","country_code":"TR","type":"education","lineage":["https://openalex.org/I15059493"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Erencan Horuz","raw_affiliation_strings":["Department of Electrical and Electronics Engineering, Izmir University of Economics, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronics Engineering, Izmir University of Economics, Izmir, Turkey","institution_ids":["https://openalex.org/I15059493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007948453","display_name":"Refik Soyak","orcid":"https://orcid.org/0000-0002-8231-012X"},"institutions":[{"id":"https://openalex.org/I15059493","display_name":"\u0130zmir University of Economics","ror":"https://ror.org/04hjr4202","country_code":"TR","type":"education","lineage":["https://openalex.org/I15059493"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Refik Soyak","raw_affiliation_strings":["Department of Electrical and Electronics Engineering, Izmir University of Economics, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronics Engineering, Izmir University of Economics, Izmir, Turkey","institution_ids":["https://openalex.org/I15059493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006865987","display_name":"Burhan Aydeniz","orcid":null},"institutions":[{"id":"https://openalex.org/I15059493","display_name":"\u0130zmir University of Economics","ror":"https://ror.org/04hjr4202","country_code":"TR","type":"education","lineage":["https://openalex.org/I15059493"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Burhan Aydeniz","raw_affiliation_strings":["Department of Electrical and Electronics Engineering, Izmir University of Economics, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronics Engineering, Izmir University of Economics, Izmir, Turkey","institution_ids":["https://openalex.org/I15059493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053176266","display_name":"Aysu Sulucay","orcid":null},"institutions":[{"id":"https://openalex.org/I15059493","display_name":"\u0130zmir University of Economics","ror":"https://ror.org/04hjr4202","country_code":"TR","type":"education","lineage":["https://openalex.org/I15059493"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Aysu Sulucay","raw_affiliation_strings":["Department of Biomedical Engineering, Izmir University of Economics, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Izmir University of Economics, Izmir, Turkey","institution_ids":["https://openalex.org/I15059493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042975565","display_name":"Kaya O\u011fuz","orcid":"https://orcid.org/0000-0002-1860-9127"},"institutions":[{"id":"https://openalex.org/I15059493","display_name":"\u0130zmir University of Economics","ror":"https://ror.org/04hjr4202","country_code":"TR","type":"education","lineage":["https://openalex.org/I15059493"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kaya Oguz","raw_affiliation_strings":["Department of Computer Engineering, Izmir University of Economics, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Izmir University of Economics, Izmir, Turkey","institution_ids":["https://openalex.org/I15059493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024772165","display_name":"Hasan Demirel","orcid":"https://orcid.org/0000-0001-5035-9634"},"institutions":[{"id":"https://openalex.org/I36515993","display_name":"Eastern Mediterranean University","ror":"https://ror.org/00excyz84","country_code":"CY","type":"education","lineage":["https://openalex.org/I36515993"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Hasan Demirel","raw_affiliation_strings":["Department of Electrical and Electronics Engineering, Eastern Mediterranean University, Famagusta, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronics Engineering, Eastern Mediterranean University, Famagusta, Turkey","institution_ids":["https://openalex.org/I36515993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086448407","display_name":"\u00d6mer Kiti\u015f","orcid":"https://orcid.org/0000-0003-4201-5449"},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Omer Kitis","raw_affiliation_strings":["Department of Neuroradiology, Ege University, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, Ege University, Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010270121","display_name":"\u00c7a\u011fda\u015f Eker","orcid":"https://orcid.org/0000-0001-5496-9587"},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cagdas Eker","raw_affiliation_strings":["Department of Psychiatry, Ege University, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Ege University, Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027453910","display_name":"Ali Saffet G\u00f6n\u00fcl","orcid":"https://orcid.org/0000-0003-3522-1359"},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ali Saffet Gonul","raw_affiliation_strings":["Department of Psychiatry, Ege University, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Ege University, Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006754641","display_name":"Devrim \u00dcnay","orcid":"https://orcid.org/0000-0003-3478-7318"},"institutions":[{"id":"https://openalex.org/I15059493","display_name":"\u0130zmir University of Economics","ror":"https://ror.org/04hjr4202","country_code":"TR","type":"education","lineage":["https://openalex.org/I15059493"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Devrim Unay","raw_affiliation_strings":["Department of Biomedical Engineering, Izmir University of Economics, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Izmir University of Economics, Izmir, Turkey","institution_ids":["https://openalex.org/I15059493"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3209,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.61245108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.8263721466064453},{"id":"https://openalex.org/keywords/covariate","display_name":"Covariate","score":0.6918507814407349},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.6771663427352905},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5409349799156189},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5346903204917908},{"id":"https://openalex.org/keywords/genetic-data","display_name":"Genetic data","score":0.46448665857315063},{"id":"https://openalex.org/keywords/voxel-based-morphometry","display_name":"Voxel-based morphometry","score":0.44715261459350586},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"Logistic