{"id":"https://openalex.org/W2738316109","doi":"https://doi.org/10.1109/memea.2017.7985922","title":"Monitoring pH, temperature and humidity in long-term stem cell culture in CO&lt;inf&gt;2&lt;/inf&gt; incubator","display_name":"Monitoring pH, temperature and humidity in long-term stem cell culture in CO&lt;inf&gt;2&lt;/inf&gt; incubator","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W2738316109","doi":"https://doi.org/10.1109/memea.2017.7985922","mag":"2738316109"},"language":"en","primary_location":{"id":"doi:10.1109/memea.2017.7985922","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea.2017.7985922","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043502027","display_name":"Dhanesh Kattipparambil Rajan","orcid":"https://orcid.org/0000-0001-9210-9481"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Dhanesh Kattipparambil Rajan","raw_affiliation_strings":["BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland"],"affiliations":[{"raw_affiliation_string":"BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051757454","display_name":"Jarmo Verho","orcid":"https://orcid.org/0000-0002-8272-4760"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jarmo Verho","raw_affiliation_strings":["BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland"],"affiliations":[{"raw_affiliation_string":"BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031874991","display_name":"Joose Kreutzer","orcid":"https://orcid.org/0000-0001-5964-8707"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Joose Kreutzer","raw_affiliation_strings":["BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland"],"affiliations":[{"raw_affiliation_string":"BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031669192","display_name":"Hannu V\u00e4lim\u00e4ki","orcid":"https://orcid.org/0000-0002-9611-1711"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Hannu Valimaki","raw_affiliation_strings":["BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland"],"affiliations":[{"raw_affiliation_string":"BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012771769","display_name":"Heimo Ihalainen","orcid":"https://orcid.org/0000-0002-2213-8110"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Heimo Ihalainen","raw_affiliation_strings":["BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland"],"affiliations":[{"raw_affiliation_string":"BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010105730","display_name":"Jukka Lekkala","orcid":"https://orcid.org/0000-0001-9293-2240"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jukka Lekkala","raw_affiliation_strings":["BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland"],"affiliations":[{"raw_affiliation_string":"BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068440034","display_name":"Mimmi Patrikoski","orcid":"https://orcid.org/0000-0001-9586-6189"},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]},{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mimmi Patrikoski","raw_affiliation_strings":["Adult Stem Cell Group, Tampere University Hospital, Tampere, Finland"],"affiliations":[{"raw_affiliation_string":"Adult Stem Cell Group, Tampere University Hospital, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110","https://openalex.org/I4210126318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056903166","display_name":"Susanna Miettinen","orcid":"https://orcid.org/0000-0002-0647-9556"},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]},{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Susanna Miettinen","raw_affiliation_strings":["Adult Stem Cell Group, Tampere University Hospital, Tampere, Finland"],"affiliations":[{"raw_affiliation_string":"Adult Stem Cell Group, Tampere University Hospital, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110","https://openalex.org/I4210126318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5043502027"],"corresponding_institution_ids":["https://openalex.org/I4210133110"],"apc_list":null,"apc_paid":null,"fwci":0.5098,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.63473729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"470","last_page":"474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/incubator","display_name":"Incubator","score":0.9729958772659302},{"id":"https://openalex.org/keywords/laboratory-flask","display_name":"Laboratory flask","score":0.7509725093841553},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.6902186274528503},{"id":"https://openalex.org/keywords/process-engineering","display_name":"Process engineering","score":0.5601102709770203},{"id":"https://openalex.org/keywords/microcarrier","display_name":"Microcarrier","score":0.4790414571762085},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.4453476667404175},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42816686630249023},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.42216750979423523},{"id":"https://openalex.org/keywords/subculture","display_name":"Subculture (biology)","score":0.4203358292579651},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.38057100772857666},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3495587706565857},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.3482881188392639},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2868911921977997},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.28019532561302185},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20956888794898987},{"id":"https://openalex.org/keywords/horticulture","display_name":"Horticulture","score":0.13944131135940552},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.08541476726531982}],"concepts":[{"id":"https://openalex.org/C21905920","wikidata":"https://www.wikidata.org/wiki/Q900452","display_name":"Incubator","level":2,"score":0.9729958772659302},{"id":"https://openalex.org/C139149728","wikidata":"https://www.wikidata.org/wiki/Q335201","display_name":"Laboratory