{"id":"https://openalex.org/W4281400804","doi":"https://doi.org/10.1109/jproc.2022.3170599","title":"Cybergenetics: Theory and Applications of Genetic Control Systems","display_name":"Cybergenetics: Theory and Applications of Genetic Control Systems","publication_year":2022,"publication_date":"2022-05-01","ids":{"openalex":"https://openalex.org/W4281400804","doi":"https://doi.org/10.1109/jproc.2022.3170599"},"language":"en","primary_location":{"id":"doi:10.1109/jproc.2022.3170599","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jproc.2022.3170599","pdf_url":"https://ieeexplore.ieee.org/ielx7/5/9779272/09779327.pdf","source":{"id":"https://openalex.org/S68686220","display_name":"Proceedings of the IEEE","issn_l":"0018-9219","issn":["0018-9219","1558-2256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the IEEE","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ieeexplore.ieee.org/ielx7/5/9779272/09779327.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018485369","display_name":"Mustafa Khammash","orcid":"https://orcid.org/0000-0002-4855-9220"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Mustafa H. Khammash","raw_affiliation_strings":["Department of Biosystems Science and Engineering, Swiss Federal Institute of Technology (ETHZ), Basel, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, Swiss Federal Institute of Technology (ETHZ), Basel, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018485369"],"corresponding_institution_ids":["https://openalex.org/I5124864"],"apc_list":null,"apc_paid":null,"fwci":3.7324,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.94581913,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"110","issue":"5","first_page":"631","last_page":"658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9697999954223633,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9632999897003174,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jargon","display_name":"Jargon","score":0.6586602926254272},{"id":"https://openalex.org/keywords/living-systems","display_name":"Living systems","score":0.5541465282440186},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5437312126159668},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.5143526792526245},{"id":"https://openalex.org/keywords/feeling","display_name":"Feeling","score":0.4405985474586487},{"id":"https://openalex.org/keywords/cognitive-science","display_name":"Cognitive science","score":0.3666672706604004},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.35550346970558167},{"id":"https://openalex.org/keywords/management-science","display_name":"Management science","score":0.34459054470062256},{"id":"https://openalex.org/keywords/engineering-ethics","display_name":"Engineering ethics","score":0.32748177647590637},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3238556385040283},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.23721233010292053},{"id":"https://openalex.org/keywords/epistemology","display_name":"Epistemology","score":0.2158069610595703},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.18156060576438904}],"concepts":[{"id":"https://openalex.org/C2777611551","wikidata":"https://www.wikidata.org/wiki/Q17951","display_name":"Jargon","level":2,"score":0.6586602926254272},{"id":"https://openalex.org/C2776184637","wikidata":"https://www.wikidata.org/wiki/Q6506039","display_name":"Living systems","level":2,"score":0.5541465282440186},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5437312126159668},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.5143526792526245},{"id":"https://openalex.org/C122980154","wikidata":"https://www.wikidata.org/wiki/Q205555","display_name":"Feeling","level":2,"score":0.4405985474586487},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3666672706604004},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.35550346970558167},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.34459054470062256},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.32748177647590637},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3238556385040283},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23721233010292053},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.2158069610595703},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.18156060576438904},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/jproc.2022.3170599","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jproc.2022.3170599","pdf_url":"https://ieeexplore.ieee.org/ielx7/5/9779272/09779327.pdf","source":{"id":"https://openalex.org/S68686220","display_name":"Proceedings of the IEEE","issn_l":"0018-9219","issn":["0018-9219","1558-2256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the IEEE","raw_type":"journal-article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/557061","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/557061","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the IEEE, 110 (5)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"doi:10.3929/ethz-b-000557061","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000557061","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1109/jproc.2022.3170599","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jproc.2022.3170599","pdf_url":"https://ieeexplore.ieee.org/ielx7/5/9779272/09779327.pdf","source":{"id":"https://openalex.org/S68686220","display_name":"Proceedings