{"id":"https://openalex.org/W4377235562","doi":"https://doi.org/10.1109/jbhi.2023.3278303","title":"A Medically Assisted Model for Precise Segmentation of Osteosarcoma Nuclei on Pathological Images","display_name":"A Medically Assisted Model for Precise Segmentation of Osteosarcoma Nuclei on Pathological Images","publication_year":2023,"publication_date":"2023-05-22","ids":{"openalex":"https://openalex.org/W4377235562","doi":"https://doi.org/10.1109/jbhi.2023.3278303","pmid":"https://pubmed.ncbi.nlm.nih.gov/37216252"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2023.3278303","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2023.3278303","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108047848","display_name":"Jia Wu","orcid":"https://orcid.org/0000-0001-9013-0818"},"institutions":[{"id":"https://openalex.org/I10899854","display_name":"Jiangxi University of Traditional Chinese Medicine","ror":"https://ror.org/03jy32q83","country_code":"CN","type":"education","lineage":["https://openalex.org/I10899854"]},{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","CN"],"is_corresponding":true,"raw_author_name":"Jia Wu","raw_affiliation_strings":["School of Computer, Jiangxi University of Chinese Medicine, Nanchang, China","School of Computer Science and Engineering, Central South University, Changsha, China","Research Center for Artificial Intelligence, Monash University, Clayton, VIC, Australia"],"raw_orcid":"https://orcid.org/0000-0001-9013-0818","affiliations":[{"raw_affiliation_string":"School of Computer, Jiangxi University of Chinese Medicine, Nanchang, China","institution_ids":["https://openalex.org/I10899854"]},{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Research Center for Artificial Intelligence, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102873926","display_name":"Tingyu Yuan","orcid":"https://orcid.org/0000-0003-0895-8726"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingyu Yuan","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-0895-8726","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101541748","display_name":"Jiachen Zeng","orcid":"https://orcid.org/0000-0003-2619-7908"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiachen Zeng","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-2619-7908","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027630663","display_name":"Fangfang Gou","orcid":"https://orcid.org/0000-0003-0453-8222"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangfang Gou","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-0453-8222","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5108047848"],"corresponding_institution_ids":["https://openalex.org/I10899854","https://openalex.org/I139660479","https://openalex.org/I56590836"],"apc_list":null,"apc_paid":null,"fwci":6.3051,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.97263428,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"27","issue":"8","first_page":"3982","last_page":"3993"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7611110210418701},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6773616671562195},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6199955940246582},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5744436979293823},{"id":"https://openalex.org/keywords/sharpening","display_name":"Sharpening","score":0.49695876240730286},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.48984214663505554},{"id":"https://openalex.org/keywords/pathological","display_name":"Pathological","score":0.43780121207237244},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.4362068772315979},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.39281779527664185},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3407049775123596},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.21814337372779846}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7611110210418701},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6773616671562195},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6199955940246582},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5744436979293823},{"id":"https://openalex.org/C2781137444","wikidata":"https://www.wikidata.org/wiki/Q237105","display_name":"Sharpening","level":2,"score":0.49695876240730286},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.48984214663505554},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.43780121207237244},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.4362068772315979},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.39281779527664185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3407049775123596},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21814337372779846},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2023.3278303","