flask","level":2,"score":0.7509725093841553},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.6902186274528503},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.5601102709770203},{"id":"https://openalex.org/C176999471","wikidata":"https://www.wikidata.org/wiki/Q6839314","display_name":"Microcarrier","level":3,"score":0.4790414571762085},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4453476667404175},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42816686630249023},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.42216750979423523},{"id":"https://openalex.org/C87863119","wikidata":"https://www.wikidata.org/wiki/Q842756","display_name":"Subculture (biology)","level":2,"score":0.4203358292579651},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.38057100772857666},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3495587706565857},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3482881188392639},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2868911921977997},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28019532561302185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20956888794898987},{"id":"https://openalex.org/C144027150","wikidata":"https://www.wikidata.org/wiki/Q48803","display_name":"Horticulture","level":1,"score":0.13944131135940552},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.08541476726531982},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/memea.2017.7985922","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea.2017.7985922","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W18861359","https://openalex.org/W1540069182","https://openalex.org/W1989214699","https://openalex.org/W2005198474","https://openalex.org/W2006955864","https://openalex.org/W2009891171","https://openalex.org/W2023456442","https://openalex.org/W2025229312","https://openalex.org/W2041228288","https://openalex.org/W2072651373","https://openalex.org/W2076406161","https://openalex.org/W2088798578","https://openalex.org/W2100188402","https://openalex.org/W2122339603","https://openalex.org/W2128195864","https://openalex.org/W2128957474","https://openalex.org/W2327407167","https://openalex.org/W2331859668","https://openalex.org/W2334989805","https://openalex.org/W2342600395","https://openalex.org/W2516905987","https://openalex.org/W2737540173"],"related_works":["https://openalex.org/W2411825249","https://openalex.org/W2948179767","https://openalex.org/W2430129213","https://openalex.org/W997354256","https://openalex.org/W2057201931","https://openalex.org/W1050738719","https://openalex.org/W2063574167","https://openalex.org/W135003083","https://openalex.org/W2367183160","https://openalex.org/W2001929046"],"abstract_inverted_index":{"Cell":[0],"culture":[1,25,31,35,56,61],"in":[2,78,82,140,169,243],"stem":[3,59,171],"cell":[4,55,60,172],"research":[5,14],"is":[6,132,152],"on":[7],"the":[8,30,44,47,108,130,135,185,190,207,210,216,229,249,269],"rise,":[9],"not":[10],"only":[11],"for":[12,17,37,118,157,176,251,261],"basic":[13],"but":[15],"also":[16],"its":[18],"potential":[19],"medical":[20],"and":[21,40,74,104,134,155,167,174,246,258,266],"therapeutic":[22],"applications.":[23],"Monitoring":[24],"process":[26,80,256],"using":[27],"sensors":[28,73],"throughout":[29,107],"helps":[32],"to":[33,100,181],"optimize":[34],"conditions":[36],"optimal":[38,264],"growth":[39,265],"maximize":[41],"yield":[42],"from":[43,129,179],"cells.":[45,270],"Further,":[46],"sensor":[48,197],"data":[49,213],"gives":[50,233],"insight":[51],"into":[52],"developing":[53],"better":[54],"systems.":[57],"Typical":[58],"platforms,":[62],"e.g.":[63],"well":[64],"plates":[65],"or":[66,126,199],"flasks,":[67],"cannot":[68],"be":[69],"easily":[70],"equipped":[71],"with":[72,97,254],"impose":[75],"many":[76],"challenges":[77],"periodic":[79],"measurements":[81,136,195],"a":[83,114,141,222],"CO":[84],"<sub":[85],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[86],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sub>":[87],"incubator.":[88],"We":[89],"present":[90,226],"an":[91,234,244],"incubator":[92,131,159,245],"compatible":[93],"modular":[94,150],"measurement":[95,186],"system":[96,162],"three":[98,182],"sensors,":[99],"monitor":[101],"pH,":[102],"temperature":[103],"humidity":[105],"continuously":[106],"culture.":[109,211,230],"Sensors":[110],"are":[111,137,203],"assembled":[112],"around":[113],"flow":[115,143],"through":[116,228],"cuvette":[117],"highly":[119],"sterile":[120],"non-contact":[121],"measurements.":[122],"No":[123],"sample":[124,127],"preparation":[125],"extraction":[128],"needed":[133],"carried":[138,204],"out":[139,205,248],"closed":[142],"loop":[144],"without":[145,196],"wasting":[146],"any":[147],"medium.":[148],"The":[149,161],"assembly":[151],"novel,":[153],"reusable":[154],"feasible":[156],"humid":[158],"environments.":[160],"has":[163,187],"been":[164],"tested,":[165],"validated":[166],"used":[168],"mesenchymal":[170],"expansion":[173],"differentiation,":[175],"periods":[177],"ranging":[178],"two":[180],"weeks.":[183],"Once":[184],"commenced":[188],"at":[189],"beginning":[191],"of":[192,209,237,239,268],"culture,":[193],"continuous":[194],"recalibration":[198],"special":[200],"manual":[201],"attention":[202],"till":[206],"end":[208],"Measurement":[212],"clearly":[214],"show":[215],"interplay":[217],"between":[218],"measured":[219],"parameters,":[220],"indicating":[221],"few":[223],"stress":[224],"sources":[225],"all":[227],"Additionally,":[231],"it":[232],"overall":[235],"picture":[236],"behavior":[238],"critical":[240],"control":[241,260],"parameters":[242],"points":[247],"need":[250],"bioprocess":[252],"systems":[253],"automatic":[255],"monitoring":[257],"smart":[259],"maximum":[262],"yield,":[263],"maintenance":[267]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}