{"id":"https://openalex.org/W4391147893","doi":"https://doi.org/10.1109/jbhi.2024.3357453","title":"HOPE: Hybrid-Granularity Ordinal Prototype Learning for Progression Prediction of Mild Cognitive Impairment","display_name":"HOPE: Hybrid-Granularity Ordinal Prototype Learning for Progression Prediction of Mild Cognitive Impairment","publication_year":2024,"publication_date":"2024-01-23","ids":{"openalex":"https://openalex.org/W4391147893","doi":"https://doi.org/10.1109/jbhi.2024.3357453","pmid":"https://pubmed.ncbi.nlm.nih.gov/38261490"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2024.3357453","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2024.3357453","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2401.10966","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100369511","display_name":"Chenhui Wang","orcid":"https://orcid.org/0009-0000-0799-7606"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210164150","display_name":"Shanghai Center for Brain Science and Brain-Inspired Technology","ror":"https://ror.org/0551a0y31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210164150"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenhui Wang","raw_affiliation_strings":["Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0009-0000-0799-7606","affiliations":[{"raw_affiliation_string":"Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I4210164150","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055003565","display_name":"Yiming Lei","orcid":"https://orcid.org/0000-0002-1349-7074"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Lei","raw_affiliation_strings":["Shanghai Key Lab of Intelligent Information Processing, School of Computer Science, Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-1349-7074","affiliations":[{"raw_affiliation_string":"Shanghai Key Lab of Intelligent Information Processing, School of Computer Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tao Chen","orcid":"https://orcid.org/0009-0002-4305-5960"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210164150","display_name":"Shanghai Center for Brain Science and Brain-Inspired Technology","ror":"https://ror.org/0551a0y31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210164150"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Chen","raw_affiliation_strings":["Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0009-0002-4305-5960","affiliations":[{"raw_affiliation_string":"Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I4210164150","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100696429","display_name":"Junping Zhang","orcid":"https://orcid.org/0000-0002-5924-3360"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junping Zhang","raw_affiliation_strings":["Shanghai Key Lab of Intelligent Information Processing, School of Computer Science, Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-5924-3360","affiliations":[{"raw_affiliation_string":"Shanghai Key Lab of Intelligent Information Processing, School of Computer Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321622","display_name":"Yuxin Li","orcid":"https://orcid.org/0000-0003-2107-6744"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxin Li","raw_affiliation_strings":["Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0003-2107-6744","affiliations":[{"raw_affiliation_string":"Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I4210159575","https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049086157","display_name":"Hongming Shan","orcid":"https://orcid.org/0000-0002-0604-3197"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210164150","display_name":"Shanghai Center for Brain Science and Brain-Inspired Technology","ror":"https://ror.org/0551a0y31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210164150"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongming Shan","raw_affiliation_strings":["Institute of Science and Technology for Brain-inspired Intelligence and MOE Frontiers Center for Brain Science and Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Ministry of Education, Fudan University, Shanghai, China","Shanghai Center for Brain Science and Brain-inspired Technology, Shanghai, China","Institute of Science and Technology for Brain-inspired Intelligence and MOE Frontiers Center for Brain Science and Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Ministry of Education), Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-0604-3197","affiliations":[{"raw_affiliation_string":"Institute of Science and Technology for Brain-inspired Intelligence and MOE Frontiers Center for Brain Science and Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Ministry of Education, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I4210164150"]},{"raw_affiliation_string":"Shanghai Center for Brain Science and Brain-inspired Technology, Shanghai, China","institution_ids":["https://openalex.org/I4210164150"]},{"raw_affiliation_string":"Institute of Science and Technology for Brain-inspired Intelligence and MOE Frontiers Center for Brain Science and Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Ministry of Education), Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I4210164150","https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1547,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.94368914,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"28","issue":"11","first_page":"6429","last_page":"6440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9760000109672546,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9760000109672546,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.9605000019073486,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9434999823570251,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.9091745615005493},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.6967185735702515},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6745343208312988},{"id":"https://openalex.org/keywords/overfitting","display_name":"Overfitting","score":0.6723192930221558},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5741665363311768},{"id":"https://openalex.org/keywords/granularity","display_name":"Granularity","score":0.5498967170715332},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5302333831787109},{"id":"https://openalex.org/keywords/class","display_name":"Class (philosophy)","score":0.5176061391830444},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.4900587797164917},{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.41545528173446655},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.32390886545181274},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1811279058456421},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.12708258628845215}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.9091745615005493},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.6967185735702515},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6745343208312988},{"id":"https://openalex.org/C22019652","wikidata":"https://www.wikidata.org/wiki/Q331309","display_name":"Overfitting","level":3,"score":0.6723192930221558},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5741665363311768},{"id":"https://openalex.org/C177774035","wikidata":"https://www.wikidata.org/wiki/Q1246948","display_name":"Granularity","level":2,"score":0.5498967170715332},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5302333831787109},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.5176061391830444},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4900587797164917},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.41545528173446655},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.32390886545181274},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1811279058456421},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.12708258628845215},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/jbhi.2024.3357453","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2024.3357453","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:38261490","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38261490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null},{"id":"pmh:oai:arXiv.org:2401.10966","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2401.10966","pdf_url":"https://arxiv.org/pdf/2401.10966","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2401.10966","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2401.10966","pdf_url":"https://arxiv.org/pdf/2401.10966","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.7200000286102295,"id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G1131972899","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7693164944","display_name":null,"funder_award_id":"U24 AG072122","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391147893.pdf","grobid_xml":"https://content.openalex.org/works/W4391147893.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1434354835","https://openalex.org/W1677182931","https://openalex.org/W1821462560","https://openalex.org/W1968698114","https://openalex.org/W2010176747","https://openalex.org/W2081164888","https://openalex.org/W2121359844","https://openalex.org/W2122328291","https://openalex.org/W2127384340","https://openalex.org/W2144631174","https://openalex.org/W2148046162","https://openalex.org/W2152163581","https://openalex.org/W2168845544","https://openalex.org/W2187089797","https://openalex.org/W2298887234","https://openalex.org/W2386192529","https://openalex.org/W2440214111","https://openalex.org/W2580596898","https://openalex.org/W2593468621","https://openalex.org/W2737181152","https://openalex.org/W2752782242","https://openalex.org/W2798054687","https://openalex.org/W2806183416","https://openalex.org/W2891951760","https://openalex.org/W2902874468","https://openalex.org/W2910327763","https://openalex.org/W2916257687","https://openalex.org/W2929753309","https://openalex.org/W2962858109","https://openalex.org/W2963524571","https://openalex.org/W2973007151","https://openalex.org/W2992274074","https://openalex.org/W2992827186","https://openalex.org/W2995