{"id":"https://openalex.org/W2518557368","doi":"https://doi.org/10.1109/memea.2016.7533800","title":"Preliminary study of a low-cost point-of-care testing system using screen-printed biosensors: For early biomarkers detection related to Alzheimer Disease","display_name":"Preliminary study of a low-cost point-of-care testing system using screen-printed biosensors: For early biomarkers detection related to Alzheimer Disease","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2518557368","doi":"https://doi.org/10.1109/memea.2016.7533800","mag":"2518557368"},"language":"en","primary_location":{"id":"doi:10.1109/memea.2016.7533800","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea.2016.7533800","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017170517","display_name":"Sarah Tonello","orcid":"https://orcid.org/0000-0002-7325-7988"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sarah Tonello","raw_affiliation_strings":["Department of Information Engineering, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035415675","display_name":"Mauro Serpelloni","orcid":"https://orcid.org/0000-0001-6497-5876"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mauro Serpelloni","raw_affiliation_strings":["Department of Information Engineering, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073316266","display_name":"Nicola Francesco Lopomo","orcid":"https://orcid.org/0000-0002-5795-2606"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Francesco Lopomo","raw_affiliation_strings":["Department of Information Engineering, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073500668","display_name":"Emilio Sardini","orcid":"https://orcid.org/0000-0001-8629-7316"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emilio Sardini","raw_affiliation_strings":["Department of Information Engineering, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071655131","display_name":"Giulia Abate","orcid":"https://orcid.org/0000-0001-9161-3475"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Abate","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074986039","display_name":"Daniela Uberti","orcid":"https://orcid.org/0000-0002-5926-9122"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Letizia Uberti","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5223,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.72157904,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/printed-circuit-board","display_name":"Printed circuit board","score":0.6658944487571716},{"id":"https://openalex.org/keywords/potentiostat","display_name":"Potentiostat","score":0.6197322607040405},{"id":"https://openalex.org/keywords/reference-electrode","display_name":"Reference electrode","score":0.508740246295929},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5041574239730835},{"id":"https://openalex.org/keywords/dielectric-spectroscopy","display_name":"Dielectric spectroscopy","score":0.5032407641410828},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.479579359292984},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.4764147996902466},{"id":"https://openalex.org/keywords/point-of-care","display_name":"Point of care","score":0.44408419728279114},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"Point-of-care testing","score":0.43030819296836853},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.41731762886047363},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3831104040145874},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3207928538322449},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.2744869589805603},{"id":"https://openalex.org/keywords/electrochemistry","display_name":"Electrochemistry","score":0.25552231073379517},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.22455307841300964},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15410417318344116},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10024943947792053},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.09935817122459412},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09712973237037659}],"concepts":[{"id":"https://openalex.org/C120793396","wikidata":"https://www.wikidata.org/wiki/Q173350","display_name":"Printed circuit board","level":2,"score":0.6658944487571716},{"id":"https://openalex.org/C2779995598","wikidata":"https://www.wikidata.org/wiki/Q629290","display_name":"Potentiostat","level":4,"score":0.6197322607040405},{"id":"https://openalex.org/C40290423","wikidata":"https://www.wikidata.org/wiki/Q653954","display_name":"Reference electrode","level":4,"score":0.508740246295929},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5041574239730835},{"id":"https://openalex.org/C7040849","wikidata":"https://www.wikidata.org/wiki/Q899580","display_name":"Dielectric spectroscopy","level":4,"score":0.5032407641410828},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.479579359292984},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.4764147996902466},{"id":"https://openalex.org/C51915194","wikidata":"https://www.wikidata.org/wiki/Q17075487","display_name":"Point of care","level":2,"score":0.44408419728279114},{"id":"https://openalex.org/C64841741","wikidata":"https://www.wikidata.org/wiki/Q491983","display_name":"Point-of-care