{"id":"https://openalex.org/W2609340671","doi":"https://doi.org/10.1109/memea.2017.7985853","title":"Failure mode and effect analysis of patch-clamp laboratory instrumentation for electrophysiology measurements","display_name":"Failure mode and effect analysis of patch-clamp laboratory instrumentation for electrophysiology measurements","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W2609340671","doi":"https://doi.org/10.1109/memea.2017.7985853","mag":"2609340671"},"language":"en","primary_location":{"id":"doi:10.1109/memea.2017.7985853","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea.2017.7985853","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091706301","display_name":"Sergio Saponara","orcid":"https://orcid.org/0000-0001-6724-4219"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Sergio Saponara","raw_affiliation_strings":["Dip. Ingegneria Informazione, Universit\u00e0 di Pisa, Pisa, Italy","Dip. Scienze della Vita, Universit\u00e0 di Siena, Siena, Italy"],"affiliations":[{"raw_affiliation_string":"Dip. Ingegneria Informazione, Universit\u00e0 di Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Dip. Scienze della Vita, Universit\u00e0 di Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080577630","display_name":"Fabio Fusi","orcid":"https://orcid.org/0000-0002-5737-8309"},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Fusi","raw_affiliation_strings":["Dip. Scienze della Vita, Universit\u00e0 di Siena, Siena, Italy"],"affiliations":[{"raw_affiliation_string":"Dip. Scienze della Vita, Universit\u00e0 di Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074743737","display_name":"Simona Saponara","orcid":"https://orcid.org/0000-0002-3831-8669"},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]},{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Saponara","raw_affiliation_strings":["Dip. Ingegneria Informazione, Universit\u00e0 di Pisa, Pisa, Italy","Dip. Scienze della Vita, Universit\u00e0 di Siena, Siena, Italy"],"affiliations":[{"raw_affiliation_string":"Dip. Ingegneria Informazione, Universit\u00e0 di Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Dip. Scienze della Vita, Universit\u00e0 di Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034478383","display_name":"Massimo Macucci","orcid":"https://orcid.org/0000-0002-7943-2441"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Macucci","raw_affiliation_strings":["Dip. Ingegneria Informazione, Universit\u00e0 di Pisa, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Dip. Ingegneria Informazione, Universit\u00e0 di Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109331727","display_name":"Voicu Groza","orcid":null},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Voicu Groza","raw_affiliation_strings":["School of Inf. Tech. and Eng. (SITE), University of Ottawa, Ottawa, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"School of Inf. Tech. and Eng. (SITE), University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5091706301"],"corresponding_institution_ids":["https://openalex.org/I102064193","https://openalex.org/I108290504"],"apc_list":null,"apc_paid":null,"fwci":0.1752,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54521472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"78","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micromanipulator","display_name":"Micromanipulator","score":0.8492826223373413},{"id":"https://openalex.org/keywords/pipette","display_name":"Pipette","score":0.8028372526168823},{"id":"https://openalex.org/keywords/instrumentation","display_name":"Instrumentation (computer programming)","score":0.6932843923568726},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.6226789355278015},{"id":"https://openalex.org/keywords/current-clamp","display_name":"Current clamp","score":0.5319108366966248},{"id":"https://openalex.org/keywords/patch-clamp","display_name":"Patch clamp","score":0.5108973383903503},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.4916072487831116},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4372154176235199},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.23232987523078918},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.19390767812728882},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.09236162900924683}],"concepts":[{"id":"https://openalex.org/C2776470464","wikidata":"https://www.wikidata.org/wiki/Q1933900","display_name":"Micromanipulator","level":2,"score":0.8492826223373413},{"id":"https://openalex.org/C151552171","wikidata":"https://www.wikidata.org/wiki/Q163373","display_name":"Pipette","level":2,"score":0.8028372526168823},{"id":"https://openalex.org/C118530786","wikidata":"https://www.wikidata.org/wiki/Q1134732","display_name":"Instrumentation (computer programming)","level":2,"score":0.6932843923568726},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.6226789355278015},{"id":"https://openalex.org/C2777151030","wikidata":"https://www.wikidata.org/wiki/Q146870","display_name":"Current clamp","level":4,"score":0.5319108366966248},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.5108973383903503},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.4916072487831116},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4372154176235199},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23232987523078918},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19390767812728882},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09236162900924683},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/memea.2017.7985853","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea.2017.7985853","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"},{"id":"pmh:oai:arpi.unipi.it:11568/849824","is_oa":false,"landing_page_url":"https://ieeexplore.ieee.org/document/7985853","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W27893029","https://openalex.org/W91008694","https://openalex.org/W104295954","https://openalex.org/W1592714270","https://openalex.org/W2009667219","https://openalex.org/W2011570269","https://openalex.org/W2013014604","https://openalex.org/W2019085618","https://openalex.org/W2031906715","https://openalex.org/W2049236096","https://openalex.org/W2053438074","https://openalex.org/W2060315047","https://openalex.org/W2071043968","https://openalex.org/W2119366300","https://openalex.org/W2155346336","https://openalex.org/W2291146427","https://openalex.org/W2409907108","https://openalex.org/W4236664780","https://openalex.org/W6601153520"],"related_works":["https://openalex.org/W2982566957","https://openalex.org/W2316748260","https://openalex.org/W2609000799","https://openalex.org/W2331733109","https://openalex.org/W2007063717","https://openalex.org/W4245822815","https://openalex.org/W3184911172","https://openalex.org/W2029882011","https://openalex.org/W4225470599","https://openalex.org/W102716960"],"abstract_inverted_index":{"The":[0],"patch-clamp":[1,55,130],"technique":[2],"is":[3,51,146],"an":[4,134],"electrophysiological":[5],"method":[6],"that":[7,121],"allows":[8],"the":[9,12,20,57,61,64,66,68,70,72,76,80,103,107,125,129,140],"recording":[10],"of":[11,19,39,106,109,119,136],"macroscopic":[13],"whole-cell":[14],"current":[15,86],"as":[16,18,88],"well":[17],"microscopic":[21],"single-channel":[22],"current,":[23],"flowing":[24],"across":[25],"biological":[26],"membranes":[27],"through":[28],"ion":[29,112],"channels.":[30,113],"Though":[31],"different":[32,117],"experimental":[33],"preparations":[34],"exist,":[35],"and":[36,75,97],"various":[37],"types":[38,118],"experiments":[40,145],"can":[41,83],"be":[42],"carried":[43,147],"out":[44],"with":[45],"this":[46,115],"technique,":[47],"some":[48],"basic":[49],"instrumentation":[50,82,127],"common":[52],"to":[53],"all":[54],"workstations:":[56],"vibration":[58],"isolation":[59],"table,":[60],"Faraday":[62],"cage,":[63],"microscope,":[65],"micromanipulator,":[67],"amplifier,":[69],"pc,":[71],"pipette":[73],"puller,":[74],"microforge.":[77],"Failures":[78],"in":[79,124],"electronic":[81,126],"markedly":[84],"affect":[85],"recordings,":[87],"their":[89,137],"amplitudes":[90],"usually":[91],"range":[92],"between":[93],"a":[94,98],"few":[95,99],"pA":[96],"nA,":[100],"thus":[101],"influencing":[102],"accurate":[104],"assessment":[105],"effect":[108,138],"drugs":[110],"on":[111,139],"In":[114],"paper":[116],"failure":[120],"may":[122],"occur":[123],"for":[128],"are":[131],"discussed.":[132],"Moreover,":[133],"analysis":[135],"acquired":[141],"measurements":[142],"during":[143],"electrophysiology":[144],"out.":[148]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
