{"id":"https://openalex.org/W1677771097","doi":"https://doi.org/10.1109/mdat.2015.2452904","title":"Modeling the Effect of Intravenous Anesthetics: A Path Toward Individualization","display_name":"Modeling the Effect of Intravenous Anesthetics: A Path Toward Individualization","publication_year":2015,"publication_date":"2015-07-07","ids":{"openalex":"https://openalex.org/W1677771097","doi":"https://doi.org/10.1109/mdat.2015.2452904","mag":"1677771097"},"language":"en","primary_location":{"id":"doi:10.1109/mdat.2015.2452904","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mdat.2015.2452904","pdf_url":null,"source":{"id":"https://openalex.org/S4210176427","display_name":"IEEE Design and Test","issn_l":"2168-2356","issn":["2168-2356","2168-2364"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Design &amp; Test","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/10216/110408","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002333385","display_name":"Margarida M. Silva","orcid":"https://orcid.org/0000-0003-4436-4124"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Margarida M. Silva","raw_affiliation_strings":["Department of Information Technology, Uppsala University, Uppsala, Sweden","Department of Information Technology; Uppsala University; Uppsala Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Information Technology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Department of Information Technology; Uppsala University; Uppsala Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043092463","display_name":"Alexander Medvedev","orcid":"https://orcid.org/0000-0002-6608-250X"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I4210158519","display_name":"Informa (Sweden)","ror":"https://ror.org/04yt64d76","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210154378","https://openalex.org/I4210158519"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Alexander Medvedev","raw_affiliation_strings":["Dept. Information Technology, Uppsala University, Uppsala, Sweden","[Dept. Information Technology, Uppsala University, Uppsala, Sweden]"],"affiliations":[{"raw_affiliation_string":"Dept. Information Technology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I4210158519"]},{"raw_affiliation_string":"[Dept. Information Technology, Uppsala University, Uppsala, Sweden]","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058932060","display_name":"Torbj\u00f6rn Wigren","orcid":"https://orcid.org/0000-0003-2580-8906"},"institutions":[{"id":"https://openalex.org/I4210158519","display_name":"Informa (Sweden)","ror":"https://ror.org/04yt64d76","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210154378","https://openalex.org/I4210158519"]},{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Torbjorn Wigren","raw_affiliation_strings":["Dept. Information Technology, Uppsala University, Uppsala, Sweden","[Dept. Information Technology, Uppsala University, Uppsala, Sweden]"],"affiliations":[{"raw_affiliation_string":"Dept. Information Technology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I4210158519"]},{"raw_affiliation_string":"[Dept. Information Technology, Uppsala University, Uppsala, Sweden]","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027560360","display_name":"Teresa Mendon\u00e7a","orcid":"https://orcid.org/0000-0001-7539-7549"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Teresa Mendonca","raw_affiliation_strings":["SYSTEC-Research Center for Systems and Tecnhologies, Fac. Engenharia, Universidade do Porto, Porto, Portugal","[SYSTEC-Research Center for Systems and Tecnhologies, Fac. Engenharia, Universidade do Porto, Porto, Portugal]"],"affiliations":[{"raw_affiliation_string":"SYSTEC-Research Center for Systems and Tecnhologies, Fac. Engenharia, Universidade do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"[SYSTEC-Research Center for Systems and Tecnhologies, Fac. Engenharia, Universidade do Porto, Porto, Portugal]","institution_ids":["https://openalex.org/I182534213"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002333385"],"corresponding_institution_ids":["https://openalex.org/I123387679"],"apc_list":null,"apc_paid":null,"fwci":1.0473,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.76573611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"32","issue":"5","first_page":"17","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9782000184059143,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.968999981880188,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/path","display_name":"Path (computing)","score":0.6518977880477905},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5922583341598511},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"Pharmacodynamics","score":0.560421347618103},{"id":"https://openalex.org/keywords/closed-loop","display_name":"Closed