testing","level":2,"score":0.43030819296836853},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.41731762886047363},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3831104040145874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3207928538322449},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2744869589805603},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.25552231073379517},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.22455307841300964},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15410417318344116},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10024943947792053},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09935817122459412},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09712973237037659},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/memea.2016.7533800","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea.2016.7533800","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"},{"id":"pmh:oai:iris.unibs.it:11379/482772","is_oa":false,"landing_page_url":"http://hdl.handle.net/11379/482772","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:www.research.unipd.it:11577/3457102","is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/3457102","pdf_url":null,"source":{"id":"https://openalex.org/S4377196283","display_name":"Research Padua  Archive (University of Padua)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.5799999833106995}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W640012366","https://openalex.org/W1607905899","https://openalex.org/W1964869332","https://openalex.org/W1965160653","https://openalex.org/W1997526132","https://openalex.org/W2011164637","https://openalex.org/W2016235622","https://openalex.org/W2021841134","https://openalex.org/W2021880533","https://openalex.org/W2027779691","https://openalex.org/W2033515000","https://openalex.org/W2033528517","https://openalex.org/W2036195533","https://openalex.org/W2048353097","https://openalex.org/W2093479189","https://openalex.org/W2109664941","https://openalex.org/W2142019112","https://openalex.org/W2314593202","https://openalex.org/W2331178321"],"related_works":["https://openalex.org/W2791085736","https://openalex.org/W2075397032","https://openalex.org/W2120030360","https://openalex.org/W1988673641","https://openalex.org/W2046227952","https://openalex.org/W4237777802","https://openalex.org/W629065209","https://openalex.org/W1969898966","https://openalex.org/W2412038252","https://openalex.org/W2265099823"],"abstract_inverted_index":{"Among":[0],"neurodegenerative":[1],"diseases,":[2],"Alzheimer":[3],"Disease":[4],"(AD)":[5],"represents":[6],"one":[7,286],"of":[8,24,29,92,100,105,115,172,182,206,228,237,245,271,276,279],"the":[9,93,98,101,106,111,116,156,173,180,204,207,211,229,235,238,260,285],"most":[10],"widespread":[11],"pathologies,":[12],"for":[13,158],"which":[14],"an":[15,25],"early":[16],"diagnosis":[17],"is":[18,253,262],"still":[19],"missing.":[20],"A":[21],"peculiar":[22],"expression":[23],"altered":[26],"conformational":[27],"isoform":[28],"p53":[30,273],"protein":[31],"was":[32,153],"reported":[33],"to":[34,40,57,62,65,71,110,130,209,215,240,264,267,291,297],"be":[35,265],"a":[36,49,73,141,159,165,225,257,293],"potential":[37],"biomarker":[38],"able":[39],"distinguish":[41],"AD":[42,280],"subjects":[43],"from":[44,232,287],"healthy":[45],"population,":[46],"quantifiable":[47],"using":[48,191],"blood-based":[50],"enzyme-linked":[51],"immunosorbent":[52],"assay":[53],"(ELISA).":[54],"In":[55,120],"order":[56],"overcome":[58],"ELISA":[59,288],"limitations,":[60],"related":[61],"reliability":[63],"and":[64,104,113,124,135,162,185,255,299],"improve":[66],"sensitivity,":[67],"this":[68],"study":[69,252],"aimed":[70],"realize":[72,131,292],"low":[74,216,294],"cost":[75],"highly":[76,300],"sensitive":[77],"portable":[78],"point-of-care":[79],"(PoC)":[80],"testing":[81,171],"system":[82],"based":[83],"on":[84,145],"screen":[85],"printed":[86],"electrochemical":[87],"sensors":[88],"(SPES).":[89],"The":[90,150,251],"development":[91],"platform":[94],"specifically":[95],"included":[96],"both":[97],"design":[99],"sensing":[102],"probe":[103],"electronic":[107],"circuit":[108,152,174,208,239,261],"devoted":[109],"conditioning":[112,151],"acquisition":[114],"transduced":[117],"electric":[118],"signal.":[119],"particular,":[121],"silver,":[122],"carbon":[123],"silver-silver":[125],"chloride":[126],"were":[127,175],"selected":[128],"respectively":[129],"conductive":[132],"tracks,":[133],"working":[134],"counter":[136],"electrodes,":[137],"reference":[138],"electrode":[139],"in":[140,179,218,274],"three-electrodes":[142],"configuration":[143],"focusing":[144],"Anodic":[146],"Stripping":[147],"Voltammetry":[148],"(ASV).":[149],"designed":[154],"following":[155],"scheme":[157],"common":[160],"potentiostat,":[161],"produced":[163],"as":[164],"Printed":[166],"Circuit":[167],"Board":[168],"(PCB).":[169],"Initial":[170],"performed":[176],"recording":[177],"changes":[178,217],"conductivity":[181],"NaCl":[183,219],"solution":[184],"quantifying":[186],"electrodes":[187],"coating":[188],"with":[189,200,284],"antibodies":[190,246],"Electrochemical":[192],"Impedance":[193],"Spectroscopy":[194],"(EIS)":[195],"principle.":[196],"Preliminary":[197],"results":[198,283],"obtained":[199],"saline":[201],"solution,":[202],"showed":[203,234],"ability":[205,236],"give":[210],"best":[212],"response":[213],"corresponding":[214],"concentration":[220,270],"(sensitivity":[221,248],"0.2":[222],"mA/(mg/ml)),":[223],"suggesting":[224],"good":[226],"sensitivity":[227],"platform.":[230,302],"Results":[231],"EIS":[233],"discriminate":[241],"between":[242],"different":[243],"concentrations":[244],"coatings":[247],"80":[249],"\u03bcA/\u03bcg).":[250],"on-going":[254],"after":[256],"proper":[258],"calibration,":[259],"intended":[263],"optimized":[266],"quantify":[268],"unknown":[269],"unfolded":[272],"samples":[275],"peripheral":[277],"blood":[278],"patients,":[281],"compared":[282],"analysis,":[289],"aiming":[290],"cost,":[295],"easy":[296],"use":[298],"precise":[301]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}