{"id":"https://openalex.org/W4398151607","doi":"https://doi.org/10.1109/lcsys.2024.3402942","title":"Model Extraction From Clinical Data Subject to Large Uncertainties and Poor Identifiability","display_name":"Model Extraction From Clinical Data Subject to Large Uncertainties and Poor Identifiability","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4398151607","doi":"https://doi.org/10.1109/lcsys.2024.3402942"},"language":"en","primary_location":{"id":"doi:10.1109/lcsys.2024.3402942","is_oa":true,"landing_page_url":"https://doi.org/10.1109/lcsys.2024.3402942","pdf_url":"https://ieeexplore.ieee.org/ielx7/7782633/7912304/10534818.pdf","source":{"id":"https://openalex.org/S4306422535","display_name":"IEEE Control Systems Letters","issn_l":"2475-1456","issn":["2475-1456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Control Systems Letters","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/7782633/7912304/10534818.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004573956","display_name":"Clara M. Ionescu","orcid":"https://orcid.org/0000-0001-7685-035X"},"institutions":[{"id":"https://openalex.org/I12607205","display_name":"University College Ghent","ror":"https://ror.org/00rs45z86","country_code":"BE","type":"education","lineage":["https://openalex.org/I12607205"]},{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Clara M. Ionescu","raw_affiliation_strings":["Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-7685-035X","affiliations":[{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I12607205"]},{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013255393","display_name":"Robin De Keyser","orcid":null},"institutions":[{"id":"https://openalex.org/I12607205","display_name":"University College Ghent","ror":"https://ror.org/00rs45z86","country_code":"BE","type":"education","lineage":["https://openalex.org/I12607205"]},{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Robin De Keyser","raw_affiliation_strings":["Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium"],"raw_orcid":"https://orcid.org/0009-0001-5439-0978","affiliations":[{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I12607205"]},{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073964670","display_name":"Dana Copo\u0163","orcid":"https://orcid.org/0000-0002-6010-830X"},"institutions":[{"id":"https://openalex.org/I12607205","display_name":"University College Ghent","ror":"https://ror.org/00rs45z86","country_code":"BE","type":"education","lineage":["https://openalex.org/I12607205"]},{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dana Copot","raw_affiliation_strings":["Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-6010-830X","affiliations":[{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I12607205"]},{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046106298","display_name":"Erhan Yumuk","orcid":"https://orcid.org/0000-0001-9416-6690"},"institutions":[{"id":"https://openalex.org/I12607205","display_name":"University College Ghent","ror":"https://ror.org/00rs45z86","country_code":"BE","type":"education","lineage":["https://openalex.org/I12607205"]},{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Erhan Yumuk","raw_affiliation_strings":["Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-9416-6690","affiliations":[{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I12607205"]},{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063197926","display_name":"Amani R. Ynineb","orcid":"https://orcid.org/0009-0004-9642-2810"},"institutions":[{"id":"https://openalex.org/I12607205","display_name":"University College Ghent","ror":"https://ror.org/00rs45z86","country_code":"BE","type":"education","lineage":["https://openalex.org/I12607205"]},{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Amani Ynineb","raw_affiliation_strings":["Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I12607205"]},{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086502873","display_name":"Ghada Ben Othman","orcid":"https://orcid.org/0000-0001-6481-0537"},"institutions":[{"id":"https://openalex.org/I12607205","display_name":"University College Ghent","ror":"https://ror.org/00rs45z86","country_code":"BE","type":"education","lineage":["https://openalex.org/I12607205"]},{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ghada Ben Othman","raw_affiliation_strings":["Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I12607205"]},{"raw_affiliation_string":"Department of Electromechanics, Systems and Metal Engineering, Tech Lane Science Park 125, Faculty of Engineering and Architecture, Ghent University, Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045009356","display_name":"Martine Neckebroek","orcid":null},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Martine Neckebroek","raw_affiliation_strings":["Department of Anesthesiology, Ghent University Hospital, Ghent, Belgium","Department of Anesthesiology, Corneel Heymanlaan 10, Ghent University Hospital, Gent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Ghent University Hospital, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]},{"raw_affiliation_string":"Department of Anesthesiology, Corneel Heymanlaan 10, Ghent University Hospital, Gent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5004573956"],"corresponding_institution_ids":["https://openalex.org/I12607205","https://openalex.org/I32597200"],"apc_list":null,"apc_paid":null,"fwci":4.2807,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.93656493,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"8","issue":null,"first_page":"2151","last_page":"2156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13248","display_name":"Healthcare