{"id":"https://openalex.org/W4410985762","doi":"https://doi.org/10.1109/jbhi.2025.3576436","title":"ADFound: A Foundation Model for Diagnosis and Prognosis of Alzheimer\u2019s Disease","display_name":"ADFound: A Foundation Model for Diagnosis and Prognosis of Alzheimer\u2019s Disease","publication_year":2025,"publication_date":"2025-06-03","ids":{"openalex":"https://openalex.org/W4410985762","doi":"https://doi.org/10.1109/jbhi.2025.3576436","pmid":"https://pubmed.ncbi.nlm.nih.gov/40460008"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2025.3576436","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3576436","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://ira.lib.polyu.edu.hk/bitstream/10397/113627/1/Yang_ADFound_Foundation_Model.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053115879","display_name":"Guangqian Yang","orcid":"https://orcid.org/0000-0001-9990-4058"},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Guangqian Yang","raw_affiliation_strings":["Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China","Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0001-9990-4058","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China","institution_ids":["https://openalex.org/I14243506"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101323907","display_name":"Kangrui Du","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kangrui Du","raw_affiliation_strings":["School of Computational Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA","School of Computational Science and Engineering, Georgia Institute of Technology, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computational Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"School of Computational Science and Engineering, Georgia Institute of Technology, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhihan Yang","orcid":"https://orcid.org/0009-0006-5865-9221"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Zhihan Yang","raw_affiliation_strings":["Department of Computer Science, National University of Singapore, Singapore","4Paradigm Inc., Shanghai, China"],"raw_orcid":"https://orcid.org/0009-0006-5865-9221","affiliations":[{"raw_affiliation_string":"Department of Computer Science, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"4Paradigm Inc., Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100783342","display_name":"Ye Du","orcid":"https://orcid.org/0000-0002-3057-1862"},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ye Du","raw_affiliation_strings":["Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China","Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0002-3057-1862","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China","institution_ids":["https://openalex.org/I14243506"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003263050","display_name":"Eva YW Cheung","orcid":"https://orcid.org/0000-0002-4618-7865"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Eva Yi Wah Cheung","raw_affiliation_strings":["Department of Diagnostic Radiology, School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China","Department of Diagnostic Radiology, School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0002-4618-7865","affiliations":[{"raw_affiliation_string":"Department of Diagnostic Radiology, School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Department of Diagnostic Radiology, School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yongping Zheng","orcid":"https://orcid.org/0000-0002-3407-9226"},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yongping Zheng","raw_affiliation_strings":["Department of Biomedical Engineering and Research Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong SAR, China","Department of Biomedical Engineering and Research Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0002-3407-9226","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Research Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong SAR, China","institution_ids":["https://openalex.org/I14243506"]},{"raw_affiliation_string":"Department of Biomedical Engineering and Research Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong, China","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048057799","display_name":"Mo Yang","orcid":"https://orcid.org/0000-0002-3863-8187"},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Mo Yang","raw_affiliation_strings":["Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China","Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China","institution_ids":["https://openalex.org/I14243506"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054960040","display_name":"Zoe Kourtzi","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zoe Kourtzi","raw_affiliation_strings":["Department of Psychology, University of Cambridge, Cambridgeshire, U.K","Department of Psychology, University of Cambridge, Cambridgeshire, UK"],"raw_orcid":"https://orcid.org/0000-0001-9441-7832","affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Cambridge, Cambridgeshire, U.K","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Psychology, University of Cambridge, Cambridgeshire, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033880300","display_name":"Carola\u2010Bibiane Sch\u00f6nlieb","orcid":"https://orcid.org/0000-0003-0099-6306"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carola-Bibiane Sch\u00f6nlieb","raw_affiliation_strings":["Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridgeshire, U.K","Department of Applied Math- ¨ ematics and Theoretical Physics, University of Cambridge, Cam bridgeshire, UK"],"raw_orcid":"https://orcid.org/0000-0003-0099-6306","affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridgeshire, U.K","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Applied Math- ¨ ematics and Theoretical Physics, University of Cambridge, Cam bridgeshire, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100602079","display_name":"Shujun Wang","orcid":"https://orcid.org/0000-0003-1495-3278"},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Shujun Wang","raw_affiliation_strings":["Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China","Department of Biomedical Engineering and Research Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0003-1495-3278","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China","institution_ids":["https://openalex.org/I14243506"]},{"raw_affiliation_string":"Department of Biomedical Engineering and Research Institute for Smart Ageing, The Hong Kong Polytechnic University, Hong