{"id":"https://openalex.org/W4401163310","doi":"https://doi.org/10.1109/jbhi.2024.3436099","title":"Semi-Supervised Instance Segmentation in Whole Slide Images via Dense Spatial Variability Enhancing","display_name":"Semi-Supervised Instance Segmentation in Whole Slide Images via Dense Spatial Variability Enhancing","publication_year":2024,"publication_date":"2024-07-31","ids":{"openalex":"https://openalex.org/W4401163310","doi":"https://doi.org/10.1109/jbhi.2024.3436099","pmid":"https://pubmed.ncbi.nlm.nih.gov/39083392"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2024.3436099","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2024.3436099","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001205723","display_name":"Jiahui Yu","orcid":"https://orcid.org/0000-0003-1314-2481"},"institutions":[{"id":"https://openalex.org/I4391767668","display_name":"State Key Laboratory of Modern Optical Instruments","ror":"https://ror.org/018fpas51","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767668","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahui Yu","raw_affiliation_strings":["Department of Biomedical Engineering, MOE Key Laboratory of Biomedical Engineering, State Key Laboratory of Modern Optical Instrumentation, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, MOE Key Laboratory of Biomedical Engineering, State Key Laboratory of Modern Optical Instrumentation, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4391767668","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070211309","display_name":"Tianyu Ma","orcid":"https://orcid.org/0000-0002-2326-5760"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyu Ma","raw_affiliation_strings":["Innovation Center for Smart Medical Technologies and Devices, Binjiang Institute of Zhejiang University, Hangzhou, China","Innovation Center for Smart Medical Technologies & Devices, Binjiang Institute of Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Center for Smart Medical Technologies and Devices, Binjiang Institute of Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Center for Smart Medical Technologies & Devices, Binjiang Institute of Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102213164","display_name":"Hua Dong","orcid":"https://orcid.org/0000-0002-3543-8796"},"institutions":[{"id":"https://openalex.org/I4210108177","display_name":"Zhejiang Police College","ror":"https://ror.org/01rxaf991","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210108177"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Hua","raw_affiliation_strings":["Zhejiang Police College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Police College, Hangzhou, China","institution_ids":["https://openalex.org/I4210108177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769711","display_name":"Feng Chen","orcid":"https://orcid.org/0000-0003-0756-1700"},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Chen","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China","Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576"]},{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210166576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066999889","display_name":"Junfen Fu","orcid":"https://orcid.org/0000-0001-6405-1251"},"institutions":[{"id":"https://openalex.org/I4210113495","display_name":"Children's Hospital of Zhejiang University","ror":"https://ror.org/025fyfd20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113495"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfen Fu","raw_affiliation_strings":["Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou, China","Department of Endocrinology, National Clinical Research Center for Children's Health, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou, China","institution_ids":["https://openalex.org/I4210113495"]},{"raw_affiliation_string":"Department of Endocrinology, National Clinical Research Center for Children's Health, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210113495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008781594","display_name":"Yingke Xu","orcid":"https://orcid.org/0000-0002-8317-0608"},"institutions":[{"id":"https://openalex.org/I4391767668","display_name":"State Key Laboratory of Modern Optical Instruments","ror":"https://ror.org/018fpas51","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767668","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingke Xu","raw_affiliation_strings":["Department of Biomedical Engineering, MOE Key Laboratory of Biomedical Engineering, State Key Laboratory of Modern Optical Instrumentation, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-8317-0608","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, MOE Key Laboratory of Biomedical Engineering, State Key Laboratory of Modern Optical Instrumentation, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4391767668","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5325,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.82667324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"29","issue":"12","first_page":"9073","last_page":"9083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12111","display_name":"Industrial Vision Systems and Defect Detection","score":0.9760000109672546,"subfield":{"id":"https://openalex.org/subfields/2209","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12111","display_name":"Industrial