{"id":"https://openalex.org/W4386857837","doi":"https://doi.org/10.1109/jbhi.2023.3317272","title":"scMIC: A Deep Multi-Level Information Fusion Framework for Clustering Single-Cell Multi-Omics Data","display_name":"scMIC: A Deep Multi-Level Information Fusion Framework for Clustering Single-Cell Multi-Omics Data","publication_year":2023,"publication_date":"2023-09-19","ids":{"openalex":"https://openalex.org/W4386857837","doi":"https://doi.org/10.1109/jbhi.2023.3317272","pmid":"https://pubmed.ncbi.nlm.nih.gov/37725723"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2023.3317272","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2023.3317272","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009537698","display_name":"Youlin Zhan","orcid":"https://orcid.org/0009-0009-5676-4820"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210104064","display_name":"Shenzhen Academy of Robotics","ror":"https://ror.org/01h027j09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210104064"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youlin Zhan","raw_affiliation_strings":["State Key Laboratory of Radio Frequency Heterogeneous Integration, Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China"],"raw_orcid":"https://orcid.org/0009-0009-5676-4820","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Radio Frequency Heterogeneous Integration, Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]},{"raw_affiliation_string":"Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China","institution_ids":["https://openalex.org/I4210104064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076383030","display_name":"Jiahan Liu","orcid":"https://orcid.org/0000-0001-5100-5336"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210104064","display_name":"Shenzhen Academy of Robotics","ror":"https://ror.org/01h027j09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210104064"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahan Liu","raw_affiliation_strings":["State Key Laboratory of Radio Frequency Heterogeneous Integration, Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0001-5100-5336","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Radio Frequency Heterogeneous Integration, Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]},{"raw_affiliation_string":"Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China","institution_ids":["https://openalex.org/I4210104064"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030129372","display_name":"Le Ou-Yang","orcid":"https://orcid.org/0000-0003-4007-4568"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210104064","display_name":"Shenzhen Academy of Robotics","ror":"https://ror.org/01h027j09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210104064"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Ou-Yang","raw_affiliation_strings":["State Key Laboratory of Radio Frequency Heterogeneous Integration, Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0003-4007-4568","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Radio Frequency Heterogeneous Integration, Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen Key Laboratory of Media Security, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), College of Electronics and Information Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]},{"raw_affiliation_string":"Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, China","institution_ids":["https://openalex.org/I4210104064"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6053,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.91041083,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"27","issue":"12","first_page":"6121","last_page":"6132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.8103222846984863},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7016972899436951},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.5305619239807129},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4824134111404419},{"id":"https://openalex.org/keywords/omics","display_name":"Omics","score":0.4773699939250946},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4624159038066864},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.37198930978775024},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35555219650268555},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2929420471191406},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13348710536956787}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.8103222846984863},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7016972899436951},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.5305619239807129},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4824134111404419},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.4773699939250946},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4624159038066864},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.37198930978775024},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35555219650268555},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2929420471191406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13348710536956787},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2023.3317272","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2023.3317272","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:37725723","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37725723