{"id":"https://openalex.org/W4404238529","doi":"https://doi.org/10.1109/jbhi.2024.3496495","title":"Biomedical Information Integration via Adaptive Large Language Model Construction","display_name":"Biomedical Information Integration via Adaptive Large Language Model Construction","publication_year":2024,"publication_date":"2024-11-11","ids":{"openalex":"https://openalex.org/W4404238529","doi":"https://doi.org/10.1109/jbhi.2024.3496495","pmid":"https://pubmed.ncbi.nlm.nih.gov/39527417"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2024.3496495","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2024.3496495","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053458745","display_name":"Xingsi Xue","orcid":"https://orcid.org/0000-0002-3008-8782"},"institutions":[{"id":"https://openalex.org/I83791580","display_name":"Fujian University of Technology","ror":"https://ror.org/03c8fdb16","country_code":"CN","type":"education","lineage":["https://openalex.org/I83791580"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xingsi Xue","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Big Data Mining and Applications, Fujian University of Technology, Fuzhou, China","Fujian Provincial Key Laboratory of Big Data Mining and Applications, Fujian University of Technology, Fuzhou, Fujian, China"],"raw_orcid":"https://orcid.org/0000-0002-3008-8782","affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Big Data Mining and Applications, Fujian University of Technology, Fuzhou, China","institution_ids":["https://openalex.org/I83791580"]},{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Big Data Mining and Applications, Fujian University of Technology, Fuzhou, Fujian, China","institution_ids":["https://openalex.org/I83791580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088155157","display_name":"Mu\u2010En Wu","orcid":"https://orcid.org/0000-0002-4839-3849"},"institutions":[{"id":"https://openalex.org/I118292597","display_name":"National Taipei University of Technology","ror":"https://ror.org/00cn92c09","country_code":"TW","type":"education","lineage":["https://openalex.org/I118292597"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Mu-En Wu","raw_affiliation_strings":["Department of Information and Finance Management, National Taipei University of Technology, Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-4839-3849","affiliations":[{"raw_affiliation_string":"Department of Information and Finance Management, National Taipei University of Technology, Taipei, Taiwan","institution_ids":["https://openalex.org/I118292597"]}]},{"author_position":"last","author":{"id":null,"display_name":"Fazlullah Khan","orcid":"https://orcid.org/0000-0002-6002-7024"},"institutions":[{"id":"https://openalex.org/I13591777","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428","country_code":"CN","type":"education","lineage":["https://openalex.org/I13591777","https://openalex.org/I142263535"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fazlullah Khan","raw_affiliation_strings":["School of Computer Science, Faculty of Science and Engineering, University of Nottingham Ningbo China, Ningbo, Zhejiang, China","School of Computer Science, University of Nottingham Ningbo China, Ningbo, Zhejiang, China"],"raw_orcid":"https://orcid.org/0000-0002-6002-7024","affiliations":[{"raw_affiliation_string":"School of Computer Science, Faculty of Science and Engineering, University of Nottingham Ningbo China, Ningbo, Zhejiang, China","institution_ids":["https://openalex.org/I13591777"]},{"raw_affiliation_string":"School of Computer Science, University of Nottingham Ningbo China, Ningbo, Zhejiang, China","institution_ids":["https://openalex.org/I13591777"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053458745"],"corresponding_institution_ids":["https://openalex.org/I83791580"],"apc_list":null,"apc_paid":null,"fwci":0.3106,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66648584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"29","issue":"9","first_page":"6381","last_page":"6394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10028","display_name":"Topic Modeling","score":0.9045000076293945,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10028","display_name":"Topic Modeling","score":0.9045000076293945,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7144996523857117},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.4385421574115753},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.401427686214447},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.33551496267318726}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7144996523857117},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.4385421574115753},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.401427686214447},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.33551496267318726}],"mesh":[{"descriptor_ui":"D000098342","descriptor_name":"Large Language Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098342","descriptor_name":"Large Language Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098342","descriptor_name":"Large Language Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098342","descriptor_name":"Large