{"id":"https://openalex.org/W4413319035","doi":"https://doi.org/10.1109/jbhi.2025.3599891","title":"Recursive Statistical Invariants Elimination for High-Risk Disease Diagnosis With Feature Selection","display_name":"Recursive Statistical Invariants Elimination for High-Risk Disease Diagnosis With Feature Selection","publication_year":2025,"publication_date":"2025-08-19","ids":{"openalex":"https://openalex.org/W4413319035","doi":"https://doi.org/10.1109/jbhi.2025.3599891","pmid":"https://pubmed.ncbi.nlm.nih.gov/40828729"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2025.3599891","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3599891","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yi-Fan Qi","orcid":"https://orcid.org/0009-0004-6836-4254"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Fan Qi","raw_affiliation_strings":["International Business School, Hainan University, Haikou, China"],"raw_orcid":"https://orcid.org/0009-0004-6836-4254","affiliations":[{"raw_affiliation_string":"International Business School, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051850582","display_name":"Yuan\u2010Hai Shao","orcid":"https://orcid.org/0000-0002-1628-6133"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan-Hai Shao","raw_affiliation_strings":["School of Mathematics and Statistics, Hainan University, Haikou, China"],"raw_orcid":"https://orcid.org/0000-0002-1628-6133","affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041009542","display_name":"Chun\u2010Na Li","orcid":"https://orcid.org/0000-0001-7033-0089"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-Na Li","raw_affiliation_strings":["School of Mathematics and Statistics, Hainan University, Haikou, China"],"raw_orcid":"https://orcid.org/0000-0001-7033-0089","affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013051763","display_name":"Zhiquan Qi","orcid":"https://orcid.org/0000-0001-9289-9110"},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Quan Qi","raw_affiliation_strings":["School of Economics and Management, University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-9289-9110","affiliations":[{"raw_affiliation_string":"School of Economics and Management, University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21722732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"3","first_page":"2153","last_page":"2166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.8059999942779541,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.8059999942779541,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10057","display_name":"Face and Expression Recognition","score":0.7146000266075134,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.656826376914978},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6210436820983887},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5086098909378052},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4871932864189148},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.47861331701278687},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.43554699420928955},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3951975703239441},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.28335806727409363},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12248936295509338}],"concepts":[{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.656826376914978},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6210436820983887},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5086098909378052},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4871932864189148},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.47861331701278687},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43554699420928955},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3951975703239441},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28335806727409363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12248936295509338},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2025.3599891","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3599891","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:40828729","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40828729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1093109463","display_name":null,"funder_award_id":"62466014","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6214398767","display_name":null,"funder_award_id":"T2293774","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7495504246","display_name":null,"funder_award_id":"12271131","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1538628429","https://openalex.org/W1548410411","https://openalex.org/W1596717185","https://openalex.org/W1992116297","https://openalex.org/W2057266281","https://openalex.org/W2087347434","https://openalex.org/W2103291381","https://openalex.org/W2104068492","https://openalex.org/W2112483442","https://openalex.org/W2120888944","https://openalex.org/W2125865219","https://openalex.org/W2138550913","https://openalex.org/W2143426320","https://openalex.org/W2149466042","https://openalex.org/W2167101736","https://openalex.org/W2177704039","https://openalex.org/W2267339884","https://openalex.org/W2615824740","https://openalex.org/W2746324357","https://openalex.org/W2802906787","https://openalex.org/W2884692446","https://openalex.org/W2960086270","https://openalex.org/W2965743638","https://openalex.org/W2996092187","https://openalex.org/W3020644100","https://openalex.org/W3074864365","https://openalex.org/W3087050764","https://openalex.org/W3129954143","https://openalex.org/W3132461044","https://openalex.org/W3134934271","https://openalex.org/W3156338075","https://openalex.org/W3191029526","https://openalex.org/W3199724960","https://openalex.org/W4205560432","https://openalex.org/W4224222011","https://openalex.org/W4238688872","https://openalex.org/W4239510810","https://openalex.org/W4289530080","https://openalex.org/W4313201240","https://openalex.org/W4318911933","https://openalex.org/W4319600721","https://openalex.org/W4366967163","https://openalex.org/W4366984820","https://openalex.org/W4376136910","https://openalex.org/W4377010603","https://openalex.org/W4381614701","https://openalex.org/W4386022636","https://openalex.org/W4389163295","https://openalex.org/W4390061288"],"related_works":["https://openalex.org/W4205762803","https://openalex.org/W2535856026","https://openalex.org/W2265065644","https://openalex.org/W3147584709","https://openalex.org/W2134699697","https://openalex.org/W3017188156","https://openalex.org/W2322875716","https://openalex.org/W2977677679","https://openalex.org/W4386564352","https://openalex.org/W2952668426"],"abstract_inverted_index":{"Feature":[0],"selection":[1],"for":[2,8,60,70,85,122,164],"high-risk":[3,96,165],"disease":[4,97,166],"diagnosis":[5],"is":[6],"critical":[7],"accurate":[9],"risk":[10],"assessment,":[11],"yet":[12],"existing":[13],"methods":[14],"fail":[15],"to":[16,23,120],"incorporate":[17],"medical":[18,44],"domain":[19,45,66,75],"knowledge,":[20,67],"potentially":[21],"leading":[22],"suboptimal":[24],"diagnostic":[25,63],"decisions.":[26],"To":[27],"address":[28],"this":[29],"limitation,":[30],"we":[31],"propose":[32],"recursive":[33,81],"statistical":[34,57],"invariants":[35,58],"elimination":[36,83],"(RSIE),":[37],"a":[38,126],"novel":[39],"framework":[40],"that":[41,108],"systematically":[42],"integrates":[43],"knowledge":[46,76],"into":[47],"feature":[48,82,87,137],"selection.":[49,90],"RSIE":[50,93,109,154],"comprises":[51],"three":[52],"complementary":[53],"components:":[54],"learning":[55],"using":[56],"(LUSI)":[59],"extracting":[61],"reliable":[62],"patterns":[64],"from":[65],"kernel":[68],"alignment":[69],"establishing":[71],"meaningful":[72],"correlations":[73],"between":[74],"and":[77,80,89,102,161],"dataset":[78],"features,":[79],"(RFE)":[84],"systematic":[86],"ranking":[88],"We":[91],"evaluate":[92],"on":[94],"15":[95],"datasets":[98,118],"spanning":[99],"cardiovascular,":[100],"neurological,":[101],"oncological":[103],"conditions.":[104],"Experimental":[105],"results":[106],"show":[107],"achieves":[110,133],"an":[111],"average":[112],"accuracy":[113],"of":[114,153],"88.74%":[115],"across":[116],"all":[117],"compared":[119],"83.28%":[121],"traditional":[123],"SVM-RFE,":[124],"representing":[125],"5.46%":[127],"improvement.":[128],"Specifically,":[129],"the":[130,151],"LUSI-RFE*":[131],"variant":[132],"superior":[134],"performance,":[135],"reducing":[136],"dimensions":[138],"by":[139],"45%":[140],"-74%":[141],"while":[142],"maintaining":[143],"high":[144,156],"classification":[145],"accuracy.":[146],"The":[147],"experiments":[148],"simultaneously":[149],"demonstrate":[150],"stability":[152],"against":[155],"noise":[157],"conditions,":[158],"computational":[159],"efficiency,":[160],"model":[162],"interpretability":[163],"diagnosis.":[167]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}