{"id":"https://openalex.org/W2159982024","doi":"https://doi.org/10.1109/jproc.2002.804680","title":"Rapid development of nucleic acid diagnostics","display_name":"Rapid development of nucleic acid diagnostics","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2159982024","doi":"https://doi.org/10.1109/jproc.2002.804680","mag":"2159982024"},"language":"en","primary_location":{"id":"doi:10.1109/jproc.2002.804680","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jproc.2002.804680","pdf_url":null,"source":{"id":"https://openalex.org/S68686220","display_name":"Proceedings of the IEEE","issn_l":"0018-9219","issn":["0018-9219","1558-2256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the IEEE","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111446906","display_name":"J. Patrick Fitch","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138311","display_name":"Lawrence Livermore National Security","ror":"https://ror.org/03z21mf61","country_code":"US","type":"government","lineage":["https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J.P. Fitch","raw_affiliation_strings":["Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA","institution_ids":["https://openalex.org/I4210138311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112156788","display_name":"Shea N. Gardner","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138311","display_name":"Lawrence Livermore National Security","ror":"https://ror.org/03z21mf61","country_code":"US","type":"government","lineage":["https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.N. Gardner","raw_affiliation_strings":["Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA","institution_ids":["https://openalex.org/I4210138311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012674363","display_name":"Tom Kuczmarski","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138311","display_name":"Lawrence Livermore National Security","ror":"https://ror.org/03z21mf61","country_code":"US","type":"government","lineage":["https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.A. Kuczmarski","raw_affiliation_strings":["Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA","institution_ids":["https://openalex.org/I4210138311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060071039","display_name":"Stefan Kurtz","orcid":"https://orcid.org/0000-0001-5783-0054"},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Kurtz","raw_affiliation_strings":["Center for Bioinformatics, University of Hamburg, Hamburg, Germany"],"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, University of Hamburg, Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109394858","display_name":"Richard Myers","orcid":null},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"funder","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Myers","raw_affiliation_strings":["Centers for Disease Control and Prevention, Atlanta, GA, USA"],"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention, Atlanta, GA, USA","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108531502","display_name":"L. Ott","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138311","display_name":"Lawrence Livermore National Security","ror":"https://ror.org/03z21mf61","country_code":"US","type":"government","lineage":["https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.L. Ott","raw_affiliation_strings":["Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA","institution_ids":["https://openalex.org/I4210138311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110264999","display_name":"T. \u0160lezak","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138311","display_name":"Lawrence Livermore National Security","ror":"https://ror.org/03z21mf61","country_code":"US","type":"government","lineage":["https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.R. Slezak","raw_affiliation_strings":["Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA","institution_ids":["https://openalex.org/I4210138311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000038945","display_name":"Elizabeth Vitalis","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138311","display_name":"Lawrence Livermore National Security","ror":"https://ror.org/03z21mf61","country_code":"US","type":"government","lineage":["https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.A. Vitalis","raw_affiliation_strings":["Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA","institution_ids":["https://openalex.org/I4210138311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083445132","display_name":"Adam Zem\u0142a","orcid":"https://orcid.org/0000-0003-0504-8647"},"institutions":[{"id":"https://openalex.org/I4210138311","display_name":"Lawrence Livermore National Security","ror":"https://ror.org/03z21mf61","country_code":"US","type":"government","lineage":["https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.T. Zemla","raw_affiliation_strings":["Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA","institution_ids":["https://openalex.org/I4210138311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049114011","display_name":"Paula McCready","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138311","display_name":"Lawrence Livermore National Security","ror":"https://ror.org/03z21mf61","country_code":"US","type":"government","lineage":["https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.M. McCready","raw_affiliation_strings":["Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA"],"affiliations":[{"raw_affiliation_string":"Chemical and Biological National