{"id":"https://openalex.org/W3042092800","doi":"https://doi.org/10.1109/lra.2020.3007476","title":"Detection and Control of Air Liquid Interface with an Open-Channel Microfluidic Chip for Circulating Tumor Cells Isolation from Human Whole Blood","display_name":"Detection and Control of Air Liquid Interface with an Open-Channel Microfluidic Chip for Circulating Tumor Cells Isolation from Human Whole Blood","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3042092800","doi":"https://doi.org/10.1109/lra.2020.3007476","mag":"3042092800"},"language":"en","primary_location":{"id":"doi:10.1109/lra.2020.3007476","is_oa":false,"landing_page_url":"https://doi.org/10.1109/lra.2020.3007476","pdf_url":null,"source":{"id":"https://openalex.org/S4210169774","display_name":"IEEE Robotics and Automation Letters","issn_l":"2377-3766","issn":["2377-3766"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Robotics and Automation Letters","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043217108","display_name":"Bilal Turan","orcid":"https://orcid.org/0000-0003-1183-5268"},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Bilal Turan","raw_affiliation_strings":["Department of Micro-Nano Mechanical Science & Engineering, Nagoya University, Nagoya, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Micro-Nano Mechanical Science & Engineering, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057044360","display_name":"Yusuke Tomori","orcid":null},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Tomori","raw_affiliation_strings":["Department of Micro-Nano Mechanical Science & Engineering, Nagoya University, Nagoya, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Micro-Nano Mechanical Science & Engineering, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032442411","display_name":"Taisuke Masuda","orcid":"https://orcid.org/0000-0002-7853-9511"},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taisuke Masuda","raw_affiliation_strings":["Department of Micro-Nano Mechanical Science & Engineering, Nagoya University, Nagoya, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Micro-Nano Mechanical Science & Engineering, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025344756","display_name":"Ruixuan Weng","orcid":null},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ruixuan Weng","raw_affiliation_strings":["Department of Micro-Nano Mechanical Science & Engineering, Nagoya University, Nagoya, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Micro-Nano Mechanical Science & Engineering, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051966982","display_name":"Larina Tzu\u2010Wei Shen","orcid":"https://orcid.org/0000-0003-1389-6697"},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Larina Tzu-Wei Shen","raw_affiliation_strings":["Department of Clinical Research and Regional Innovation, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Research and Regional Innovation, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108666197","display_name":"Satoshi Matsusaka","orcid":null},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Matsusaka","raw_affiliation_strings":["Department of Clinical Research and Regional Innovation, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Research and Regional Innovation, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091532948","display_name":"Fumihito Arai","orcid":"https://orcid.org/0000-0002-2508-1615"},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumihito Arai","raw_affiliation_strings":["Department of Micro-Nano Mechanical Science & Engineering, Nagoya University, Nagoya, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Micro-Nano Mechanical Science & Engineering, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087716691","display_name":"Jin\u2010Hyun Kim","orcid":"https://orcid.org/0000-0002-1616-1891"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinhyun Kim","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064000503","display_name":"Youngjin Choi","orcid":"https://orcid.org/0000-0002-5009-9059"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youngjin Choi","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5043217108"],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":null,"apc_paid":null,"fwci":0.3433,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.54401361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interface","display_name":"Interface (matter)","score":0.6762226223945618},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.6525160670280457},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.5893422365188599},{"id":"https://openalex.org/keywords/microchannel","display_name":"Microchannel","score":0.5699288249015808},{"id":"https://openalex.org/keywords/circulating-tumor-cell","display_name":"Circulating tumor cell","score":0.5557714700698853},{"id":"https://openalex.org/keywords/flow-control","display_name":"Flow control (data)","score":0.4887509346008301},{"id":"https://openalex.org/keywords/airflow","display_name":"Airflow","score":0.4656342566013336},{"id":"https://openalex.org/keywords/microfluidic-chip","display_name":"Microfluidic chip","score":0.45673298835754395},{"id":"https://openalex.org/keywords/position","display_name":"Position (finance)","score":0.4564533233642578},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.4332137107849121},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41309261322021484},{"id":"https://openalex.org/keywords/capillary-action","display_name":"Capillary