of the IEEE","issn_l":"0018-9219","issn":["0018-9219","1558-2256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the IEEE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.4000000059604645,"display_name":"Industry, innovation and infrastructure"}],"awards":[{"id":"https://openalex.org/G2315048599","display_name":null,"funder_award_id":"743269","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G3677077610","display_name":null,"funder_award_id":"743269","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8051717526","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8318064016","display_name":null,"funder_award_id":"Horizon","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320923","display_name":"Branco Weiss Fellowship \u2013 Society in Science","ror":"https://ror.org/05a28rw58"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281400804.pdf","grobid_xml":"https://content.openalex.org/works/W4281400804.grobid-xml"},"referenced_works_count":174,"referenced_works":["https://openalex.org/W1503248986","https://openalex.org/W1563426240","https://openalex.org/W1590222219","https://openalex.org/W1637936532","https://openalex.org/W1645305843","https://openalex.org/W1921421686","https://openalex.org/W1964261044","https://openalex.org/W1967146963","https://openalex.org/W1978319180","https://openalex.org/W1985528545","https://openalex.org/W1991932257","https://openalex.org/W1994794118","https://openalex.org/W1995924881","https://openalex.org/W2003885556","https://openalex.org/W2009163705","https://openalex.org/W2013164796","https://openalex.org/W2018435536","https://openalex.org/W2030513350","https://openalex.org/W2032408161","https://openalex.org/W2032579724","https://openalex.org/W2035018687","https://openalex.org/W2036546758","https://openalex.org/W2037857799","https://openalex.org/W2037913229","https://openalex.org/W2041042514","https://openalex.org/W2042321087","https://openalex.org/W2043946672","https://openalex.org/W2045475749","https://openalex.org/W2046649943","https://openalex.org/W2053240640","https://openalex.org/W2055621713","https://openalex.org/W2057013484","https://openalex.org/W2059053384","https://openalex.org/W2066594542","https://openalex.org/W2073265884","https://openalex.org/W2079004206","https://openalex.org/W2085061065","https://openalex.org/W2086760563","https://openalex.org/W2092122738","https://openalex.org/W2098199730","https://openalex.org/W2104722000","https://openalex.org/W2106362845","https://openalex.org/W2106411386","https://openalex.org/W2107342968","https://openalex.org/W2109110326","https://openalex.org/W2114870653","https://openalex.org/W2117056464","https://openalex.org/W2119435255","https://openalex.org/W2120661262","https://openalex.org/W2125108766","https://openalex.org/W2125744693","https://openalex.org/W2126794261","https://openalex.org/W2127793379","https://openalex.org/W2129858956","https://openalex.org/W2132583277","https://openalex.org/W2133254839","https://openalex.org/W2133403209","https://openalex.org/W2134759932","https://openalex.org/W2135541516","https://openalex.org/W2136451426","https://openalex.org/W2137088684","https://openalex.org/W2138835511","https://openalex.org/W2140237950","https://openalex.org/W2142688660","https://openalex.org/W2149109097","https://openalex.org/W2155202381","https://openalex.org/W2155418451","https://openalex.org/W2156781574","https://openalex.org/W2159423248","https://openalex.org/W2160051211","https://openalex.org/W2161406501","https://openalex.org/W2161782059","https://openalex.org/W2162647894","https://openalex.org/W2164200677","https://openalex.org/W2166499263","https://openalex.org/W2171280873","https://openalex.org/W2177943983","https://openalex.org/W2247294682","https://openalex.org/W2265835549","https://openalex.org/W2282407256","https://openalex.org/W2305757214","https://openalex.org/W2314564135","https://openalex.org/W2317320159","https://openalex.org/W2326526548","https://openalex.org/W2411639680","https://openalex.org/W2415248855","https://openalex.org/W2472786230","https://openalex.org/W2477731233","https://openalex.org/W2485078737","https://openalex.org/W2507618556","https://openalex.org/W2528271650","https://openalex.org/W2559919850","https://openalex.org/W2560220907","https://openalex.org/W2564089345","https://openalex.org/W2588456700","https://openalex.org/W2607621829","https://openalex.org/W2626249246","https://openalex.org/W2739045401","https://openalex.org/W2741123712","https://openalex.org/W2747801569","https://openalex.org/W2762171009","https://openalex.org/W2767587403","https://openalex.org/W2769086206","https://openalex.org/W2782502312","https://openalex.org/W2783304919","https://openalex.org/W2788613898","https://openalex.org/W2792353080","https://openalex.org/W2794402253","https://openalex.org/W2803345807","https://openalex.org/W2804461679","https://openalex.org/W2804986266","https://openalex.org/W2808037978","https://openalex.org/W2889985834","https://openalex.org/W2897187678","https://openalex.org/W2897387579","https://openalex.org/W2903216094","https://openalex.org/W2911925649","https://openalex.org/W2914908364","https://openalex.org/W2917657657","https