{"id":"https://openalex.org/W2884297817","doi":"https://doi.org/10.1109/mci.2018.2840659","title":"Identifying DNA Methylation Modules Associated with a Cancer by Probabilistic Evolutionary Learning","display_name":"Identifying DNA Methylation Modules Associated with a Cancer by Probabilistic Evolutionary Learning","publication_year":2018,"publication_date":"2018-07-20","ids":{"openalex":"https://openalex.org/W2884297817","doi":"https://doi.org/10.1109/mci.2018.2840659","mag":"2884297817"},"language":"en","primary_location":{"id":"doi:10.1109/mci.2018.2840659","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mci.2018.2840659","pdf_url":null,"source":{"id":"https://openalex.org/S104797584","display_name":"IEEE Computational Intelligence Magazine","issn_l":"1556-603X","issn":["1556-603X","1556-6048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Computational Intelligence Magazine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012207088","display_name":"Je\u2010Keun Rhee","orcid":"https://orcid.org/0000-0003-4811-8895"},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Je-Keun Rhee","raw_affiliation_strings":["Cancer Research Institute, College of Medicine, Catholic University of Korea, Seoul, KOREA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, College of Medicine, Catholic University of Korea, Seoul, KOREA","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100327302","display_name":"Soo\u2010Jin Kim","orcid":"https://orcid.org/0000-0002-3803-9096"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo-Jin Kim","raw_affiliation_strings":["College of Agriculture and Life Sciences, Seoul National University, Seoul, KOREA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Agriculture and Life Sciences, Seoul National University, Seoul, KOREA","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107826037","display_name":"Byoung\u2010Tak Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byoung-Tak Zhang","raw_affiliation_strings":["School of Computer Science & Engineering, Seoul National University, Seoul, KOREA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science & Engineering, Seoul National University, Seoul, KOREA","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0928,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.47970599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"13","issue":"3","first_page":"12","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9865999817848206,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9850000143051147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7649214267730713},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6011029481887817},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.4824241101741791},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.45814958214759827},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41502851247787476},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.41407954692840576},{"id":"https://openalex.org/keywords/illumina-methylation-assay","display_name":"Illumina Methylation Assay","score":0.41119885444641113},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3610362410545349},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2820397615432739},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1847326159477234}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7649214267730713},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6011029481887817},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4824241101741791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45814958214759827},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41502851247787476},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41407954692840576},{"id":"https://openalex.org/C136953436","wikidata":"https://www.wikidata.org/wiki/Q6000286","display_name":"Illumina Methylation Assay","level":5,"score":0.41119885444641113},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3610362410545349},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2820397615432739},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1847326159477234}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mci.2018.2840659","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mci.2018.2840659","pdf_url":null,"source":{"id":"https://openalex.org/S104797584","display_name":"IEEE Computational Intelligence Magazine","issn_l":"1556-603X","issn":["1556-603X","1556-6048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Computational Intelligence Magazine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W177889397","https://openalex.org/W1595610987","https://openalex.org/W1967197633","https://openalex.org/W1967794190","https://openalex.org/W1970184785","https://openalex.org/W1973770389","https://openalex.org/W1976741677","https://openalex.org/W1979015284","https://openalex.org/W1980726773","https://openalex.org/W1983365668","https://openalex.org/W1985444222","https://openalex.org/W1988901915","https://openalex.org/W1990081343","https://openalex.org/W1990702536","https://openalex.org/W1990958459","https://openalex.org/W1997062296","https://openalex.org/W2003256314","https://openalex.org/W2004078197","https://openalex.org/W2006519998","https://openalex.org/W2010457001","https://openalex.org/W2012063336","https://openalex.org/W2015275401","https://openalex.org/W2030701454","https://openalex.org/W2030882091","https://openalex.org/W2035008060","https://openalex.org/W2039068432","https://openalex.org/W2053360669","https://openalex.org/W2058337538","https://openalex.org/W2063110913","https://openalex.org/W2066669827","https://openalex.org/W2067812245","https://openalex.org/W2072573412","https://openalex.org/W2074746593","https://openalex.org/W2082594247","https://openalex.org/W2084123458","https://openalex.org/W2084411478","https://openalex.org/W2086162615","https://openalex.org/W2086842668","https://openalex.org/W2096920054","https://openalex.org/W2098771739","https://openalex.org/W2103138948","https://openalex.org/W2103714979","https://openalex.org/W2106292881","https://openalex.org/W2111824814","https://openalex.org/W2112636933","https://openalex.org/W2114366647","https://openalex.org/W2116961716","https://openalex.org/W2121887268","https://openalex.org/W2122953117","https://openalex.org/W2123032740","https://openalex.org/W2123739134","https://openalex.org/W2127009065","https://openalex.org/W2130410032","https://openalex.org/W2130722148","https://openalex.org/W2132946679","https://openalex.org/W2141410747","https://openalex.org/W2142179089","https://openalex.org/W2143142289","https://openalex.org/W2146390965","https://openalex.org/W2146414563","https://openalex.org/W2147692639","https://openalex.org/W2154342596","https://openalex.org/W2154458783","https://openalex.org/W2162665049","https://openalex.org/W2165839500","https://openalex.org/W2167483411","https://openalex.org/W2168470080","https://openalex.org/W2473702296","https://openalex.org/W2483031229","https://openalex.org/W2579970155","https://openalex.org/W6607301943","https://openalex.org/W6674455858","https://openalex.org/W6721836249"],"related_works":["https://openalex.org/W2902329290","https://openalex.org/W2139872319","https://openalex.org/W2052355316","https://openalex.org/W2046964473","https://openalex.org/W2107880877","https://openalex.org/W2151182744","https://openalex.org/W2024490794","https://openalex.org/W2054863651","https://openalex.org/W1998349112","https://openalex.org/W2109340786"],"abstract_inverted_index":{"DNA":[0,20,37,48,68,107,121],"methylation":[1,21,38,49,96,108,122],"leads":[2],"to":[3,15,30,46,53,63,77,86,102,119],"inhibition":[4],"of":[5,19,35,59,67,94],"downstream":[6],"gene":[7],"expression.":[8],"Recently,":[9],"considerable":[10],"studies":[11,27],"have":[12],"been":[13],"made":[14],"determine":[16],"the":[17,32],"effects":[18],"on":[22],"complex":[23],"disease.":[24,78],"However,":[25],"further":[26],"are":[28,74],"necessary":[29],"find":[31],"multiple":[33],"interactions":[34],"many":[36],"sites":[39,70],"and":[40,104],"their":[41],"association":[42],"with":[43],"cancer.":[44,125],"Here,":[45],"assess":[47],"modules":[50,123],"potentially":[51,75],"relevant":[52,76],"disease,":[54],"we":[55],"use":[56],"an":[57],"Estimation":[58],"Distribution":[60],"Algorithm":[61],"(EDA)":[62],"identify":[64,120],"high-order":[65],"interaction":[66],"methylated":[69],"(or":[71],"modules)":[72],"that":[73,90,115],"The":[79,98,111],"method":[80],"builds":[81],"a":[82,88,92],"probabilistic":[83],"dependency":[84],"model":[85],"produce":[87],"solution":[89],"is":[91,100,117],"set":[93],"discriminative":[95],"sites.":[97],"algorithm":[99],"applied":[101],"array-":[103],"sequencing-based":[105],"high-throughput":[106],"profiling":[109],"datasets.":[110],"experimental":[112],"results":[113],"show":[114],"it":[116],"able":[118],"for":[124]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
