{"id":"https://openalex.org/W2802599954","doi":"https://doi.org/10.1109/jssc.2018.2820705","title":"High-Density Redox Amplified Coulostatic Discharge-Based Biosensor Array","display_name":"High-Density Redox Amplified Coulostatic Discharge-Based Biosensor Array","publication_year":2018,"publication_date":"2018-04-27","ids":{"openalex":"https://openalex.org/W2802599954","doi":"https://doi.org/10.1109/jssc.2018.2820705","mag":"2802599954","pmid":"https://pubmed.ncbi.nlm.nih.gov/30559530"},"language":"en","primary_location":{"id":"doi:10.1109/jssc.2018.2820705","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jssc.2018.2820705","pdf_url":null,"source":{"id":"https://openalex.org/S83637746","display_name":"IEEE Journal of Solid-State Circuits","issn_l":"0018-9200","issn":["0018-9200","1558-173X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Solid-State Circuits","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103197083","display_name":"Alexander Sun","orcid":"https://orcid.org/0000-0003-2374-2069"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander C. Sun","raw_affiliation_strings":["Electrical and Computer Engineering Department, University of California, San Diego, La Jolla, CA 92093 USA","Electrical and Computer Engineering Department, University of California at San Diego, San Diego, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2374-2069","affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering Department, University of California, San Diego, La Jolla, CA 92093 USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Electrical and Computer Engineering Department, University of California at San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018941756","display_name":"Enrique Alvarez-Fontecilla","orcid":"https://orcid.org/0000-0002-2446-0445"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Enrique Alvarez-Fontecilla","raw_affiliation_strings":["Electrical and Computer Engineering Department, University of California, San Diego, La Jolla, CA 92093 USA","Electrical and Computer Engineering Department, University of California at San Diego, San Diego, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2446-0445","affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering Department, University of California, San Diego, La Jolla, CA 92093 USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Electrical and Computer Engineering Department, University of California at San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104027059","display_name":"A. G. Venkatesh","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. G. Venkatesh","raw_affiliation_strings":["Electrical and Computer Engineering Department, University of California, San Diego, La Jolla, CA 92093 USA","Electrical and Computer Engineering Department, University of California at San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering Department, University of California, San Diego, La Jolla, CA 92093 USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Electrical and Computer Engineering Department, University of California at San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073197979","display_name":"Eliah Aronoff\u2010Spencer","orcid":"https://orcid.org/0000-0002-6279-5027"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eliah Aronoff-Spencer","raw_affiliation_strings":["School of Medicine, University of California, San Diego, La Jolla, CA 92093 USA","School of Medicine, University of California at San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of California, San Diego, La Jolla, CA 92093 USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"School of Medicine, University of California at San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040823901","display_name":"Drew A. Hall","orcid":"https://orcid.org/0000-0003-0674-074X"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drew A. Hall","raw_affiliation_strings":["Electrical and Computer Engineering Department, University of California, San Diego, La Jolla, CA 92093 USA","Electrical and Computer Engineering Department, University of California at San Diego, San Diego, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-0674-074X","affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering Department, University of California, San Diego, La Jolla, CA 92093 USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Electrical and Computer Engineering Department, University of California at San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":2645,"currency":"USD","value_usd":2645},"apc_paid":null,"fwci":2.0584,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.84421682,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"53","issue":"7","first_page":"2054","last_page":"2064"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.6095030307769775},{"id":"https://openalex.org/keywords/redox","display_name":"Redox","score":0.5639559030532837},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4587985873222351},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.37762337923049927},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32259601354599},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3004167675971985},{"id":"https://openalex.org/keywords/metallurgy","display_name":"Metallurgy","score":0.13299471139907837}],"concepts":[{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.6095030307769775},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.5639559030532837},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4587985873222351},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.37762337923049927},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32259601354599},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3004167675971985},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.13299471139907837}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/jssc.2018.2820705","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jssc.2018.2820705","pdf_url":null,"source":{"id":"https://openalex.org/S83637746","display_name":"IEEE