Language Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098342","descriptor_name":"Large Language Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098426","descriptor_name":"Adaptive Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2024.3496495","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2024.3496495","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:39527417","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39527417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6369165936","display_name":null,"funder_award_id":"62172095","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1513234768","https://openalex.org/W1515763603","https://openalex.org/W1569429022","https://openalex.org/W1571212500","https://openalex.org/W1752649312","https://openalex.org/W2126105956","https://openalex.org/W2250539671","https://openalex.org/W2440300016","https://openalex.org/W2787079105","https://openalex.org/W3011411500","https://openalex.org/W3012000912","https://openalex.org/W3094988667","https://openalex.org/W3095319910","https://openalex.org/W3114757058","https://openalex.org/W3118902969","https://openalex.org/W3128650879","https://openalex.org/W3162462834","https://openalex.org/W3171177851","https://openalex.org/W3207780522","https://openalex.org/W4200466119","https://openalex.org/W4239025696","https://openalex.org/W4242175814","https://openalex.org/W4296312224","https://openalex.org/W4307280064","https://openalex.org/W4311903220","https://openalex.org/W4360898106","https://openalex.org/W4368283499","https://openalex.org/W4379380529","https://openalex.org/W4379802172","https://openalex.org/W4382397550","https://openalex.org/W4387789903","https://openalex.org/W4388129119","https://openalex.org/W4388267487","https://openalex.org/W4389060313","https://openalex.org/W4391840390","https://openalex.org/W4394851557","https://openalex.org/W4398784872","https://openalex.org/W4400679621","https://openalex.org/W4405058948"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W3204019825"],"abstract_inverted_index":{"Integrating":[0],"diverse":[1,66],"biomedical":[2,54,96,117,236],"knowledge":[3],"information":[4],"is":[5,53,164,182],"essential":[6],"to":[7,34,68,99,146,184,218],"enhance":[8],"the":[9,39,116,186,193,220,228,241],"accuracy":[10],"and":[11,20,38,61,104,112,119,149,171,209,215],"efficiency":[12,229],"of":[13,42,121,196,222,230],"medical":[14],"diagnoses,":[15],"facilitate":[16],"personalized":[17],"treatment":[18],"plans,":[19],"ultimately":[21],"improve":[22,192],"patient":[23],"outcomes.":[24],"However,":[25,106],"Biomedical":[26,153],"Information":[27,154],"Integration":[28,155],"(BII)":[29],"faces":[30],"significant":[31],"challenges":[32],"due":[33,98],"variations":[35],"in":[36,51,127,232],"terminology":[37],"complex":[40],"structure":[41],"entity":[43,55,130,204,243],"descriptions":[44],"across":[45,65],"different":[46,107],"datasets.":[47],"A":[48],"critical":[49],"step":[50],"BII":[52],"alignment,":[56],"which":[57,189,238],"involves":[58],"accurately":[59],"identifying":[60],"matching":[62,131,205,244],"equivalent":[63],"entities":[64],"datasets":[67,217],"ensure":[69,124],"seamless":[70],"data":[71,97],"integration.":[72],"In":[73],"recent":[74],"years,":[75],"Large":[76],"Language":[77],"Model":[78],"(LLMs),":[79],"such":[80],"as":[81,90],"Bidirectional":[82],"Encoder":[83],"Representations":[84],"from":[85],"Transformers":[86],"(BERTs),":[87],"have":[88],"emerged":[89],"valuable":[91],"tools":[92],"for":[93,152,166],"discerning":[94],"heterogeneous":[95,129,198,235],"their":[100,125],"deep":[101],"contextual":[102],"embeddings":[103],"bidirectionality.":[105],"LLMs":[108,151],"capture":[109],"various":[110],"nuances":[111],"complexity":[113],"levels":[114],"within":[115],"data,":[118],"none":[120],"them":[122],"can":[123,190],"effectiveness":[126],"all":[128],"tasks.":[132],"To":[133],"address":[134],"this":[135],"issue,":[136],"we":[137],"propose":[138],"a":[139,158,173,179],"novel":[140],"Two-Stage":[141],"LLM":[142],"construction":[143],"(TSLLM)":[144],"framework":[145],"adaptively":[147,233],"select":[148],"combine":[150,185],"(BII).":[156],"First,":[157],"Multi-Objective":[159],"Genetic":[160,175],"Programming":[161],"(MOGP)":[162],"algorithm":[163],"proposed":[165],"generating":[167],"versatile":[168],"high-level":[169],"LLMs,":[170,188],"then,":[172],"Single-Objective":[174],"Algorithm":[176],"(SOGA)":[177],"employs":[178],"confidence-based":[180],"strategy":[181],"presented":[183],"built":[187],"further":[191],"discriminative":[194],"power":[195],"distinguishing":[197],"entities.":[199],"The":[200,224],"experiment":[201],"utilizes":[202],"OAEI's":[203],"datasets,":[206],"i.e.,":[207],"Benchmark":[208],"Conference,":[210],"along":[211],"with":[212],"LargeBio,":[213],"Disease":[214],"Phenotype":[216],"test":[219],"performance":[221],"TSLLM.":[223],"experimental":[225],"findings":[226],"validate":[227],"TSLLM":[231],"differentiating":[234],"entities,":[237],"significantly":[239],"outperforms":[240],"leading":[242],"techniques.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-02T09:04:35.204637","created_date":"2025-10-10T00:00:00"}