194170","https://openalex.org/W3000959322","https://openalex.org/W3023079706","https://openalex.org/W3025729836","https://openalex.org/W3034941949","https://openalex.org/W3041479049","https://openalex.org/W3047901047","https://openalex.org/W3099325804","https://openalex.org/W3128525963","https://openalex.org/W3130956902","https://openalex.org/W3141232563","https://openalex.org/W3170883289","https://openalex.org/W3172917901","https://openalex.org/W3212256035","https://openalex.org/W3213192039","https://openalex.org/W3214379748","https://openalex.org/W4206237889","https://openalex.org/W4206353576","https://openalex.org/W4212839184","https://openalex.org/W4214813080","https://openalex.org/W4214938808","https://openalex.org/W4220739453","https://openalex.org/W4241074797","https://openalex.org/W4243865866","https://openalex.org/W4247665917","https://openalex.org/W4281723345","https://openalex.org/W4281945262","https://openalex.org/W4283716850","https://openalex.org/W4287254563","https://openalex.org/W4288514409","https://openalex.org/W4293372361","https://openalex.org/W4295312788","https://openalex.org/W4304148444","https://openalex.org/W4305000041","https://openalex.org/W4309845474","https://openalex.org/W4312749457","https://openalex.org/W4312823383","https://openalex.org/W4317438147","https://openalex.org/W4317940091","https://openalex.org/W4364385324","https://openalex.org/W4367174198","https://openalex.org/W4378697095","https://openalex.org/W4382469095","https://openalex.org/W4386362681","https://openalex.org/W4387211275","https://openalex.org/W4387211589","https://openalex.org/W4387211596","https://openalex.org/W4388785253","https://openalex.org/W4390872651","https://openalex.org/W6638523607","https://openalex.org/W6678280795","https://openalex.org/W6685449024","https://openalex.org/W6752523896","https://openalex.org/W6761274798","https://openalex.org/W6766978945","https://openalex.org/W6789954222","https://openalex.org/W6803494062","https://openalex.org/W6838596489","https://openalex.org/W6846271418","https://openalex.org/W6848367531","https://openalex.org/W6849422177"],"related_works":["https://openalex.org/W4362597605","https://openalex.org/W1574414179","https://openalex.org/W2905433371","https://openalex.org/W3009056573","https://openalex.org/W4297676672","https://openalex.org/W2922073769","https://openalex.org/W4281702477","https://openalex.org/W3112714922","https://openalex.org/W3040691452","https://openalex.org/W4388685194"],"abstract_inverted_index":{"Mild":[0],"cognitive":[1,81],"impairment":[2],"(MCI)":[3],"is":[4,55],"often":[5],"at":[6],"high":[7],"risk":[8],"of":[9,136,168,187],"progression":[10,104,107,118],"to":[11,17,43,65,100,131,149,163],"Alzheimer's":[12],"disease":[13],"(AD).":[14],"Existing":[15],"works":[16],"identify":[18],"the":[19,59,133,151,165,176,180,185,188],"progressive":[20],"MCI":[21,25,31,39,52,106],"(pMCI)":[22],"typically":[23],"require":[24],"subtype":[26,53],"labels,":[27],"pMCI":[28],"vs.":[29],"stable":[30],"(sMCI),":[32],"determined":[33],"by":[34,75,120],"whether":[35],"or":[36],"not":[37],"an":[38,84,112,158],"patient":[40],"will":[41],"progress":[42],"AD":[44,88,102,137,171],"after":[45],"a":[46,92,126],"long":[47],"follow-up.":[48],"However,":[49],"prospectively":[50],"acquiring":[51],"data":[54],"time-consuming":[56],"and":[57,68,80,145,170,179],"resource-intensive;":[58],"resultant":[60],"small":[61],"datasets":[62,183],"could":[63],"lead":[64],"severe":[66],"overfitting":[67],"difficulty":[69],"in":[70],"extracting":[71],"discriminative":[72],"information.":[73],"Inspired":[74],"that":[76,116],"various":[77],"longitudinal":[78],"biomarkers":[79],"measurements":[82],"present":[83],"ordinal":[85,103,113,129,134],"pathway":[86],"on":[87,175],"progression,":[89],"we":[90],"propose":[91],"novel":[93,127],"Hybrid-granularity":[94],"Ordinal":[95],"PrototypE":[96],"learning":[97,153],"(HOPE)":[98],"method":[99],"characterize":[101],"for":[105],"prediction.":[108],"First,":[109],"HOPE":[110,124,156,190],"learns":[111],"metric":[114],"space":[115],"enables":[117],"prediction":[119],"prototype":[121,152],"comparison.":[122],"Second,":[123],"leverages":[125],"hybrid-granularity":[128],"loss":[130],"learn":[132,164],"nature":[135],"via":[138],"effectively":[139],"integrating":[140],"instance-to-instance":[141],"ordinality,":[142],"instance-to-class":[143],"compactness,":[144],"class-to-class":[146],"separation.":[147],"Third,":[148],"make":[150],"more":[154],"stable,":[155],"employs":[157],"exponential":[159],"moving":[160],"average":[161],"strategy":[162],"global":[166],"prototypes":[167],"NC":[169],"dynamically.":[172],"Experimental":[173],"results":[174],"internal":[177],"ADNI":[178],"external":[181],"NACC":[182],"demonstrate":[184],"superiority":[186],"proposed":[189],"over":[191],"existing":[192],"state-of-the-art":[193],"methods":[194],"as":[195,197],"well":[196],"its":[198],"interpretability.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4}],"updated_date":"2026-07-20T07:56:41.581041","created_date":"2025-10-10T00:00:00"}