{"id":"https://openalex.org/W4411949397","doi":"https://doi.org/10.1109/jbhi.2025.3584802","title":"Leveraging Vision-Language Embeddings for Zero-Shot Learning in Histopathology Images","display_name":"Leveraging Vision-Language Embeddings for Zero-Shot Learning in Histopathology Images","publication_year":2025,"publication_date":"2025-07-02","ids":{"openalex":"https://openalex.org/W4411949397","doi":"https://doi.org/10.1109/jbhi.2025.3584802","pmid":"https://pubmed.ncbi.nlm.nih.gov/40601464"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2025.3584802","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3584802","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1109/jbhi.2025.3584802","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075100287","display_name":"Md Mamunur Rahaman","orcid":"https://orcid.org/0000-0003-2268-2092"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Md Mamunur Rahaman","raw_affiliation_strings":["School of Computer Science and Engineering, University of New South Wales, Sydney, NSW, Australia","School of Computer Science and Engineering, University of New South Wales, Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0003-2268-2092","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, University of New South Wales, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Computer Science and Engineering, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074720807","display_name":"Ewan K.A. Millar","orcid":"https://orcid.org/0000-0002-9778-3253"},"institutions":[{"id":"https://openalex.org/I1311436738","display_name":"New South Wales Department of Health","ror":"https://ror.org/03tb4gf50","country_code":"AU","type":"government","lineage":["https://openalex.org/I1311436738","https://openalex.org/I2801351115"]},{"id":"https://openalex.org/I4210123059","display_name":"St George Hospital","ror":"https://ror.org/02pk13h45","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210123059"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ewan K. A. Millar","raw_affiliation_strings":["Department of Anatomical Pathology, NSW Health Pathology, St. George Hospital, Sydney, NSW, Australia","Department of Anatomical Pathology, NSW Health Pathology, St. George Hospital, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomical Pathology, NSW Health Pathology, St. George Hospital, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I4210123059","https://openalex.org/I1311436738"]},{"raw_affiliation_string":"Department of Anatomical Pathology, NSW Health Pathology, St. George Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210123059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023548565","display_name":"Erik Meijering","orcid":"https://orcid.org/0000-0001-8015-8358"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Erik Meijering","raw_affiliation_strings":["School of Computer Science and Engineering, University of New South Wales, Sydney, NSW, Australia","School of Computer Science and Engineering, University of New South Wales, Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0001-8015-8358","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, University of New South Wales, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Computer Science and Engineering, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4753,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.92814279,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"30","issue":"1","first_page":"539","last_page":"550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11894","display_name":"Radiology practices and education","score":0.9725000262260437,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11894","display_name":"Radiology practices and education","score":0.9725000262260437,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9549000263214111,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9279000163078308,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6847449541091919},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6044337749481201},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5342442393302917},{"id":"https://openalex.org/keywords/shot","display_name":"Shot (pellet)","score":0.5112693309783936},{"id":"https://openalex.org/keywords/histopathology","display_name":"Histopathology","score":0.49222055077552795},{"id":"https://openalex.org/keywords/zero","display_name":"Zero (linguistics)","score":0.48261603713035583},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.4392507076263428},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.34813225269317627},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13733473420143127},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.10892939567565918}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6847449541091919},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6044337749481201},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5342442393302917},{"id":"https://openalex.org/C2778344882","wikidata":"https://www.wikidata.org/wiki/Q278938","display_name":"Shot (pellet)","level":2,"score":0.5112693309783936},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.49222055077552795},{"id":"https://openalex.org/C2780813799","wikidata":"https://www.wikidata.org/wiki/Q3274237","display_name":"Zero (linguistics)","level":2,"score":0.48261603713035583},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.4392507076263428},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.34813225269317627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13733473420143127},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10892939567565918},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2025.3584802","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3584802","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:40601464","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40601464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1109/jbhi.2025.3584802","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3584802","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W2010792435","https://openalex.org/W2148309496","https://openalex.org/W2194775991","https://openalex.org/W2912354537","https://openalex.org/W2914836117","https://openalex.org/W2963446712","https://openalex.org/W2963460810","https://openalex.org/W3044088237","https://openalex.org/W3128210037","https://openalex.org/W3135547872","https://openalex.org/W3138973186","https://openalex.org/W3159481202","https://openalex.org/W3173220247","https://openalex.org/W3198377975","https://openalex.org/W3206795303","https://openalex.org/W3207797062","https://openalex.org/W3209367260","https://openalex.org/W3212889265","https://openalex.org/W3214733388","https://openalex.org/W4281853941","https://openalex.org/W4287379322","https://openalex.org/W4288809219","https://openalex.org/W4292325804","https://openalex.org/W4296027312","https://openalex.org/W4297095628","https://openalex.org/W4312443924","https://openalex.org/W4312468136","https://openalex.org/W4312747482","https://openalex.org/W4312765357","https://openalex.org/W4317473799","https://openalex.org/W4321201254","https://openalex.org/W4378639300","https://openalex.org/W4385573131","https://openalex.org/W4385948838","https://openalex.org/W4386065596","https://openalex.org/W4386071624","https://openalex.org/W4387199878","https://openalex.org/W4390871773","https://openalex.org/W4390871890","https://openalex.org/W4390872508","https://openalex.org/W4392172801","https://openalex.org/W4392190141","https://openalex.org/W4392947532","https://openalex.org/W4401752139","https://openalex.org/W4402753843","https://openalex.org/W4403089513","https://openalex.org/W4404421211","https://openalex.org/W4414360310"],"related_works":["https://openalex.org/W2074502265","https://openalex.org/W4214877189","https://openalex.org/W3039419443","https://openalex.org/W2773965352","https://openalex.org/W4386772532","https://openalex.org/W2381179799","https://openalex.org/W4393212117","https://openalex.org/W4411535265","https://openalex.org/W2980279061","https://openalex.org/W2334685461"],"abstract_inverted_index":{"Zero-shot":[0],"learning":[1],"(ZSL)":[2],"offers":[3],"tremendous":[4],"potential":[5,178],"for":[6,68],"histopathology":[7,40,70,167],"image":[8,71,97],"analysis,":[9],"enabling":[10],"models":[11],"to":[12,14,39,45,81,130,142,148,179],"generalize":[13],"unseen":[15],"classes":[16],"without":[17,33],"extensive":[18],"labeled":[19],"data.":[20],"Recent":[21],"vision-language":[22],"model":[23],"(VLM)":[24],"advancements":[25],"have":[26],"expanded":[27],"ZSL":[28],"capabilities,":[29],"allowing":[30],"task":[31],"performance":[32,165],"task-specific":[34],"fine-tuning.":[35],"However,":[36],"applying":[37],"VLMs":[38],"presents":[41],"considerable":[42],"challenges":[43],"due":[44],"the":[46,52],"complexity":[47],"of":[48,55],"histopathological":[49],"imagery":[50],"and":[51,85,106,117,126,177],"nuanced":[53],"nature":[54],"diagnostic":[56],"tasks.":[57],"We":[58],"propose":[59],"Multi-Resolution":[60],"Prompt-guided":[61],"Hybrid":[62],"Embedding":[63],"(MR-PHE),":[64],"a":[65,90,113],"novel":[66],"framework":[67],"zero-shot":[69,163],"classification.":[72,156],"MR-PHE":[73,160],"mimics":[74],"pathologists'":[75],"workflow":[76],"through":[77],"multiresolution":[78],"patch":[79,101,136],"extraction":[80],"capture":[82],"key":[83],"cellular":[84],"tissue":[86],"features.":[87],"It":[88],"introduces":[89],"hybrid":[91],"embedding":[92],"strategy":[93],"that":[94],"integrates":[95],"global":[96,107],"embeddings":[98],"with":[99,123],"weighted":[100],"embeddings,":[102,150],"effectively":[103],"combining":[104],"local":[105],"contextual":[108],"information.":[109],"Additionally,":[110],"we":[111],"develop":[112],"comprehensive":[114],"prompt":[115],"generation":[116],"selection":[118],"framework,":[119],"enriching":[120],"class":[121,149],"descriptions":[122],"domain-specific":[124],"synonyms":[125],"clinically":[127],"relevant":[128],"features":[129],"enhance":[131],"semantic":[132],"understanding.":[133],"A":[134],"similarity-based":[135],"weighting":[137],"mechanism":[138],"assigns":[139],"attention-like":[140],"weights":[141],"patches":[143],"based":[144],"on":[145,166],"their":[146],"relevance":[147],"emphasizing":[151],"diagnostically":[152],"important":[153],"regions":[154],"during":[155],"Experimental":[157],"results":[158],"demonstrate":[159],"significantly":[161],"improves":[162],"classification":[164],"datasets,":[168],"often":[169],"surpassing":[170],"fully":[171],"supervised":[172],"models,":[173],"showing":[174],"its":[175],"effectiveness":[176],"advance":[180],"computational":[181],"pathology.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-11T18:08:03.149640","created_date":"2025-10-10T00:00:00"}