Journal of Solid-State Circuits","issn_l":"0018-9200","issn":["0018-9200","1558-173X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Solid-State Circuits","raw_type":"journal-article"},{"id":"pmid:30559530","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30559530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of solid-state circuits","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5569591","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6294472","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6200000047683716,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G6175108314","display_name":null,"funder_award_id":"R21 AI121914","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G679116031","display_name":null,"funder_award_id":"P30AI036214","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7700055435","display_name":"Point-of-Care Electrochemical Immunosignaturing","funder_award_id":"5r21ai121914-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1487705477","https://openalex.org/W1637379315","https://openalex.org/W1965229166","https://openalex.org/W1965934122","https://openalex.org/W1969689748","https://openalex.org/W1971580027","https://openalex.org/W1972889821","https://openalex.org/W1973279852","https://openalex.org/W1989157562","https://openalex.org/W1990874746","https://openalex.org/W1993723732","https://openalex.org/W1999177427","https://openalex.org/W1999967778","https://openalex.org/W2000763754","https://openalex.org/W2013074264","https://openalex.org/W2017757915","https://openalex.org/W2029977520","https://openalex.org/W2039469634","https://openalex.org/W2046536957","https://openalex.org/W2049953591","https://openalex.org/W2075721554","https://openalex.org/W2080400496","https://openalex.org/W2098606699","https://openalex.org/W2128158388","https://openalex.org/W2128508216","https://openalex.org/W2128752057","https://openalex.org/W2145853701","https://openalex.org/W2150769312","https://openalex.org/W2154912664","https://openalex.org/W2170129161","https://openalex.org/W2181103586","https://openalex.org/W2182654896","https://openalex.org/W2188285942","https://openalex.org/W2288373993","https://openalex.org/W2312665451","https://openalex.org/W2324358122","https://openalex.org/W2325229160","https://openalex.org/W2332313353","https://openalex.org/W2503289128","https://openalex.org/W2594517589","https://openalex.org/W2769595542","https://openalex.org/W2802599954","https://openalex.org/W6629425038","https://openalex.org/W6686045200","https://openalex.org/W6696411838"],"related_works":["https://openalex.org/W2046430340","https://openalex.org/W2322026400","https://openalex.org/W2383021773","https://openalex.org/W4206515393","https://openalex.org/W1990396141","https://openalex.org/W2056670287","https://openalex.org/W1929958295","https://openalex.org/W2226641048","https://openalex.org/W2002555800","https://openalex.org/W2021425015"],"abstract_inverted_index":{"High-density":[0],"biosensor":[1,57],"arrays":[2],"are":[3,23,40],"essential":[4],"for":[5,31,47],"many":[6],"cutting-edge":[7],"biomedical":[8],"applications":[9],"including":[10],"point-of-care":[11],"vaccination":[12],"screening":[13],"to":[14,44,76,103,127],"detect":[15],"multiple":[16],"highly-contagious":[17],"diseases.":[18],"Typical":[19],"electrochemical":[20,56],"biosensing":[21],"techniques":[22],"based":[24],"on":[25],"the":[26,79,84,107,133],"measurement":[27],"of":[28,83,116,140],"sub-pA":[29],"currents":[30],"micron-sized":[32],"sensors":[33,134],"requiring":[34],"highly-sensitive":[35],"readout":[36,85,98],"circuits.":[37],"Such":[38],"circuits":[39],"often":[41],"too":[42],"complex":[43,136],"scale":[45],"down":[46],"high-density":[48,54],"arrays.":[49],"In":[50],"this":[51],"paper,":[52],"a":[53,67,94,112],"4,096-pixel":[55],"array":[58],"in":[59,145],"180":[60],"nm":[61],"CMOS":[62],"is":[63,125,148],"presented.":[64],"It":[65],"uses":[66],"coulostatic":[68],"discharge":[69],"sensing":[70],"technique":[71],"and":[72,81,142],"interdigitated":[73,91,109],"electrode":[74],"geometry":[75],"reduce":[77],"both":[78],"complexity":[80],"size":[82],"circuitry.":[86],"Each":[87],"biopixel":[88],"contains":[89],"an":[90],"microelectrode":[92],"with":[93,135],"13":[95],"aA":[96],"low-leakage":[97],"circuit":[99],"directly":[100],"underneath.":[101],"Compared":[102],"standard":[104],"planar":[105],"electrodes,":[106],"implemented":[108],"electrodes":[110],"achieve":[111],"maximum":[113],"amplification":[114],"factor":[115],"10.5\u00d7":[117],"from":[118],"redox":[119],"cycling.":[120],"The":[121,138],"array's":[122],"sensor":[123],"density":[124],"comparable":[126],"state-of-the-art":[128],"arrays,":[129],"all":[130],"without":[131],"augmenting":[132],"post-processing.":[137],"detection":[139],"anti-Rubella":[141],"anti-Mumps":[143],"antibodies":[144],"human":[146],"serum":[147],"demonstrated.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}