{"id":"https://openalex.org/W4401880007","doi":"https://doi.org/10.1109/jbhi.2024.3442468","title":"BIGFormer: A Graph Transformer With Local Structure Awareness for Diagnosis and Pathogenesis Identification of Alzheimer's Disease Using Imaging Genetic Data","display_name":"BIGFormer: A Graph Transformer With Local Structure Awareness for Diagnosis and Pathogenesis Identification of Alzheimer's Disease Using Imaging Genetic Data","publication_year":2024,"publication_date":"2024-08-26","ids":{"openalex":"https://openalex.org/W4401880007","doi":"https://doi.org/10.1109/jbhi.2024.3442468","pmid":"https://pubmed.ncbi.nlm.nih.gov/39186432"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2024.3442468","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2024.3442468","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12239711/pdf/nihms-2046741.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032177649","display_name":"Qi Zou","orcid":"https://orcid.org/0000-0002-8662-5874"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Zou","raw_affiliation_strings":["School of Computer Science, Qufu Normal University, Rizhao, China","School of Control Science and Engineering, Shandong University, Jinan, Shandong, China"],"raw_orcid":"https://orcid.org/0000-0002-8662-5874","affiliations":[{"raw_affiliation_string":"School of Computer Science, Qufu Normal University, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]},{"raw_affiliation_string":"School of Control Science and Engineering, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007539735","display_name":"Junliang Shang","orcid":"https://orcid.org/0000-0002-8488-2228"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junliang Shang","raw_affiliation_strings":["School of Computer Science, Qufu Normal University, Rizhao, China","School of Computer Science at Qufu Normal University, Rizhao, Shandong, China"],"raw_orcid":"https://orcid.org/0000-0002-8488-2228","affiliations":[{"raw_affiliation_string":"School of Computer Science, Qufu Normal University, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]},{"raw_affiliation_string":"School of Computer Science at Qufu Normal University, Rizhao, Shandong, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jin-Xing Liu","orcid":"https://orcid.org/0000-0001-6104-2149"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Xing Liu","raw_affiliation_strings":["School of Computer Science, Qufu Normal University, Rizhao, China","School of Computer Science at Qufu Normal University, Rizhao, Shandong, China"],"raw_orcid":"https://orcid.org/0000-0001-6104-2149","affiliations":[{"raw_affiliation_string":"School of Computer Science, Qufu Normal University, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]},{"raw_affiliation_string":"School of Computer Science at Qufu Normal University, Rizhao, Shandong, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"last","author":{"id":null,"display_name":"Rui Gao","orcid":"https://orcid.org/0000-0002-3599-7678"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Gao","raw_affiliation_strings":["School of Control Science and Engineering, Shandong University, Jinan, China","School of Control Science and Engineering, Shandong University, Jinan, Shandong, China"],"raw_orcid":"https://orcid.org/0000-0002-3599-7678","affiliations":[{"raw_affiliation_string":"School of Control Science and Engineering, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Control Science and Engineering, Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4801,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.61295999,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"29","issue":"1","first_page":"495","last_page":"506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.974399983882904,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.974399983882904,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9416000247001648,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.914900004863739,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5648888349533081},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5536389350891113},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5205063223838806},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"Pathogenesis","score":0.4391267001628876},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4336956739425659},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40458810329437256},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.35580945014953613},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.23584580421447754},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.1711347997188568},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11757400631904602}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5648888349533081},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5536389350891113},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5205063223838806},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4391267001628876},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4