{"id":"https://openalex.org/W4412431410","doi":"https://doi.org/10.1109/med64031.2025.11073470","title":"Root Contours Guided Design of a Multicellular PID Controller","display_name":"Root Contours Guided Design of a Multicellular PID Controller","publication_year":2025,"publication_date":"2025-06-10","ids":{"openalex":"https://openalex.org/W4412431410","doi":"https://doi.org/10.1109/med64031.2025.11073470"},"language":"en","primary_location":{"id":"doi:10.1109/med64031.2025.11073470","is_oa":false,"landing_page_url":"https://doi.org/10.1109/med64031.2025.11073470","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 33rd Mediterranean Conference on Control and Automation (MED)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003774344","display_name":"Vittoria Martinelli","orcid":"https://orcid.org/0000-0002-9891-7970"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Vittoria Martinelli","raw_affiliation_strings":["University of Naples Federico II,Department of Mathematics and Applications \"R. Caccioppoli\",Naples,Italy,80126"],"affiliations":[{"raw_affiliation_string":"University of Naples Federico II,Department of Mathematics and Applications \"R. Caccioppoli\",Naples,Italy,80126","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053589804","display_name":"Davide Fiore","orcid":"https://orcid.org/0000-0002-4011-5836"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Fiore","raw_affiliation_strings":["University of Naples Federico II,Department of Mathematics and Applications \"R. Caccioppoli\",Naples,Italy,80126"],"affiliations":[{"raw_affiliation_string":"University of Naples Federico II,Department of Mathematics and Applications \"R. Caccioppoli\",Naples,Italy,80126","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044284478","display_name":"Davide Salzano","orcid":"https://orcid.org/0000-0003-3560-8609"},"institutions":[{"id":"https://openalex.org/I2800920820","display_name":"Istituto Universitario di Studi Superiori di Pavia","ror":"https://ror.org/0290wsh42","country_code":"IT","type":"education","lineage":["https://openalex.org/I2800920820"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Salzano","raw_affiliation_strings":["SSM - School for Advanced Studies,Naples,Italy"],"affiliations":[{"raw_affiliation_string":"SSM - School for Advanced Studies,Naples,Italy","institution_ids":["https://openalex.org/I2800920820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034953482","display_name":"Mario di Bernardo","orcid":"https://orcid.org/0000-0002-2171-4745"},"institutions":[{"id":"https://openalex.org/I2800920820","display_name":"Istituto Universitario di Studi Superiori di Pavia","ror":"https://ror.org/0290wsh42","country_code":"IT","type":"education","lineage":["https://openalex.org/I2800920820"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Di Bernardo","raw_affiliation_strings":["SSM - School for Advanced Studies,Naples,Italy"],"affiliations":[{"raw_affiliation_string":"SSM - School for Advanced Studies,Naples,Italy","institution_ids":["https://openalex.org/I2800920820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003774344"],"corresponding_institution_ids":["https://openalex.org/I71267560"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18773796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"138","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.988099992275238,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.988099992275238,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.963699996471405,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9330000281333923,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pid-controller","display_name":"PID controller","score":0.7783768177032471},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.6318233013153076},{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.5341419577598572},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4584346413612366},{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.42759907245635986},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.36977168917655945},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2634297013282776},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.21544116735458374},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1931227147579193},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18159052729606628},{"id":"https://openalex.org/keywords/temperature-control","display_name":"Temperature control","score":0.10144215822219849},{"id":"https://openalex.org/keywords/agronomy","display_name":"Agronomy","score":0.0562308132648468}],"concepts":[{"id":"https://openalex.org/C47116090","wikidata":"https://www.wikidata.org/wiki/Q716829","display_name":"PID controller","level":3,"score":0.7783768177032471},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.6318233013153076},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.5341419577598572},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4584346413612366},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.42759907245635986},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.36977168917655945},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2634297013282776},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.21544116735458374},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1931227147579193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18159052729606628},{"id":"https://openalex.org/C536315585","wikidata":"https://www.wikidata.org/wiki/Q7698332","display_name":"Temperature control","level":2,"score":0.10144215822219849},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0562308132648468},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/med64031.2025.11073470","is_oa":false,"landing_page_url":"https://doi.org/10.1109/med64031.2025.11073470","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 33rd Mediterranean Conference on Control and Automation (MED)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2247294682","https://openalex.org/W2623066589","https://openalex.org/W2935954872","https://openalex.org/W2970596022","https://openalex.org/W2975521369","https://openalex.org/W3011703570","https://openalex.org/W3034855607","https://openalex.org/W3044384970","https://openalex.org/W3207755008","https://openalex.org/W3207983752","https://openalex.org/W4210447823","https://openalex.org/W4281400804","https://openalex.org/W4285098893","https://openalex.org/W4285140318","https://openalex.org/W4316174672","https://openalex.org/W4381199030","https://openalex.org/W4399310893","https://openalex.org/W4406933335"],"related_works":["https://openalex.org/W2522472446","https://openalex.org/W1963836821","https://openalex.org/W2145740829","https://openalex.org/W4281994149","https://openalex.org/W345142232","https://openalex.org/W2167345368","https://openalex.org/W4320922540","https://openalex.org/W82747921","https://openalex.org/W1989195983","https://openalex.org/W2000675896"],"abstract_inverted_index":{"Ensuring":[0],"a":[1,8,25,40,58,93,119],"stable":[2],"and":[3,19,55,71,128],"robust":[4],"phenotype":[5],"expression":[6],"is":[7],"key":[9,26],"challenge":[10,60],"for":[11,61],"the":[12,85,109,115,131],"correct":[13],"operation":[14],"of":[15,108,118,130],"synthetically":[16],"engineered":[17],"cells,":[18],"feedback":[20,95],"has":[21,80],"been":[22,36,81],"highlighted":[23],"as":[24],"mechanism":[27],"to":[28,44,67,83,113],"achieve":[29],"this":[30,99],"goal.":[31],"Biomolecular":[32],"PID":[33,121,133],"controllers":[34],"have":[35],"extensively":[37],"leveraged":[38],"at":[39],"single":[41],"cell":[42,90],"level":[43],"regulate":[45],"gene":[46],"expression.":[47],"However,":[48],"single-cell":[49],"architectures":[50],"suffer":[51],"from":[52],"limited":[53],"modularity":[54,129],"might":[56],"pose":[57],"significant":[59],"their":[62],"in":[63,136,139],"vivo":[64],"implementation":[65],"due":[66],"high":[68],"metabolic":[69],"load":[70],"possible":[72],"incompatible":[73],"reactions.":[74],"To":[75],"overcome":[76],"these":[77],"limitations,":[78],"it":[79],"proposed":[82],"distribute":[84],"control":[86,96,116],"actions":[87],"over":[88],"different":[89],"populations":[91],"realizing":[92],"multicellular":[94,120,132],"architecture.":[97],"In":[98],"paper":[100],"we":[101],"provide":[102],"design":[103],"guidelines":[104],"derived":[105],"by":[106],"means":[107],"root":[110],"contours":[111],"method":[112],"tune":[114],"gains":[117],"controller.":[122],"We":[123],"then":[124],"validate":[125],"performance,":[126],"robustness":[127],"controller":[134],"through":[135],"silico":[137],"simulations":[138],"BSim.":[140]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