loop","score":0.43606075644493103},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.43378564715385437},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3396615982055664},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.21034133434295654},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.1874730885028839},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.14974847435951233},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.12638482451438904}],"concepts":[{"id":"https://openalex.org/C2777735758","wikidata":"https://www.wikidata.org/wiki/Q817765","display_name":"Path (computing)","level":2,"score":0.6518977880477905},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5922583341598511},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.560421347618103},{"id":"https://openalex.org/C3019251811","wikidata":"https://www.wikidata.org/wiki/Q5135346","display_name":"Closed loop","level":2,"score":0.43606075644493103},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.43378564715385437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3396615982055664},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21034133434295654},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.1874730885028839},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14974847435951233},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.12638482451438904}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/mdat.2015.2452904","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mdat.2015.2452904","pdf_url":null,"source":{"id":"https://openalex.org/S4210176427","display_name":"IEEE Design and Test","issn_l":"2168-2356","issn":["2168-2356","2168-2364"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Design &amp; Test","raw_type":"journal-article"},{"id":"pmh:oai:repositorio-aberto.up.pt:10216/110408","is_oa":true,"landing_page_url":"https://hdl.handle.net/10216/110408","pdf_url":null,"source":{"id":"https://openalex.org/S4306401934","display_name":"Open Repository of the University of Porto (University of Porto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I182534213","host_organization_name":"Universidade do Porto","host_organization_lineage":["https://openalex.org/I182534213"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio-aberto.up.pt:10216/110408","is_oa":true,"landing_page_url":"https://hdl.handle.net/10216/110408","pdf_url":null,"source":{"id":"https://openalex.org/S4306401934","display_name":"Open Repository of the University of Porto (University of Porto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I182534213","host_organization_name":"Universidade do Porto","host_organization_lineage":["https://openalex.org/I182534213"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8319257716","display_name":null,"funder_award_id":"Advanced Grant 247035","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"}],"funders":[{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W105181866","https://openalex.org/W213501209","https://openalex.org/W1565942442","https://openalex.org/W1602393082","https://openalex.org/W1722122222","https://openalex.org/W1978058504","https://openalex.org/W2019116530","https://openalex.org/W2019826771","https://openalex.org/W2021247017","https://openalex.org/W2023263680","https://openalex.org/W2042613429","https://openalex.org/W2046012301","https://openalex.org/W2052880612","https://openalex.org/W2066996342","https://openalex.org/W2091787052","https://openalex.org/W2122171313","https://openalex.org/W2124432577","https://openalex.org/W2165879714","https://openalex.org/W2172008557","https://openalex.org/W2343639839","https://openalex.org/W2488700677","https://openalex.org/W2913465992","https://openalex.org/W2958569496","https://openalex.org/W6604201397","https://openalex.org/W6635844270"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W2254638634","https://openalex.org/W2369345461"],"abstract_inverted_index":{"The":[0],"modeling":[1],"of":[2,5,33],"the":[3,9,15,31,41,64,68],"effect":[4],"intravenous":[6],"anesthetics":[7],"in":[8,63],"human":[10],"body":[11],"that":[12,51],"accounts":[13],"for":[14,24,29,53],"interpatient":[16],"and":[17,57],"intrapatient":[18],"variability":[19],"is":[20],"essential":[21],"not":[22],"only":[23],"therapy":[25],"individualization,":[26],"but":[27],"also":[28],"enabling":[30],"construction":[32],"reduced":[34,49],"complexity":[35],"feedback":[36],"controllers.":[37],"This":[38],"paper":[39],"reviews":[40],"path":[42],"from":[43],"complex":[44],"pharmacokinetic/pharmacodynamic":[45],"(PK/PD)":[46],"models":[47,50],"to":[48],"allow":[52],"runtime":[54,60],"parameter":[55],"estimation":[56],"provide":[58],"good":[59],"prediction":[61],"capabilities":[62],"closed-loop":[65],"CPSs":[66],"delivering":[67],"anesthesia.":[69]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}