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2023.3278303","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:37216252","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37216252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6399999856948853,"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure"}],"awards":[{"id":"https://openalex.org/G1193797685","display_name":null,"funder_award_id":"2023JJ30701","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G3788387963","display_name":null,"funder_award_id":"2023JJ60116","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"}],"funders":[{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1903029394","https://openalex.org/W2132162500","https://openalex.org/W2792433889","https://openalex.org/W2937975340","https://openalex.org/W2964227007","https://openalex.org/W2966434031","https://openalex.org/W2980073683","https://openalex.org/W3036052161","https://openalex.org/W3036234658","https://openalex.org/W3094502228","https://openalex.org/W3107410755","https://openalex.org/W3109301572","https://openalex.org/W4214709605","https://openalex.org/W4220663381","https://openalex.org/W4281954109","https://openalex.org/W4283274313","https://openalex.org/W4283827181","https://openalex.org/W4288277460","https://openalex.org/W4288903219","https://openalex.org/W4289667213","https://openalex.org/W4292091702","https://openalex.org/W4294974894","https://openalex.org/W4312443924","https://openalex.org/W4312726009","https://openalex.org/W4312977443","https://openalex.org/W4312983118","https://openalex.org/W4313118352","https://openalex.org/W4379744812","https://openalex.org/W4382467366","https://openalex.org/W6766844300","https://openalex.org/W6784333009","https://openalex.org/W6797784111"],"related_works":["https://openalex.org/W2329932281","https://openalex.org/W64535957","https://openalex.org/W2043790407","https://openalex.org/W2348902545","https://openalex.org/W2321247741","https://openalex.org/W2136313643","https://openalex.org/W2087564795","https://openalex.org/W2011367085","https://openalex.org/W3136545447","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Osteosarcoma":[0],"is":[1,82,129,144,152,200],"the":[2,47,62,115,135,141,147,156,159,189,195,204,212],"most":[3],"common":[4],"malignant":[5],"bone":[6],"tumor":[7],"with":[8,93],"a":[9],"high":[10],"degree":[11,136],"of":[12,54,90,117,137,158,188],"malignancy":[13],"and":[14,37,52,74,97,110,127,134,194],"misdiagnosis":[15],"rates.":[16],"Pathological":[17],"images":[18,92,171],"are":[19],"crucial":[20],"for":[21,77],"its":[22,208],"diagnosis.":[23],"However,":[24],"underdeveloped":[25,68],"regions":[26],"currently":[27],"lack":[28,53],"sufficient":[29],"high-level":[30],"pathologists,":[31],"leading":[32],"to":[33,87,113,131,155],"uncertain":[34],"diagnostic":[35],"accuracy":[36],"efficiency.":[38],"Existing":[39],"research":[40],"on":[41,165],"pathological":[42,79,170,191],"image":[43,192],"segmentation":[44,123,196],"often":[45],"neglects":[46],"differences":[48],"in":[49,64,67,140,185,211],"staining":[50],"styles":[51],"data,":[55],"without":[56],"considering":[57],"medical":[58,213],"backgrounds.":[59],"To":[60],"alleviate":[61,114],"difficulty":[63],"diagnosing":[65],"osteosarcoma":[66,78,169,190],"areas,":[69],"an":[70],"intelligent":[71],"assisted":[72],"diagnosis":[73],"treatment":[75],"scheme":[76,182],"images,":[80,133],"ENMViT,":[81],"proposed.":[83],"ENMViT":[84],"utilizes":[85],"KIN":[86],"achieve":[88],"normalization":[89],"mismatched":[91],"limited":[94],"GPU":[95],"resources":[96],"uses":[98],"traditional":[99],"data":[100],"enhancement":[101],"methods,":[102],"such":[103],"as":[104],"cleaning,":[105],"cropping,":[106],"mosaic,":[107],"Laplacian":[108],"sharpening,":[109],"other":[111],"techniques":[112],"issue":[116],"insufficient":[118],"data.":[119],"A":[120],"multi-path":[121],"semantic":[122],"network":[124],"combining":[125],"Transformer":[126],"CNN":[128],"used":[130],"segment":[132],"edge":[138],"offset":[139],"spatial":[142],"domain":[143],"introduced":[145],"into":[146],"loss":[148],"function.":[149],"Finally,":[150],"noise":[151],"filtered":[153],"according":[154],"size":[157],"connecting":[160],"domain.":[161],"This":[162],"article":[163],"experimented":[164],"more":[166],"than":[167,203],"2000":[168],"from":[172],"Central":[173],"South":[174],"University.":[175],"The":[176],"experimental":[177],"results":[178],"demonstrate":[179],"that":[180],"this":[181],"performs":[183],"well":[184],"each":[186],"stage":[187],"processing,":[193],"results'":[197],"IoU":[198],"index":[199],"9.4%":[201],"higher":[202],"comparative":[205],"models,":[206],"demonstrating":[207],"significant":[209],"value":[210],"industry.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":7}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
