{"id":"https://openalex.org/W2344834175","doi":"https://doi.org/10.1109/mdat.2016.2560137","title":"In Vitro Long-Term Performance Evaluation and Improvement in the Response Time of CMOS-Based Implantable Glucose Sensors","display_name":"In Vitro Long-Term Performance Evaluation and Improvement in the Response Time of CMOS-Based Implantable Glucose Sensors","publication_year":2016,"publication_date":"2016-04-28","ids":{"openalex":"https://openalex.org/W2344834175","doi":"https://doi.org/10.1109/mdat.2016.2560137","mag":"2344834175"},"language":"en","primary_location":{"id":"doi:10.1109/mdat.2016.2560137","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mdat.2016.2560137","pdf_url":null,"source":{"id":"https://openalex.org/S4210176427","display_name":"IEEE Design and Test","issn_l":"2168-2356","issn":["2168-2356","2168-2364"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Design & Test","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011667196","display_name":"Takashi Tokuda","orcid":"https://orcid.org/0000-0002-9117-2988"},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Tokuda","raw_affiliation_strings":["Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9117-2988","affiliations":[{"raw_affiliation_string":"Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111808939","display_name":"Toshikazu Kawamura","orcid":null},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshikazu Kawamura","raw_affiliation_strings":["Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002112031","display_name":"Keita Masuda","orcid":"https://orcid.org/0000-0002-4403-3619"},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keita Masuda","raw_affiliation_strings":["Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110799329","display_name":"Tomohiro Hirai","orcid":null},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Hirai","raw_affiliation_strings":["Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078853590","display_name":"Hironari Takehara","orcid":"https://orcid.org/0000-0001-7689-1186"},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironari Takehara","raw_affiliation_strings":["Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030986387","display_name":"Yasumi Ohta","orcid":"https://orcid.org/0000-0002-0333-4626"},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasumi Ohta","raw_affiliation_strings":["Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113629872","display_name":"Mayumi Motoyama","orcid":null},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayumi Motoyama","raw_affiliation_strings":["Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084784050","display_name":"Hiroaki Takehara","orcid":"https://orcid.org/0000-0003-3222-8483"},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Takehara","raw_affiliation_strings":["Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011980614","display_name":"Toshihiko Noda","orcid":"https://orcid.org/0000-0001-6964-9148"},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiko Noda","raw_affiliation_strings":["Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036088892","display_name":"Kiyotaka Sasagawa","orcid":"https://orcid.org/0000-0002-5718-3958"},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyotaka Sasagawa","raw_affiliation_strings":["Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025399403","display_name":"Jun Ohta","orcid":"https://orcid.org/0000-0001-8194-9020"},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Ohta","raw_affiliation_strings":["Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111420683","display_name":"Teru Okitsu","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Teru Okitsu","raw_affiliation_strings":["Institute of Industrial Science, The University of Tokyo, Meguro-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Industrial Science, The University of Tokyo, Meguro-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056412116","display_name":"Shoji Takeuchi","orcid":"https://orcid.org/0000-0001-6946-0409"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoji Takeuchi","raw_affiliation_strings":["Institute of Industrial Science, The University of Tokyo, Meguro-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Industrial Science, The University of Tokyo, Meguro-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.891,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.76612056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"33","issue":"4","first_page":"37","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/response-time","display_name":"Response time","score":0.7776341438293457},{"id":"https://openalex.org/keywords/cmos","display_name":"CMOS","score":0.6541377902030945},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5715227723121643},{"id":"https://openalex.org/keywords/saline","display_name":"Saline","score":0.4757941961288452},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4565436840057373},{"id":"https://openalex.org/keywords/term","display_name":"Term (time)","score":0.44844844937324524},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.4451924264431},{"id":"https://openalex.org/keywords/continuous-glucose-monitoring","display_name":"Continuous glucose monitoring","score":0.41282740235328674},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.3988988995552063},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38287487626075745},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3155619204044342},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.2815493047237396},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.24528393149375916},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2425033450126648},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18476134538650513},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07185056805610657}],"concepts":[{"id":"https://openalex.org/C19012869","wikidata":"https://www.wikidata.org/wiki/Q578372","display_name":"Response time","level":2,"score":0.7776341438293457},{"id":"https://openalex.org/C46362747","wikidata":"https://www.wikidata.org/wiki/Q173431","display_name":"CMOS","level":2,"score":0.6541377902030945},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5715227723121643},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4757941961288452},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4565436840057373},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.44844844937324524},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.4451924264431},{"id":"https://openalex.org/C2986379492","wikidata":"https://www.wikidata.org/wiki/Q1638492","display_name":"Continuous glucose monitoring","level":4,"score":0.41282740235328674},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.3988988995552063},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38287487626075745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3155619204044342},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2815493047237396},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.24528393149375916},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2425033450126648},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18476134538650513},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07185056805610657},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mdat.2016.2560137","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mdat.2016.2560137","pdf_url":null,"source":{"id":"https://openalex.org/S4210176427","display_name":"IEEE Design and Test","issn_l":"2168-2356","issn":["2168-2356","2168-2364"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Design & Test","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1343359797","display_name":"Implantable glucose sensor toward fully implantable glucose monitoring system(Fostering Joint International Research)","funder_award_id":"15KK0209","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2000136305","display_name":"Implantable optical diagnostic and therapeutic devices based on biophotonic LSI technology","funder_award_id":"15K21164","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G765160889","display_name":"Implantable gcluose sensor toward fully implantable glucose monitoring system","funder_award_id":"23360157","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309398","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055"},{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"},{"id":"https://openalex.org/F4320324799","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1971775068","https://openalex.org/W1979789349","https://openalex.org/W1994795068","https://openalex.org/W1996289659","https://openalex.org/W2007320634","https://openalex.org/W2045397747","https://openalex.org/W2045747400","https://openalex.org/W2048852426","https://openalex.org/W2060267700","https://openalex.org/W2070891925","https://openalex.org/W2096424603","https://openalex.org/W2112740753","https://openalex.org/W2164989510","https://openalex.org/W2165125030","https://openalex.org/W3144073233"],"related_works":["https://openalex.org/W2046430340","https://openalex.org/W2383021773","https://openalex.org/W2322026400","https://openalex.org/W4206515393","https://openalex.org/W1990396141","https://openalex.org/W1929958295","https://openalex.org/W2226641048","https://openalex.org/W2002555800","https://openalex.org/W2056670287","https://openalex.org/W2021425015"],"abstract_inverted_index":{"This":[0],"article":[1],"confirmed":[2],"that":[3,42],"the":[4,24,44,55],"sensor":[5,25,57],"retains":[6],"its":[7],"measurement":[8],"capability":[9],"for":[10,27],"more":[11],"than":[12],"150":[13],"days":[14],"in":[15],"a":[16],"saline":[17],"solution.":[18],"In":[19],"addition,":[20],"an":[21,29],"optimization":[22],"of":[23,43,47],"structure":[26],"obtaining":[28],"improved":[30],"response":[31,37],"time":[32,38],"was":[33,52],"carried":[34],"out.":[35],"A":[36],"as":[39,41],"short":[40],"conventional":[45],"self-monitoring":[46],"blood":[48],"glucose":[49],"(SMBG)":[50],"technology":[51],"obtained":[53],"with":[54],"optimized":[56],"structure.":[58]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}