336956739425659},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40458810329437256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35580945014953613},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23584580421447754},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.1711347997188568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11757400631904602},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/jbhi.2024.3442468","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2024.3442468","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:39186432","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39186432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12239711","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12239711/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12239711/pdf/nihms-2046741.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE J Biomed Health Inform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12239711","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12239711/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12239711/pdf/nihms-2046741.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE J Biomed Health Inform","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G104586243","display_name":null,"funder_award_id":"U01-AG-024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1298807586","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320327918","funder_display_name":"H. Lundbeck A/S"},{"id":"https://openalex.org/G1593117279","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320309470","funder_display_name":"Meso Scale Diagnostics"},{"id":"https://openalex.org/G1650819308","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320308604","funder_display_name":"Biogen"},{"id":"https://openalex.org/G1880935189","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320327918","funder_display_name":"H. Lundbeck A/S"},{"id":"https://openalex.org/G1999068260","display_name":"Alzheimer's Disease Neuroimaging Initiative","funder_award_id":"3u01ag024904-10s2","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2100670906","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320310388","funder_display_name":"Novartis Pharmaceuticals Corporation"},{"id":"https://openalex.org/G2152643862","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320311551","funder_display_name":"Northern California Institute for Research and Education"},{"id":"https://openalex.org/G2189010064","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G2340207221","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320310045","funder_display_name":"BioClinica"},{"id":"https://openalex.org/G2423387114","display_name":null,"funder_award_id":"W81XWH-12-2\u20130012","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G2471646051","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320327918","funder_display_name":"H. Lundbeck A/S"},{"id":"https://openalex.org/G2522063444","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320332193","funder_display_name":"Genentech"},{"id":"https://openalex.org/G2701527398","display_name":"Alzheimer's Disease Neuroimaging Initiative (ADNI4)","funder_award_id":"5u19ag024904-17","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2835601961","display_name":null,"funder_award_id":"U01AG024904","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G2957681590","display_name":null,"funder_award_id":"U19-AG024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G29951154","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G3131374986","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307115","funder_display_name":"Bristol-Myers Squibb"},{"id":"https://openalex.org/G3216574877","display_name":null,"funder_award_id":"W81XWH-12-2-","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G3553156159","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307115","funder_display_name":"Bristol-Myers Squibb"},{"id":"https://openalex.org/G3710456697","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307758","funder_display_name":"Eli Lilly and Company"},{"id":"https://openalex.org/G3752451908","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320327235","funder_display_name":"Servier"},{"id":"https://openalex.org/G3870774570","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320332193","funder_display_name":"Genentech"},{"id":"https://openalex.org/G3908963977","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4475667458","display_name":null,"funder_award_id":"W81XWH-12-2-","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4501223628","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320329118","funder_display_name":"IXICO"},{"id":"https://openalex.org/G470063782","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4800177743","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320310045","funder_display_name":"BioClinica"},{"id":"https://openalex.org/G5207404921","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G5209990037","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G528601746","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G5365730499","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320308668","funder_display_name":"University