{"id":"https://openalex.org/W4400526357","doi":"https://doi.org/10.1109/mci.2024.3401348","title":"Rearrange Anatomy Inputs Like LEGO Bricks: Applying InSSS-P and a Mobile-Dense Hybrid Network to Distill Vascular Significance From Retina OCT-Angiography","display_name":"Rearrange Anatomy Inputs Like LEGO Bricks: Applying InSSS-P and a Mobile-Dense Hybrid Network to Distill Vascular Significance From Retina OCT-Angiography","publication_year":2024,"publication_date":"2024-07-11","ids":{"openalex":"https://openalex.org/W4400526357","doi":"https://doi.org/10.1109/mci.2024.3401348"},"language":"en","primary_location":{"id":"doi:10.1109/mci.2024.3401348","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/mci.2024.3401348","pdf_url":null,"source":{"id":"https://openalex.org/S104797584","display_name":"IEEE Computational Intelligence Magazine","issn_l":"1556-603X","issn":["1556-603X","1556-6048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Computational Intelligence Magazine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045149653","display_name":"Kao-Jung Chang","orcid":"https://orcid.org/0000-0002-2238-7387"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kao-Jung Chang","raw_affiliation_strings":["National Yang Ming Chiao Tung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"National Yang Ming Chiao Tung University, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046542915","display_name":"Tai\u2010Chi Lin","orcid":"https://orcid.org/0000-0003-1163-0457"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tai-Chi Lin","raw_affiliation_strings":["National Yang Ming Chiao Tung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"National Yang Ming Chiao Tung University, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084779468","display_name":"Chih\u2010Chien Hsu","orcid":"https://orcid.org/0000-0003-2354-2999"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Chien Hsu","raw_affiliation_strings":["National Yang Ming Chiao Tung University, Taiwan","Show Chwan Memorial Hospital, Taiwan"],"affiliations":[{"raw_affiliation_string":"National Yang Ming Chiao Tung University, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Show Chwan Memorial Hospital, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029792396","display_name":"De\u2010Kuang Hwang","orcid":"https://orcid.org/0000-0001-6346-8485"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"De-Kuang Hwang","raw_affiliation_strings":["National Yang Ming Chiao Tung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"National Yang Ming Chiao Tung University, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018898425","display_name":"Shih\u2010Jen Chen","orcid":"https://orcid.org/0000-0001-9798-1578"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Jen Chen","raw_affiliation_strings":["National Yang Ming Chiao Tung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"National Yang Ming Chiao Tung University, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047465008","display_name":"Shih\u2010Hwa Chiou","orcid":"https://orcid.org/0000-0002-8651-5755"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Hwa Chiou","raw_affiliation_strings":["National Yang Ming Chiao Tung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"National Yang Ming Chiao Tung University, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078277351","display_name":"Cheng-Yi Li","orcid":null},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Yi Li","raw_affiliation_strings":["National Yang Ming Chiao Tung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"National Yang Ming Chiao Tung University, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028977984","display_name":"Ling Chen","orcid":"https://orcid.org/0000-0002-1512-6672"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ling Chen","raw_affiliation_strings":["National Yang Ming Chiao Tung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"National Yang Ming Chiao Tung University, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090187817","display_name":"Cherng-Ru Hsu","orcid":"https://orcid.org/0000-0002-4390-0389"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cherng-Ru Hsu","raw_affiliation_strings":["National Yang Ming Chiao Tung University, Taiwan","Show Chwan Memorial Hospital, Taiwan"],"affiliations":[{"raw_affiliation_string":"National Yang Ming Chiao Tung University, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Show Chwan Memorial Hospital, Taiwan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024496316","display_name":"Wei-Hao Chang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143126","display_name":"Acer (Taiwan)","ror":"https://ror.org/03xajsx66","country_code":"TW","type":"company","lineage":["https://openalex.org/I4210143126"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Hao Chang","raw_affiliation_strings":["Acer Medical Inc., Taiwan"],"affiliations":[{"raw_affiliation_string":"Acer Medical