Technology and Patient Monitoring","score":0.983299970626831,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identifiability","display_name":"Identifiability","score":0.8993858695030212},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5807545185089111},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5792093276977539},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.40292978286743164},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.26394444704055786},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2515180706977844}],"concepts":[{"id":"https://openalex.org/C122770356","wikidata":"https://www.wikidata.org/wiki/Q1656753","display_name":"Identifiability","level":2,"score":0.8993858695030212},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5807545185089111},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5792093276977539},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.40292978286743164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26394444704055786},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2515180706977844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/lcsys.2024.3402942","is_oa":true,"landing_page_url":"https://doi.org/10.1109/lcsys.2024.3402942","pdf_url":"https://ieeexplore.ieee.org/ielx7/7782633/7912304/10534818.pdf","source":{"id":"https://openalex.org/S4306422535","display_name":"IEEE Control Systems Letters","issn_l":"2475-1456","issn":["2475-1456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Control Systems Letters","raw_type":"journal-article"},{"id":"pmh:oai:archive.ugent.be:01J8FD0MZ9REAAJ3EABNX6TPAG","is_oa":true,"landing_page_url":"http://hdl.handle.net/1854/LU-01J8FD0MZ9REAAJ3EABNX6TPAG","pdf_url":"https://biblio.ugent.be/publication/01J8FD0MZ9REAAJ3EABNX6TPAG/file/01J8FD6FD84KSBH8CB113WCQ4T.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2475-1456","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1109/lcsys.2024.3402942","is_oa":true,"landing_page_url":"https://doi.org/10.1109/lcsys.2024.3402942","pdf_url":"https://ieeexplore.ieee.org/ielx7/7782633/7912304/10534818.pdf","source":{"id":"https://openalex.org/S4306422535","display_name":"IEEE Control Systems Letters","issn_l":"2475-1456","issn":["2475-1456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Control Systems Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/1","score":0.6499999761581421,"display_name":"No poverty"}],"awards":[{"id":"https://openalex.org/G1196538527","display_name":null,"funder_award_id":"101043225","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G2121609774","display_name":"Adaptive Multi-Drug Infusion Control System for General Anesthesia in Major Surgery","funder_award_id":"101043225","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4398151607.pdf"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2122171313","https://openalex.org/W2161853498","https://openalex.org/W2245245862","https://openalex.org/W2488700677","https://openalex.org/W3017077780","https://openalex.org/W3090852721","https://openalex.org/W3198449724","https://openalex.org/W4200219349","https://openalex.org/W4229034769","https://openalex.org/W4297510490","https://openalex.org/W4312822477","https://openalex.org/W4319068871","https://openalex.org/W4382998947","https://openalex.org/W4387546339","https://openalex.org/W4391305577","https://openalex.org/W4391848980","https://openalex.org/W4391952088","https://openalex.org/W4393082337","https://openalex.org/W4399037293"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2724847603","https://openalex.org/W2034041141","https://openalex.org/W2184661725","https://openalex.org/W112856298","https://openalex.org/W2573470972","https://openalex.org/W2105626102","https://openalex.org/W2131038454","https://openalex.org/W4240568257"],"abstract_inverted_index":{"This":[0,64],"letter":[1],"presents":[2],"an":[3],"extension":[4],"to":[5,12,35,47,59,73,95],"system":[6],"theory":[7],"as":[8],"a":[9],"novel":[10],"approach":[11,91,101],"provide":[13],"models":[14,122],"from":[15,107],"clinical":[16,105],"data":[17,106],"under":[18],"large":[19,60],"uncertainty":[20],"and":[21,38,82,127],"poor":[22],"identifiability":[23],"conditions.":[24],"These":[25],"difficult":[26],"conditions":[27],"are":[28],"often":[29],"present":[30],"in":[31,104],"medical":[32],"systems":[33],"due":[34,58],"ethical,":[36],"safety":[37],"regulatory":[39],"limitations":[40],"regarding":[41],"application":[42],"of":[43,55,70,88,99,113,133],"persistent":[44],"drug-related":[45],"excitation":[46],"human":[48],"body.":[49],"Furthermore,":[50],"drug-dose":[51],"effect":[52],"relationship":[53],"is":[54,65,92],"particular":[56],"challenge":[57],"inter-and":[61],"intra-patient":[62],"variability.":[63],"strengthened":[66],"by":[67],"the":[68,75,89],"lack":[69],"suitable":[71,128],"instrumentation":[72],"measure":[74],"necessary":[76],"information,":[77],"rather":[78],"making":[79],"available":[80],"inferences":[81],"surrogate":[83],"metrics.":[84],"A":[85],"notable":[86],"advantage":[87],"proposed":[90,119],"its":[93],"robustness":[94],"uncertainty.":[96],"The":[97,118],"efficacy":[98],"our":[100],"was":[102],"examined":[103],"patients":[108],"monitored":[109],"during":[110],"induction":[111],"phase":[112],"target":[114],"controlled":[115],"intravenous":[116],"anesthesia.":[117,134],"method":[120],"delivered":[121],"with":[123],"physiological":[124],"explainable":[125],"parameters":[126],"for":[129],"closed":[130],"loop":[131],"control":[132]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