of Southern California"},{"id":"https://openalex.org/G5381939979","display_name":"EFFECTS OF TRAUMATIC BRAIN INJURY (TBI) AND POST TRAUMATIC STRESS DISORDER (PTSD) ON ALZHEIMER'S DISEASE (AD) IN VETERANS USING IMAGING AND BIOMARKERS IN THE AD NEUROIMAGING INITIATIVE (ADNI)\"","funder_award_id":"W81XWH1220012","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5654639750","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320310045","funder_display_name":"BioClinica"},{"id":"https://openalex.org/G5740349702","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320309470","funder_display_name":"Meso Scale Diagnostics"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G613619302","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320310388","funder_display_name":"Novartis Pharmaceuticals Corporation"},{"id":"https://openalex.org/G6173816828","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G6210868510","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320308604","funder_display_name":"Biogen"},{"id":"https://openalex.org/G6334930974","display_name":"\u590d\u6742\u75be\u75c5\u5168\u57fa\u56e0\u7ec4SNP\u9ad8\u9636\u4e92\u4f5c\u6a21\u5f0f\u7684\u7f51\u7edc\u6316\u6398\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61972226","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6371410416","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320308604","funder_display_name":"Biogen"},{"id":"https://openalex.org/G6412110892","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320332193","funder_display_name":"Genentech"},{"id":"https://openalex.org/G6447063303","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320309470","funder_display_name":"Meso Scale Diagnostics"},{"id":"https://openalex.org/G6719828067","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320329118","funder_display_name":"IXICO"},{"id":"https://openalex.org/G6792506723","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320307115","funder_display_name":"Bristol-Myers Squibb"},{"id":"https://openalex.org/G72415811","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320311551","funder_display_name":"Northern California Institute for Research and Education"},{"id":"https://openalex.org/G7298697282","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320329118","funder_display_name":"IXICO"},{"id":"https://openalex.org/G764699806","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7799614282","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G781725486","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307758","funder_display_name":"Eli Lilly and Company"},{"id":"https://openalex.org/G7974007073","display_name":null,"funder_award_id":"61902216","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8151151163","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8228018387","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G8281378126","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320327235","funder_display_name":"Servier"},{"id":"https://openalex.org/G839208290","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320310388","funder_display_name":"Novartis Pharmaceuticals Corporation"},{"id":"https://openalex.org/G8852128998","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320327235","funder_display_name":"Servier"},{"id":"https://openalex.org/G8895907669","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G8897063270","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320308668","funder_display_name":"University of Southern California"},{"id":"https://openalex.org/G8957659042","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320307758","funder_display_name":"Eli Lilly and Company"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307132","display_name":"Alzheimer's Drug Discovery Foundation","ror":"https://ror.org/0185drb55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307776","display_name":"Merck","ror":"https://ror.org/02891sr49"},{"id":"https://openalex.org/F4320307779","display_name":"Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320309117","display_name":"AbbVie","ror":"https://ror.org/02g5p4n58"},{"id":"https://openalex.org/F4320309470","display_name":"Meso Scale Diagnostics","ror":"https://ror.org/05jgy0m16"},{"id":"https://openalex.org/F4320309697","display_name":"Alzheimer's Disease Neuroimaging Initiative","ror":"https://ror.org/01j20wc74"},{"id":"https://openalex.org/F4320310045","display_name":"BioClinica","ror":"https://ror.org/03t95yr58"},{"id":"https://openalex.org/F4320310388","display_name":"Novartis Pharmaceuticals Corporation","ror":"https://ror.org/028fhxy95"},{"id":"https://openalex.org/F4320310465","display_name":"Takeda Pharmaceutical