{"id":"https://openalex.org/W3031800850","doi":"https://doi.org/10.1109/lcsys.2020.2997214","title":"Positive Dynamical Networks in Neuronal Regulation: How Tunable Variability Coexists With Robustness","display_name":"Positive Dynamical Networks in Neuronal Regulation: How Tunable Variability Coexists With Robustness","publication_year":2020,"publication_date":"2020-05-25","ids":{"openalex":"https://openalex.org/W3031800850","doi":"https://doi.org/10.1109/lcsys.2020.2997214","mag":"3031800850"},"language":"en","primary_location":{"id":"doi:10.1109/lcsys.2020.2997214","is_oa":false,"landing_page_url":"https://doi.org/10.1109/lcsys.2020.2997214","pdf_url":null,"source":{"id":"https://openalex.org/S4306422535","display_name":"IEEE Control Systems Letters","issn_l":"2475-1456","issn":["2475-1456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Control Systems Letters","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orbi.uliege.be/handle/2268/303264","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049699562","display_name":"Alessio Franci","orcid":"https://orcid.org/0000-0002-3911-625X"},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alessio Franci","raw_affiliation_strings":["National Autonomous University of Mexico, Ciudad Universitaria, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Autonomous University of Mexico, Ciudad Universitaria, Mexico City, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044317847","display_name":"Timothy O\u2019Leary","orcid":"https://orcid.org/0000-0002-1029-0158"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy O'Leary","raw_affiliation_strings":["University of Cambridge, Cambridge, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge, Cambridge, U.K","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031951160","display_name":"Jorge Golowasch","orcid":"https://orcid.org/0000-0002-6183-3175"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I118118575","display_name":"New Jersey Institute of Technology","ror":"https://ror.org/05e74xb87","country_code":"US","type":"education","lineage":["https://openalex.org/I118118575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Golowasch","raw_affiliation_strings":["New Jersey Institute of Technology, Rutgers University-Newark, Newark, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Jersey Institute of Technology, Rutgers University-Newark, Newark, USA","institution_ids":["https://openalex.org/I118118575","https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5414,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.81909711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"4","first_page":"946","last_page":"951"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.7806788086891174},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.46423545479774475},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4381415843963623},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41583260893821716},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3538668155670166},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33928632736206055},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1908942461013794},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09064143896102905},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08050358295440674}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.7806788086891174},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.46423545479774475},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4381415843963623},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41583260893821716},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3538668155670166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33928632736206055},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1908942461013794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09064143896102905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08050358295440674},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1109/lcsys.2020.2997214","is_oa":false,"landing_page_url":"https://doi.org/10.1109/lcsys.2020.2997214","pdf_url":null,"source":{"id":"https://openalex.org/S4306422535","display_name":"IEEE Control Systems Letters","issn_l":"2475-1456","issn":["2475-1456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Control Systems Letters","raw_type":"journal-article"},{"id":"pmh:oai:generic.eprints.org:1210709","is_oa":false,"landing_page_url":"http://publications.eng.cam.ac.uk/1210709/","pdf_url":null,"source":{"id":"https://openalex.org/S4406922847","display_name":"Cambridge University Engineering Department Publications Database","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/303264","is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/303264","pdf_url":null,"source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Control Systems Letters, 4 (4), 946 - 951 (2020-10)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/307920","is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/307920","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.55013","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.55013","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:orbi.ulg.ac.be:2268/303264","is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/303264","pdf_url":null,"source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Control Systems Letters, 4 (4), 946 - 951 (2020-10)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G397590604","display_name":null,"funder_award_id":"IN102420","funder_id":"https://openalex.org/F4320335100","funder_display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico"},{"id":"https://openalex.org/G4693569542","display_name":null,"funder_award_id":"A1-S-10610","funder_id":"https://openalex.org/F4320324348","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, Guatemala"},{"id":"https://openalex.org/G5193598099","display_name":null,"funder_award_id":"DMS1715808","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320324348","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, Guatemala","ror":"https://ror.org/03pr08s76"},{"id":"https://openalex.org/F4320335100","display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1800303662","https://openalex.org/W2016767879","https://openalex.org/W2059668389","https://openalex.org/W2065914874","https://openalex.org/W2069268251","https://openalex.org/W2073910627","https://openalex.org/W2078108567","https://openalex.org/W2096352618","https://openalex.org/W2107325419","https://openalex.org/W2112092311","https://openalex.org/W2137303544","https://openalex.org/W2138377715","https://openalex.org/W2147741970","https://openalex.org/W2150228750","https://openalex.org/W2151526882","https://openalex.org/W2153030835","https://openalex.org/W2247294682","https://openalex.org/W2766422122","https://openalex.org/W2942764308","https://openalex.org/W2944680555","https://openalex.org/W2947083862","https://openalex.org/W2952311807"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W2156260160"],"abstract_inverted_index":{"Neuronal":[0],"systems":[1],"exhibit":[2],"highly":[3],"stable":[4],"and":[5,18,24,74,99],"tunable":[6,169],"behaviors":[7],"in":[8,19,42,70,132],"spite":[9,20],"of":[10,21,89,113,127,143,147,179],"huge":[11],"variability":[12,44,73,170],"at":[13],"the":[14,48,86,90,145,148,159,180],"molecular":[15,62,115],"component":[16],"level":[17],"persistent":[22],"physiological":[23],"pathological":[25],"perturbations.":[26,57],"How":[27],"is":[28,80,190],"this":[29,118],"robust":[30,137,175],"flexibility":[31],"achieved?":[32],"Homeostatic":[33],"integral":[34,82],"control":[35,83],"has":[36],"been":[37],"shown":[38],"to":[39,56,154,171,187],"be":[40,110,152,172],"key":[41],"reconciling":[43,71],"with":[45,136,174],"stability,":[46,72],"but":[47],"explanatory":[49],"model":[50,183],"used":[51],"lacks":[52],"basic":[53],"robustness":[54],"properties":[55,146],"We":[58],"suggest":[59],"that":[60,81],"positive":[61,119,149],"regulatory":[63],"networks":[64],"may":[65],"play":[66],"a":[67,96,164],"major":[68],"role":[69],"robustness.":[75],"The":[76,177],"idea":[77],"we":[78],"propose":[79],"happens":[84],"along":[85,103,117],"dominant":[87,120],"direction":[88,94],"network.":[91],"This":[92],"slow":[93],"generates":[95],"strongly":[97],"attractive,":[98],"thus":[100,139],"robust,":[101],"subspace":[102,121],"which":[104,162],"almost":[105],"perfect":[106],"homeostatic":[107],"regulation":[108,182],"can":[109,151],"achieved.":[111],"Fluctuations":[112],"relevant":[114],"variables":[116],"explain":[122],"how":[123],"big,":[124],"positively-correlated":[125],"variations":[126],"biophysical":[128],"parameters":[129],"(as":[130],"measured":[131],"experiments)":[133],"are":[134],"compatible":[135,173],"regulation,":[138],"explaining":[140],"flexibility.":[141],"Because":[142],"robustness,":[144],"network":[150],"subject":[153],"slower":[155],"tuning":[156],"processes":[157],"(like":[158],"circadian":[160],"rhythm),":[161],"provides":[163],"biologically":[165],"plausible":[166],"basis":[167],"for":[168,184],"regulation.":[176],"relevance":[178],"proposed":[181],"control-theoretical":[185],"approaches":[186],"neurological":[188],"diseases":[189],"also":[191],"discussed.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