Security Program, LLNL, University of California, Livermore, CA, USA","institution_ids":["https://openalex.org/I4210138311"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5111446906"],"corresponding_institution_ids":["https://openalex.org/I4210138311"],"apc_list":null,"apc_paid":null,"fwci":10.2549,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.98802178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"90","issue":"11","first_page":"1708","last_page":"1721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleic-acid","display_name":"Nucleic acid","score":0.7982628345489502},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5767195820808411},{"id":"https://openalex.org/keywords/polymerase-chain-reaction","display_name":"Polymerase chain reaction","score":0.4994077682495117},{"id":"https://openalex.org/keywords/pathogen","display_name":"Pathogen","score":0.48674702644348145},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4782527983188629},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.47079339623451233},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.4675171673297882},{"id":"https://openalex.org/keywords/human-pathogen","display_name":"Human pathogen","score":0.4512861371040344},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3150867223739624},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.21671393513679504},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.19391155242919922},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19112062454223633},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12320545315742493}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7982628345489502},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5767195820808411},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4994077682495117},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.48674702644348145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4782527983188629},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.47079339623451233},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4675171673297882},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.4512861371040344},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3150867223739624},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.21671393513679504},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.19391155242919922},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19112062454223633},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12320545315742493}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/jproc.2002.804680","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jproc.2002.804680","pdf_url":null,"source":{"id":"https://openalex.org/S68686220","display_name":"Proceedings of the IEEE","issn_l":"0018-9219","issn":["0018-9219","1558-2256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the IEEE","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338286","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W163268065","https://openalex.org/W1527632333","https://openalex.org/W1593454066","https://openalex.org/W1627236244","https://openalex.org/W1993865292","https://openalex.org/W2001321345","https://openalex.org/W2017754509","https://openalex.org/W2020065011","https://openalex.org/W2036295979","https://openalex.org/W2038070375","https://openalex.org/W2052831012","https://openalex.org/W2059333155","https://openalex.org/W2090958477","https://openalex.org/W2102626325","https://openalex.org/W2138270253","https://openalex.org/W2148312059","https://openalex.org/W2156818800","https://openalex.org/W2168909179","https://openalex.org/W2171582839","https://openalex.org/W2257885802","https://openalex.org/W2307354773","https://openalex.org/W2484922775","https://openalex.org/W2533248932","https://openalex.org/W2616853883","https://openalex.org/W4229721748","https://openalex.org/W4253055460","https://openalex.org/W4289259741","https://openalex.org/W4300422748","https://openalex.org/W4300542642"],"related_works":["https://openalex.org/W2800646135","https://openalex.org/W4312210177","https://openalex.org/W2788776646","https://openalex.org/W1982139772","https://openalex.org/W1986258113","https://openalex.org/W2021313608","https://openalex.org/W4390971436","https://openalex.org/W4283780917","https://openalex.org/W2166512720","https://openalex.org/W2913517611"],"abstract_inverted_index":{"There":[0],"has":[1],"been":[2],"a":[3,29],"significant":[4],"increase,":[5],"fueled":[6],"by":[7],"technologies":[8],"front":[9],"the":[10,15,50,54,92],"human":[11,93],"genome":[12],"project,":[13],"in":[14],"availability":[16],"of":[17,67],"nucleic":[18,35],"acid":[19,36],"sequence":[20,37,70],"information":[21,38],"for":[22,84],"viruses":[23],"and":[24,39,60,64,74,80,91],"bacteria.":[25],"This":[26],"paper":[27],"presents":[28],"computer-assisted":[30],"process":[31],"that":[32],"begins":[33],"with":[34,47],"produces":[40],"highly":[41],"specific":[42,59,85],"pathogen":[43],"signatures.":[44],"When":[45],"combined":[46],"instrumentation":[48],"using":[49],"polymerase":[51],"chain":[52],"reaction,":[53],"resulting":[55],"diagnostics":[56],"are":[57,77,82],"both":[58],"sensitive.":[61],"The":[62],"computational":[63],"engineering":[65],"aspects":[66],"converting":[68],"raw":[69],"data":[71,81],"into":[72],"pathogen-specific":[73],"instrument-ready":[75],"assays":[76],"presented.":[78],"Examples":[79],"presented":[83],"pathogens,":[86],"including":[87],"foot-and-mouth":[88],"disease":[89],"virus":[90],"immunodeficiency":[94],"virus.":[95]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