://openalex.org/W2935954872","https://openalex.org/W2944698683","https://openalex.org/W2949263858","https://openalex.org/W2949593751","https://openalex.org/W2950135916","https://openalex.org/W2950265181","https://openalex.org/W2951054273","https://openalex.org/W2951169596","https://openalex.org/W2951863665","https://openalex.org/W2952545994","https://openalex.org/W2952738056","https://openalex.org/W2954255554","https://openalex.org/W2963418941","https://openalex.org/W2963671418","https://openalex.org/W2964163153","https://openalex.org/W2964524361","https://openalex.org/W2967509223","https://openalex.org/W2971658418","https://openalex.org/W2972769843","https://openalex.org/W2975521369","https://openalex.org/W2978143021","https://openalex.org/W2995579925","https://openalex.org/W2998307067","https://openalex.org/W3011047818","https://openalex.org/W3011238582","https://openalex.org/W3011827142","https://openalex.org/W3036145647","https://openalex.org/W3044384970","https://openalex.org/W3044445219","https://openalex.org/W3085126126","https://openalex.org/W3087683406","https://openalex.org/W3101754689","https://openalex.org/W3103757230","https://openalex.org/W3103811267","https://openalex.org/W3106718781","https://openalex.org/W3109906235","https://openalex.org/W3126750443","https://openalex.org/W3158340414","https://openalex.org/W3165837477","https://openalex.org/W3167338276","https://openalex.org/W3189192537","https://openalex.org/W3201218862","https://openalex.org/W3203011645","https://openalex.org/W3205596578","https://openalex.org/W3206780719","https://openalex.org/W3207755008","https://openalex.org/W4211059059","https://openalex.org/W4220658974","https://openalex.org/W4226069241","https://openalex.org/W4239833133","https://openalex.org/W4281768956","https://openalex.org/W4385644632","https://openalex.org/W6741633172","https://openalex.org/W6762335022","https://openalex.org/W6772602878"],"related_works":["https://openalex.org/W3040422808","https://openalex.org/W4317528635","https://openalex.org/W2499956125","https://openalex.org/W2553927761","https://openalex.org/W2501778858","https://openalex.org/W2485612408","https://openalex.org/W235416042","https://openalex.org/W3214311004","https://openalex.org/W4390504469","https://openalex.org/W1973149853"],"abstract_inverted_index":{"There":[0],"is":[1,54,81,128,133,230,243],"no":[2],"design":[3,18,41,87,219,275],"template":[4,42,67,146],"more":[5],"important":[6],"than":[7],"DNA.":[8,278],"Within":[9],"the":[10,17,35,44,112,122,144,176,179,185,206,217,239,250,258,268,277],"sequences":[11],"of":[12,22,32,38,178,190,199,216,226,236,249,257,270,274],"this":[13,40,66,79,139,171,223,271],"exquisite":[14],"substance":[15],"lie":[16],"plans":[19],"for":[20,25,152,255],"each":[21],"us":[23],"and":[24,68,88,114,155,157,167,187,214],"every":[26],"living":[27,95],"organism.":[28],"Shaped":[29],"over":[30],"billions":[31],"years":[33],"by":[34,98],"creative":[36,265],"machinations":[37],"evolution,":[39],"encodes":[43],"most":[45,272],"complex":[46],"dynamical":[47],"systems":[48,93,120],"known":[49],"to":[50,63,86,110,117,142,205,210,231,245,260,267],"us.":[51],"Yet,":[52],"it":[53,132,242],"only":[55],"in":[56,78,94,162,222],"our":[57,70,83,90,153],"lifetimes":[58],"that":[59,75,127,252],"we":[60,100,107],"are":[61,108],"able":[62],"directly":[64],"edit":[65],"engineer":[69],"own":[71,91,234,264],"designs.":[72],"The":[73],"story":[74],"I":[76,173,201],"tell":[77],"article":[80],"about":[82,238],"early":[84],"attempts":[85],"commission":[89],"control":[92,119,194],"cells.":[96],"Guided":[97],"what":[99],"have":[101,148],"learned":[102],"from":[103],"controlling":[104],"man-made":[105],"systems,":[106],"beginning":[109],"develop":[111,211],"theory":[113],"methodologies":[115],"needed":[116,209],"build":[118],"at":[121],"molecular":[123],"level,":[124],"an":[125,212],"endeavor":[126],"as":[129,131],"challenging":[130],"rewarding.":[134],"If":[135],"carried":[136],"out":[137],"responsibly,":[138],"new":[140,186],"ability":[141],"reshape":[143],"DNA":[145],"can":[147],"a":[149,182,197,247],"tremendous":[150],"benefit":[151],"health":[154],"well-being,":[156],"will":[158,174,202],"drive":[159],"major":[160],"advances":[161],"basic":[163],"science,":[164],"industrial":[165],"biotechnology,":[166],"medical":[168],"therapy.":[169],"In":[170],"article,":[172],"take":[175],"readers":[177],"proceedings":[180],"on":[181],"journey":[183],"through":[184],"promising":[188],"world":[189],"rationally":[191],"designed":[192],"genetic":[193],"systems.":[195],"Using":[196],"minimum":[198],"jargon,":[200],"introduce":[203],"them":[204],"biological":[207],"concepts":[208,220],"understanding":[213],"appreciation":[215],"main":[218],"emerging":[221],"nascent":[224],"area":[225],"research.":[227],"My":[228],"goal":[229],"convey":[232],"my":[233],"sense":[235],"excitement":[237],"possibilities,":[240],"but":[241],"also":[244],"impart":[246],"feeling":[248],"opportunities":[251],"lay":[253],"ahead":[254],"members":[256],"IEEE":[259],"contribute":[261],"with":[262],"their":[263],"ideas":[266],"shaping":[269],"versatile":[273],"templates,":[276]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":2}],"updated_date":"2026-04-13T07:58:08.660418","created_date":"2025-10-10T00:00:00"}