Vision Systems and Defect Detection","score":0.9760000109672546,"subfield":{"id":"https://openalex.org/subfields/2209","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.973800003528595,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12549","display_name":"Image and Object Detection Techniques","score":0.9735000133514404,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6620587706565857},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6494845747947693},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6438271999359131},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5763123631477356},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5271068811416626},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5076242685317993}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6620587706565857},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6494845747947693},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6438271999359131},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5763123631477356},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5271068811416626},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5076242685317993}],"mesh":[{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2024.3436099","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2024.3436099","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:39083392","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39083392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1428309924","display_name":null,"funder_award_id":"226-2024-00059","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W2288892845","https://openalex.org/W2964227007","https://openalex.org/W3007464329","https://openalex.org/W3106546328","https://openalex.org/W3107410755","https://openalex.org/W3113410735","https://openalex.org/W3172949220","https://openalex.org/W3186275964","https://openalex.org/W3197957534","https://openalex.org/W3204269530","https://openalex.org/W3207797062","https://openalex.org/W4292325804","https://openalex.org/W4293057377","https://openalex.org/W4307093169","https://openalex.org/W4311287567","https://openalex.org/W4312429056","https://openalex.org/W4360770906","https://openalex.org/W4365450264","https://openalex.org/W4366750994","https://openalex.org/W4367397193","https://openalex.org/W4376127444","https://openalex.org/W4381716343","https://openalex.org/W4385151899","https://openalex.org/W4385267483","https://openalex.org/W4385652395","https://openalex.org/W4386066020","https://openalex.org/W4386071535","https://openalex.org/W4386071792","https://openalex.org/W4386071966","https://openalex.org/W4386076346","https://openalex.org/W4386083213","https://openalex.org/W4386321913","https://openalex.org/W4386634600","https://openalex.org/W4386883045","https://openalex.org/W4387211383","https://openalex.org/W4387211614","https://openalex.org/W4403069564"],"related_works":["https://openalex.org/W2058170566","https://openalex.org/W2755342338","https://openalex.org/W2772917594","https://openalex.org/W2775347418","https://openalex.org/W2166024367","https://openalex.org/W3116076068","https://openalex.org/W2229312674","https://openalex.org/W2951359407","https://openalex.org/W2079911747","https://openalex.org/W1969923398"],"abstract_inverted_index":{"Current":[0],"whole":[1],"slide":[2],"image":[3],"(WSI)":[4],"segmentation":[5,39,80,134,150],"aims":[6],"at":[7],"extracting":[8],"tumor":[9,18],"regions":[10],"from":[11],"the":[12,62,70,83,88,115],"background.":[13],"Unlike":[14],"this,":[15],"segmenting":[16],"distinct":[17],"areas":[19],"(instances)":[20],"within":[21],"a":[22,45,79],"WSI":[23],"driven":[24,54],"by":[25,55,96,152],"limited":[26],"annotated":[27,145],"data":[28],"remains":[29],"under-explored.":[30],"In":[31,82],"this":[32,107],"paper,":[33],"we":[34,59,85],"formally":[35],"propose":[36],"semi-supervised":[37],"instance":[38,133],"(Semi-IS)":[40],"in":[41,130],"WSIs.":[42],"We":[43,73,98,109],"address":[44,106],"key":[46],"challenge:":[47],"learning":[48,76],"intra-class":[49],"similarity":[50],"and":[51,101,117,123],"inter-class":[52],"dissimilarity":[53],"unlabeled":[56],"data.":[57,146],"Specifically,":[58],"generally":[60],"perceive":[61],"patch":[63,71],"as":[64],"composed":[65],"of":[66,90,119],"tokens":[67],"(together),":[68],"not":[69],"alone.":[72],"employ":[74],"contrastive":[75],"to":[77,105,113],"develop":[78],"framework.":[81],"Semi-IS,":[84,120],"find":[86],"that":[87,129],"boundaries":[89],"segmented":[91],"instances":[92],"are":[93],"usually":[94],"disturbed":[95],"noise.":[97],"jointly":[99],"eliminate":[100],"preserve":[102],"noise":[103],"features":[104],"problem.":[108],"conduct":[110],"extensive":[111],"experiments":[112],"evaluate":[114],"effectiveness":[116],"generalizability":[118],"including":[121],"histopathology":[122],"cellular":[124],"pathology.":[125],"The":[126],"results":[127,141],"show":[128],"clinical":[131],"multi":[132],"tasks,":[135],"Semi-IS":[136,147],"achieves":[137],"almost":[138],"full-supervised":[139],"state-of-the-art":[140],"with":[142],"only":[143],"30%":[144],"can":[148],"improve":[149],"accuracy":[151],"about":[153],"2%":[154],"on":[155],"public":[156],"cell":[157],"pathology":[158],"datasets.":[159]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}