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G1957408769","display_name":null,"funder_award_id":"62173235","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4434048650","display_name":null,"funder_award_id":"61602309","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5686221967","display_name":null,"funder_award_id":"2022A1515010146","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1902027874","https://openalex.org/W1977556410","https://openalex.org/W1986962710","https://openalex.org/W1987246402","https://openalex.org/W2010653277","https://openalex.org/W2066617774","https://openalex.org/W2069089843","https://openalex.org/W2069295116","https://openalex.org/W2113054345","https://openalex.org/W2117647978","https://openalex.org/W2157305458","https://openalex.org/W2169658215","https://openalex.org/W2187089797","https://openalex.org/W2222512263","https://openalex.org/W2598326928","https://openalex.org/W2624831627","https://openalex.org/W2743416243","https://openalex.org/W2752426001","https://openalex.org/W2769933977","https://openalex.org/W2800392236","https://openalex.org/W2887910040","https://openalex.org/W2895456557","https://openalex.org/W2919115771","https://openalex.org/W2923950283","https://openalex.org/W2937917790","https://openalex.org/W2951381561","https://openalex.org/W2953251392","https://openalex.org/W2979911343","https://openalex.org/W2984644935","https://openalex.org/W2985765936","https://openalex.org/W3003192283","https://openalex.org/W3009302866","https://openalex.org/W3021145032","https://openalex.org/W3029148360","https://openalex.org/W3093858607","https://openalex.org/W3138479716","https://openalex.org/W3140715906","https://openalex.org/W3164736847","https://openalex.org/W3172821627","https://openalex.org/W3173294575","https://openalex.org/W3173463846","https://openalex.org/W3175563851","https://openalex.org/W3186473305","https://openalex.org/W3200375535","https://openalex.org/W3202332579","https://openalex.org/W3213303594","https://openalex.org/W4220816080","https://openalex.org/W4225278475","https://openalex.org/W4226219101","https://openalex.org/W4281636170","https://openalex.org/W4282928095","https://openalex.org/W4283815719","https://openalex.org/W4294127637","https://openalex.org/W4312354047","https://openalex.org/W4327683140","https://openalex.org/W4379521442","https://openalex.org/W6685380521"],"related_works":["https://openalex.org/W177137871","https://openalex.org/W4292302930","https://openalex.org/W4386960635","https://openalex.org/W4298130764","https://openalex.org/W2594649246","https://openalex.org/W2804364458","https://openalex.org/W2924366642","https://openalex.org/W3184567430","https://openalex.org/W4286491824","https://openalex.org/W2955498781"],"abstract_inverted_index":{"Cell":[0],"type":[1,33],"identification":[2],"is":[3,168],"a":[4,26,60,101,108],"crucial":[5],"step":[6],"towards":[7],"the":[8,23,94,126,132,161,172,176,182,188,191,195,202,221],"study":[9],"of":[10,25,28,37,55,96,129,175,223],"cellular":[11],"heterogeneity":[12],"and":[13,85,89,131,140,143,152,194,207],"biological":[14],"processes.":[15],"Advances":[16],"in":[17],"single-cell":[18,49,56,119,217],"sequencing":[19],"technology":[20],"have":[21],"enabled":[22],"development":[24],"variety":[27],"clustering":[29,43,98,118,166,192,212],"methods":[30,39],"for":[31,42,68,77,117],"cell":[32,69,97,151],"identification.":[34],"However,":[35],"most":[36],"existing":[38,78,226],"are":[40],"designed":[41],"single":[44],"omic":[45],"data":[46,58,67,84],"such":[47],"as":[48,199,201],"RNA-sequencing":[50],"(scRNA-seq)":[51],"data.":[52,121],"The":[53],"accumulation":[54],"multi-omics":[57,83,120,218],"provides":[59],"great":[61],"opportunity":[62],"to":[63,81,92,156,170],"integrate":[64,82,125],"different":[65,148],"omics":[66,149],"clustering,":[70],"but":[71],"also":[72],"raise":[73],"new":[74,109],"computational":[75],"challenges":[76],"methods.":[79,228],"How":[80],"leverage":[86],"their":[87],"consensus":[88],"complementary":[90],"information":[91,112,128,146,203],"improve":[93],"accuracy":[95],"still":[99],"remains":[100],"challenge.":[102],"In":[103],"this":[104],"study,":[105],"we":[106],"propose":[107],"deep":[110],"multi-level":[111],"fusion":[113],"framework,":[114],"named":[115],"scMIC,":[116],"Our":[122],"model":[123],"can":[124],"attribute":[127],"cells":[130,137],"potential":[133],"structural":[134],"relationship":[135],"among":[136],"from":[138,150],"local":[139],"global":[141],"levels,":[142,154],"reduce":[144],"redundant":[145],"between":[147,190,205],"feature":[153],"leading":[155],"more":[157,210],"discriminative":[158],"representations.":[159],"Moreover,":[160],"proposed":[162],"multiple":[163],"collaborative":[164],"supervised":[165],"strategy":[167],"able":[169],"guide":[171],"learning":[173,181,197],"process":[174],"core":[177],"encoding":[178],"part":[179,193],"by":[180],"high-confidence":[183],"target":[184],"distribution,":[185],"which":[186],"facilitates":[187],"interaction":[189],"representation":[196],"part,":[198],"well":[200],"exchange":[204],"omics,":[206],"finally":[208],"obtain":[209],"robust":[211],"results.":[213],"Experiments":[214],"on":[215],"seven":[216],"datasets":[219],"show":[220],"superiority":[222],"scMIC":[224],"over":[225],"state-of-the-art":[227]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":8}],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2025-10-10T00:00:00"}