Inc., Taiwan","institution_ids":["https://openalex.org/I4210143126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5045149653"],"corresponding_institution_ids":["https://openalex.org/I148366613"],"apc_list":null,"apc_paid":null,"fwci":0.4307,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63413637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"19","issue":"3","first_page":"12","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retina","display_name":"Retina","score":0.7571850419044495},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6450552940368652},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4899424910545349},{"id":"https://openalex.org/keywords/vascular-network","display_name":"Vascular network","score":0.47648733854293823},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.448444664478302},{"id":"https://openalex.org/keywords/angiography","display_name":"Angiography","score":0.44764116406440735},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.39426541328430176},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.23903143405914307},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1919555366039276},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.14842963218688965},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14367040991783142}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.7571850419044495},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6450552940368652},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4899424910545349},{"id":"https://openalex.org/C3019347889","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Vascular network","level":2,"score":0.47648733854293823},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.448444664478302},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.44764116406440735},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.39426541328430176},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.23903143405914307},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1919555366039276},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14842963218688965},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14367040991783142}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mci.2024.3401348","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/mci.2024.3401348","pdf_url":null,"source":{"id":"https://openalex.org/S104797584","display_name":"IEEE Computational Intelligence Magazine","issn_l":"1556-603X","issn":["1556-603X","1556-6048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Computational Intelligence Magazine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5400000214576721,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[{"id":"https://openalex.org/G2717455720","display_name":null,"funder_award_id":"V113C-164","funder_id":"https://openalex.org/F4320327358","funder_display_name":"Taipei Veterans General Hospital"},{"id":"https://openalex.org/G5655978113","display_name":null,"funder_award_id":"V113C-125","funder_id":"https://openalex.org/F4320327358","funder_display_name":"Taipei Veterans General Hospital"},{"id":"https://openalex.org/G8466435551","display_name":null,"funder_award_id":"V113C-108","funder_id":"https://openalex.org/F4320327358","funder_display_name":"Taipei Veterans General Hospital"},{"id":"https://openalex.org/G8770439150","display_name":null,"funder_award_id":"113VACS-007","funder_id":"https://openalex.org/F4320327358","funder_display_name":"Taipei Veterans General Hospital"}],"funders":[{"id":"https://openalex.org/F4320327358","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":102,"referenced_works":["https://openalex.org/W1493353512","https://openalex.org/W1522301498","https://openalex.org/W1849277567","https://openalex.org/W1977349774","https://openalex.org/W1992868980","https://openalex.org/W2033011949","https://openalex.org/W2061273505","https://openalex.org/W2194775991","https://openalex.org/W2308432453","https://openalex.org/W2399208400","https://openalex.org/W2504150216","https://openalex.org/W2516809705","https://openalex.org/W2557738935","https://openalex.org/W2612758615","https://openalex.org/W2758333670","https://openalex.org/W2768337277","https://openalex.org/W2788633781","https://openalex.org/W2796809202","https://openalex.org/W2802200505","https://openalex.org/W2808335993","https://openalex.org/W2898477488","https://openalex.org/W2901004898","https://openalex.org/W2904843285","https://openalex.org/W2916772305","https://openalex.org/W2919371914","https://openalex.org/W2943370629","https://openalex.org/W2946391413","https://openalex.org/W2962843949","https://openalex.org/W2963446712","https://openalex.org/W2964546533","https://openalex.org/W2964677890","https://openalex.org/W2966833946","https://openalex.org/W2969332598","https://openalex.org/W2973072407","https://openalex.org/W2981731882","https://openalex.org/W2984511630","https://openalex.org/W2988157455","https://openalex.org/W2988577829","https://openalex.org/W2995765759","https://openalex.org/W2998014461","https://openalex.org/W3000600153","https://openalex.org/W3001818707","https://openalex.org/W3006229125","https://openalex.org/W3009284279","https://openalex.org/W3013681994","https://openalex.org/W3023998086","https://openalex.org/W3028361198","https://openalex.org/W3048713063","https://openalex.org/W3068821485","https://openalex.org/W3086667591","https://openalex.org/W3087837424","https://openalex.org/W3109390731","https://openalex.org/W3113225488","https://openalex.org/W3114230740","https://openalex.org/W3124614131","https://openalex.org/W3138785910","https://openalex.org/W3153454972","https://openalex.org/W3160936555","https://openalex.org/W3161281120","https://openalex.org/W3161637586","https://openalex.org/W3164440025","https://openalex.org/W3164717194","https://openalex.org/W3183341983","https://openalex.org/W3186197713","https://openalex.org/W3203049650","https://openalex.org/W3211317523","https://openalex.org/W3215326316","https://openalex.org/W4200141400","https://openalex.org/W4210348187","https://openalex.org/W4220814249","https://openalex.org/W4220898502","https://openalex.org/W4221070533","https://openalex.org/W4223430324","https://openalex.org/W4224690709","https://openalex.org/W4285428167","https://openalex.org/W4286539651","https://openalex.org/W4290851427","https://openalex.org/W4291777774","https://openalex.org/W4293812268","https://openalex.org/W4297775537","https://openalex.org/W4300235091","https://openalex.org/W4308738068","https://openalex.org/W4309635755","https://openalex.org/W4311304837","https://openalex.org/W4316469714","https://openalex.org/W4319065851","https://openalex.org/W4320481750","https://openalex.org/W4324134638","https://openalex.org/W4387211590","https://openalex.org/W4400188660","https://openalex.org/W6631190155","https://openalex.org/W6734194636","https://openalex.org/W6737664043","https://openalex.org/W6737947904","https://openalex.org/W6749499586","https://openalex.org/W6752170072","https://openalex.org/W6754669440","https://openalex.org/W6762718338","https://openalex.org/W6764249507","https://openalex.org/W6767229288","https://openalex.org/W6798234632","https://openalex.org/W6839504310"],"related_works":["https://openalex.org/W2362796209","https://openalex.org/W2027168247","https://openalex.org/W2038488634","https://openalex.org/W3196308482","https://openalex.org/W61628834","https://openalex.org/W1948903846","https://openalex.org/W4384120863","https://openalex.org/W2349900298","https://openalex.org/W2139631936","https://openalex.org/W115168111"],"abstract_inverted_index":{"Medical":[0],"deep":[1,153],"neural":[2],"networks":[3],"(DNNs)":[4],"trained":[5,90],"upon":[6],"coarse":[7],"image":[8],"inputs":[9,64],"are":[10],"inherently":[11],"insensible":[12],"to":[13,48,92,129,141,177,218,233],"fine-grained":[14],"anatomic":[15],"features.":[16],"To":[17,81],"enhance":[18],"DNN":[19],"perception":[20],"on":[21],"delicate":[22],"microvascular":[23,53,221],"structures,":[24],"we":[25,89,137],"proposed":[26,87],"using":[27],"a":[28,38,123],"straightforward":[29],"angiographic":[30],"mobile-dense":[31],"hybrid":[32],"network":[33],"(AMDenseNet)":[34],"in":[35,164,204],"tandem":[36],"with":[37],"flexible":[39],"input":[40,150,174,195],"split,":[41],"suppression,":[42],"and":[43,57,116,162,202,223],"swap":[44],"perturbation":[45,151],"(InSSS-P)":[46],"framework":[47],"perform":[49],"explainable":[50],"diagnostics":[51],"for":[52],"diseases.":[54],"Mechanistically,":[55],"InSSS-P":[56,140],"AMDenseNet":[58,91,111,143,183],"conjointly":[59],"(1)":[60],"decompose":[61],"complex":[62],"anatomy":[63,78,215],"into":[65],"LEGO-like":[66],"blocks,":[67],"then":[68],"(2)":[69],"distill":[70,219],"plexus-wise":[71,139,220],"vascular":[72],"block":[73],"significance":[74,199,222],"from":[75,101],"the":[76,83,86,102,130,142,145,169,182,198,205,225],"rearranged":[77],"input-output":[79],"samplings.":[80],"validate":[82],"robustness":[84],"of":[85,200,207,228],"model,":[88],"detect":[93],"blind-threatening":[94],"retina":[95],"exudative":[96],"age-related":[97],"macular":[98],"degeneration":[99],"(exAMD)":[100],"micrometer-scaled":[103],"optic":[104],"coherence":[105],"tomographic":[106],"angiography":[107],"(OCTA),":[108],"wherein":[109],"our":[110],"annotated":[112],"triple-specific":[113,184],"(plexus,":[114],"branch,":[115],"exudate":[117],"activity)":[118],"neovascular":[119],"(NV)":[120],"features":[121,161],"at":[122,152],"diagnostic":[124],"precision":[125],"that":[126,149],"is":[127],"comparable":[128],"gold":[131],"standard":[132],"dye-based":[133],"angiography.":[134],"Interestingly,":[135],"when":[136],"applied":[138],"predictions,":[144],"permutate":[146],"results":[147],"demonstrated":[148],"capillary":[154,172],"plexus":[155],"(DCP)":[156],"layer":[157],"abrogated":[158],"model-awared":[159],"exAMD":[160,166,179,208],"resulted":[163],"false-negative":[165],"impressions.":[167],"On":[168],"contrary,":[170],"choroid":[171],"(CC)":[173],"perturbations":[175],"contributed":[176],"false-positive":[178],"characterization.":[180,209],"Notably,":[181],"NV":[185],"annotation":[186],"functionality":[187],"was":[188],"disrupted":[189],"by":[190],"either":[191],"DCP":[192,201],"or":[193],"CC":[194,203],"perturbations,":[196],"indicating":[197],"task":[206],"In":[210],"sum,":[211],"this":[212],"study":[213],"employed":[214],"decomposition":[216],"approaches":[217],"highlighted":[224],"analytic":[226],"potential":[227],"leveraging":[229],"an":[230],"anatomy-sensible":[231],"model":[232],"discover":[234],"novel":[235],"disease":[236],"biomarkers.":[237]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2025-12-26T23:08:49.675405","created_date":"2025-10-10T00:00:00"}
