{"id":"https://openalex.org/W4285334154","doi":"https://doi.org/10.1109/la-cci48322.2021.9769823","title":"Machine Learning Techniques to Determine Mutation Impact in Proteins Associated to Neurofibromatosis","display_name":"Machine Learning Techniques to Determine Mutation Impact in Proteins Associated to Neurofibromatosis","publication_year":2021,"publication_date":"2021-11-02","ids":{"openalex":"https://openalex.org/W4285334154","doi":"https://doi.org/10.1109/la-cci48322.2021.9769823"},"language":"en","primary_location":{"id":"doi:10.1109/la-cci48322.2021.9769823","is_oa":false,"landing_page_url":"https://doi.org/10.1109/la-cci48322.2021.9769823","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE Latin American Conference on Computational Intelligence (LA-CCI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110924381","display_name":"Haider Rodriguez Pinto","orcid":null},"institutions":[{"id":"https://openalex.org/I90803817","display_name":"Universidad del Rosario","ror":"https://ror.org/0108mwc04","country_code":"CO","type":"education","lineage":["https://openalex.org/I90803817"]}],"countries":["CO"],"is_corresponding":true,"raw_author_name":"Haider Rodriguez Pinto","raw_affiliation_strings":["Universidad del Rosario,Biomedical Engineering Program Escuela Colombiana de Ingenier&#x00ED;a Julio Garavito,Bogota,D.C.,Colombia"],"affiliations":[{"raw_affiliation_string":"Universidad del Rosario,Biomedical Engineering Program Escuela Colombiana de Ingenier&#x00ED;a Julio Garavito,Bogota,D.C.,Colombia","institution_ids":["https://openalex.org/I90803817"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101180605","display_name":"Tatiana Tellez Silva","orcid":null},"institutions":[{"id":"https://openalex.org/I90803817","display_name":"Universidad del Rosario","ror":"https://ror.org/0108mwc04","country_code":"CO","type":"education","lineage":["https://openalex.org/I90803817"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Tatiana Tellez Silva","raw_affiliation_strings":["Universidad del Rosario,Biomedical Engineering Program Escuela Colombiana de Ingenier&#x00ED;a Julio Garavito,Bogota,D.C.,Colombia"],"affiliations":[{"raw_affiliation_string":"Universidad del Rosario,Biomedical Engineering Program Escuela Colombiana de Ingenier&#x00ED;a Julio Garavito,Bogota,D.C.,Colombia","institution_ids":["https://openalex.org/I90803817"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022419670","display_name":"\u00c1lvaro D. Orjuela-Ca\u00f1\u00f3n","orcid":"https://orcid.org/0000-0002-2057-7603"},"institutions":[{"id":"https://openalex.org/I90803817","display_name":"Universidad del Rosario","ror":"https://ror.org/0108mwc04","country_code":"CO","type":"education","lineage":["https://openalex.org/I90803817"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Alvaro David Orjuela-Canon","raw_affiliation_strings":["Universidad del Rosario,Biomedical Engineering Program Escuela Colombiana de Ingenier&#x00ED;a Julio Garavito,Bogota,D.C.,Colombia"],"affiliations":[{"raw_affiliation_string":"Universidad del Rosario,Biomedical Engineering Program Escuela Colombiana de Ingenier&#x00ED;a Julio Garavito,Bogota,D.C.,Colombia","institution_ids":["https://openalex.org/I90803817"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110924381"],"corresponding_institution_ids":["https://openalex.org/I90803817"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.30672792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9071000218391418,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.690876305103302},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.681370735168457},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.6537257432937622},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.6406314373016357},{"id":"https://openalex.org/keywords/neurofibromatosis","display_name":"Neurofibromatosis","score":0.6378070712089539},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6342583894729614},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.581773042678833},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.4971204102039337},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.495477557182312},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.43432867527008057},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.17242372035980225},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1189238429069519},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11465808749198914},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1023072898387909},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08454352617263794}],"concepts":[{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.690876305103302},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.681370735168457},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6537257432937622},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.6406314373016357},{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.6378070712089539},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6342583894729614},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.581773042678833},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.4971204102039337},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.495477557182312},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.43432867527008057},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.17242372035980225},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1189238429069519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11465808749198914},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1023072898387909},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08454352617263794},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/la-cci48322.2021.9769823","is_oa":false,"landing_page_url":"https://doi.org/10.1109/la-cci48322.2021.9769823","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE Latin American Conference on Computational Intelligence (LA-CCI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.44999998807907104,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W2023011946","https://openalex.org/W2056866789","https://openalex.org/W2069224035","https://openalex.org/W2083372736","https://openalex.org/W2108073386","https://openalex.org/W2137224782","https://openalex.org/W2157450466","https://openalex.org/W2267930101","https://openalex.org/W2580434384","https://openalex.org/W2705752345","https://openalex.org/W2721701181","https://openalex.org/W2901312569","https://openalex.org/W2955704392","https://openalex.org/W2995098893","https://openalex.org/W2997833137","https://openalex.org/W3005210932","https://openalex.org/W3013916086","https://openalex.org/W3022872417","https://openalex.org/W3034154128","https://openalex.org/W3036197410","https://openalex.org/W3081392831","https://openalex.org/W3090266264","https://openalex.org/W3125393037","https://openalex.org/W3133283981","https://openalex.org/W3138120997","https://openalex.org/W3189420019","https://openalex.org/W6688612899","https://openalex.org/W6739607658","https://openalex.org/W6775306233"],"related_works":["https://openalex.org/W2389017212","https://openalex.org/W2411243649","https://openalex.org/W1984608671","https://openalex.org/W2412849376","https://openalex.org/W2473970815","https://openalex.org/W4396689146","https://openalex.org/W4200112873","https://openalex.org/W2955796858","https://openalex.org/W4224941037","https://openalex.org/W2004826645"],"abstract_inverted_index":{"Nowadays,":[0],"computational":[1,134],"intelligence":[2],"has":[3,14],"been":[4],"employed":[5,63],"to":[6,10,51,64,86,104,121,123],"predict":[7],"aspects":[8],"related":[9],"detect":[11],"diseases,":[12],"which":[13],"become":[15],"an":[16],"essential":[17],"practice":[18],"in":[19,130],"health":[20],"around":[21],"the":[22,28,55,66,70,88,91,101,107,111,115,124,127],"world.":[23],"Specifically,":[24],"this":[25,118],"work":[26],"used":[27],"application":[29],"of":[30,90,117,126],"support":[31],"vector":[32],"machines,":[33],"artificial":[34,97],"neural":[35,98],"networks,":[36],"and":[37,68,79],"random":[38],"forest":[39],"models":[40,67,135],"extracted":[41,139],"from":[42,54,140],"machine":[43],"learning":[44],"approaches":[45],"for":[46,73],"finding":[47],"relevant":[48],"mutations":[49],"associated":[50],"Neurofibromatosis.":[52],"Information":[53],"protein":[56,112,141],"composition":[57],"based":[58,132,136],"on":[59,133,137],"amino":[60],"acids":[61],"was":[62,84],"train":[65],"determine":[69,105],"mutation":[71,108,128],"impact":[72,110],"genetic":[74],"diseases":[75],"as":[76],"Neurofibromatosis":[77],"one":[78],"two.":[80],"A":[81],"cross-validation":[82],"method":[83],"implemented":[85],"analyze":[87],"generalization":[89],"mentioned":[92],"models.":[93],"Results":[94],"show":[95],"that":[96],"networks":[99],"hold":[100],"best":[102],"performance":[103],"if":[106],"can":[109],"structure.":[113],"Finally,":[114],"aim":[116],"study":[119],"is":[120],"contribute":[122],"understanding":[125],"effect":[129],"biomolecules":[131],"information":[138],"sequence":[142],"data.":[143]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-03-01T08:55:55.761014","created_date":"2025-10-10T00:00:00"}