regression","score":0.43674567341804504},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.40708547830581665},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.3605666756629944},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3524324893951416},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.33066368103027344},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3286988139152527},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.28302085399627686},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2772877812385559},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.11888867616653442}],"concepts":[{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.8263721466064453},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.6918507814407349},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.6771663427352905},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5409349799156189},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5346903204917908},{"id":"https://openalex.org/C2993807623","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genetic data","level":3,"score":0.46448665857315063},{"id":"https://openalex.org/C200134340","wikidata":"https://www.wikidata.org/wiki/Q845664","display_name":"Voxel-based morphometry","level":4,"score":0.44715261459350586},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.43674567341804504},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.40708547830581665},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.3605666756629944},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3524324893951416},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.33066368103027344},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3286988139152527},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.28302085399627686},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2772877812385559},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.11888867616653442},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/memea.2019.8802207","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea.2019.8802207","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.5600000023841858}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1763728629","https://openalex.org/W2006956275","https://openalex.org/W2094520437","https://openalex.org/W2152101431","https://openalex.org/W2153635508","https://openalex.org/W2165315953","https://openalex.org/W2798022325","https://openalex.org/W2802138237","https://openalex.org/W2802830659","https://openalex.org/W2803308918","https://openalex.org/W2884021537","https://openalex.org/W2889065082","https://openalex.org/W2889107381","https://openalex.org/W2899586618","https://openalex.org/W2913535288","https://openalex.org/W2914072580"],"related_works":["https://openalex.org/W4297910665","https://openalex.org/W2735909486","https://openalex.org/W2007506293","https://openalex.org/W1972685664","https://openalex.org/W4248388699","https://openalex.org/W117090150","https://openalex.org/W2909777330","https://openalex.org/W2033457680","https://openalex.org/W2770192663","https://openalex.org/W2883083307"],"abstract_inverted_index":{"Detection":[0],"of":[1,6,56,76,111,139,148,155,159,173,197,237,240,249,266,277,295,306],"Bipolar":[2],"Disease":[3],"(BD),":[4],"one":[5],"the":[7,54,92,99,103,146,149,153,174,195,198,234,238,262,291],"most":[8],"common":[9],"neuroanatomical":[10],"abnormalities,":[11],"using":[12,143,160],"machine":[13],"learning":[14],"algorithms":[15],"together":[16],"with":[17,207],"Magnetic":[18],"Resonance":[19],"Imaging":[20],"(MRI)":[21],"data":[22,59,112,151,176,201,231],"has":[23],"been":[24,179],"widely":[25],"studied.":[26],"BD":[27,77,258],"is":[28,86,119,129,191,210,245],"a":[29,115,122,215],"highly":[30],"heritable":[31],"disease,":[32],"yet":[33],"not":[34],"all":[35],"siblings":[36],"tend":[37],"to":[38,88,97,193],"have":[39,44,178],"it":[40],"despite":[41],"they":[42],"might":[43],"similar":[45],"genetic":[46],"and":[47,64,79,90,107,121,142,169,184,202,233,242,251,259,273,288,302],"environmental":[48],"risk":[49],"factors.":[50],"In":[51,95,257,286],"this":[52],"paper,":[53],"classifications":[55],"two":[57,123,175],"self-acquired":[58],"groups,":[60],"namely":[61],"26BD":[62],"patients":[63],"38":[65],"unrelated":[66],"Healthy":[67,74],"Controls":[68],"(HCs)":[69],"as":[70,72,137,214,280,282,309,311],"well":[71,281,310],"27":[73],"Siblings":[75],"(BDHSs)":[78],"38HCs":[80],"are":[81,135,284,313],"examined.":[82],"Voxel-Based":[83],"Morphometry":[84],"(VBM)":[85],"utilized":[87],"segment":[89],"pre-process":[91],"MRI":[93],"data.":[94],"order":[96],"obtain":[98],"morphological":[100],"alterations":[101],"in":[102],"Gray":[104],"Matter":[105,109],"(GM)":[106],"White":[108],"(WM)":[110],"groups":[113,177,232],"separately,":[114],"general":[116],"linear":[117],"model":[118],"configured":[120],"sample":[124],"t-test":[125],"based":[126],"statistical":[127],"method":[128],"used.":[130],"The":[131,157,217],"obtained":[132],"differentiated":[133],"voxels":[134],"considered":[136],"Voxel":[138],"Interests":[140],"(VOIs)":[141],"VOIs":[144,200],"reduces":[145],"dimension":[147,196],"original":[150],"into":[152,212],"number":[154],"VOIs.":[156],"effects":[158],"different":[161],"covariates":[162],"(i.e.":[163],"total":[164],"intracranial":[165],"volume":[166],"(TIV),":[167],"age,":[168],"sex)":[170],"on":[171],"classification":[172,235,264,293],"studied":[180],"for":[181,229,254,268,271,275,297,300,304],"GM-only,":[182],"WM-only,":[183],"their":[185],"combination.":[186],"Principle":[187],"Component":[188],"Analysis":[189],"(PCA)":[190],"used":[192],"reduce":[194],"extracted":[199,278,307],"Support":[203],"Vector":[204],"Machine":[205],"(SVM)":[206],"Gaussian":[208],"kernel":[209],"taken":[211],"account":[213],"classifier.":[216],"experimental":[218],"results":[219,228],"indicate":[220],"that":[221,248],"among":[222],"three":[223],"covariates,":[224],"TIV":[225],"provides":[226],"better":[227],"both":[230,255],"accuracies":[236,265,294],"combination":[239],"GM":[241,279,308],"WM":[243,283,312],"maps":[244],"higher":[246],"than":[247],"GM-only":[250],"WM-":[252],"only":[253],"groups.":[256],"HC":[260,289],"comparison,":[261,290],"highest":[263,292],"70.3%":[267],"GM,":[269,298],"79.7%":[270],"WM,":[272,301],"82.8%":[274],"fusion":[276,305],"obtained.":[285,314],"BDHS":[287],"72.3%":[296],"76.9%":[299],"78.5%":[303]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}