{"id":"https://openalex.org/W4413104853","doi":"https://doi.org/10.1109/jbhi.2025.3596817","title":"MOKAN: A Multi-Omics Data Analysis Framework Using Kolmogorov\u2013Arnold Networks","display_name":"MOKAN: A Multi-Omics Data Analysis Framework Using Kolmogorov\u2013Arnold Networks","publication_year":2025,"publication_date":"2025-08-11","ids":{"openalex":"https://openalex.org/W4413104853","doi":"https://doi.org/10.1109/jbhi.2025.3596817","pmid":"https://pubmed.ncbi.nlm.nih.gov/40788803"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2025.3596817","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3596817","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025977133","display_name":"Jiali He","orcid":null},"institutions":[{"id":"https://openalex.org/I75867142","display_name":"Xiamen University of Technology","ror":"https://ror.org/01285e189","country_code":"CN","type":"education","lineage":["https://openalex.org/I75867142"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingguang He","raw_affiliation_strings":["Fujian Key Laboratory of Pattern Recognition and Image Understanding, School of Computer and Information Engineering, Xiamen University of Technology, Xiamen, China"],"raw_orcid":"https://orcid.org/0009-0003-3139-3572","affiliations":[{"raw_affiliation_string":"Fujian Key Laboratory of Pattern Recognition and Image Understanding, School of Computer and Information Engineering, Xiamen University of Technology, Xiamen, China","institution_ids":["https://openalex.org/I75867142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042079993","display_name":"Shunxin Xiao","orcid":"https://orcid.org/0000-0003-1187-8719"},"institutions":[{"id":"https://openalex.org/I75867142","display_name":"Xiamen University of Technology","ror":"https://ror.org/01285e189","country_code":"CN","type":"education","lineage":["https://openalex.org/I75867142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunxin Xiao","raw_affiliation_strings":["Fujian Key Laboratory of Pattern Recognition and Image Understanding, School of Computer and Information Engineering, Xiamen University of Technology, Xiamen, China"],"raw_orcid":"https://orcid.org/0000-0003-1187-8719","affiliations":[{"raw_affiliation_string":"Fujian Key Laboratory of Pattern Recognition and Image Understanding, School of Computer and Information Engineering, Xiamen University of Technology, Xiamen, China","institution_ids":["https://openalex.org/I75867142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032715565","display_name":"Sujia Huang","orcid":"https://orcid.org/0000-0002-4745-2157"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sujia Huang","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0002-4745-2157","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","institution_ids":["https://openalex.org/I36399199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100372731","display_name":"Jianmin Li","orcid":"https://orcid.org/0000-0001-8800-4505"},"institutions":[{"id":"https://openalex.org/I75867142","display_name":"Xiamen University of Technology","ror":"https://ror.org/01285e189","country_code":"CN","type":"education","lineage":["https://openalex.org/I75867142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianmin Li","raw_affiliation_strings":["Fujian Key Laboratory of Pattern Recognition and Image Understanding, School of Computer and Information Engineering, Xiamen University of Technology, Xiamen, China"],"raw_orcid":"https://orcid.org/0000-0001-8800-4505","affiliations":[{"raw_affiliation_string":"Fujian Key Laboratory of Pattern Recognition and Image Understanding, School of Computer and Information Engineering, Xiamen University of Technology, Xiamen, China","institution_ids":["https://openalex.org/I75867142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032628425","display_name":"Da\u2010Han Wang","orcid":"https://orcid.org/0000-0002-5901-0778"},"institutions":[{"id":"https://openalex.org/I75867142","display_name":"Xiamen University of Technology","ror":"https://ror.org/01285e189","country_code":"CN","type":"education","lineage":["https://openalex.org/I75867142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Da-Han Wang","raw_affiliation_strings":["Fujian Key Laboratory of Pattern Recognition and Image Understanding, School of Computer and Information Engineering, Xiamen University of Technology, Xiamen, China"],"raw_orcid":"https://orcid.org/0000-0002-5901-0778","affiliations":[{"raw_affiliation_string":"Fujian Key Laboratory of Pattern Recognition and Image Understanding, School of Computer and Information Engineering, Xiamen University of