{"id":"https://openalex.org/W4388756595","doi":"https://doi.org/10.1109/jbhi.2023.3333828","title":"CellDialog: A Computational Framework for Ligand-Receptor-Mediated Cell-Cell Communication Analysis","display_name":"CellDialog: A Computational Framework for Ligand-Receptor-Mediated Cell-Cell Communication Analysis","publication_year":2023,"publication_date":"2023-11-17","ids":{"openalex":"https://openalex.org/W4388756595","doi":"https://doi.org/10.1109/jbhi.2023.3333828","pmid":"https://pubmed.ncbi.nlm.nih.gov/37976192"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2023.3333828","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2023.3333828","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007339758","display_name":"Lihong Peng","orcid":"https://orcid.org/0000-0002-2321-3901"},"institutions":[{"id":"https://openalex.org/I49934816","display_name":"Hunan University of Technology","ror":"https://ror.org/04j3vr751","country_code":"CN","type":"education","lineage":["https://openalex.org/I49934816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lihong Peng","raw_affiliation_strings":["College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou, Hunan, China"],"raw_orcid":"https://orcid.org/0000-0002-2321-3901","affiliations":[{"raw_affiliation_string":"College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I49934816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101841833","display_name":"Wei Xiong","orcid":"https://orcid.org/0009-0004-9887-049X"},"institutions":[{"id":"https://openalex.org/I49934816","display_name":"Hunan University of Technology","ror":"https://ror.org/04j3vr751","country_code":"CN","type":"education","lineage":["https://openalex.org/I49934816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xiong","raw_affiliation_strings":["School of Computer Science, Hunan University of Technology, Zhuzhou, Hunan, China"],"raw_orcid":"https://orcid.org/0009-0004-9887-049X","affiliations":[{"raw_affiliation_string":"School of Computer Science, Hunan University of Technology, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I49934816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053680321","display_name":"Chendi Han","orcid":"https://orcid.org/0009-0005-6037-2724"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chendi Han","raw_affiliation_strings":["School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China"],"raw_orcid":"https://orcid.org/0009-0005-6037-2724","affiliations":[{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101725945","display_name":"Zejun Li","orcid":"https://orcid.org/0000-0002-8751-9387"},"institutions":[{"id":"https://openalex.org/I96478251","display_name":"Hunan Institute of Technology","ror":"https://ror.org/04n3k2k71","country_code":"CN","type":"education","lineage":["https://openalex.org/I96478251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zejun Li","raw_affiliation_strings":["School of Computer Science, Hunan Institute of Technology, Hengyang, China"],"raw_orcid":"https://orcid.org/0000-0002-8751-9387","affiliations":[{"raw_affiliation_string":"School of Computer Science, Hunan Institute of Technology, Hengyang, China","institution_ids":["https://openalex.org/I96478251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036210249","display_name":"Xing Chen","orcid":"https://orcid.org/0000-0001-9028-5342"},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Chen","raw_affiliation_strings":["School of Science, Jiangnan University, Wuxi, China"],"raw_orcid":"https://orcid.org/0000-0001-9028-5342","affiliations":[{"raw_affiliation_string":"School of Science, Jiangnan University, Wuxi, China","institution_ids":["https://openalex.org/I111599522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.2738,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.98736077,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"28","issue":"1","first_page":"580","last_page":"591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.7041390538215637},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7033323645591736},{"id":"https://openalex.org/keywords/communication-source","display_name":"Communication source","score":0.6708207726478577},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.4802949130535126},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.4354323744773865},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.41746094822883606},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36007165908813477},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.234056293964386},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.18388810753822327},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.11423727869987488}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.7041390538215637},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7033323645591736},{"id":"https://openalex.org/C198104137","wikidata":"https://www.wikidata.org/wiki/Q974688","display_name":"Communication source","level":2,"score":0.6708207726478577},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4802949130535126},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.4354323744773865},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.41746094822883606},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36007165908813477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.234056293964386},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.18388810753822327},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11423727869987488},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2023.3333828","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2023.3333828","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:37976192","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37976192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3220252743","display_name":"\u57fa\u4e8e\u56fe\u4e0e\u7ec4\u5408\u4f18\u5316\u7684\u751f\u7269\u6570\u636e\u548c\u7f51\u7edc\u6570\u636e\u6316\u6