Company","ror":"https://ror.org/04hjbmv12"},{"id":"https://openalex.org/F4320311551","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":null},{"id":"https://openalex.org/F4320329118","display_name":"IXICO","ror":"https://ror.org/00paezp73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320332457","display_name":"GE Healthcare","ror":"https://ror.org/03yt24h27"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401880007.pdf"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W2119698875","https://openalex.org/W2144041638","https://openalex.org/W2161633633","https://openalex.org/W2166348468","https://openalex.org/W2317350755","https://openalex.org/W2337323496","https://openalex.org/W2588581329","https://openalex.org/W2786073924","https://openalex.org/W2793804994","https://openalex.org/W2794167820","https://openalex.org/W2799812114","https://openalex.org/W2805257646","https://openalex.org/W2899335103","https://openalex.org/W2907492528","https://openalex.org/W2942489367","https://openalex.org/W2970771711","https://openalex.org/W2973007151","https://openalex.org/W2981153408","https://openalex.org/W2982638646","https://openalex.org/W2991909137","https://openalex.org/W2998710796","https://openalex.org/W3002127012","https://openalex.org/W3003138016","https://openalex.org/W3026137507","https://openalex.org/W3038748576","https://openalex.org/W3094502228","https://openalex.org/W3111341622","https://openalex.org/W3122452030","https://openalex.org/W3125656453","https://openalex.org/W3127597934","https://openalex.org/W3130727496","https://openalex.org/W3134105939","https://openalex.org/W3135491122","https://openalex.org/W3154990320","https://openalex.org/W3158631207","https://openalex.org/W3159530258","https://openalex.org/W3179744756","https://openalex.org/W3184812167","https://openalex.org/W3197290161","https://openalex.org/W3199008037","https://openalex.org/W4205106947","https://openalex.org/W4220861022","https://openalex.org/W4221135625","https://openalex.org/W4223499953","https://openalex.org/W4224325634","https://openalex.org/W4229332226","https://openalex.org/W4229453556","https://openalex.org/W4283725425","https://openalex.org/W4285132881","https://openalex.org/W4286210821","https://openalex.org/W4292649687","https://openalex.org/W4295909205","https://openalex.org/W4306910185","https://openalex.org/W4307846480","https://openalex.org/W4319866156","https://openalex.org/W4385245566","https://openalex.org/W6754929296","https://openalex.org/W6776684981","https://openalex.org/W6810465265","https://openalex.org/W6866662688"],"related_works":["https://openalex.org/W2365906682","https://openalex.org/W2356836538","https://openalex.org/W2388744202","https://openalex.org/W4394738710","https://openalex.org/W2390136389","https://openalex.org/W2370452961","https://openalex.org/W2361179295","https://openalex.org/W2384962392","https://openalex.org/W2417892315","https://openalex.org/W2349363628"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,144],"(AD)":[2],"is":[3,73,103,112],"a":[4,16,53,97,139],"highly":[5],"inheritable":[6],"neurological":[7],"disorder,":[8],"and":[9,63,79,131,164],"brain":[10,77],"imaging":[11],"genetics":[12],"(BIG)":[13],"has":[14],"become":[15],"rapidly":[17],"advancing":[18],"field":[19],"for":[20,60,143],"comprehensive":[21],"understanding":[22],"its":[23],"pathogenesis.":[24],"However,":[25],"most":[26],"of":[27,34,46,65],"the":[28,32,35,69,85,91,119,125,159],"existing":[29],"approaches":[30],"underestimate":[31],"complexity":[33,48],"interactions":[36],"among":[37],"factors":[38,70],"that":[39,150],"cause":[40],"AD.":[41,173],"To":[42],"take":[43],"full":[44],"appreciate":[45],"these":[47],"interactions,":[49],"we":[50],"propose":[51],"BIGFormer,":[52],"graph":[54,72],"Transformer":[55],"with":[56,75,99],"local":[57,100,107,126],"structural":[58],"awareness,":[59],"AD":[61,160],"diagnosis":[62],"identification":[64],"pathogenic":[66],"mechanisms.":[67],"Specifically,":[68],"interaction":[71,92,133],"constructed":[74],"lesion":[76],"regions":[78],"risk":[80],"genes":[81],"as":[82],"nodes,":[83,110],"where":[84],"connection":[86],"between":[87,93],"nodes":[88],"intuitively":[89],"represents":[90],"nodes.":[94],"After":[95],"that,":[96],"perception":[98],"structure":[101,108,127],"awareness":[102],"built":[104],"to":[105,166,172],"extract":[106],"around":[109],"which":[111],"then":[113],"injected":[114],"into":[115,128,138],"node":[116],"representation.":[117],"Then,":[118],"global":[120],"reliance":[121],"inference":[122],"component":[123],"assembles":[124],"higher-order":[129],"structure,":[130],"multi-level":[132],"structures":[134],"are":[135],"jointly":[136],"aggregated":[137],"classification":[140,156],"projection":[141],"head":[142],"state":[145],"prediction.":[146],"Experimental":[147],"results":[148],"show":[149],"BIGFormer":[151],"demonstrated":[152],"superiority":[153],"in":[154],"four":[155],"tasks":[157],"on":[158],"neuroimaging":[161],"initiative":[162],"dataset":[163],"proved":[165],"identify":[167],"biomarkers":[168],"closely":[169],"intimately":[170],"related":[171]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-08-08T07:41:36.138363","created_date":"2025-10-10T00:00:00"}