{"id":"https://openalex.org/W4409580951","doi":"https://doi.org/10.1109/jbhi.2025.3562364","title":"Exploiting Trusted Execution Environments and Distributed Computation for Genomic Association Tests","display_name":"Exploiting Trusted Execution Environments and Distributed Computation for Genomic Association Tests","publication_year":2025,"publication_date":"2025-04-18","ids":{"openalex":"https://openalex.org/W4409580951","doi":"https://doi.org/10.1109/jbhi.2025.3562364","pmid":"https://pubmed.ncbi.nlm.nih.gov/40249680"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2025.3562364","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3562364","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082285724","display_name":"Cl\u00e1udia Brito","orcid":"https://orcid.org/0000-0003-4293-9887"},"institutions":[{"id":"https://openalex.org/I4210166615","display_name":"INESC TEC","ror":"https://ror.org/05fa8ka61","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210125590","https://openalex.org/I4210166615"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Cl\u00e1udia V. Brito","raw_affiliation_strings":["HASLab, INESC TEC &amp; University of Minho, Braga, Portugal","HASLab, INESC TEC &amp; University of Minho, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-4293-9887","affiliations":[{"raw_affiliation_string":"HASLab, INESC TEC &amp; University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543","https://openalex.org/I4210166615"]},{"raw_affiliation_string":"HASLab, INESC TEC &amp; University of Minho, Portugal","institution_ids":["https://openalex.org/I4210166615","https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089291118","display_name":"Pedro G. Ferreira","orcid":"https://orcid.org/0000-0003-3838-8664"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210166615","display_name":"INESC TEC","ror":"https://ror.org/05fa8ka61","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210125590","https://openalex.org/I4210166615"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro G. Ferreira","raw_affiliation_strings":["Department of Computer Science, Faculty of Sciences, University of Porto, Porto, Portugal","Department of Computer Science, Faculty of Sciences, University of Porto and LIAAD, INESC TEC, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-3838-8664","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Faculty of Sciences, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Department of Computer Science, Faculty of Sciences, University of Porto and LIAAD, INESC TEC, Portugal","institution_ids":["https://openalex.org/I4210166615","https://openalex.org/I182534213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054409160","display_name":"Jo\u00e3o Paulo","orcid":"https://orcid.org/0000-0001-9752-2822"},"institutions":[{"id":"https://openalex.org/I4210166615","display_name":"INESC TEC","ror":"https://ror.org/05fa8ka61","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210125590","https://openalex.org/I4210166615"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o T. Paulo","raw_affiliation_strings":["HASLab, INESC TEC &amp; University of Minho, Braga, Portugal","HASLab, INESC TEC &amp; University of Minho, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-9752-2822","affiliations":[{"raw_affiliation_string":"HASLab, INESC TEC &amp; University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543","https://openalex.org/I4210166615"]},{"raw_affiliation_string":"HASLab, INESC TEC &amp; University of Minho, Portugal","institution_ids":["https://openalex.org/I4210166615","https://openalex.org/I99682543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082285724"],"corresponding_institution_ids":["https://openalex.org/I4210166615","https://openalex.org/I99682543"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08279748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"2","first_page":"913","last_page":"920"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11986","display_name":"Scientific Computing and Data Management","score":0.9505000114440918,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11986","display_name":"Scientific Computing and Data Management","score":0.9505000114440918,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.790695309638977},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.500706672668457},{"id":"https://openalex.org/keywords/association-rule-learning","display_name":"Association rule