398\u7b97\u6cd5\u7814\u7a76","funder_award_id":"11931008","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4031356638","display_name":null,"funder_award_id":"61803151","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G487486546","display_name":null,"funder_award_id":"92370131","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G579333840","display_name":"\u57fa\u4e8e\u591a\u6e90\u6570\u636e\u878d\u5408\u7684\u836f\u7269\u54cd\u5e94\u548c\u836f\u7269\u76f8\u5173\u975e\u7f16\u7801RNA\u9776\u70b9\u9884\u6d4b\u7814\u7a76","funder_award_id":"61972399","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G632310686","display_name":null,"funder_award_id":"62172158","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1016059894","https://openalex.org/W2016987827","https://openalex.org/W2035503835","https://openalex.org/W2053174787","https://openalex.org/W2070602352","https://openalex.org/W2104919659","https://openalex.org/W2117513900","https://openalex.org/W2135344118","https://openalex.org/W2140095548","https://openalex.org/W2167980479","https://openalex.org/W2170564629","https://openalex.org/W2309770165","https://openalex.org/W2332292689","https://openalex.org/W2340409592","https://openalex.org/W2772424778","https://openalex.org/W2783252067","https://openalex.org/W2793168264","https://openalex.org/W2906881526","https://openalex.org/W2908139053","https://openalex.org/W2915536738","https://openalex.org/W2920615695","https://openalex.org/W2949225171","https://openalex.org/W2949471597","https://openalex.org/W2950389803","https://openalex.org/W2962001321","https://openalex.org/W2975507539","https://openalex.org/W2981350712","https://openalex.org/W2992151131","https://openalex.org/W3007935255","https://openalex.org/W3009797991","https://openalex.org/W3011443213","https://openalex.org/W3012498554","https://openalex.org/W3022836409","https://openalex.org/W3026876979","https://openalex.org/W3032266082","https://openalex.org/W3044145717","https://openalex.org/W3092318937","https://openalex.org/W3094645479","https://openalex.org/W3099810371","https://openalex.org/W3107527779","https://openalex.org/W3114457750","https://openalex.org/W3123592252","https://openalex.org/W3130232612","https://openalex.org/W3132661792","https://openalex.org/W3132704218","https://openalex.org/W3133453494","https://openalex.org/W3136918052","https://openalex.org/W3138055079","https://openalex.org/W3155546248","https://openalex.org/W3163061470","https://openalex.org/W3170959707","https://openalex.org/W3172441129","https://openalex.org/W3184931457","https://openalex.org/W3201642687","https://openalex.org/W3202143517","https://openalex.org/W3202711716","https://openalex.org/W3205475594","https://openalex.org/W4200144569","https://openalex.org/W4206140576","https://openalex.org/W4221038504","https://openalex.org/W4281716326","https://openalex.org/W4283588821","https://openalex.org/W4283592141","https://openalex.org/W4285092846","https://openalex.org/W4293049961","https://openalex.org/W4306404361","https://openalex.org/W4312094047","https://openalex.org/W4313561039","https://openalex.org/W4322754494","https://openalex.org/W4377231491","https://openalex.org/W4380370418","https://openalex.org/W4386162834","https://openalex.org/W4386575275","https://openalex.org/W4387583204","https://openalex.org/W6680012447","https://openalex.org/W6757519749","https://openalex.org/W6760634923","https://openalex.org/W6775769155","https://openalex.org/W6779238151"],"related_works":["https://openalex.org/W2993833576","https://openalex.org/W2776877297","https://openalex.org/W3125718803","https://openalex.org/W2127920220","https://openalex.org/W3119288169","https://openalex.org/W2945097178","https://openalex.org/W4388741024","https://openalex.org/W3122953031","https://openalex.org/W3123743600","https://openalex.org/W4320855289"],"abstract_inverted_index":{"Intercellular":[0],"communication":[1,12,26,42,98,142],"significantly":[2],"influences":[3],"tumor":[4],"progression,":[5],"metastasis,":[6],"and":[7,23,35,65,70,84,104,114,120,137],"therapy":[8],"resistance.":[9],"An":[10],"intercellular":[11,25,41,55,97,129,141,155],"inference":[13],"method":[14],"includes":[15],"two":[16],"main":[17],"procedures:":[18],"ligand-receptor":[19],"interaction":[20],"(LRI)":[21],"curation":[22],"LRI-mediated":[24,96],"strength":[27,99],"measurement.":[28],"The":[29],"construction":[30],"of":[31,63,112],"a":[32,47,89,134,148],"comprehensive,":[33],"high-confident":[34,76],"well-organized":[36],"LRI":[37,79,102],"database":[38],"contributes":[39],"to":[40,52,93,153],"inference.":[43],"Here,":[44],"we":[45],"developed":[46],"computational":[48],"framework":[49],"named":[50],"CellDialog":[51,73,87,113,125,132,146],"reconstruct":[53],"an":[54],"connectivity":[56],"network":[57,138],"based":[58],"on":[59],"the":[60,95,115],"combined":[61],"expression":[62],"ligands":[64],"receptors":[66],"involved":[67],"in":[68],"sender":[69],"receiver":[71],"cells.":[72],"first":[74],"captures":[75],"LRIs":[77],"through":[78],"feature":[80,82],"extraction,":[81],"selection,":[83],"classification.":[85],"Furthermore,":[86],"uses":[88],"three-point":[90],"estimation":[91],"approach":[92],"measure":[94],"by":[100],"combining":[101],"filtering":[103],"single-cell":[105],"RNA":[106],"sequencing":[107],"data.":[108],"A":[109],"comparison":[110],"analysis":[111],"other":[116],"tools":[117],"was":[118,122],"conducted,":[119],"it":[121],"found":[123],"that":[124,150],"can":[126],"efficiently":[127],"decode":[128],"communications.":[130],"Additionally,":[131],"offers":[133],"heatmap":[135],"view":[136,139],"for":[140],"visualization.":[143],"In":[144],"summary,":[145],"provides":[147],"tool":[149],"allows":[151],"researchers":[152],"analyze":[154],"signal":[156],"transduction.":[157],"It":[158],"is":[159],"freely":[160],"available":[161],"at":[162],"https://github.com/plhhnu/CellDialog.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2023-11-18T00:00:00"}