{"id":"https://openalex.org/W2020637347","doi":"https://doi.org/10.1109/mcdm.2014.7007200","title":"Gene interaction networks boost genetic algorithm performance in biomarker discovery","display_name":"Gene interaction networks boost genetic algorithm performance in biomarker discovery","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2020637347","doi":"https://doi.org/10.1109/mcdm.2014.7007200","mag":"2020637347"},"language":"en","primary_location":{"id":"doi:10.1109/mcdm.2014.7007200","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mcdm.2014.7007200","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE Symposium on Computational Intelligence in Multi-Criteria Decision-Making (MCDM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021432827","display_name":"Charalampos Moschopoulos","orcid":null},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Charalampos Moschopoulos","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780"]},{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium","institution_ids":["https://openalex.org/I39327780","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085611600","display_name":"Du\u0161an Popovi\u0107","orcid":"https://orcid.org/0000-0002-5912-0360"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dusan Popovic","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780"]},{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium","institution_ids":["https://openalex.org/I39327780","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022628045","display_name":"Rocco Langone","orcid":"https://orcid.org/0000-0002-7583-7003"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rocco Langone","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780"]},{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium","institution_ids":["https://openalex.org/I39327780","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078854904","display_name":"Johan A. K. Suykens","orcid":"https://orcid.org/0000-0002-8846-6352"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Johan Suykens","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780"]},{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium","institution_ids":["https://openalex.org/I39327780","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018814006","display_name":"Bart De Moor","orcid":"https://orcid.org/0000-0002-1154-5028"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bart De Moor","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780"]},{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium","institution_ids":["https://openalex.org/I39327780","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041984163","display_name":"Yves Moreau","orcid":"https://orcid.org/0000-0002-4647-6560"},"institutions":[{"id":"https://openalex.org/I39327780","display_name":"iMinds","ror":"https://ror.org/03baec336","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I39327780"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Yves Moreau","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics/iMinds Medical IT KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I39327780"]},{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics / iMinds Medical IT, KU Leuven, Belgium","institution_ids":["https://openalex.org/I39327780","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":"144","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7253101468086243},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6365230083465576},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.5066514611244202},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4914740324020386},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.4886665642261505},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.48030656576156616},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.46612051129341125},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.4343104064464569},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.20983079075813293},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19852489233016968},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14563491940498352},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11673155426979065},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.0894072949886322},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.0893644392490387}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7253101468086243},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6365230083465576},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.5066514611244202},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4914740324020386},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.4886665642261505},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.48030656576156616},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.46612051129341125},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.4343104064464569},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.20983079075813293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19852489233016968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14563491940498352},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11673155426979065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0894072949886322},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.0893644392490387},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/mcdm.2014.7007200","is_oa":false,"landing_page_url":"https://doi.org/10.1109/mcdm.2014.7007200","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE Symposium on Computational Intelligence in Multi-Criteria Decision-Making (MCDM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W11515763","https://openalex.org/W77027826","https://openalex.org/W148801571","https://openalex.org/W322284776","https://openalex.org/W1417555467","https://openalex.org/W1498436455","https://openalex.org/W1553860693","https://openalex.org/W1559956479","https://openalex.org/W1594031697","https://openalex.org/W1639032689","https://openalex.org/W1979229300","https://openalex.org/W1982606761","https://openalex.org/W1992314595","https://openalex.org/W1998096683","https://openalex.org/W2004131797","https://openalex.org/W2008138631","https://openalex.org/W2020541351","https://openalex.org/W2048654286","https://openalex.org/W2059507684","https://openalex.org/W2080581393","https://openalex.org/W2094229819","https://openalex.org/W2097571405","https://openalex.org/W2105924489","https://openalex.org/W2123500593","https://openalex.org/W2125414037","https://openalex.org/W2139151957","https://openalex.org/W2142183404","https://openalex.org/W2152150600","https://openalex.org/W2154976095","https://openalex.org/W2170989872","https://openalex.org/W2496050832","https://openalex.org/W2904250082","https://openalex.org/W2911964244","https://openalex.org/W2996739384","https://openalex.org/W3083113686","https://openalex.org/W3085162807","https://openalex.org/W4232638001","https://openalex.org/W4243694527","https://openalex.org/W4255720866","https://openalex.org/W6600477597","https://openalex.org/W6603149584","https://openalex.org/W6682679816"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W2938786841","https://openalex.org/W4224009465","https://openalex.org/W2783664667","https://openalex.org/W4306674287","https://openalex.org/W4286629047","https://openalex.org/W4205958290","https://openalex.org/W4384212932","https://openalex.org/W2132587163","https://openalex.org/W2034442997"],"abstract_inverted_index":{"In":[0,15,70,91],"recent":[1],"years,":[2],"the":[3,16,19,27,37,105,111,150,160],"advent":[4],"of":[5,12,21,114,132,143,152],"high-throughput":[6],"techniques":[7],"led":[8],"to":[9,31,59,118],"significant":[10],"acceleration":[11],"biomarker":[13,161],"discovery.":[14],"same":[17],"time,":[18],"popularity":[20],"machine":[22],"learning":[23,46],"methods":[24],"grown":[25],"in":[26,52,149,159],"field,":[28],"mostly":[29],"due":[30],"inherit":[32],"analytical":[33],"problems":[34],"associated":[35],"with":[36],"data":[38],"resulting":[39],"from":[40,134],"these":[41],"massively":[42],"parallelized":[43],"experiments.":[44],"However,":[45],"algorithms":[47],"are":[48,63],"very":[49],"often":[50],"utilized":[51],"their":[53],"basic":[54],"form,":[55],"hence":[56],"sometimes":[57],"failing":[58],"consider":[60],"interactions":[61],"that":[62,82,101,141],"present":[64],"between":[65],"biological":[66,99,144],"subjects":[67],"(i.e.":[68],"genes).":[69],"this":[71,92,153],"context,":[72],"we":[73,95],"propose":[74],"a":[75,87,98,119],"new":[76],"methodology,":[77],"based":[78],"on":[79,97,126],"genetic":[80,89,121,147],"algorithms,":[81],"integrates":[83],"prior":[84],"information":[85],"through":[86],"novel":[88],"operator.":[90],"particular":[93],"application,":[94],"rely":[96],"knowledge":[100,145],"is":[102],"captured":[103],"by":[104,123],"gene":[106],"interaction":[107],"networks.":[108],"We":[109],"demonstrate":[110],"advantageous":[112],"performance":[113],"our":[115],"method":[116],"compared":[117],"simple":[120],"algorithm":[122,148],"testing":[124],"it":[125],"several":[127],"microarray":[128],"datasets":[129],"containing":[130],"samples":[131],"tissue":[133],"cancer":[135],"patients.":[136],"The":[137],"obtained":[138],"results":[139],"suggest":[140],"inclusion":[142],"into":[146],"form":[151],"operator":[154],"can":[155],"boost":[156],"its":[157],"effectiveness":[158],"discovery":[162],"problem.":[163]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}