Technology, Xiamen, China","institution_ids":["https://openalex.org/I75867142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5025977133"],"corresponding_institution_ids":["https://openalex.org/I75867142"],"apc_list":null,"apc_paid":null,"fwci":4.2681,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.94571575,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"30","issue":"2","first_page":"1830","last_page":"1840"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9736999869346619,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9736999869346619,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.9176999926567078,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6291807293891907},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.35281628370285034},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3475795090198517}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6291807293891907},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.35281628370285034},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3475795090198517}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2025.3596817","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3596817","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:40788803","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40788803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7736715390","display_name":null,"funder_award_id":"2025J08128","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"}],"funders":[{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1930624869","https://openalex.org/W2294798173","https://openalex.org/W2604723872","https://openalex.org/W2611138580","https://openalex.org/W2672266311","https://openalex.org/W3003192283","https://openalex.org/W3012736453","https://openalex.org/W3047056765","https://openalex.org/W3097791049","https://openalex.org/W3116663947","https://openalex.org/W3124379712","https://openalex.org/W3170986249","https://openalex.org/W3191867763","https://openalex.org/W3208416462","https://openalex.org/W3213224786","https://openalex.org/W4210546025","https://openalex.org/W4212958784","https://openalex.org/W4239510810","https://openalex.org/W4283747441","https://openalex.org/W4300689006","https://openalex.org/W4323660135","https://openalex.org/W4380303551","https://openalex.org/W4382787257","https://openalex.org/W4385459199","https://openalex.org/W4386221519","https://openalex.org/W4392238005","https://openalex.org/W4392381738","https://openalex.org/W4393156830","https://openalex.org/W4394725002","https://openalex.org/W4395954533","https://openalex.org/W4399171935","https://openalex.org/W4400349830"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"With":[0],"the":[1,17,56,93,96,153,187,208],"advancement":[2],"of":[3,9,20,30,58,98,156,186],"high-throughput":[4],"sequencing":[5],"technology,":[6],"large":[7],"amounts":[8],"multi-omics":[10,24,43,63,76,134],"data":[11,25,64,107,135,149,175,210],"have":[12],"been":[13],"accumulated.":[14],"Due":[15],"to":[16,54,91,104,170],"comprehensive":[18,160],"representation":[19],"different":[21,143],"molecular":[22],"layers,":[23],"enable":[26],"a":[27,66,73,87,183,197],"deep":[28],"understanding":[29],"cancer":[31,224],"analysis,":[32,108],"including":[33],"subtype":[34],"classification,":[35],"biomarker":[36],"identification":[37],"and":[38,68,122,161,202],"so":[39],"on.":[40],"However,":[41],"existing":[42,221],"integration":[44,77],"methods":[45,222],"either":[46],"rely":[47],"on":[48],"complex":[49,174],"feature":[50,140],"engineering":[51],"or":[52],"fail":[53],"capture":[55],"heterogeneity":[57],"multi-source":[59],"data.":[60,188],"To":[61],"integrate":[62],"in":[65,95,101,223],"complementary":[67],"collaborative":[69],"manner,":[70],"we":[71],"propose":[72],"Kolmogorov-Arnold":[74],"Networks-based":[75],"analysis":[78],"framework,":[79],"termed":[80],"MOKAN.":[81],"In":[82],"detail,":[83],"MOKAN":[84,129,165],"first":[85],"employs":[86,166],"sample-weighted":[88],"random":[89],"sampler":[90],"reduce":[92],"difference":[94],"number":[97],"samples":[99],"involved":[100],"training.":[102],"Then,":[103],"perform":[105],"this":[106],"our":[109,216],"proposed":[110,217],"model,":[111],"MOKAN,":[112],"leverages":[113],"KAN's":[114,167],"architecture,":[115],"utilizing":[116],"its":[117],"learnable":[118],"edge-weight":[119],"activation":[120],"functions":[121],"flexible":[123],"network":[124],"structure.":[125,211],"This":[126],"design":[127],"makes":[128],"particularly":[130],"well-suited":[131],"for":[132,159],"handling":[133],"by":[136],"efficiently":[137],"capturing":[138,182],"diverse":[139],"spaces":[141],"across":[142],"omics":[144,158],"layers.":[145],"It":[146],"integrates":[147],"heterogeneous":[148],"types":[150],"while":[151],"preserving":[152],"unique":[154],"contributions":[155],"each":[157,180],"accurate":[162],"representation.":[163],"Moreover,":[164],"decomposition":[168],"property":[169],"break":[171],"down":[172],"high-dimensional":[173],"into":[176],"multiple":[177],"low-dimensional":[178],"subspaces,":[179],"independently":[181],"specific":[184],"aspect":[185],"These":[189],"subspace":[190],"representations":[191],"are":[192],"then":[193],"systematically":[194],"integrated":[195],"through":[196],"one-dimensional":[198],"function":[199],"that":[200,215],"overlays":[201],"combines":[203],"their":[204],"contributions,":[205],"effectively":[206],"reconstructing":[207],"global":[209],"Experimental":[212],"results":[213],"demonstrate":[214],"model":[218],"outperforms":[219],"other":[220],"classification":[225],"tasks.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1}],"updated_date":"2026-02-07T06:11:34.122080","created_date":"2025-10-10T00:00:00"}