action","score":0.37775135040283203},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3335725665092468},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.263038694858551},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.2431149184703827},{"id":"https://openalex.org/keywords/capillary-number","display_name":"Capillary number","score":0.16040894389152527},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.1562119722366333},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.0765620768070221}],"concepts":[{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.6762226223945618},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6525160670280457},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.5893422365188599},{"id":"https://openalex.org/C63662833","wikidata":"https://www.wikidata.org/wiki/Q6839341","display_name":"Microchannel","level":2,"score":0.5699288249015808},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.5557714700698853},{"id":"https://openalex.org/C186766456","wikidata":"https://www.wikidata.org/wiki/Q612457","display_name":"Flow control (data)","level":2,"score":0.4887509346008301},{"id":"https://openalex.org/C116067010","wikidata":"https://www.wikidata.org/wiki/Q4698686","display_name":"Airflow","level":2,"score":0.4656342566013336},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.45673298835754395},{"id":"https://openalex.org/C198082294","wikidata":"https://www.wikidata.org/wiki/Q3399648","display_name":"Position (finance)","level":2,"score":0.4564533233642578},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.4332137107849121},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41309261322021484},{"id":"https://openalex.org/C196806460","wikidata":"https://www.wikidata.org/wiki/Q188603","display_name":"Capillary action","level":2,"score":0.37775135040283203},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3335725665092468},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.263038694858551},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2431149184703827},{"id":"https://openalex.org/C28413391","wikidata":"https://www.wikidata.org/wiki/Q785542","display_name":"Capillary number","level":3,"score":0.16040894389152527},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.1562119722366333},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0765620768070221},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/lra.2020.3007476","is_oa":false,"landing_page_url":"https://doi.org/10.1109/lra.2020.3007476","pdf_url":null,"source":{"id":"https://openalex.org/S4210169774","display_name":"IEEE Robotics and Automation Letters","issn_l":"2377-3766","issn":["2377-3766"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Robotics and Automation Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1835655851","https://openalex.org/W1966361812","https://openalex.org/W1976320478","https://openalex.org/W2038727507","https://openalex.org/W2042582159","https://openalex.org/W2050547995","https://openalex.org/W2068725790","https://openalex.org/W2070495288","https://openalex.org/W2084316403","https://openalex.org/W2110735634","https://openalex.org/W2135461398","https://openalex.org/W2139799027","https://openalex.org/W2287945026","https://openalex.org/W2607045925","https://openalex.org/W2610282507","https://openalex.org/W2791986466","https://openalex.org/W2903733677","https://openalex.org/W2917918011"],"related_works":["https://openalex.org/W2240397985","https://openalex.org/W2394297731","https://openalex.org/W2892022418","https://openalex.org/W2387714547","https://openalex.org/W4380187938","https://openalex.org/W2163143718","https://openalex.org/W2744335730","https://openalex.org/W1973375609","https://openalex.org/W2743352711","https://openalex.org/W2985619524"],"abstract_inverted_index":{"We":[0,66,79,112,137,156],"have":[1,157,178],"proposed":[2,30,106],"a":[3,36,68,102,164,183,187],"bio-automation":[4],"system":[5,104],"to":[6,25,55,71,85,107,131],"isolate":[7,26],"and":[8,75],"recover":[9],"circulating":[10],"tumor":[11],"cells":[12],"(CTCs)":[13],"individually":[14],"from":[15,97],"whole":[16,129],"blood.":[17],"An":[18],"open-channel":[19],"microfluidic":[20,31,52],"chip-based":[21],"approach":[22],"is":[23,105,163],"used":[24],"the":[27,44,48,51,60,63,87,90,94,98,116,123],"CTCs.":[28,171],"The":[29],"chip":[32,53,69],"design":[33,70],"can":[34],"form":[35],"stable":[37],"air-liquid":[38,64,73,91,109,145,160,174],"interface.":[39,65,92],"CTCs":[40,181],"are":[41],"trapped":[42],"by":[43],"gaps":[45],"in":[46,114,182],"between":[47],"pillars":[49],"of":[50,62,89,125,128,141,144,147,153,170],"due":[54],"capillary":[56],"force":[57],"associated":[58],"with":[59,150,186],"meniscus":[61],"propose":[67],"stabilize":[72],"interface":[74,110,146,161,175],"sample":[76],"flow":[77,117],"speed.":[78],"introduce":[80],"an":[81,139],"image":[82,99],"analysis":[83,100],"algorithm":[84],"detect":[86],"position":[88,142,162],"Using":[93],"visual":[95],"feedback":[96],"algorithm,":[101],"control":[103,108],"position.":[111],"succeeded":[113],"stabilizing":[115],"speed,":[118],"making":[119],"it":[120],"feasible":[121],"for":[122,167],"isolation":[124],"5":[126],"mL":[127],"blood":[130],"be":[132],"completed":[133],"within":[134],"30":[135],"min.":[136],"achieved":[138,179],"average":[140],"error":[143],"4":[148],"\u03bcm":[149],"standard":[151],"deviation":[152],"7":[154],"\u03bcm.":[155],"confirmed":[158],"that":[159],"deciding":[165],"factor":[166],"trapping":[168,180],"area":[169],"By":[172],"controlling":[173],"position,":[176],"we":[177],"narrow":[184],"band":[185],"high":[188],"concentration.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}