Kong, China","institution_ids":["https://openalex.org/I14243506"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5053115879"],"corresponding_institution_ids":["https://openalex.org/I14243506"],"apc_list":null,"apc_paid":null,"fwci":2.0811,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.87199548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"29","issue":"11","first_page":"8395","last_page":"8408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11714","display_name":"Multimodal Machine Learning Applications","score":0.1671999990940094,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11714","display_name":"Multimodal Machine Learning Applications","score":0.1671999990940094,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11307","display_name":"Domain Adaptation and Few-Shot Learning","score":0.14669999480247498,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10775","display_name":"Generative Adversarial Networks and Image Synthesis","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foundation","display_name":"Foundation (evidence)","score":0.6928118467330933},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.60451340675354},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.43342939019203186},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42442572116851807},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1973574161529541},{"id":"https://openalex.org/keywords/history","display_name":"History","score":0.1446971893310547}],"concepts":[{"id":"https://openalex.org/C2780966255","wikidata":"https://www.wikidata.org/wiki/Q5474306","display_name":"Foundation (evidence)","level":2,"score":0.6928118467330933},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.60451340675354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43342939019203186},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42442572116851807},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1973574161529541},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.1446971893310547},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/jbhi.2025.3576436","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3576436","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:40460008","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40460008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null},{"id":"pmh:oai:ira.lib.polyu.edu.hk:10397/113627","is_oa":true,"landing_page_url":"http://hdl.handle.net/10397/113627","pdf_url":"http://ira.lib.polyu.edu.hk/bitstream/10397/113627/1/Yang_ADFound_Foundation_Model.pdf","source":{"id":"https://openalex.org/S4306400205","display_name":"PolyU Institutional Research Archive (Hong Kong Polytechnic University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I14243506","host_organization_name":"Hong Kong Polytechnic University","host_organization_lineage":["https://openalex.org/I14243506"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal/Magazine Article"}],"best_oa_location":{"id":"pmh:oai:ira.lib.polyu.edu.hk:10397/113627","is_oa":true,"landing_page_url":"http://hdl.handle.net/10397/113627","pdf_url":"http://ira.lib.polyu.edu.hk/bitstream/10397/113627/1/Yang_ADFound_Foundation_Model.pdf","source":{"id":"https://openalex.org/S4306400205","display_name":"PolyU Institutional Research Archive (Hong Kong Polytechnic University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I14243506","host_organization_name":"Hong Kong Polytechnic University","host_organization_lineage":["https://openalex.org/I14243506"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal/Magazine Article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2252064583","display_name":null,"funder_award_id":"C5055-24G","funder_id":"https://openalex.org/F4320322598","funder_display_name":"Hong Kong Polytechnic University"}],"funders":[{"id":"https://openalex.org/F4320322598","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410985762.pdf","grobid_xml":"https://content.openalex.org/works/W4410985762.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,22],"(AD)":[2],"is":[3,89],"an":[4],"incurable":[5],"neurodegenerative":[6],"disorder":[7],"characterized":[8],"by":[9,96,148],"progressive":[10],"cognitive":[11],"and":[12,18,28,43,61,80,117,135,175,197],"functional":[13],"decline.":[14],"Consequently,":[15],"early":[16],"diagnosis":[17,60,196],"accurate":[19],"prediction":[20],"of":[21,25,34,57,73,170,190,199],"progression":[23],"are":[24,40],"paramount":[26],"importance":[27],"inherently":[29],"complex,":[30],"necessitating":[31],"the":[32,49,92,167,195,202],"integration":[33],"multi-modal":[35,51,76,107,119,131,139,171],"data.":[36],"While":[37],"existing":[38],"methods":[39,185],"typically":[41],"task-specific":[42],"lack":[44],"generalization,":[45],"we":[46,122,156],"present":[47],"ADFound,":[48],"first":[50],"foundation":[52,207],"model":[53,208],"for":[54,162],"AD":[55],"capable":[56],"simultaneously":[58],"addressing":[59],"prognosis":[62,198],"tasks":[63,192],"through":[64],"a":[65,70,124,158,187],"unified":[66],"framework.":[67],"ADFound":[68,88,113,182],"leverages":[69],"substantial":[71],"amount":[72],"unlabeled":[74,115],"3D":[75,106],"neuroimaging,":[77],"including":[78],"paired":[79,116],"unpaired":[81],"data,":[82,121,218],"to":[83,100,142,165,194,212],"achieve":[84],"its":[85,220],"objectives.":[86],"Specifically,":[87],"developed":[90],"upon":[91],"Multi-modal":[93,163],"Vim":[94],"encoder":[95],"Vision":[97],"Mamba":[98],"block":[99],"capture":[101],"long-range":[102],"dependencies":[103],"inherent":[104],"in":[105],"medical":[108],"images.":[109],"To":[110],"efficiently":[111],"pre-train":[112],"on":[114],"upaired":[118],"neuroimaging":[120],"proposed":[123],"novel":[125],"self-supervised":[126],"learning":[127],"framework":[128],"that":[129,181,205],"integrates":[130],"masked":[132],"autoencoder":[133],"(MAE)":[134],"contrastive":[136],"learning.":[137],"The":[138],"MAE":[140],"aims":[141],"learn":[143],"local":[144],"relations":[145],"among":[146],"modalities":[147],"reconstructing":[149],"images":[150],"with":[151],"unmasked":[152],"image":[153],"patches.":[154],"Additionally,":[155],"introduce":[157],"Dual":[159],"Contrastive":[160],"Learning":[161],"Data":[164],"enhance":[166],"discriminative":[168],"capabilities":[169],"representations":[172],"from":[173],"intra-modal":[174],"inter-modal":[176],"perspectives.":[177],"Our":[178],"experiments":[179],"demonstrate":[180],"outperforms":[183],"state-of-the-art":[184],"across":[186],"wide":[188],"range":[189],"downstream":[191],"relevant":[193],"AD.":[200],"Furthermore,":[201],"results":[203],"indicate":[204],"our":[206],"can":[209],"be":[210],"extended":[211],"more":[213],"modalities,":[214],"such":[215],"as":[216],"non-image":[217],"showing":[219],"versatility.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-15T08:27:34.491423","created_date":"2025-10-10T00:00:00"}