learning","score":0.42485517263412476},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.42043644189834595},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.3887938857078552},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.2211359143257141},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.20775684714317322}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.790695309638977},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.500706672668457},{"id":"https://openalex.org/C193524817","wikidata":"https://www.wikidata.org/wiki/Q386780","display_name":"Association rule learning","level":2,"score":0.42485517263412476},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.42043644189834595},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.3887938857078552},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2211359143257141},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.20775684714317322},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067917","descriptor_name":"Cloud Computing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000067917","descriptor_name":"Cloud Computing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016494","descriptor_name":"Computer Security","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016494","descriptor_name":"Computer Security","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2025.3562364","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3562364","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:40249680","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40249680","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G753383093","display_name":null,"funder_award_id":"10566/BI-M-ED_B2/2023","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W192579163","https://openalex.org/W1981655091","https://openalex.org/W2026938524","https://openalex.org/W2141481372","https://openalex.org/W2173213060","https://openalex.org/W2198130350","https://openalex.org/W2507351359","https://openalex.org/W2542459869","https://openalex.org/W2568218703","https://openalex.org/W2794716113","https://openalex.org/W2801006204","https://openalex.org/W2896938420","https://openalex.org/W2900090083","https://openalex.org/W2915050524","https://openalex.org/W2952870794","https://openalex.org/W3006887636","https://openalex.org/W3010009703","https://openalex.org/W3010061636","https://openalex.org/W3042654233","https://openalex.org/W3094450711","https://openalex.org/W3124225934","https://openalex.org/W3126988667","https://openalex.org/W3135713626","https://openalex.org/W3140171369","https://openalex.org/W3162800482","https://openalex.org/W3195285310","https://openalex.org/W3195593967","https://openalex.org/W3214372523","https://openalex.org/W4282562840","https://openalex.org/W4296551883","https://openalex.org/W4310916456","https://openalex.org/W4379742799","https://openalex.org/W4386609582"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2415164632","https://openalex.org/W2751920613","https://openalex.org/W2238349241","https://openalex.org/W2355668701","https://openalex.org/W2370453500","https://openalex.org/W2392697706","https://openalex.org/W366033468"],"abstract_inverted_index":{"Breakthroughs":[0],"in":[1,104],"sequencing":[2],"technologies":[3],"led":[4],"to":[5,37,69,75,131],"an":[6],"exponential":[7],"growth":[8],"of":[9,23,126],"genomic":[10,57,96],"data,":[11],"providing":[12],"novel":[13],"biological":[14],"insights":[15],"and":[16,44,54,110,124],"therapeutic":[17],"applications.":[18],"However,":[19],"analyzing":[20],"large":[21],"amounts":[22],"sensitive":[24],"data":[25,28,42,97],"raises":[26],"key":[27],"privacy":[29],"concerns,":[30],"specifically":[31],"when":[32],"the":[33,86,90,94,122],"information":[34],"is":[35],"outsourced":[36],"untrusted":[38,76],"third-party":[39],"infrastructures":[40],"for":[41],"storage":[43],"processing":[45],"(e.g.,":[46],"cloud":[47],"computing).":[48],"We":[49],"introduce":[50],"Gyosa,":[51,127],"a":[52,80,108],"secure":[53,109],"privacy-preserving":[55],"distributed":[56,111],"analysis":[58,74],"solution.":[59],"By":[60,99],"leveraging":[61],"trusted":[62],"execution":[63],"environments":[64],"(TEEs),":[65],"Gyosa":[66,78,106],"allows":[67],"users":[68],"confidentially":[70],"delegate":[71],"their":[72],"GWAS":[73,116],"infrastructures.":[77],"implements":[79],"computation":[81,87],"partitioning":[82],"scheme":[83,103],"that":[84,113],"reduces":[85],"done":[88],"inside":[89],"TEEs":[91],"while":[92],"safeguarding":[93],"users'":[95],"privacy.":[98],"integrating":[100],"this":[101],"security":[102,134],"Glow,":[105],"provides":[107],"environment":[112],"facilitates":[114],"diverse":[115],"studies.":[117],"The":[118],"experimental":[119],"evaluation":[120],"validates":[121],"applicability":[123],"scalability":[125],"reinforcing":[128],"its":[129],"ability":[130],"provide":[132],"enhanced":[133],"guarantees.":[135]},"counts_by_year":[],"updated_date":"2026-02-08T09:19:03.324500","created_date":"2025-10-10T00:00:00"}
